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Entry version 51 (12 Aug 2020)
Sequence version 1 (05 Apr 2011)
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Protein

Complex I-ESSS

Gene

LMJF_34_4320

Organism
Leishmania major
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.ARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complex I-ESSSARBA annotation
Alternative name(s):
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialARBA annotation
NADH-ubiquinone oxidoreductase ESSS subunitARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LMJF_34_4320Imported, LMJF_34_4350Imported, LMJF_34_4380Imported, LMJF_34_4410Imported, LMJF_34_4440Imported, LMJF_34_4470Imported, LMJF_34_4500Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania majorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5664 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiscobaEuglenozoaKinetoplasteaMetakinetoplastinaTrypanosomatidaTrypanosomatidaeLeishmaniinaeLeishmania
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000542 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 34

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
TriTrypDB:LmjF.34.4320
TriTrypDB:LmjF.34.4350
TriTrypDB:LmjF.34.4380
TriTrypDB:LmjF.34.4410
TriTrypDB:LmjF.34.4440
TriTrypDB:LmjF.34.4470
TriTrypDB:LmjF.34.4500

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 68HelicalSequence analysisAdd BLAST19

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, MitochondrionARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Complex I is composed of 45 different subunits.

ARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I NDUFB11 subunit family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SMV1, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_2150713_0_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019329, NADH_UbQ_OxRdtase_ESSS_su

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10183, ESSS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4Q291-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRWNQRMAK MAFRRSKFRR LAWGDGDPYP YTPRATFRYQ WDDWPMWEKM
60 70 80 90 100
WHLAVGVLGV EFAVWAYYSK LNSRMDWARE EALRRMRLRR EAQELMILEG
110
ETFPSDIQPD RH
Length:112
Mass (Da):13,834
Last modified:April 5, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DCAD2CB0C9A0205
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF523363 Genomic DNA Translation: AAN40018.1
FR796430 Genomic DNA Translation: CAJ08171.1
FR796430 Genomic DNA Translation: CAJ08174.1
FR796430 Genomic DNA Translation: CAJ08177.1
FR796430 Genomic DNA Translation: CAJ08181.1
FR796430 Genomic DNA Translation: CAJ08184.1
FR796430 Genomic DNA Translation: CAJ08187.1
FR796430 Genomic DNA Translation: CAJ08190.1

NCBI Reference Sequences

More...
RefSeqi
XP_001686539.1, XM_001686487.1
XP_001686542.1, XM_001686490.1
XP_001686545.1, XM_001686493.1
XP_001686548.1, XM_001686496.1
XP_001686551.1, XM_001686499.1
XP_001686554.1, XM_001686502.1
XP_001686557.1, XM_001686505.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAJ08171; CAJ08171; LMJF_34_4320
CAJ08174; CAJ08174; LMJF_34_4350
CAJ08177; CAJ08177; LMJF_34_4380
CAJ08181; CAJ08181; LMJF_34_4410
CAJ08184; CAJ08184; LMJF_34_4440
CAJ08187; CAJ08187; LMJF_34_4470
CAJ08190; CAJ08190; LMJF_34_4500

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LmjF.34.4320:pep
LmjF.34.4350:pep
LmjF.34.4380:pep
LmjF.34.4410:pep
LmjF.34.4440:pep
LmjF.34.4470:pep
LmjF.34.4500:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5655217
5655220
5655223
5655226
5655229
5655232
5655235

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lma:LMJF_34_4320
lma:LMJF_34_4350
lma:LMJF_34_4380
lma:LMJF_34_4410
lma:LMJF_34_4440
lma:LMJF_34_4470
lma:LMJF_34_4500

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523363 Genomic DNA Translation: AAN40018.1
FR796430 Genomic DNA Translation: CAJ08171.1
FR796430 Genomic DNA Translation: CAJ08174.1
FR796430 Genomic DNA Translation: CAJ08177.1
FR796430 Genomic DNA Translation: CAJ08181.1
FR796430 Genomic DNA Translation: CAJ08184.1
FR796430 Genomic DNA Translation: CAJ08187.1
FR796430 Genomic DNA Translation: CAJ08190.1
RefSeqiXP_001686539.1, XM_001686487.1
XP_001686542.1, XM_001686490.1
XP_001686545.1, XM_001686493.1
XP_001686548.1, XM_001686496.1
XP_001686551.1, XM_001686499.1
XP_001686554.1, XM_001686502.1
XP_001686557.1, XM_001686505.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblProtistsiCAJ08171; CAJ08171; LMJF_34_4320
CAJ08174; CAJ08174; LMJF_34_4350
CAJ08177; CAJ08177; LMJF_34_4380
CAJ08181; CAJ08181; LMJF_34_4410
CAJ08184; CAJ08184; LMJF_34_4440
CAJ08187; CAJ08187; LMJF_34_4470
CAJ08190; CAJ08190; LMJF_34_4500
GeneDBiLmjF.34.4320:pep
LmjF.34.4350:pep
LmjF.34.4380:pep
LmjF.34.4410:pep
LmjF.34.4440:pep
LmjF.34.4470:pep
LmjF.34.4500:pep
GeneIDi5655217
5655220
5655223
5655226
5655229
5655232
5655235
KEGGilma:LMJF_34_4320
lma:LMJF_34_4350
lma:LMJF_34_4380
lma:LMJF_34_4410
lma:LMJF_34_4440
lma:LMJF_34_4470
lma:LMJF_34_4500

Organism-specific databases

EuPathDBiTriTrypDB:LmjF.34.4320
TriTrypDB:LmjF.34.4350
TriTrypDB:LmjF.34.4380
TriTrypDB:LmjF.34.4410
TriTrypDB:LmjF.34.4440
TriTrypDB:LmjF.34.4470
TriTrypDB:LmjF.34.4500

Phylogenomic databases

eggNOGiENOG502SMV1, Eukaryota
HOGENOMiCLU_2150713_0_0_1

Family and domain databases

InterProiView protein in InterPro
IPR019329, NADH_UbQ_OxRdtase_ESSS_su
PfamiView protein in Pfam
PF10183, ESSS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4Q291_LEIMA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4Q291
Secondary accession number(s): Q8I6Y5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: August 12, 2020
This is version 51 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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