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Entry version 106 (29 Sep 2021)
Sequence version 1 (19 Jul 2005)
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Protein

DNA-directed RNA polymerase subunit beta

Gene

LMJF_25_0620

Organism
Leishmania major
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationARBA annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LMJF_25_0620Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania majorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5664 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiscobaEuglenozoaKinetoplasteaMetakinetoplastinaTrypanosomatidaTrypanosomatidaeLeishmaniinaeLeishmania
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000542 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
TriTrypDB:LmjF.25.0620
TriTrypDB:LMJLV39_250012100
TriTrypDB:LMJSD75_250012000

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationARBA annotation, NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5664.LmjF.25.0620

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini467 – 785RNA_pol_Rpb2_1InterPro annotationAdd BLAST319
Domaini859 – 920RNA_pol_Rpb2_3InterPro annotationAdd BLAST62
Domaini972 – 1042RNA_pol_Rpa2_4InterPro annotationAdd BLAST71
Domaini1108 – 1506RNA_pol_Rpb2_6InterPro annotationAdd BLAST399
Domaini1508 – 1608RNA_pol_Rpb2_7InterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 35Polar residuesSequence analysisAdd BLAST35

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0216, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_244489_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4QA33

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00653, RNA_pol_B_RPB2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.270.10, 1 hit
2.40.50.150, 1 hit
3.90.1110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR037033, DNA-dir_RNAP_su2_hyb_sf
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR037034, RNA_pol_Rpb2_2_sf
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR014724, RNA_pol_RPB2_OB-fold
IPR009674, Rpa2_dom_4

The PANTHER Classification System

More...
PANTHERi
PTHR20856, PTHR20856, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06883, RNA_pol_Rpa2_4, 1 hit
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04565, RNA_pol_Rpb2_3, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4QA33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRSSHYSA KSLSSSAGES MVTSHSTGSS SRHRRTGTVC IHEPRAPPMK
60 70 80 90 100
MTAMELLQHI RNSITRLKYI CERQYHTAAL DQASEVAVTS FFERLRKKLS
110 120 130 140 150
KLEFSRSHIG TPETGGPQQL KYIAKEARQL MSTAQEVVRD TANTSVTATC
160 170 180 190 200
VYEGMQHHHM QEAMAELEEL SALLAERPNE QPSRVSVDLL ADLVAFHIDE
210 220 230 240 250
FDAFMALRVE AFVREMQSEG AFYTGPVMTD ASQKATPVGV CSAVLLDVAV
260 270 280 290 300
GVRPARSARI VLEHARHQIS KVENRLHAAD IALQECQLAG EVAAEGQQRQ
310 320 330 340 350
RAEVQRREFT IMKERIRHAL RQLDRVQQAW LEEEQSIFTR AASGSHDLAA
360 370 380 390 400
LMQTKHLHEA EVIEEVQRLH DQTIHACLPF ATPQYHRRYG ETYGQPCHVR
410 420 430 440 450
LGFHFLPDAN TAAEMAAAAG STNAAAPSSL MLRTLSTEYF ALMRQLRVAP
460 470 480 490 500
VDYDTYDYLV PSKEQFWVNF ASFPEMVKGA RCALRNVDAR LDHFRALEEQ
510 520 530 540 550
KEVGGYFIMN GGERILRALL MQRCNVPINI YREKFVTQGP HFSAKAVVIR
560 570 580 590 600
CKRPSGLTAQ NYFYYTTQGE VIFSFARKVV WHLPAPLLLN AMSTQSVSAV
610 620 630 640 650
ELQRLLTIGM PDGNHVARVE ALLQHHRRKP YGDLRHFIDY ITVLGRMYRE
660 670 680 690 700
YHQNSSTFHF LPLYAKGSTC QHDAWYGMFM VRRHVLPHLN SCDVATPDLA
710 720 730 740 750
PDATAQKLLA WLSPALLAEL DRKFDAMIAI TRQLYLFIDG AVEHQGNDVP
760 770 780 790 800
AYQELFTVSQ VLMGAFEVCL NRYMRGFVYR LARHLPAALF RRILSLRTLL
810 820 830 840 850
PPVDAEDTMR QVRQFAEFCG RHGGSDPLDQ LARLLVTGNI NLDREEDFYC
860 870 880 890 900
PQTSGWVVMA EHLNFYRFFE QLRCVHRGKT IADMRSSEVR KYPCEAYGFI
910 920 930 940 950
CMVQSPDGED CGVLNHLSVS TISSNSPDAA MTAQLREIVR KAVPGVRSRA
960 970 980 990 1000
TLSTVVDQLC ETVPVWMEGE LLGYLSPADA VEAAATLRER KALTLRSQVH
1010 1020 1030 1040 1050
VTGIVRRKDA SPLHTLEVVY VAPKSKDPAG LYVFYDCGRL MRPVQRLESS
1060 1070 1080 1090 1100
VRKDATHLPF PLVFIGTWEQ SWLDIAAVPS DPLDAVVQLN RKYEYMEQNG
1110 1120 1130 1140 1150
TNLISLTSAT IPFFEHNCSP RNLFQCGLSK QSSGTQLQAL AWRKEAKLFR
1160 1170 1180 1190 1200
TYCPQRYISR TLPMDYYGLD DVNLGVNAVI AILAYTGYDM DDAVIINSTA
1210 1220 1230 1240 1250
AQRGMLTAGV TVAKIVTASG KGSDKDDVFV FHNLLSTGER FTAELEANGL
1260 1270 1280 1290 1300
PPKRANASLD AFSFDRDHKY PGLRDNNDVY CCAKRVERVD PFTNKAVYEY
1310 1320 1330 1340 1350
TRHHATKWRH FDKGEDAWVQ QVIPLVYSGP DPTSVLMIFR IPRPPTVGDK
1360 1370 1380 1390 1400
FSSRHGQKGT LPLHIRSHDL PFATASGITP DVIINPHAFP SRMTVGMVLE
1410 1420 1430 1440 1450
IMTAKVGAIE GRFIDNSAWS TVDEQPRVAE LIGEALVKAG YNRYGREHLI
1460 1470 1480 1490 1500
DGISGEEMKA DVFMGICGYQ RLRHMVSDKW QARARTDAHT YRAVTKTGQP
1510 1520 1530 1540 1550
VKGRKRHGGV RVGEMERDGL LSHGISEVVV DRLLHVSDKT KAFICPRCGS
1560 1570 1580 1590 1600
LLSLYERHAT EYGTWRTCRF CGAGADESTD SIAMVEIPQV LRLWAAELTS
1610
IGIRVVLKTS ELSDFV
Length:1,616
Mass (Da):181,596
Last modified:July 19, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3BBE7334B64B69B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR796421 Genomic DNA Translation: CAJ04831.1

NCBI Reference Sequences

More...
RefSeqi
XP_001683815.1, XM_001683763.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAJ04831; CAJ04831; LMJF_25_0620

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LmjF.25.0620:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5652471

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lma:LMJF_25_0620

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796421 Genomic DNA Translation: CAJ04831.1
RefSeqiXP_001683815.1, XM_001683763.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5664.LmjF.25.0620

Genome annotation databases

EnsemblProtistsiCAJ04831; CAJ04831; LMJF_25_0620
GeneDBiLmjF.25.0620:pep
GeneIDi5652471
KEGGilma:LMJF_25_0620

Organism-specific databases

VEuPathDBiTriTrypDB:LmjF.25.0620
TriTrypDB:LMJLV39_250012100
TriTrypDB:LMJSD75_250012000

Phylogenomic databases

eggNOGiKOG0216, Eukaryota
HOGENOMiCLU_244489_0_0_1
InParanoidiQ4QA33

Family and domain databases

CDDicd00653, RNA_pol_B_RPB2, 1 hit
Gene3Di2.40.270.10, 1 hit
2.40.50.150, 1 hit
3.90.1110.10, 1 hit
InterProiView protein in InterPro
IPR015712, DNA-dir_RNA_pol_su2
IPR007120, DNA-dir_RNAP_su2_dom
IPR037033, DNA-dir_RNAP_su2_hyb_sf
IPR007121, RNA_pol_bsu_CS
IPR007644, RNA_pol_bsu_protrusion
IPR037034, RNA_pol_Rpb2_2_sf
IPR007645, RNA_pol_Rpb2_3
IPR007641, RNA_pol_Rpb2_7
IPR014724, RNA_pol_RPB2_OB-fold
IPR009674, Rpa2_dom_4
PANTHERiPTHR20856, PTHR20856, 1 hit
PfamiView protein in Pfam
PF06883, RNA_pol_Rpa2_4, 1 hit
PF04563, RNA_pol_Rpb2_1, 1 hit
PF04565, RNA_pol_Rpb2_3, 1 hit
PF00562, RNA_pol_Rpb2_6, 1 hit
PF04560, RNA_pol_Rpb2_7, 1 hit
PROSITEiView protein in PROSITE
PS01166, RNA_POL_BETA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4QA33_LEIMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4QA33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 29, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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