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UniProtKB - Q4QE15 (Q4QE15_LEIMA)
Protein
Submitted name:
Putative glycogen synthase kinase
Gene
GSK3
Organism
Leishmania major
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- signal transduction Source: GO_Central
Keywordsi
Molecular function | KinaseImported, Transferase |
Ligand | Nucleotide-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GSK3Imported ORF Names:LMJF_18_0270Imported |
Organismi | Leishmania majorImported |
Taxonomic identifieri | 5664 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Leishmaniinae › Leishmania › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | TriTrypDB:LmjF.18.0270 TriTrypDB:LMJLV39_180008100 TriTrypDB:LMJSD75_180008000 |
Subcellular locationi
Nucleus
- nuclear lumen Source: GeneDB
Other locations
- ciliary plasm Source: GeneDB
- ciliary tip Source: GeneDB
- cytoplasm Source: GO_Central
Interactioni
Protein-protein interaction databases
STRINGi | 5664.LmjF.18.0270 |
Chemistry databases
BindingDBi | Q4QE15 |
Structurei
3D structure databases
SMRi | Q4QE15 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q4QE15 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 313 | Protein kinaseInterPro annotationAdd BLAST | 294 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.ARBA annotation
Phylogenomic databases
eggNOGi | KOG0658, Eukaryota |
HOGENOMi | CLU_000288_181_20_1 |
InParanoidi | Q4QE15 |
OMAi | CLHAFFD |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4QE15-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLNAAAAAD ERSRKEMDRF QVERMAGQGT FGTVQLGKEK STGMSVAIKK
60 70 80 90 100
VIQDPRFRNR ELQIMQDLAV LHHPNIVQLQ SYFYTLGERD RRDIYLNVVM
110 120 130 140 150
EYVPDTLHRC CRNYYRRQVA PPPILIKVFL FQLIRSIGCL HLPSVNVCHR
160 170 180 190 200
DIKPHNVLVN EADGTLKLCD FGSAKKLSPS EPNVAYICSR YYRAPELIFG
210 220 230 240 250
NQHYTTAVDI WSVGCIFAEM MLGEPIFRGD NSAGQLHEIV RVLGCPSREV
260 270 280 290 300
LRKLNPSHTD VDLYNSKGIP WSNVFSDHSL KDAKEAYDLL SALLQYLPEE
310 320 330 340 350
RMKPYEALCH PYFDELHDPA TKLPNNKDLP EDLFRFLPNE IEVMSEAQKA
KLVRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR796414 Genomic DNA Translation: CAJ03501.1 |
RefSeqi | XP_001682433.1, XM_001682381.1 |
Genome annotation databases
EnsemblProtistsi | CAJ03501; CAJ03501; LMJF_18_0270 |
GeneIDi | 5650907 |
KEGGi | lma:LMJF_18_0270 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR796414 Genomic DNA Translation: CAJ03501.1 |
RefSeqi | XP_001682433.1, XM_001682381.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3E3P | X-ray | 2.00 | A/B | 1-355 | [»] | |
SMRi | Q4QE15 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 5664.LmjF.18.0270 |
Chemistry databases
BindingDBi | Q4QE15 |
ChEMBLi | CHEMBL2311227 |
Genome annotation databases
EnsemblProtistsi | CAJ03501; CAJ03501; LMJF_18_0270 |
GeneIDi | 5650907 |
KEGGi | lma:LMJF_18_0270 |
Organism-specific databases
VEuPathDBi | TriTrypDB:LmjF.18.0270 TriTrypDB:LMJLV39_180008100 TriTrypDB:LMJSD75_180008000 |
Phylogenomic databases
eggNOGi | KOG0658, Eukaryota |
HOGENOMi | CLU_000288_181_20_1 |
InParanoidi | Q4QE15 |
OMAi | CLHAFFD |
Miscellaneous databases
EvolutionaryTracei | Q4QE15 |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4QE15_LEIMA | |
Accessioni | Q4QE15Primary (citable) accession number: Q4QE15 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | May 25, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |