UniProtKB - Q4Q0R9 (MTNA_LEIMA)
Protein
Methylthioribose-1-phosphate isomerase
Gene
LmjF36.4930
Organism
Leishmania major
Status
Functioni
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation
Catalytic activityi
- EC:5.3.1.23UniRule annotation
: L-methionine biosynthesis via salvage pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotationProteins known to be involved in the 6 steps of the subpathway in this organism are:
- Methylthioribose-1-phosphate isomerase (LmjF36.4930)
- Probable methylthioribulose-1-phosphate dehydratase (LmjF28.1840)
- no protein annotated in this organism
- no protein annotated in this organism
- 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase (LMJF_20_0970)
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate, the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 177 | Transition state stabilizerUniRule annotation | 1 | |
Active sitei | 257 | Proton donorUniRule annotation | 1 |
GO - Molecular functioni
- S-methyl-5-thioribose-1-phosphate isomerase activity Source: GO_Central
GO - Biological processi
- L-methionine salvage from methylthioadenosine Source: GO_Central
- L-methionine salvage from S-adenosylmethionine Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase |
Biological process | Amino-acid biosynthesis, Methionine biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00904;UER00874 |
Names & Taxonomyi
Protein namesi | Recommended name: Methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)Short name: M1PiUniRule annotation Short name: MTR-1-P isomeraseUniRule annotation Alternative name(s): S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation Translation initiation factor eIF-2B subunit alpha/beta/delta-like proteinUniRule annotation |
Gene namesi | ORF Names:LmjF36.4930, LmjF_36_4930 |
Organismi | Leishmania major |
Taxonomic identifieri | 5664 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Leishmaniinae › Leishmania › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | TriTrypDB:LmjF.36.4930 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000402001 | 1 – 375 | Methylthioribose-1-phosphate isomeraseAdd BLAST | 375 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q4Q0R9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q4Q0R9 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1468, Eukaryota |
InParanoidi | Q4Q0R9 |
Family and domain databases
Gene3Di | 1.20.120.420, 1 hit 3.40.50.10470, 1 hit |
HAMAPi | MF_01678, Salvage_MtnA, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR005251, IF-M1Pi IPR042529, IF_2B-like_C IPR011559, Initiation_fac_2B_a/b/d IPR027363, M1Pi_N IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00524, eIF-2B_rel, 1 hit TIGR00512, salvage_mtnA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4Q0R9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMSKPHHATL ESIKYTPGSL RLLDQRKLPL ETVFDDVLTV EDIWSAIKEM
60 70 80 90 100
RVRGAPAIAV SAALGIAVAT QRKAANGELK SGREVQTFLL TSCDFVMTSR
110 120 130 140 150
PTAVNLFNCL RDLKAQVDKL DPTKAAAEVA QAFVELAEAV YTNDVAFNEG
160 170 180 190 200
IMRHGAAHIL AAAKAEGRDK VSILTICNTG ALATSRYGTA LGVVRQLFYD
210 220 230 240 250
GKLERVYACE TRPWNQGARL TVYECVQEDI PCTLICDGAA SSLMLNRKID
260 270 280 290 300
AVVVGADRIC QNGDTANKIG TYNLAVSAKF HGVKLYVAAP TTTLDVKTAS
310 320 330 340 350
GNHVEIEERE PTEITTNLVT KQRVVADGPH LSIWNPVFDI TPSELITGGI
360 370
ITEKGVQAPA ASAPYYDIAS IIAQA
Sequence cautioni
The sequence CAJ09465 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR796432 Genomic DNA Translation: CAJ09465.1 Different initiation. |
RefSeqi | XP_001687079.1, XM_001687027.1 |
Genome annotation databases
EnsemblProtistsi | CAJ09465; CAJ09465; LMJF_36_4930 |
GeneDBi | LmjF.36.4930:pep |
GeneIDi | 5655795 |
KEGGi | lma:LMJF_36_4930 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FR796432 Genomic DNA Translation: CAJ09465.1 Different initiation. |
RefSeqi | XP_001687079.1, XM_001687027.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2A0U | X-ray | 2.10 | A/B | 1-375 | [»] | |
SMRi | Q4Q0R9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 5664.LmjF.36.4930 |
Genome annotation databases
EnsemblProtistsi | CAJ09465; CAJ09465; LMJF_36_4930 |
GeneDBi | LmjF.36.4930:pep |
GeneIDi | 5655795 |
KEGGi | lma:LMJF_36_4930 |
Organism-specific databases
EuPathDBi | TriTrypDB:LmjF.36.4930 |
Phylogenomic databases
eggNOGi | KOG1468, Eukaryota |
InParanoidi | Q4Q0R9 |
Enzyme and pathway databases
UniPathwayi | UPA00904;UER00874 |
Miscellaneous databases
EvolutionaryTracei | Q4Q0R9 |
Family and domain databases
Gene3Di | 1.20.120.420, 1 hit 3.40.50.10470, 1 hit |
HAMAPi | MF_01678, Salvage_MtnA, 1 hit |
InterProi | View protein in InterPro IPR000649, IF-2B-related IPR005251, IF-M1Pi IPR042529, IF_2B-like_C IPR011559, Initiation_fac_2B_a/b/d IPR027363, M1Pi_N IPR037171, NagB/RpiA_transferase-like |
Pfami | View protein in Pfam PF01008, IF-2B, 1 hit |
SUPFAMi | SSF100950, SSF100950, 1 hit |
TIGRFAMsi | TIGR00524, eIF-2B_rel, 1 hit TIGR00512, salvage_mtnA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTNA_LEIMA | |
Accessioni | Q4Q0R9Primary (citable) accession number: Q4Q0R9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2010 |
Last sequence update: | November 30, 2010 | |
Last modified: | December 2, 2020 | |
This is version 74 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families