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Entry version 104 (18 Sep 2019)
Sequence version 1 (02 Aug 2005)
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Protein
Submitted name:

OCA2 melanosomal transmembrane protein

Gene

Oca2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-5662702 Melanin biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
OCA2 melanosomal transmembrane proteinImported
Submitted name:
Pink-eyed dilutionImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Oca2Imported
Synonyms:LOC100365773Imported, LOC308670Imported, pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
2318412 Oca2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei326 – 351HelicalSequence analysisAdd BLAST26
Transmembranei358 – 374HelicalSequence analysisAdd BLAST17
Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
Transmembranei426 – 444HelicalSequence analysisAdd BLAST19
Transmembranei512 – 535HelicalSequence analysisAdd BLAST24
Transmembranei626 – 648HelicalSequence analysisAdd BLAST23
Transmembranei654 – 671HelicalSequence analysisAdd BLAST18
Transmembranei683 – 705HelicalSequence analysisAdd BLAST23
Transmembranei725 – 743HelicalSequence analysisAdd BLAST19
Transmembranei816 – 839HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000014465 Expressed in 6 organ(s), highest expression level in heart

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000019498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini346 – 779CitMHSInterPro annotationAdd BLAST434

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili598 – 618Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2639 Eukaryota
COG1055 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182724

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000047303

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAPIAIR

Database of Orthologous Groups

More...
OrthoDBi
495573at2759

TreeFam database of animal gene trees

More...
TreeFami
TF323556

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004680 Cit_transptr-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03600 CitMHS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4LEV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHLENKDIRL ASAMLEVELH QTSALSVPTC PDPGRPLTVK PTASNYELGQ
60 70 80 90 100
ADPCIPHAGE AAGKSPCVPE HAEFGSFLMK GRTHSPLSQF SSSLKDLSFK
110 120 130 140 150
EDTPLLWNSP QKKRSQFMPV HHPEFIATED SWESGLTVWE QKCMLGKEVA
160 170 180 190 200
DLSALASSEK GDLAGGVHLR AQVSKLGCCV RWMKITGLFV FVVLCSILFS
210 220 230 240 250
LYPDQGKLWQ LLAVSPLENY SVTLSGRADS IILQLDLAGA LMPGGPSGSG
260 270 280 290 300
KEEHVMVVVT QTDAVGNRWR RPQQVTHNWT VPLNPRSEHV VVSRTFEIVS
310 320 330 340 350
REAVSISIQA SLQQTRLVPL LLAHQFLGAS VEAQVASAVA ILTGVYTLII
360 370 380 390 400
FEIVHRTLAA MLGALAALAA LAVVGDRPSL THVVEWIDFE TLALLFGMMI
410 420 430 440 450
LVAIFSETGF FDYCAVKAYQ LSRGRVWAMI IMLCLMAAIL SAFLDNVTTM
460 470 480 490 500
LLFTPVTIRL CEVLNLDPRQ VLIAEVIFTN IGGAATAIGD PPNVIIVSNQ
510 520 530 540 550
ELRKMGLDFA GFTAHMFLGI CLVLLVSFPL LRLLYWNKKL YNKEPSEIVE
560 570 580 590 600
LKHEIHVWRL TAQRISPASR EETAVRGLLL EKVLALEHLL AQRLHTFHRQ
610 620 630 640 650
ISQEDKNWET NIQELQRKHR ISDRSLLVKC LTVLGFVISM FFLNSFVPGI
660 670 680 690 700
HLDLGWIAIL GAIWLLILAD IHDFEIILHR VEWATLLFFA ALFVLMEALT
710 720 730 740 750
HLHLVEYVGE QTALLIKMVP EDQRFAAAIV LIVWVSALAS SLIDNIPFTA
760 770 780 790 800
TMIPVLLNLS QDPEISLPAL PLMYALALGA CLGGNGTLIG ASANVVCAGI
810 820 830 840
AEQHGYGFSF MEFFRLGFPM MLMSCTIGMC YLLIAHVVVG WN
Length:842
Mass (Da):92,899
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD213C6C5F2A2B175
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07003542 Genomic DNA No translation available.
AABR07003543 Genomic DNA No translation available.
AABR07003544 Genomic DNA No translation available.
AABR07003545 Genomic DNA No translation available.
AABR07003546 Genomic DNA No translation available.
AABR07003547 Genomic DNA No translation available.
AABR07003548 Genomic DNA No translation available.
AABR07003549 Genomic DNA No translation available.
AABR07003550 Genomic DNA No translation available.
AABR07003551 Genomic DNA No translation available.
AB191343 mRNA Translation: BAE03195.1

NCBI Reference Sequences

More...
RefSeqi
NP_001258422.1, NM_001271493.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000019498; ENSRNOP00000019498; ENSRNOG00000014465

Database of genes from NCBI RefSeq genomes

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GeneIDi
100365773

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:100365773

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07003542 Genomic DNA No translation available.
AABR07003543 Genomic DNA No translation available.
AABR07003544 Genomic DNA No translation available.
AABR07003545 Genomic DNA No translation available.
AABR07003546 Genomic DNA No translation available.
AABR07003547 Genomic DNA No translation available.
AABR07003548 Genomic DNA No translation available.
AABR07003549 Genomic DNA No translation available.
AABR07003550 Genomic DNA No translation available.
AABR07003551 Genomic DNA No translation available.
AB191343 mRNA Translation: BAE03195.1
RefSeqiNP_001258422.1, NM_001271493.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019498

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019498; ENSRNOP00000019498; ENSRNOG00000014465
GeneIDi100365773
KEGGirno:100365773

Organism-specific databases

RGDi2318412 Oca2

Phylogenomic databases

eggNOGiKOG2639 Eukaryota
COG1055 LUCA
GeneTreeiENSGT00950000182724
HOGENOMiHOG000047303
OMAiMAPIAIR
OrthoDBi495573at2759
TreeFamiTF323556

Enzyme and pathway databases

ReactomeiR-RNO-5662702 Melanin biosynthesis

Gene expression databases

BgeeiENSRNOG00000014465 Expressed in 6 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR004680 Cit_transptr-like_dom
PfamiView protein in Pfam
PF03600 CitMHS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4LEV3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LEV3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: September 18, 2019
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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