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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Haemophilus influenzae (strain 86-028NP)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei605For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotationImported
Ordered Locus Names:NTHI0553Imported
OrganismiHaemophilus influenzae (strain 86-028NP)Imported
Taxonomic identifieri281310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000002525 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ4QNB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2InterPro annotationAdd BLAST217
Domaini278 – 426SISInterPro annotationAdd BLAST149
Domaini459 – 600SISInterPro annotationAdd BLAST142

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QNB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGIVGAVAQ RDVAEILING LHRLEYRGYD SAGVAVINKQ NELQRIRCLG
60 70 80 90 100
KVKALDEAVS EKPLIGGTGI AHTRWATHGE PSETNAHPHS SGTFAVVHNG
110 120 130 140 150
IIENHEELRE LLKSRGYVFL SQTDTEVIAH LVEWEMRSTD SLLEAVQKSV
160 170 180 190 200
KQLTGAYGMV VMDSRHPEHL VAARSGSPLV IGLGIGENFL ASDQLALLSV
210 220 230 240 250
TRRFIFLEEG DIAEITRRTV DIYDTHGNKA KREIHESNLE NDAAEKGKFR
260 270 280 290 300
HFMQKEIYEQ PTALINTMEG RINHENVIVD SIGNGAKGIL EKVEHIQIVA
310 320 330 340 350
CGTSYNAGMV ARYWFESLAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLAKEKGYMA ALTICNVAGS SLVRESDLAF MTRAGVEVGV
410 420 430 440 450
ASTKAFTTQL AALLMLVTAL GKVKGHISVE KEREIIKAMQ SLPAEIEKAL
460 470 480 490 500
AFDREIEALA EDFAEKHHAL FLGRGAFYPI AVEASLKLKE ISYIHAEAYA
510 520 530 540 550
AGELKHGPLA LIDADMPVIV VAPNNELLEK VKSNIEEVRA RGGQLYVFAD
560 570 580 590 600
KEAGFTPSEG MKIITMPKVN DIVAPIFYTI PMQLLSYYVA LIKGTDVDQP
610
RNLAKSVTVE
Length:610
Mass (Da):66,903
Last modified:July 19, 2005 - v1
Checksum:iBD9217337D680706
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000057 Genomic DNA Translation: AAX87481.1
RefSeqiWP_005686891.1, NC_007146.2

Genome annotation databases

EnsemblBacteriaiAAX87481; AAX87481; NTHI0553
KEGGihit:NTHI0553

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000057 Genomic DNA Translation: AAX87481.1
RefSeqiWP_005686891.1, NC_007146.2

3D structure databases

ProteinModelPortaliQ4QNB6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX87481; AAX87481; NTHI0553
KEGGihit:NTHI0553

Phylogenomic databases

HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ4QNB6_HAEI8
AccessioniPrimary (citable) accession number: Q4QNB6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: February 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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