UniProtKB - Q4PLS0 (Q4PLS0_MOUSE)
Protein
Submitted name:
NACHT
Gene
Nlrp2
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Submitted name: NACHTImportedSubmitted name: NLR family, pyrin domain-containing 2Imported |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3041206, Nlrp2 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
Other locations
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000035177, Expressed in primary oocyte and 28 other tissues |
Interactioni
GO - Molecular functioni
- Pyrin domain binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045077 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 180 – 387 | NACHTInterPro annotationAdd BLAST | 208 |
Sequence similaritiesi
Belongs to the NLRP family.ARBA annotation
Keywords - Domaini
Leucine-rich repeatARBA annotationPhylogenomic databases
eggNOGi | ENOG502S92U, Eukaryota |
GeneTreei | ENSGT00940000161714 |
HOGENOMi | CLU_002274_2_1_1 |
OMAi | AFYISCR |
OrthoDBi | 155336at2759 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 3 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50837, NACHT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q4PLS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHFDPLGFN LKDVLRKLDK TELNNFKRTL RSCSLPDTMK QINKLTMDLA
60 70 80 90 100
NGAQLAEILT DHCPSAWIKR VTVQILEEIN RVDLAELVVK QIEEAVLKVP
110 120 130 140 150
EEKVSSKPRE PSGTLTFPWN FVQGAKRPED KQKEEWKTRY TAKWKQNFWP
160 170 180 190 200
KCNKEIYVVT ESYKTLLALC NPKIETPFAH AIVLHGPPGS GKTTMAKQLM
210 220 230 240 250
LEWSESKQAQ IFSCAFYISC REVNNTKPCT FAHLLSMDNP SWRDCVIRDL
260 270 280 290 300
ILGKEFLFVV DGFDELTFPA GALIRDLCGD WNTVKPVEVL LGSLLKRKMA
310 320 330 340 350
PHATLLVTTR TQSLHQIFVM MDQPLLVETL GFLEQEKQEY FQKYFEDEEG
360 370 380 390 400
EEEDKGEGKA LRALKEVRCN ADLYQMASLP TACGIFCLCL ELRMKKGEDL
410 420 430 440 450
SLTCQTYTSM FLNFLCEVFS SETCEDHLNE EFQILFKKIC ILAANSLLEQ
460 470 480 490 500
VPILCEEDFL TLKLNLNNLH PMVCRHILFK DSSSTHCLSF ICLGIQQLLA
510 520 530 540 550
AIIFVQELGQ ESKGVSKYSI QNMLSREARL KNPDLSGLLP FVFGLLNETR
560 570 580 590 600
IQELKTTFGC QISTEVKRKF LECESGENKP LLLLMNMQEI LSCLYESQEE
610 620 630 640 650
GFVKEAMVLF EDISLHLKTS TDLIHASFCL KNSQNLQTMS LKVEKAVFPE
660 670 680 690 700
NVAALESTAK HQRSPDEQRM LTFWTDFCDT FNSNKKLVFL DIHESFLNSS
710 720 730 740 750
ALEILCEKLP SASCCLQKVV LKNISPDDAY EKLCLIFNGY KTISHLILQG
760 770 780 790 800
GNLDSMHHSL CEVLKNPACN LKFLSLGSCS TAAQKWDDFF PVLKVNQSLI
810 820 830 840 850
FLDLTDNSLL DKSAKLLCNI WKEPKCILQR VSLENCQLTE ACCKDLSSVL
860 870 880 890 900
MVSRTLTHLS LANNKLGDNG VKNLCESISC TECNLQTLVL WSCNITNAGC
910 920 930 940 950
HYLSKMLKQT LSLKHLDLGL NRIGTKGAKF LCEALKNPKS KLKSLWLCGC
960 970 980 990 1000
SITPLNCQDF SETLRSNKSL NTLDLSQNVL GTDAIKTFCE ALKLQICPLQ
1010 1020 1030 1040
MLRLKFDEAK PSIQNLIQEM KVSHPQLRIS SDQVDLKNPP LPHFIF
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A140LHK4 | A0A140LHK4_MOUSE | NLR family, pyrin domain-containing... | Nlrp2 | 87 | Annotation score: | ||
A0A140LJ71 | A0A140LJ71_MOUSE | NLR family, pyrin domain-containing... | Nlrp2 | 248 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC155171 Genomic DNA No translation available. DQ066881 mRNA Translation: AAY68479.1 |
RefSeqi | NP_808358.2, NM_177690.3 |
Genome annotation databases
Ensembli | ENSMUST00000045022; ENSMUSP00000045077; ENSMUSG00000035177 |
GeneIDi | 232827 |
KEGGi | mmu:232827 |
UCSCi | uc009fae.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC155171 Genomic DNA No translation available. DQ066881 mRNA Translation: AAY68479.1 |
RefSeqi | NP_808358.2, NM_177690.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045077 |
Proteomic databases
PRIDEi | Q4PLS0 |
Protocols and materials databases
Antibodypediai | 19479, 301 antibodies |
DNASUi | 232827 |
Genome annotation databases
Ensembli | ENSMUST00000045022; ENSMUSP00000045077; ENSMUSG00000035177 |
GeneIDi | 232827 |
KEGGi | mmu:232827 |
UCSCi | uc009fae.1, mouse |
Organism-specific databases
CTDi | 55655 |
MGIi | MGI:3041206, Nlrp2 |
Phylogenomic databases
eggNOGi | ENOG502S92U, Eukaryota |
GeneTreei | ENSGT00940000161714 |
HOGENOMi | CLU_002274_2_1_1 |
OMAi | AFYISCR |
OrthoDBi | 155336at2759 |
Miscellaneous databases
BioGRID-ORCSi | 232827, 3 hits in 17 CRISPR screens |
ChiTaRSi | Nlrp2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035177, Expressed in primary oocyte and 28 other tissues |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 3 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50837, NACHT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4PLS0_MOUSE | |
Accessioni | Q4PLS0Primary (citable) accession number: Q4PLS0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 19, 2005 |
Last sequence update: | July 19, 2005 | |
Last modified: | February 10, 2021 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |