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Entry version 70 (05 Jun 2019)
Sequence version 1 (19 Jul 2005)
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Protein
Submitted name:

Uncharacterized protein

Gene

LMJF_32_0970

Organism
Leishmania major
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LMJF_32_0970Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania majorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5664 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000542 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 32

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TriTrypDB:LmjF.32.0970

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini299 – 412Calpain catalyticInterPro annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni50 – 76DisorderedSequence analysisAdd BLAST27
Regioni456 – 527DisorderedSequence analysisAdd BLAST72
Regioni719 – 773DisorderedSequence analysisAdd BLAST55
Regioni985 – 1051DisorderedSequence analysisAdd BLAST67
Regioni1139 – 1163DisorderedSequence analysisAdd BLAST25
Regioni1409 – 1478DisorderedSequence analysisAdd BLAST70
Regioni1610 – 1687DisorderedSequence analysisAdd BLAST78
Regioni1716 – 1774DisorderedSequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi500 – 514PolarSequence analysisAdd BLAST15
Compositional biasi723 – 740PolarSequence analysisAdd BLAST18
Compositional biasi986 – 1000PolarSequence analysisAdd BLAST15
Compositional biasi1149 – 1163PolarSequence analysisAdd BLAST15
Compositional biasi1428 – 1443PolarSequence analysisAdd BLAST16
Compositional biasi1610 – 1641PolarSequence analysisAdd BLAST32
Compositional biasi1656 – 1673PolarSequence analysisAdd BLAST18
Compositional biasi1742 – 1774PolarSequence analysisAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J7ZR Eukaryota
ENOG410XPG8 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000259644

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4Q5I5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00648 Peptidase_C2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4Q5I5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSKASSVPS RAALPVACSS FVNNRFCSLP LWDDAQVAQE NWGGPLAVSV
60 70 80 90 100
PSGGGDGGKE AKQALSKAKT LTGGRNAPTC AGEAHFEDEA TRHSVEAFIA
110 120 130 140 150
LLGPPLQSDA EAGQVCDGSS PDKVTWLRPA EVFSPFRPVV HRNVTPFVNP
160 170 180 190 200
YATAEALVPV DAKAEEDRCE ELLSAAACNA SSSTGHRKSA GLARQSDVAT
210 220 230 240 250
PEPQAFHLLY PETISVLDTF SHEERGLWSN CTPTESVRRY RALPSLMQPY
260 270 280 290 300
DGALIAGCAE TPAQACESRY STSLRHKLKQ AEQLAALTKA PPFLMSAFNS
310 320 330 340 350
ALLAVEQAQR YVPEGWYLWE LVYPHAPGTC HPVYNPFGKY AVKLFVDGAY
360 370 380 390 400
RKVLVDDCLP VDVLGRPLLS TTSRKELWPC LIAKAVLKAL GAVSGVQALT
410 420 430 440 450
SSPELIVATL LGNWVPQYLS PRHNAVSATA LLLLYQRQLT QLESLAEPFV
460 470 480 490 500
KESIGSAAGH GGADSAGDVT RKDRKSSARG HHVSVVASPP KRTPANGADK
510 520 530 540 550
PSVRRQQNSR SSGVSGGEKE EEGALKPLRA TEYCEPVMDE PLPEQPFYVC
560 570 580 590 600
GLHAPPAEAL KSEAARTARG GYGFGPQLYT IHAMRPFRNT VALLLHTTPR
610 620 630 640 650
ACLSEGIFEE DRDADDVSAL HDWSSRTARR GAQAAGAMKP PRVLDGVAPA
660 670 680 690 700
DANAAQGDPT PITDMVVMDS DRAASVTSCW LTLEEFILRM DTIIVWRKLT
710 720 730 740 750
GRYTNAVSVS GESLLRHQGH VSATGDNGPS DSSSSAASRR KSPPARRGET
760 770 780 790 800
ATTAAAASGA TTQPPTPSPP SSMWWKLTAE KAVEAVVIVS SPALTEAVGR
810 820 830 840 850
GALAEKVPPA TALLSQSWLS VGFPDKVASC GESLESAEAQ LQRRVHFHRV
860 870 880 890 900
QWDRAEPLNH IGSLTYANGV LCSTVLYFRP GVHLIRVDLH HVQAADKISF
910 920 930 940 950
LSDAEMDVQL DLSHDASRDG FACVTDAGVY PAVQSCDTET VWLKRVFSLA
960 970 980 990 1000
APTCVTLQLS TLDSTEDVGA HRQIYTAASR ASAAASGGRS GGNHSNAAAS
1010 1020 1030 1040 1050
GRGAPQGGGT AAGAGKSGYA SPAPGGSTAA DGKKRGEGPL TADATNGAVS
1060 1070 1080 1090 1100
TVPARDTSVS ILRFTSLVLV NLDRPEDFCV GTAGRLVKLH LKPNEKGYLI
1110 1120 1130 1140 1150
MAYTIVPSLM AQNVQRQNKA ADVAGGAGSL LPTVASMDSL AEEEGLQPPE
1160 1170 1180 1190 1200
SSSLGNSFSP AASTAPPPLF PAGRWKLVLR SNAELQTFDT VSHDLHNVAI
1210 1220 1230 1240 1250
VADLPRGGSP VLFRRTCTIA ETTHVSIVAD LHAPVPMPYT VRIVRLPAPT
1260 1270 1280 1290 1300
ASASTSTTPR ALRGPNNNIL PAGVSEPLAA DAGRGAGAVP SRGSMFVVYE
1310 1320 1330 1340 1350
SPPTQQRLFV ADVLLSAAAD TSLAKGGKGL ATSSSTGGGM TVYGIEATVA
1360 1370 1380 1390 1400
EADAAAWNER CRRSQEDAFL QYREAAEEQA SVSNERDLVE YQQNPVAFVQ
1410 1420 1430 1440 1450
RKREASAQRR QFATEAAEKA IPRSSTIARK RSGMTQRQSH HLSAGPENLP
1460 1470 1480 1490 1500
KDSPRRQSLC AQPETAQEGD IRHSLDNVDP DTIVRMNVHL SFSTSRAEVR
1510 1520 1530 1540 1550
ADTPVPDALA ELRKHMRETV SWLQEWNELG SAGGESAAAA CSVNPMGAAT
1560 1570 1580 1590 1600
SSGSKLGAQR GQRDAAAAAA AAATAEDALR TEAARQSRVE YLRNPQHLFV
1610 1620 1630 1640 1650
PSFDSEYNTD AAETPTLTSS ASFAHRARHD ASGNSSGTGA AHPAATGGAQ
1660 1670 1680 1690 1700
GARSYRRELS QASVGTSASL SDDPQSPYPP PVLMQDGPAT QFRYAAPLQQ
1710 1720 1730 1740 1750
PQYCIELLPL RSWEESPSVA SQGKDGAGGS GAAGAAASNR GKRLKSSGSA
1760 1770 1780 1790 1800
SAALSAPARP HSSGSVMPSG SSPRSFAEVT PSGLCAAAAA AACTLSCPLT
1810 1820 1830 1840 1850
AAERETFLLL LRRPLADASE SWDLALGQAR VAKSESQAQL RSGFHAYYEA
1860 1870 1880 1890
MVEQKAASGD TSGIAAPIVY RSLLSLKEEE LGVSLRPTKS LVFT
Length:1,894
Mass (Da):199,683
Last modified:July 19, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F71DE2F53BF95BB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR796428 Genomic DNA Translation: CAJ08617.1

NCBI Reference Sequences

More...
RefSeqi
XP_001685413.1, XM_001685361.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAJ08617; CAJ08617; LMJF_32_0970

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LmjF.32.0970:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5656210

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lma:LMJF_32_0970

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796428 Genomic DNA Translation: CAJ08617.1
RefSeqiXP_001685413.1, XM_001685361.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAJ08617; CAJ08617; LMJF_32_0970
GeneDBiLmjF.32.0970:pep
GeneIDi5656210
KEGGilma:LMJF_32_0970

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.32.0970

Phylogenomic databases

eggNOGiENOG410J7ZR Eukaryota
ENOG410XPG8 LUCA
HOGENOMiHOG000259644
InParanoidiQ4Q5I5

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4Q5I5_LEIMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4Q5I5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 5, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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