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Protein

Phosphoglycerate kinase

Gene

PGKC

Organism
Leishmania major
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (LMJF_30_2980), Glyceraldehyde-3-phosphate dehydrogenase (LMJF_30_2970)
  2. Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase, cytosolic (PGKB), Phosphoglycerate kinase (LMJF_30_3380), Phosphoglycerate kinase, glycosomal (PGKC), Phosphoglycerate kinase (PGKC), Phosphoglycerate kinase (PGKB)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase (LMJF_35_0020), Pyruvate kinase (LMJF_35_0030)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Binding sitei220ATPUniRule annotation1
Binding sitei342ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi372 – 375ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:PGKCImported
ORF Names:LMJF_20_0100Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000000542 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.20.0100

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei446 – 469HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi5664.LmjF.20.0100

Structurei

3D structure databases

ProteinModelPortaliQ4QD34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingUniRule annotation3
Regioni62 – 65Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1367 Eukaryota
COG0126 LUCA
HOGENOMiHOG000227107
InParanoidiQ4QD34
KOiK00927
OMAiYFVMDAF

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR027250 Pgk_euglenozoa
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PIRSF500126 Pgk_euglenozoa, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q4QD34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVLKKSID DATVRDKKVL IRVDFNVPVK NGKITNDFRI RSALPTIQKV
60 70 80 90 100
LKEGGSCILM SHLGRPKGAR MSDPSPEKGV RGYEEAATLR PVAARIAELL
110 120 130 140 150
GQKVEFAPDC LDAAAYASKL KNGDVLLLEN VRFYAEEGSK KEEERDAMAK
160 170 180 190 200
VLASYADLYV SDAFGTAHRD SATMTGIPKV LGAGYAGYLM EKEINYFSRV
210 220 230 240 250
LNNPPRPLVA IVGGAKVSDK IELLDNMLSR INYLVIGGAM AYTFQKAQGR
260 270 280 290 300
KIGISMCEED KLDLAKSLLK KAQERGVQVF LPVDHVCNKE FKAADSPLVT
310 320 330 340 350
ESVDVPDGYM ALDIGPRTIH MYEEVIGRCK SAIWNGPMGV FEMPCYSKGT
360 370 380 390 400
FAVAKAMGTG TQKNGLLSII GGGDSASAAE LSGEAKNMSH VSTGGGASLE
410 420 430 440 450
LLEGKTLPGV AILTDKDVKE RGASCRFAFG VGSPSREACP LRCGHIFGGA
460 470
SIVREIVKLV VALLIGIFIG RRMSTKLIR
Length:479
Mass (Da):51,542
Last modified:July 19, 2005 - v1
Checksum:i90564DD2F8ECBC8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796416 Genomic DNA Translation: CAJ03528.1
RefSeqiXP_001682764.1, XM_001682712.1

Genome annotation databases

EnsemblProtistsiLmjF.20.0100:mRNA; LmjF.20.0100:pep; LmjF.20.0100
GeneDBiLmjF.20.0100:pep
GeneIDi5651282
KEGGilma:LMJF_20_0100

Similar proteinsi

Entry informationi

Entry nameiQ4QD34_LEIMA
AccessioniPrimary (citable) accession number: Q4QD34
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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