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Protein

HTH-type transcriptional repressor PurR

Gene

purR

Organism
Haemophilus influenzae (strain 86-028NP)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.UniRule annotation

Pathwayi: purine nucleotide biosynthesis

This protein regulates the pathway purine nucleotide biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway purine nucleotide biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73CorepressorUniRule annotation1
Binding sitei188CorepressorUniRule annotation1
Binding sitei190CorepressorUniRule annotation1
Binding sitei219CorepressorUniRule annotation1
Binding sitei273CorepressorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifUniRule annotationAdd BLAST20
DNA bindingi48 – 56UniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processPurine biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

UniPathwayi
UPA00488

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor PurRUniRule annotation
Alternative name(s):
Pur regulon repressorUniRule annotation
Purine nucleotide synthesis repressorUniRule annotation
Gene namesi
Name:purRUniRule annotation
Ordered Locus Names:NTHI1404
OrganismiHaemophilus influenzae (strain 86-028NP)
Taxonomic identifieri281310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000002525 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002796601 – 336HTH-type transcriptional repressor PurRAdd BLAST336

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ4QL70
SMRiQ4QL70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 56HTH lacI-typeUniRule annotationAdd BLAST55

Domaini

Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000220180
KOiK03604
OMAiNPFFPQL
OrthoDBiPOG091H01VT

Family and domain databases

CDDicd01392 HTH_LacI, 1 hit
HAMAPiMF_01277 HTH_type_PurR, 1 hit
InterProiView protein in InterPro
IPR000843 HTH_LacI
IPR010982 Lambda_DNA-bd_dom_sf
IPR028082 Peripla_BP_I
IPR023588 Tscrpt_reg_HTH_PurR
PfamiView protein in Pfam
PF00356 LacI, 1 hit
PRINTSiPR00036 HTHLACI
SMARTiView protein in SMART
SM00354 HTH_LACI, 1 hit
SUPFAMiSSF47413 SSF47413, 1 hit
SSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00356 HTH_LACI_1, 1 hit
PS50932 HTH_LACI_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4QL70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATIKDVAKM AGVSTTTVSH VINKTRFVAK DTEEAVLSAI KQLNYSPSAV
60 70 80 90 100
ARSLKVNTTK SIGMIVTTSE APYFAEIIHS VEEHCYRQGY SLFLCNTQND
110 120 130 140 150
PEKVKNHLEM LAKKRVDGLL VMCSEYTQDS LDLLSSFSTI PMVVMDWGPN
160 170 180 190 200
ANTDVIDDHS FDGGYLATKH LIECGHKKIG IICGELNKTT ARTRYEGFEK
210 220 230 240 250
AMEEAKLTIN PSWVLEGAFE PEDGYECMNR LLTQEELPTA LFCCNDVMAL
260 270 280 290 300
GAISALTEKG LRVPEDMSII GYDDIHASRF YAPPLTTIHQ SKLRLGRQAV
310 320 330
NILLERITHK DEGVQQYSRI DITPELIIRK SVKSIL
Length:336
Mass (Da):37,469
Last modified:July 19, 2005 - v1
Checksum:iEC9E1F38098123C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000057 Genomic DNA Translation: AAX88227.1
RefSeqiWP_005660510.1, NC_007146.2

Genome annotation databases

EnsemblBacteriaiAAX88227; AAX88227; NTHI1404
KEGGihit:NTHI1404

Similar proteinsi

Entry informationi

Entry nameiPURR_HAEI8
AccessioniPrimary (citable) accession number: Q4QL70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 19, 2005
Last modified: February 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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