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Entry version 117 (29 Sep 2021)
Sequence version 1 (19 Jul 2005)
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Protein
Submitted name:

p-glycoprotein

Gene

MDR1

Organism
Leishmania major
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi487 – 494ATPPROSITE-ProRule annotation8
Nucleotide bindingi1132 – 1139ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.201.26, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
p-glycoproteinImported (EC:3.6.3.44Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDR1Imported
ORF Names:LMJF_34_0990Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania majorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5664 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiscobaEuglenozoaKinetoplasteaMetakinetoplastinaTrypanosomatidaTrypanosomatidaeLeishmaniinaeLeishmania
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000542 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 34

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
TriTrypDB:LmjF.34.0990
TriTrypDB:LMJLV39_340016800
TriTrypDB:LMJSD75_340016800

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei131 – 158HelicalSequence analysisAdd BLAST28
Transmembranei178 – 199HelicalSequence analysisAdd BLAST22
Transmembranei254 – 271HelicalSequence analysisAdd BLAST18
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei358 – 380HelicalSequence analysisAdd BLAST23
Transmembranei392 – 410HelicalSequence analysisAdd BLAST19
Transmembranei772 – 800HelicalSequence analysisAdd BLAST29
Transmembranei820 – 844HelicalSequence analysisAdd BLAST25
Transmembranei922 – 939HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5664.LmjF.34.0990

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4Q3A6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 418ABC transmembrane type-1InterPro annotationAdd BLAST285
Domaini452 – 695ABC transporterInterPro annotationAdd BLAST244
Domaini775 – 1063ABC transmembrane type-1InterPro annotationAdd BLAST289
Domaini1097 – 1335ABC transporterInterPro annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0055, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_17_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4Q3A6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits
3.40.50.300, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
IPR039421, Type_1_exporter

The PANTHER Classification System

More...
PANTHERi
PTHR24221, PTHR24221, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4Q3A6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEGSERGAS AKGGSVFEWE DRQGSFSPHQ PIAEGLVERG DCCEHNDYRY
60 70 80 90 100
GPAPQSRELI DMSHTYDVYV DEGKLALVNK PADQSDSTHG GSGYDSRNPL
110 120 130 140 150
FSAEEEVKRA AVNESVSPIA IFRYADTTDR ALMIIGTIFA ICSGAGMPFF
160 170 180 190 200
SFIFGRIAMD LMSGVGSVEL SAAKMSLIMV YVGIGMFVTC GGHVLCWTVT
210 220 230 240 250
ASRQEGRIRL NFFRAVLRQD IGWHDEHSPG ELTARMTGDT HVIQNGINDK
260 270 280 290 300
LSQGIMNGAM GIIGYIAGFA FSWELTLVMV GMMPFIIVMT AIIGNIVSKM
310 320 330 340 350
TESSLKHFAK AGSLATEVME NIRTVQVFGR EDYELQRFAE AVLHAQDRGI
360 370 380 390 400
RKEFAGNLSA AVIMALVYLS YTIAFFFGSY LVEWGRRDMA DIISTFLAVL
410 420 430 440 450
MGSLGLGFVA PSVTAFTESR AAAYAIFKAI DRVPPVDIDA DGVPVTGFEQ
460 470 480 490 500
SIEFRNVRFS YPTRPDMILF RDLNLTIRCG QKIAFSGSSG CGKSSMLGLI
510 520 530 540 550
QRFYDPAGGT VLCDGVDMRE LCLRDWRDQI GIVSQEPNLF AGTMMENVRV
560 570 580 590 600
GKPNATEEEV IEACRQANVH DTIMSLPDQY NTPVGAVGSQ LSGGQKQRIA
610 620 630 640 650
IARALVKRPP ILLLDEATSA LDRKSEMEVQ RSLDRLMEKG GMTVIVIAHR
660 670 680 690 700
LATIRNVDCI YYVKYDGAEG SKITESGTFD ELMELGGEFA AMARIQGVST
710 720 730 740 750
GDVRSGARGQ DCGKANDFLN VILDEAALAH LDEEAPRTAR QKVPIEELAK
760 770 780 790 800
WEVNDVNVGF RRLMGMNKDK SWAVALGILG SAVGGAARPT SSILMGYMLR
810 820 830 840 850
VLGEYSVNKN VEQLRSGTNL YAPLFILFSF ATFLGWVLHG FYGYAGEHLT
860 870 880 890 900
TKIRVLLFRQ IMRQDMNFFD IPGRDAGTLA GMLSGDCEAV HQLWGPSIGL
910 920 930 940 950
KVQTVCIVAS GVVVSFIYQW KLALVALACM PLLIGCSLAE RTMMNGYTKS
960 970 980 990 1000
KEGDTSDTIV TEALSSVRTV TSFNMKADRV EAFEATLRVE TPRSVKKGII
1010 1020 1030 1040 1050
AGSIYGATQF IYYSAYALCF WYGSKLIDRG EAQFTDVMIA SMSILLGAQN
1060 1070 1080 1090 1100
AGEAGAFATK LADAERSAKR VFSVIDRVPD VDIEQPGDKD LGKGCDVDFR
1110 1120 1130 1140 1150
KVQFIYSARP KQVVLASVNL RFGDGTANGL MGQTGCGKST IIQMLARFYD
1160 1170 1180 1190 1200
RRSGLICVNG KDLSSLDIAE WRRNISVVLQ EPNLFSGTVR ENIRYAREDA
1210 1220 1230 1240 1250
TDDEVEEAAR LAQIHWEIVK WPDGYNTEVG YKGSALSGGQ KQRVAIARGL
1260 1270 1280 1290 1300
LRRPKLLLLD EATSALDNVT EAKVQEGINA YQAKYGVTSV SIAHRLTTIR
1310 1320 1330 1340
HCDQIILLDS GHIIEQGSHE ELMALGGEYM MRYDLYTGAS S
Length:1,341
Mass (Da):146,912
Last modified:July 19, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA19AB37A6E81671F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR796430 Genomic DNA Translation: CAJ07806.1

NCBI Reference Sequences

More...
RefSeqi
XP_001686192.1, XM_001686140.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAJ07806; CAJ07806; LMJF_34_0990

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LmjF.34.0990:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5654856

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lma:LMJF_34_0990

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796430 Genomic DNA Translation: CAJ07806.1
RefSeqiXP_001686192.1, XM_001686140.1

3D structure databases

SMRiQ4Q3A6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5664.LmjF.34.0990

Protein family/group databases

TCDBi3.A.1.201.26, the atp-binding cassette (abc) superfamily

Genome annotation databases

EnsemblProtistsiCAJ07806; CAJ07806; LMJF_34_0990
GeneDBiLmjF.34.0990:pep
GeneIDi5654856
KEGGilma:LMJF_34_0990

Organism-specific databases

VEuPathDBiTriTrypDB:LmjF.34.0990
TriTrypDB:LMJLV39_340016800
TriTrypDB:LMJSD75_340016800

Phylogenomic databases

eggNOGiKOG0055, Eukaryota
HOGENOMiCLU_000604_17_2_1
InParanoidiQ4Q3A6

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
3.40.50.300, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
IPR039421, Type_1_exporter
PANTHERiPTHR24221, PTHR24221, 2 hits
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4Q3A6_LEIMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4Q3A6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 29, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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