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UniProtKB - Q4Q5S8 (Q4Q5S8_LEIMA)

Entry version 113 (19 Jan 2022)
Sequence version 1 (19 Jul 2005)
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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

NMT

Organism
Leishmania major
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferaseUniRule annotationARBA annotation, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.97, 2950

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q4Q5S8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferaseUniRule annotationARBA annotation (EC:2.3.1.97UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NMTImported
ORF Names:LMJF_32_0080Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania majorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5664 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Leishmaniinae › Leishmania ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000542 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 32

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		TriTrypDB:LmjF.32.0080
TriTrypDB:LMJLV39_320005800
TriTrypDB:LMJSD75_320005800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1949483

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		5664.LmjF.32.0080

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q4Q5S8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4Q5S8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q4Q5S8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 213NMTInterPro annotationAdd BLAST179
Domaini229 – 412NMT_CInterPro annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni14 – 15Coenzyme A bindingCombined sources2
Regioni169 – 171Coenzyme A bindingCombined sources3
Regioni177 – 181Coenzyme A bindingCombined sources5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 24Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NMT family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2779, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022882_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4Q5S8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR000903, MyristoylCoA_TrFase
IPR022677, MyristoylCoA_TrFase_C
IPR022678, MyristoylCoA_TrFase_CS
IPR022676, MyristoylCoA_TrFase_N

The PANTHER Classification System

More...PANTHERi		PTHR11377, PTHR11377, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01233, NMT, 1 hit
PF02799, NMT_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF015892, N-myristl_transf, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55729, SSF55729, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00975, NMT_1, 1 hit
PS00976, NMT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4Q5S8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRNPSNSDA AHAFWSTQPV PQTEDETEKI VFAGPMDEPK TVADIPEEPY 
        60         70         80         90        100
PIASTFEWWT PNMEAADDIH AIYELLRDNY VEDDDSMFRF NYSEEFLQWA 
       110        120        130        140        150
LCPPNYIPDW HVAVRRKADK KLLAFIAGVP VTLRMGTPKY MKVKAQEKGE 
       160        170        180        190        200
GEEAAKYDEP RHICEINFLC VHKQLREKRL APILIKEATR RVNRTNVWQA 
       210        220        230        240        250
VYTAGVLLPT PYASGQYFHR SLNPEKLVEI RFSGIPAQYQ KFQNPMAMLK 
       260        270        280        290        300
RNYQLPSAPK NSGLREMKPS DVPQVRRILM NYLDSFDVGP VFSDAEISHY 
       310        320        330        340        350
LLPRDGVVFT YVVENDKKVT DFFSFYRIPS TVIGNSNYNL LNAAYVHYYA 
       360        370        380        390        400
ATSIPLHQLI LDLLIVAHSR GFDVCNMVEI LDNRSFVEQL KFGAGDGHLR 
       410        420 
YYFYNWAYPK IKPSQVALVM L
Length:421
Mass (Da):48,514
Last modified:July 19, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE29E51E961B90B44
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FR796428 Genomic DNA Translation: CAJ08448.1

NCBI Reference Sequences

More...RefSeqi		XP_001685320.1, XM_001685268.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		CAJ08448; CAJ08448; LMJF_32_0080

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5656116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		lma:LMJF_32_0080

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796428 Genomic DNA Translation: CAJ08448.1
RefSeqiXP_001685320.1, XM_001685268.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WSAX-ray1.60A3-421[»]
3H5ZX-ray1.49A5-421[»]
4A2ZX-ray2.31A5-421[»]
4A30X-ray1.50A5-421[»]
4A31X-ray2.09A5-421[»]
4A32X-ray2.20A5-421[»]
4A33X-ray2.40A5-421[»]
4C7HX-ray1.40A11-421[»]
4C7IX-ray1.30A11-421[»]
4CGLX-ray1.48A11-421[»]
4CGMX-ray1.70A11-421[»]
4CGNX-ray1.69A11-421[»]
4CGOX-ray1.30A11-421[»]
4CGPX-ray1.40A11-421[»]
4CYNX-ray1.40A11-421[»]
4CYOX-ray1.50A11-421[»]
4CYPX-ray1.55A11-421[»]
4CYQX-ray1.65A11-421[»]
4UCMX-ray2.32A5-421[»]
4UCNX-ray1.80A5-421[»]
4UCPX-ray1.50A4-421[»]
5A27X-ray1.37A11-421[»]
5A28X-ray1.48A11-421[»]
5AG4X-ray1.99A5-421[»]
5AG5X-ray2.00A5-421[»]
5AG6X-ray2.00A5-421[»]
5AG7X-ray2.60A5-421[»]
5AGEX-ray2.00A5-421[»]
5G20X-ray1.52A11-421[»]
5G21X-ray1.50A11-421[»]
6EU5X-ray1.50A5-421[»]
6EWFX-ray1.54A5-421[»]
6GNHX-ray1.89A5-421[»]
6GNSX-ray1.80A11-421[»]
6GNTX-ray1.60A11-421[»]
6GNUX-ray1.54A5-421[»]
6GNVX-ray2.20A11-421[»]
6QD9X-ray1.46A1-421[»]
6QDAX-ray1.60A1-421[»]
6QDBX-ray1.40A1-421[»]
6QDCX-ray1.40A1-421[»]
6QDDX-ray1.65A1-421[»]
6QDEX-ray1.45A1-421[»]
6QDFX-ray1.49A1-421[»]
6QDGX-ray1.98A1-421[»]
6QDHX-ray1.45A1-421[»]
6TW7X-ray1.40AAA4-421[»]
6TW8X-ray1.79AAA/CCC4-421[»]
SMRiQ4Q5S8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.32.0080

Chemistry databases

BindingDBiQ4Q5S8
ChEMBLiCHEMBL1949483

Genome annotation databases

EnsemblProtistsiCAJ08448; CAJ08448; LMJF_32_0080
GeneIDi5656116
KEGGilma:LMJF_32_0080

Organism-specific databases

VEuPathDBiTriTrypDB:LmjF.32.0080
TriTrypDB:LMJLV39_320005800
TriTrypDB:LMJSD75_320005800

Phylogenomic databases

eggNOGiKOG2779, Eukaryota
HOGENOMiCLU_022882_1_0_1
InParanoidiQ4Q5S8

Enzyme and pathway databases

BRENDAi2.3.1.97, 2950
SABIO-RKiQ4Q5S8

Miscellaneous databases

EvolutionaryTraceiQ4Q5S8

Family and domain databases

InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR000903, MyristoylCoA_TrFase
IPR022677, MyristoylCoA_TrFase_C
IPR022678, MyristoylCoA_TrFase_CS
IPR022676, MyristoylCoA_TrFase_N
PANTHERiPTHR11377, PTHR11377, 1 hit
PfamiView protein in Pfam
PF01233, NMT, 1 hit
PF02799, NMT_C, 1 hit
PIRSFiPIRSF015892, N-myristl_transf, 1 hit
SUPFAMiSSF55729, SSF55729, 2 hits
PROSITEiView protein in PROSITE
PS00975, NMT_1, 1 hit
PS00976, NMT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4Q5S8_LEIMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4Q5S8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: January 19, 2022
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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