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Protein

Mitoguardin 1

Gene

Miga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of mitochondrial fusion (PubMed:26711011). Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • mitochondrial fusion Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Mitoguardin 1
Alternative name(s):
Protein FAM73ACurated
Gene namesi
Name:Miga1By similarity
Synonyms:Fam73aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1924567 Miga1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 32HelicalSequence analysisAdd BLAST18
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Disruption phenotypei

Mitochondrial fragmentation: mitochondria become round and show loss of cristae (PubMed:26711011). Female mice show decreased quality of oocytes (PubMed:26716412). Mice lacking both Miga1 and Miga2 show strongly reduced quality of oocytes and are subfertile (PubMed:26716412).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856471 – 600Mitoguardin 1Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4QQM5
PeptideAtlasiQ4QQM5
PRIDEiQ4QQM5

PTM databases

iPTMnetiQ4QQM5
PhosphoSitePlusiQ4QQM5

Expressioni

Gene expression databases

BgeeiENSMUSG00000054942 Expressed in 238 organ(s), highest expression level in cerebellum
CleanExiMM_C030011O14RIK
ExpressionAtlasiQ4QQM5 baseline and differential
GenevisibleiQ4QQM5 MM

Interactioni

Subunit structurei

Homodimer and heterodimer; forms heterodimers with MIGA2. Interacts with PLD6/MitoPLD.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072836

Structurei

3D structure databases

ProteinModelPortaliQ4QQM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 163Poly-Asp4

Sequence similaritiesi

Belongs to the mitoguardin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3831 Eukaryota
ENOG410Y4ER LUCA
GeneTreeiENSGT00390000008565
HOGENOMiHOG000286032
HOVERGENiHBG106606
InParanoidiQ4QQM5
OMAiCCFFKDQ
OrthoDBiEOG091G03WK
PhylomeDBiQ4QQM5
TreeFamiTF313896

Family and domain databases

InterProiView protein in InterPro
IPR019392 Miga
PANTHERiPTHR21508 PTHR21508, 1 hit
PfamiView protein in Pfam
PF10265 Miga, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4QQM5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDETVSRSQ FSLKTYAVRV FALPVSWYYS LSQIKFSPVA KKLFMVTAVS
60 70 80 90 100
AVSVIFLAHH FKRRRGKQKG KVLPWEPEHL LLEHTRRAAS EKGSSCSSSR
110 120 130 140 150
QNLTLSLSST KEKGSQCCNY PNGGLLSRYS GSAQSLGSVQ SVNSCHSCAC
160 170 180 190 200
GNSNSWDKAD DDDIRLVNIP VTTPENLYLM GMELFEEALR RWEQALTFRS
210 220 230 240 250
RQAEDEACSS VKLGAGDAIA EESVDDIISS EFIHKLEALL QRAYRLQEEF
260 270 280 290 300
EATLGGSDPN SIANDTDKDT DMSLRETMDE LGLPDAMNMD SADLFASATE
310 320 330 340 350
LAEQREAQQT FSLESFCPCP FYEEAMHLVE EGKIYSRVLR TEMLECLGDS
360 370 380 390 400
DFLAKLHCIR QAFQLILAEA DNRSFLAESG RKILSALIVK ARKNPKKFQD
410 420 430 440 450
VFDEMINFLE QTDHWDSTEL ELAARGVKNL NFYDVVLDFI LMDSFEDLEN
460 470 480 490 500
PPTSIQSVVN NRWLNSSFKE SAVASSCWSV LKQKRQQMKI SDGFFAHFYA
510 520 530 540 550
ICEHVSPVLA WGFLGPRNSL YDLCCFFKNQ VLFFLKDIFD FEKVRYSSID
560 570 580 590 600
TLAEDLTHLL IRRTELLVTC LGADALRHAT TCTSGHSHAV PTALLEAKVQ
Length:600
Mass (Da):67,536
Last modified:July 19, 2005 - v1
Checksum:iF29D8E90E4835B71
GO
Isoform 2 (identifier: Q4QQM5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     490-506: ISDGFFAHFYAICEHVS → VKLTMPQTPPQFILCGF
     507-600: Missing.

Note: No experimental confirmation available.
Show »
Length:506
Mass (Da):56,946
Checksum:i28EC872927A12A61
GO
Isoform 3 (identifier: Q4QQM5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-365: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):60,066
Checksum:iBC5275A03F249EF7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JF36A0A0G2JF36_MOUSE
Mitoguardin 1
Miga1 Fam73a
158Annotation score:
A0A0G2JE80A0A0G2JE80_MOUSE
Mitoguardin 1
Miga1 Fam73a
153Annotation score:
A0A0G2JGP3A0A0G2JGP3_MOUSE
Mitoguardin 1
Miga1 Fam73a
124Annotation score:

Sequence cautioni

The sequence BAC32059 differs from that shown. Reason: Frameshift at position 26.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321F → L in BAC39340 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024880302 – 365Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_024881490 – 506ISDGF…CEHVS → VKLTMPQTPPQFILCGF in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_024882507 – 600Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044739 mRNA Translation: BAC32059.1 Frameshift.
AK045347 mRNA Translation: BAC32322.1
AK085017 mRNA Translation: BAC39340.1
BC098205 mRNA Translation: AAH98205.1
CCDSiCCDS17916.1 [Q4QQM5-1]
CCDS51096.1 [Q4QQM5-3]
RefSeqiNP_001155847.1, NM_001162375.1 [Q4QQM5-3]
NP_777357.2, NM_174868.4 [Q4QQM5-1]
UniGeneiMm.135018

Genome annotation databases

EnsembliENSMUST00000068243; ENSMUSP00000068261; ENSMUSG00000054942 [Q4QQM5-3]
ENSMUST00000073089; ENSMUSP00000072836; ENSMUSG00000054942 [Q4QQM5-1]
ENSMUST00000199334; ENSMUSP00000143238; ENSMUSG00000054942 [Q4QQM5-2]
GeneIDi215708
KEGGimmu:215708
UCSCiuc008rte.2 mouse [Q4QQM5-1]
uc008rtf.2 mouse [Q4QQM5-2]
uc012czl.1 mouse [Q4QQM5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044739 mRNA Translation: BAC32059.1 Frameshift.
AK045347 mRNA Translation: BAC32322.1
AK085017 mRNA Translation: BAC39340.1
BC098205 mRNA Translation: AAH98205.1
CCDSiCCDS17916.1 [Q4QQM5-1]
CCDS51096.1 [Q4QQM5-3]
RefSeqiNP_001155847.1, NM_001162375.1 [Q4QQM5-3]
NP_777357.2, NM_174868.4 [Q4QQM5-1]
UniGeneiMm.135018

3D structure databases

ProteinModelPortaliQ4QQM5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072836

PTM databases

iPTMnetiQ4QQM5
PhosphoSitePlusiQ4QQM5

Proteomic databases

PaxDbiQ4QQM5
PeptideAtlasiQ4QQM5
PRIDEiQ4QQM5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068243; ENSMUSP00000068261; ENSMUSG00000054942 [Q4QQM5-3]
ENSMUST00000073089; ENSMUSP00000072836; ENSMUSG00000054942 [Q4QQM5-1]
ENSMUST00000199334; ENSMUSP00000143238; ENSMUSG00000054942 [Q4QQM5-2]
GeneIDi215708
KEGGimmu:215708
UCSCiuc008rte.2 mouse [Q4QQM5-1]
uc008rtf.2 mouse [Q4QQM5-2]
uc012czl.1 mouse [Q4QQM5-3]

Organism-specific databases

CTDi374986
MGIiMGI:1924567 Miga1

Phylogenomic databases

eggNOGiKOG3831 Eukaryota
ENOG410Y4ER LUCA
GeneTreeiENSGT00390000008565
HOGENOMiHOG000286032
HOVERGENiHBG106606
InParanoidiQ4QQM5
OMAiCCFFKDQ
OrthoDBiEOG091G03WK
PhylomeDBiQ4QQM5
TreeFamiTF313896

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA

Miscellaneous databases

ChiTaRSiFam73a mouse
PROiPR:Q4QQM5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054942 Expressed in 238 organ(s), highest expression level in cerebellum
CleanExiMM_C030011O14RIK
ExpressionAtlasiQ4QQM5 baseline and differential
GenevisibleiQ4QQM5 MM

Family and domain databases

InterProiView protein in InterPro
IPR019392 Miga
PANTHERiPTHR21508 PTHR21508, 1 hit
PfamiView protein in Pfam
PF10265 Miga, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMIGA1_MOUSE
AccessioniPrimary (citable) accession number: Q4QQM5
Secondary accession number(s): Q8BR91, Q8C3S6, Q8C8P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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