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UniProtKB - Q4Q5S8 (Q4Q5S8_LEIMA)
Protein
Glycylpeptide N-tetradecanoyltransferase
Gene
NMT
Organism
Leishmania major
Status
Functioni
Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
UniRule annotationCatalytic activityi
- N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H+ + N-tetradecanoylglycyl-[protein]UniRule annotationARBA annotationEC:2.3.1.97UniRule annotationARBA annotation
GO - Molecular functioni
- glycylpeptide N-tetradecanoyltransferase activity Source: GO_Central
GO - Biological processi
- N-terminal peptidyl-glycine N-myristoylation Source: GO_Central
Keywordsi
Molecular function | AcyltransferaseUniRule annotationARBA annotation, Transferase |
Enzyme and pathway databases
BRENDAi | 2.3.1.97, 2950 |
SABIO-RKi | Q4Q5S8 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycylpeptide N-tetradecanoyltransferaseUniRule annotationARBA annotation (EC:2.3.1.97UniRule annotationARBA annotation) |
Gene namesi | Name:NMTImported ORF Names:LMJF_32_0080Imported |
Organismi | Leishmania majorImported |
Taxonomic identifieri | 5664 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Leishmaniinae › Leishmania › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | TriTrypDB:LmjF.32.0080 TriTrypDB:LMJLV39_320005800 TriTrypDB:LMJSD75_320005800 |
Interactioni
Protein-protein interaction databases
STRINGi | 5664.LmjF.32.0080 |
Chemistry databases
BindingDBi | Q4Q5S8 |
Structurei
3D structure databases
SMRi | Q4Q5S8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q4Q5S8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 213 | NMTInterPro annotationAdd BLAST | 179 | |
Domaini | 229 – 412 | NMT_CInterPro annotationAdd BLAST | 184 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 14 – 15 | Coenzyme A bindingCombined sources | 2 | |
Regioni | 169 – 171 | Coenzyme A bindingCombined sources | 3 | |
Regioni | 177 – 181 | Coenzyme A bindingCombined sources | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 24 | Polar residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2779, Eukaryota |
HOGENOMi | CLU_022882_1_0_1 |
InParanoidi | Q4Q5S8 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000903, MyristoylCoA_TrFase IPR022677, MyristoylCoA_TrFase_C IPR022678, MyristoylCoA_TrFase_CS IPR022676, MyristoylCoA_TrFase_N |
PANTHERi | PTHR11377, PTHR11377, 1 hit |
Pfami | View protein in Pfam PF01233, NMT, 1 hit PF02799, NMT_C, 1 hit |
PIRSFi | PIRSF015892, N-myristl_transf, 1 hit |
SUPFAMi | SSF55729, SSF55729, 2 hits |
PROSITEi | View protein in PROSITE PS00975, NMT_1, 1 hit PS00976, NMT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4Q5S8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRNPSNSDA AHAFWSTQPV PQTEDETEKI VFAGPMDEPK TVADIPEEPY
60 70 80 90 100
PIASTFEWWT PNMEAADDIH AIYELLRDNY VEDDDSMFRF NYSEEFLQWA
110 120 130 140 150
LCPPNYIPDW HVAVRRKADK KLLAFIAGVP VTLRMGTPKY MKVKAQEKGE
160 170 180 190 200
GEEAAKYDEP RHICEINFLC VHKQLREKRL APILIKEATR RVNRTNVWQA
210 220 230 240 250
VYTAGVLLPT PYASGQYFHR SLNPEKLVEI RFSGIPAQYQ KFQNPMAMLK
260 270 280 290 300
RNYQLPSAPK NSGLREMKPS DVPQVRRILM NYLDSFDVGP VFSDAEISHY
310 320 330 340 350
LLPRDGVVFT YVVENDKKVT DFFSFYRIPS TVIGNSNYNL LNAAYVHYYA
360 370 380 390 400
ATSIPLHQLI LDLLIVAHSR GFDVCNMVEI LDNRSFVEQL KFGAGDGHLR
410 420
YYFYNWAYPK IKPSQVALVM L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR796428 Genomic DNA Translation: CAJ08448.1 |
RefSeqi | XP_001685320.1, XM_001685268.1 |
Genome annotation databases
EnsemblProtistsi | CAJ08448; CAJ08448; LMJF_32_0080 |
GeneIDi | 5656116 |
KEGGi | lma:LMJF_32_0080 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR796428 Genomic DNA Translation: CAJ08448.1 |
RefSeqi | XP_001685320.1, XM_001685268.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WSA | X-ray | 1.60 | A | 3-421 | [»] | |
3H5Z | X-ray | 1.49 | A | 5-421 | [»] | |
4A2Z | X-ray | 2.31 | A | 5-421 | [»] | |
4A30 | X-ray | 1.50 | A | 5-421 | [»] | |
4A31 | X-ray | 2.09 | A | 5-421 | [»] | |
4A32 | X-ray | 2.20 | A | 5-421 | [»] | |
4A33 | X-ray | 2.40 | A | 5-421 | [»] | |
4C7H | X-ray | 1.40 | A | 11-421 | [»] | |
4C7I | X-ray | 1.30 | A | 11-421 | [»] | |
4CGL | X-ray | 1.48 | A | 11-421 | [»] | |
4CGM | X-ray | 1.70 | A | 11-421 | [»] | |
4CGN | X-ray | 1.69 | A | 11-421 | [»] | |
4CGO | X-ray | 1.30 | A | 11-421 | [»] | |
4CGP | X-ray | 1.40 | A | 11-421 | [»] | |
4CYN | X-ray | 1.40 | A | 11-421 | [»] | |
4CYO | X-ray | 1.50 | A | 11-421 | [»] | |
4CYP | X-ray | 1.55 | A | 11-421 | [»] | |
4CYQ | X-ray | 1.65 | A | 11-421 | [»] | |
4UCM | X-ray | 2.32 | A | 5-421 | [»] | |
4UCN | X-ray | 1.80 | A | 5-421 | [»] | |
4UCP | X-ray | 1.50 | A | 4-421 | [»] | |
5A27 | X-ray | 1.37 | A | 11-421 | [»] | |
5A28 | X-ray | 1.48 | A | 11-421 | [»] | |
5AG4 | X-ray | 1.99 | A | 5-421 | [»] | |
5AG5 | X-ray | 2.00 | A | 5-421 | [»] | |
5AG6 | X-ray | 2.00 | A | 5-421 | [»] | |
5AG7 | X-ray | 2.60 | A | 5-421 | [»] | |
5AGE | X-ray | 2.00 | A | 5-421 | [»] | |
5G20 | X-ray | 1.52 | A | 11-421 | [»] | |
5G21 | X-ray | 1.50 | A | 11-421 | [»] | |
6EU5 | X-ray | 1.50 | A | 5-421 | [»] | |
6EWF | X-ray | 1.54 | A | 5-421 | [»] | |
6GNH | X-ray | 1.89 | A | 5-421 | [»] | |
6GNS | X-ray | 1.80 | A | 11-421 | [»] | |
6GNT | X-ray | 1.60 | A | 11-421 | [»] | |
6GNU | X-ray | 1.54 | A | 5-421 | [»] | |
6GNV | X-ray | 2.20 | A | 11-421 | [»] | |
6QD9 | X-ray | 1.46 | A | 1-421 | [»] | |
6QDA | X-ray | 1.60 | A | 1-421 | [»] | |
6QDB | X-ray | 1.40 | A | 1-421 | [»] | |
6QDC | X-ray | 1.40 | A | 1-421 | [»] | |
6QDD | X-ray | 1.65 | A | 1-421 | [»] | |
6QDE | X-ray | 1.45 | A | 1-421 | [»] | |
6QDF | X-ray | 1.49 | A | 1-421 | [»] | |
6QDG | X-ray | 1.98 | A | 1-421 | [»] | |
6QDH | X-ray | 1.45 | A | 1-421 | [»] | |
6TW7 | X-ray | 1.40 | AAA | 4-421 | [»] | |
6TW8 | X-ray | 1.79 | AAA/CCC | 4-421 | [»] | |
SMRi | Q4Q5S8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 5664.LmjF.32.0080 |
Chemistry databases
BindingDBi | Q4Q5S8 |
ChEMBLi | CHEMBL1949483 |
Genome annotation databases
EnsemblProtistsi | CAJ08448; CAJ08448; LMJF_32_0080 |
GeneIDi | 5656116 |
KEGGi | lma:LMJF_32_0080 |
Organism-specific databases
VEuPathDBi | TriTrypDB:LmjF.32.0080 TriTrypDB:LMJLV39_320005800 TriTrypDB:LMJSD75_320005800 |
Phylogenomic databases
eggNOGi | KOG2779, Eukaryota |
HOGENOMi | CLU_022882_1_0_1 |
InParanoidi | Q4Q5S8 |
Enzyme and pathway databases
BRENDAi | 2.3.1.97, 2950 |
SABIO-RKi | Q4Q5S8 |
Miscellaneous databases
EvolutionaryTracei | Q4Q5S8 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000903, MyristoylCoA_TrFase IPR022677, MyristoylCoA_TrFase_C IPR022678, MyristoylCoA_TrFase_CS IPR022676, MyristoylCoA_TrFase_N |
PANTHERi | PTHR11377, PTHR11377, 1 hit |
Pfami | View protein in Pfam PF01233, NMT, 1 hit PF02799, NMT_C, 1 hit |
PIRSFi | PIRSF015892, N-myristl_transf, 1 hit |
SUPFAMi | SSF55729, SSF55729, 2 hits |
PROSITEi | View protein in PROSITE PS00975, NMT_1, 1 hit PS00976, NMT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4Q5S8_LEIMA | |
Accessioni | Q4Q5S8Primary (citable) accession number: Q4Q5S8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | January 19, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |