Gria2

Functionⁱ

GO - Molecular functionⁱ

ionotropic glutamate receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological process	Ion transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: AMPA-selective glutamate receptor 2 flip typeImported
Gene namesⁱ	Name:Gria2Imported Synonyms:glur-2Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:95809 Gria2

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	542 – 564	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	625 – 647	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	815 – 837	HelicalSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_5004240925	25 – 883	Sequence analysisAdd BLAST		859

Proteomic databases

PRIDEⁱ	Q4LG64

PRIDEⁱ

Q4LG64

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q4LG64 MM

Genevisibleⁱ

Q4LG64 MM

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q4LG64
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	415 – 790	PBPeInterPro annotationAdd BLAST		376
Domainⁱ	425 – 490	Lig_chan-Glu_bdInterPro annotationAdd BLAST		66

Sequence similaritiesⁱ

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domainⁱ

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG1054 Eukaryota ENOG410XPSH LUCA
HOVERGENⁱ	HBG051839

Family and domain databases

InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR019594 Glu/Gly-bd IPR001508 Iono_rcpt_met IPR001320 Iontro_rcpt IPR028082 Peripla_BP_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01094 ANF_receptor, 1 hit PF00060 Lig_chan, 1 hit PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSⁱ	PR00177 NMDARECEPTOR
SMARTⁱ	View protein in SMART SM00918 Lig_chan-Glu_bd, 1 hit SM00079 PBPe, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4LG64-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ 
        60         70         80         90        100
FSTSEFRLTP HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI 
       110        120        130        140        150
TSFCGTLHVS FITPSFPTDG THPFVIQMRP DLKGALLSLI EYYQWDKFAY 
       160        170        180        190        200
LYDSDRGLST LQAVLDSAAE KKWQVTAINV GNINNDKKDE TYRSLFQDLE 
       210        220        230        240        250
LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL GFTDGDLLKI 
       260        270        280        290        300
QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT ATIKYTSALT 
       310        320        330        340        350
YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ 
       360        370        380        390        400
VQVEGLSGNI KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT 
       410        420        430        440        450
ELPSGNDTSG LENKTVVVTT ILESPYVMMK KNHEMLEGNE RYEGYCVDLA 
       460        470        480        490        500
AEIAKHCGFK YKLTIVGDGK YGARDADTKI WNGMVGELVY GKADIAIAPL 
       510        520        530        540        550
TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI 
       560        570        580        590        600
VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF 
       610        620        630        640        650
SLGAFMRQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM 
       660        670        680        690        700
VSPIESAEDL SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP 
       710        720        730        740        750
SVFVRTTAEG VARVRKSKGK YAYLLESTMN EYIEQRKPCD TMKVGGNLDS 
       760        770        780        790        800
KGYGIATPKG SSLRTPVNLA VLKLSEQGVL DKLKNKWWYD KGECGAKDSG 
       810        820        830        840        850
SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR AEAKRMKVAK 
       860        870        880 
NAQNINPSSS QNSQNFATYK EGYNVYGIES VKI

Length:883

Mass (Da):98,846

Last modified:August 2, 2005 - v1

Checksum:ⁱC019FACB4F1BA3AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB111957 mRNA Translation: BAE06155.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001077275.1, NM_001083806.1
UniGeneⁱ	Mm.220224 Mm.426957

Genome annotation databases

GeneIDⁱ	14800
UCSC genome browser More...UCSCⁱ	uc008pob.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q4LG64	Glutamate receptor 2	)	RAT		883	UniRef90_P19491
Glutamate receptor 2	)	HUMAN		883
Glutamate receptor 2		MACFA		883
Glutamate receptor 2		MOUSE		883
Glutamate receptor 2		PONAB		883
+233

Protein	Similar proteins		Species	Score	Length	Source
Q4LG64	Glutamate receptor 1	)	RAT		907	UniRef50_P19490
Glutamate receptor 1		MOUSE		907
Glutamate receptor 1		MACFA		906
Glutamate receptor 1		HUMAN		906
Glutamate receptor 2		PONAB		883
+3461

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB111957 mRNA Translation: BAE06155.1
RefSeqⁱ	NP_001077275.1, NM_001083806.1
UniGeneⁱ	Mm.220224 Mm.426957

3D structure databases

ProteinModelPortalⁱ	Q4LG64
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q4LG64

PRIDEⁱ

Q4LG64

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	14800
UCSCⁱ	uc008pob.1 mouse

Organism-specific databases

CTDⁱ	2891
MGIⁱ	MGI:95809 Gria2

Phylogenomic databases

eggNOGⁱ	KOG1054 Eukaryota ENOG410XPSH LUCA
HOVERGENⁱ	HBG051839

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Genevisibleⁱ	Q4LG64 MM

Genevisibleⁱ

Q4LG64 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR019594 Glu/Gly-bd IPR001508 Iono_rcpt_met IPR001320 Iontro_rcpt IPR028082 Peripla_BP_I
Pfamⁱ	View protein in Pfam PF01094 ANF_receptor, 1 hit PF00060 Lig_chan, 1 hit PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSⁱ	PR00177 NMDARECEPTOR
SMARTⁱ	View protein in SMART SM00918 Lig_chan-Glu_bd, 1 hit SM00079 PBPe, 1 hit
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q4LG64_MOUSE
Accessionⁱ	Q4LG64Primary (citable) accession number: Q4LG64
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	August 2, 2005
	Last sequence update:	August 2, 2005
	Last modified:	October 10, 2018
	This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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UniProtKB - Q4LG64 (Q4LG64_MOUSE)

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AMPA-selective glutamate receptor 2 flip type

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ