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Protein

UvrABC system protein C

Gene

uvrC

Organism
Haemophilus influenzae (strain 86-028NP)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:NTHI0067
OrganismiHaemophilus influenzae (strain 86-028NP)
Taxonomic identifieri281310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000002525 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002274351 – 609UvrABC system protein CAdd BLAST609

Proteomic databases

PRIDEiQ4QPI7

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ4QPI7
SMRiQ4QPI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 91GIY-YIGUniRule annotationAdd BLAST79
Domaini201 – 236UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000279961
KOiK03703
OMAiLFPIRQC
OrthoDBiPOG091H01BS

Family and domain databases

Gene3Di3.30.420.340, 1 hit
3.40.1440.10, 1 hit
HAMAPiMF_00203 UvrC, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004791 UvrC
IPR001162 UvrC_homol_region
IPR038476 UvrC_homol_region_sf
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF02151 UVR, 1 hit
PF08459 UvrC_HhH_N, 1 hit
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00278 HhH1, 2 hits
SUPFAMiSSF46600 SSF46600, 1 hit
SSF47781 SSF47781, 1 hit
SSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR00194 uvrC, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit
PS50151 UVR, 1 hit
PS50165 UVRC, 1 hit

Sequencei

Sequence statusi: Complete.

Q4QPI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDAKKFLAD VSHEPGVYRM YDDKDQVIYV GKAKDLKKRL SSYFRKNLSS
60 70 80 90 100
KKTEALVASI HHIDTMLTSS ETEALLLEHN FIKLYQPRYN VLLRDDKSYP
110 120 130 140 150
FILLTKERHP RITSYRGSKK FAGEYFGPYP HAGAVRETLS LLQKLFPVRQ
160 170 180 190 200
CENSVYSNRS RPCLQYQIGR CSAPCVQGYV SDEEYNQQVE LARLFLQGKD
210 220 230 240 250
QQVLDYLIGK MEQASRNLDF EQAARYRDQI QAVRSVIEKQ FVSNERLDDM
260 270 280 290 300
DIMSIAYQHG LACVQVMFIR QGKVLGNRSY FPKVPANTDL SELTETFVGQ
310 320 330 340 350
FYLQGHQGRS IPNSIIVDRQ LAEKSELEQL LTEQAGRKVT IQESVKGDKS
360 370 380 390 400
KYLQLAQVNA KAALNVQLKQ SSRMSERYQA LCDLLNLPEI KRMECFDISH
410 420 430 440 450
TMGNQTVASC VVFNQEGPLK SDYRRFNIEG ITGGDDYAAM EQALQKRYER
460 470 480 490 500
DLEEDKIPDI IFIDGGKGQL NRALNVFQHL QVKWDKNRPH LIGVAKGVDR
510 520 530 540 550
RAGQEVLIIS KQDREIHLPD DSLALHLIQH IRDESHNHAI SGHRKKRQKA
560 570 580 590 600
FTQSGLETIE GVGAKRRQAL LKYLGGLQGV KKATLDEIAS VPGISLKLAE

TIFETLKND
Length:609
Mass (Da):69,526
Last modified:July 19, 2005 - v1
Checksum:iED9C9E82BA2C728C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000057 Genomic DNA Translation: AAX87060.1
RefSeqiWP_011271801.1, NC_007146.2

Genome annotation databases

EnsemblBacteriaiAAX87060; AAX87060; NTHI0067
KEGGihit:NTHI0067

Similar proteinsi

Entry informationi

Entry nameiUVRC_HAEI8
AccessioniPrimary (citable) accession number: Q4QPI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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