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Protein

Interleukin-1 receptor-associated kinase-like 2

Gene

Irak2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.By similarity

Caution

Asn-335 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei237ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 224ATPPROSITE-ProRule annotation9
Nucleotide bindingi337 – 340ATPPROSITE-ProRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-168638 NOD1/2 Signaling Pathway
R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-RNO-450302 activated TAK1 mediates p38 MAPK activation
R-RNO-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-RNO-9020702 Interleukin-1 signaling
R-RNO-937042 IRAK2 mediated activation of TAK1 complex
R-RNO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-RNO-975155 MyD88 dependent cascade initiated on endosome
R-RNO-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase-like 2
Short name:
IRAK-2
Gene namesi
Name:Irak2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1309584 Irak2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002775621 – 624Interleukin-1 receptor-associated kinase-like 2Add BLAST624

Proteomic databases

PaxDbiQ4QQS0
PRIDEiQ4QQS0

PTM databases

iPTMnetiQ4QQS0
PhosphoSitePlusiQ4QQS0

Expressioni

Gene expression databases

BgeeiENSRNOG00000021817
GenevisibleiQ4QQS0 RN

Interactioni

Subunit structurei

Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034508

Structurei

3D structure databases

ProteinModelPortaliQ4QQS0
SMRiQ4QQS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 94DeathAdd BLAST82
Domaini210 – 475Protein kinasePROSITE-ProRule annotationAdd BLAST266

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063073
HOGENOMiHOG000113102
HOVERGENiHBG052145
InParanoidiQ4QQS0
KOiK04731
OMAiLSEWDWM
OrthoDBiEOG091G0YKT
PhylomeDBiQ4QQS0
TreeFamiTF328924

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR033611 IRAK2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PANTHERiPTHR24419:SF2 PTHR24419:SF2, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q4QQS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACYIYQLPS WVLDDLCRNI DTLSEWDWMQ FASYVITDLT QLRKIKSMER
60 70 80 90 100
VQGVSITREL LWWWSMRQAT VQQLVDLLCH LELYRAAQIV LSWKPAPDSL
110 120 130 140 150
SPLSAFPEAV KPGPVATSGR NLKDDQKKGQ PVKPCSFLSS GTTMAGAQQQ
160 170 180 190 200
ASCQRPCEED APCSLKTDVP DSLQSKYCST SIPKQEKLLN LPGDRLFWSE
210 220 230 240 250
ADIVQATEDF DQSHRISEGT FADIYRGQRN GVAFAFKRLR EVTGSSPGSM
260 270 280 290 300
DRFLQAEMQL CLRCCHPNIL PLLGFCTGRQ FHSLIYPYMA NGSLQDRLWA
310 320 330 340 350
QGDSDMLSWP QRASICSGLL LAVEHLHSLD IIHSNVKSAN VLLDQHLNPK
360 370 380 390 400
LAHPVAHPCP TNKKTKYTVM KTHLFQASAA YLPENFIRVG QLTKQVDIFS
410 420 430 440 450
CGIVLAEVLT GIPAMDKDRS PVYLKDLLLS EIPSNTSSVH SRKTSMGKVV
460 470 480 490 500
VKEICQKHLE RKAGLLPEAC AETWATAVSV CLRRREASLE EARVSMAGVE
510 520 530 540 550
EQLRGQLSLP WSRVSEDTGS SSNTPEETDD VDNSSLSVPS SVMVVSCARV
560 570 580 590 600
SSPPPSMGNG TAQPSTSGRQ EADSSSEACA GPQPPQEATE TSWKIEINEA
610 620
KRRLMENILL YKEEKLDSVE LFGP
Length:624
Mass (Da):69,237
Last modified:July 19, 2005 - v1
Checksum:iEF8995F30AB4FDD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098060 mRNA Translation: AAH98060.1
RefSeqiNP_001020593.1, NM_001025422.1
UniGeneiRn.17123

Genome annotation databases

EnsembliENSRNOT00000029819; ENSRNOP00000034508; ENSRNOG00000021817
GeneIDi362418
KEGGirno:362418
UCSCiRGD:1309584 rat

Similar proteinsi

Entry informationi

Entry nameiIRAK2_RAT
AccessioniPrimary (citable) accession number: Q4QQS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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