UniProtKB - Q4PLS0 (Q4PLS0_MOUSE)

BLAST

>tr|Q4PLS0|Q4PLS0_MOUSE NACHT OS=Mus musculus OX=10090 GN=Nlrp2 PE=1 SV=1
MEHFDPLGFNLKDVLRKLDKTELNNFKRTLRSCSLPDTMKQINKLTMDLANGAQLAEILT
DHCPSAWIKRVTVQILEEINRVDLAELVVKQIEEAVLKVPEEKVSSKPREPSGTLTFPWN
FVQGAKRPEDKQKEEWKTRYTAKWKQNFWPKCNKEIYVVTESYKTLLALCNPKIETPFAH
AIVLHGPPGSGKTTMAKQLMLEWSESKQAQIFSCAFYISCREVNNTKPCTFAHLLSMDNP
SWRDCVIRDLILGKEFLFVVDGFDELTFPAGALIRDLCGDWNTVKPVEVLLGSLLKRKMA
PHATLLVTTRTQSLHQIFVMMDQPLLVETLGFLEQEKQEYFQKYFEDEEGEEEDKGEGKA
LRALKEVRCNADLYQMASLPTACGIFCLCLELRMKKGEDLSLTCQTYTSMFLNFLCEVFS
SETCEDHLNEEFQILFKKICILAANSLLEQVPILCEEDFLTLKLNLNNLHPMVCRHILFK
DSSSTHCLSFICLGIQQLLAAIIFVQELGQESKGVSKYSIQNMLSREARLKNPDLSGLLP
FVFGLLNETRIQELKTTFGCQISTEVKRKFLECESGENKPLLLLMNMQEILSCLYESQEE
GFVKEAMVLFEDISLHLKTSTDLIHASFCLKNSQNLQTMSLKVEKAVFPENVAALESTAK
HQRSPDEQRMLTFWTDFCDTFNSNKKLVFLDIHESFLNSSALEILCEKLPSASCCLQKVV
LKNISPDDAYEKLCLIFNGYKTISHLILQGGNLDSMHHSLCEVLKNPACNLKFLSLGSCS
TAAQKWDDFFPVLKVNQSLIFLDLTDNSLLDKSAKLLCNIWKEPKCILQRVSLENCQLTE
ACCKDLSSVLMVSRTLTHLSLANNKLGDNGVKNLCESISCTECNLQTLVLWSCNITNAGC
HYLSKMLKQTLSLKHLDLGLNRIGTKGAKFLCEALKNPKSKLKSLWLCGCSITPLNCQDF
SETLRSNKSLNTLDLSQNVLGTDAIKTFCEALKLQICPLQMLRLKFDEAKPSIQNLIQEM
KVSHPQLRISSDQVDLKNPPLPHFIF

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History
Entry version 113 (07 Nov 2018)
Sequence version 1 (19 Jul 2005)
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Protein

Submitted name:

NACHT

Gene

Nlrp2

Organism

Mus musculus (Mouse)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
Pyrin domain binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of NF-kappaB transcription factor activity Source: MGI
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
positive regulation of interleukin-1 beta secretion Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	ATP-bindingSAAS annotation, Nucleotide-binding

Ligand

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: NACHTImported Submitted name: NLR family, pyrin domain-containing 2Imported
Gene namesⁱ	Name:Nlrp2Imported Synonyms:Nalp2Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:3041206 Nlrp2

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000035177 Expressed in 13 organ(s), highest expression level in ovarian follicle

Bgeeⁱ

ENSMUSG00000035177 Expressed in 13 organ(s), highest expression level in ovarian follicle

Interactionⁱ

GO - Molecular functionⁱ

Pyrin domain binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000045077

STRINGⁱ

10090.ENSMUSP00000045077

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	180 – 387	NACHTInterPro annotationAdd BLAST		208

Keywords - Domainⁱ

RepeatSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IM14 Eukaryota ENOG410ZI5C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140813
HOGENOMⁱ	HOG000294064
HOVERGENⁱ	HBG103856
KEGG Orthology (KO) More...KOⁱ	K19409
OMAⁱ	NDQNDML
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01Q7

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR004020 DAPIN IPR011029 DEATH-like_dom_sf IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR007111 NACHT_NTPase IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13516 LRR_6, 3 hits PF05729 NACHT, 1 hit PF02758 PYRIN, 1 hit
SMARTⁱ	View protein in SMART SM01289 PYRIN, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50837 NACHT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q4PLS0-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MEHFDPLGFN LKDVLRKLDK TELNNFKRTL RSCSLPDTMK QINKLTMDLA 
        60         70         80         90        100
NGAQLAEILT DHCPSAWIKR VTVQILEEIN RVDLAELVVK QIEEAVLKVP 
       110        120        130        140        150
EEKVSSKPRE PSGTLTFPWN FVQGAKRPED KQKEEWKTRY TAKWKQNFWP 
       160        170        180        190        200
KCNKEIYVVT ESYKTLLALC NPKIETPFAH AIVLHGPPGS GKTTMAKQLM 
       210        220        230        240        250
LEWSESKQAQ IFSCAFYISC REVNNTKPCT FAHLLSMDNP SWRDCVIRDL 
       260        270        280        290        300
ILGKEFLFVV DGFDELTFPA GALIRDLCGD WNTVKPVEVL LGSLLKRKMA 
       310        320        330        340        350
PHATLLVTTR TQSLHQIFVM MDQPLLVETL GFLEQEKQEY FQKYFEDEEG 
       360        370        380        390        400
EEEDKGEGKA LRALKEVRCN ADLYQMASLP TACGIFCLCL ELRMKKGEDL 
       410        420        430        440        450
SLTCQTYTSM FLNFLCEVFS SETCEDHLNE EFQILFKKIC ILAANSLLEQ 
       460        470        480        490        500
VPILCEEDFL TLKLNLNNLH PMVCRHILFK DSSSTHCLSF ICLGIQQLLA 
       510        520        530        540        550
AIIFVQELGQ ESKGVSKYSI QNMLSREARL KNPDLSGLLP FVFGLLNETR 
       560        570        580        590        600
IQELKTTFGC QISTEVKRKF LECESGENKP LLLLMNMQEI LSCLYESQEE 
       610        620        630        640        650
GFVKEAMVLF EDISLHLKTS TDLIHASFCL KNSQNLQTMS LKVEKAVFPE 
       660        670        680        690        700
NVAALESTAK HQRSPDEQRM LTFWTDFCDT FNSNKKLVFL DIHESFLNSS 
       710        720        730        740        750
ALEILCEKLP SASCCLQKVV LKNISPDDAY EKLCLIFNGY KTISHLILQG 
       760        770        780        790        800
GNLDSMHHSL CEVLKNPACN LKFLSLGSCS TAAQKWDDFF PVLKVNQSLI 
       810        820        830        840        850
FLDLTDNSLL DKSAKLLCNI WKEPKCILQR VSLENCQLTE ACCKDLSSVL 
       860        870        880        890        900
MVSRTLTHLS LANNKLGDNG VKNLCESISC TECNLQTLVL WSCNITNAGC 
       910        920        930        940        950
HYLSKMLKQT LSLKHLDLGL NRIGTKGAKF LCEALKNPKS KLKSLWLCGC 
       960        970        980        990       1000
SITPLNCQDF SETLRSNKSL NTLDLSQNVL GTDAIKTFCE ALKLQICPLQ 
      1010       1020       1030       1040 
MLRLKFDEAK PSIQNLIQEM KVSHPQLRIS SDQVDLKNPP LPHFIF

Length:1,046

Mass (Da):118,641

Last modified:July 19, 2005 - v1

Checksum:ⁱC504DCA8693D02C4

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A140LJ71	A0A140LJ71_MOUSE	NLR family, pyrin domain-containing... NLR family, pyrin domain-containing 2	Nlrp2	248	Annotation score:
A0A140LHK4	A0A140LHK4_MOUSE	NLR family, pyrin domain-containing... NLR family, pyrin domain-containing 2	Nlrp2	87	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC155171 Genomic DNA No translation available. DQ066881 mRNA Translation: AAY68479.1
NCBI Reference Sequences More...RefSeqⁱ	NP_808358.2, NM_177690.3
UniGeneⁱ	Mm.246598

Genome annotation databases

Ensemblⁱ	ENSMUST00000045022; ENSMUSP00000045077; ENSMUSG00000035177
GeneIDⁱ	232827
KEGGⁱ	mmu:232827
UCSC genome browser More...UCSCⁱ	uc009fae.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q4PLS0	NALP2		MOUSE		825	UniRef100_Q4PLS0

Protein	Similar proteins		Species	Score	Length	Source
Q4PLS0	NALP2		MOUSE		825	UniRef90_Q4PLS0

Protein	Similar proteins		Species	Score	Length	Source
Q4PLS0	NALP2		MOUSE		825	UniRef50_Q4PLS0
NACHT, LRR and PYD domain-containing protein 2		CRIGR		964
NLR family pyrin domain-containing 2		RAT		1045
NACHT, LRR and PYD domains-containing protein 2		MESAU		1076
UPI000B4F485D		MERUN		1053
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC155171 Genomic DNA No translation available. DQ066881 mRNA Translation: AAY68479.1
RefSeqⁱ	NP_808358.2, NM_177690.3
UniGeneⁱ	Mm.246598

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000045077

STRINGⁱ

10090.ENSMUSP00000045077

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	232827
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000045022; ENSMUSP00000045077; ENSMUSG00000035177
GeneIDⁱ	232827
KEGGⁱ	mmu:232827
UCSCⁱ	uc009fae.1 mouse

Organism-specific databases

CTDⁱ	55655
MGIⁱ	MGI:3041206 Nlrp2

Phylogenomic databases

eggNOGⁱ	ENOG410IM14 Eukaryota ENOG410ZI5C LUCA
GeneTreeⁱ	ENSGT00900000140813
HOGENOMⁱ	HOG000294064
HOVERGENⁱ	HBG103856
KOⁱ	K19409
OMAⁱ	NDQNDML
OrthoDBⁱ	EOG091G01Q7

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000035177 Expressed in 13 organ(s), highest expression level in ovarian follicle

Bgeeⁱ

ENSMUSG00000035177 Expressed in 13 organ(s), highest expression level in ovarian follicle

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR004020 DAPIN IPR011029 DEATH-like_dom_sf IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR007111 NACHT_NTPase IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF13516 LRR_6, 3 hits PF05729 NACHT, 1 hit PF02758 PYRIN, 1 hit
SMARTⁱ	View protein in SMART SM01289 PYRIN, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50837 NACHT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q4PLS0_MOUSE
Accessionⁱ	Q4PLS0Primary (citable) accession number: Q4PLS0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 19, 2005
	Last sequence update:	July 19, 2005
	Last modified:	November 7, 2018
	This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q4PLS0 (Q4PLS0_MOUSE)

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NACHT

Nlrp2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Golgi apparatus

Other locations

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ