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Entry version 64 (31 Jul 2019)
Sequence version 1 (02 Aug 2005)
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Protein
Submitted name:

DSP variant protein

Gene

DSP variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DSP variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DSP variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q4LE79

PRoteomics IDEntifications database

More...
PRIDEi
Q4LE79

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini505 – 562SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2258 – 2319DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili182 – 202Sequence analysisAdd BLAST21
Coiled coili366 – 386Sequence analysisAdd BLAST21
Coiled coili458 – 488Sequence analysisAdd BLAST31
Coiled coili1074 – 1094Sequence analysisAdd BLAST21
Coiled coili1102 – 1143Sequence analysisAdd BLAST42
Coiled coili1151 – 1199Sequence analysisAdd BLAST49
Coiled coili1218 – 1367Sequence analysisAdd BLAST150
Coiled coili1373 – 1393Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2259 – 2319PolarSequence analysisAdd BLAST61

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112198

Database of Orthologous Groups

More...
OrthoDBi
7016at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1290.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028462 Desmoplakin
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169:SF26 PTHR23169:SF26, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00681 Plectin, 8 hits
PF17902 SH3_10, 1 hit
PF18373 Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00250 PLEC, 18 hits
SM00150 SPEC, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75399 SSF75399, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q4LE79-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RAATSRAFRT PARFPGRPPI LGPLRFLRAG PPRLCLGAEP LSRLPADMSC
60 70 80 90 100
NGGSHPRINT LGRMIRAESG PDLRYEVTSG GGGTSRMYYS RRGVITDQNS
110 120 130 140 150
DGYCQTGTMS RHQNQNTIQE LLQNCSDCLM RAELIVQPEL KYGDGIQLTR
160 170 180 190 200
SRELDECFAQ ANDQMEILDS LIREMRQMGQ PCDAYQKRLL QLQEQMRALY
210 220 230 240 250
KAISVPRVRR ASSKGGGGYT CQSGSGWDEF TKHVTSECLG WMRQQRAEMD
260 270 280 290 300
MVAWGVDLAS VEQHINSHRG IHNSIGDYRW QLDKIKADLR EKSAIYQLEE
310 320 330 340 350
EYENLLKASF ERMDHLRQLQ NIIQATSREI MWINDCEEEE LLYDWSDKNT
360 370 380 390 400
NIAQKQEAFS IRMSQLEVKE KELNKLKQES DQLVLNQHPA SDKIEAYMDT
410 420 430 440 450
LQTQWSWILQ ITKCIDVHLK ENAAYFQFFE EAQSTEAYLK GLQDSIRKKY
460 470 480 490 500
PCDKNMPLQH LLEQIKELEK EREKILEYKR QVQNLVNKSK KIVQLKPRNP
510 520 530 540 550
DYRSNKPIIL RALCDYKQDQ KIVHKGDECI LKDNNERSKW YVTGPGGVDM
560 570 580 590 600
LVPSVGLIIP PPNPLAVDLS CKIEQYYEAI LALWNQLYIN MKSLVSWHYC
610 620 630 640 650
MIDIEKIRAM TIAKLKTMRQ EDYMKTIADL ELHYQEFIRN SQGSEMFGDD
660 670 680 690 700
DKRKIQSQFT DAQKHYQTLV IQLPGYPQHQ TVTTTEITHH GTCQDVNHNK
710 720 730 740 750
VIETNRENDK QETWMLMELQ KIRRQIEHCE GRMTLKNLPL ADQGSSHHIT
760 770 780 790 800
VKINELKSVQ NDSQAIAEVL NQLKDMLANF RGSEKYCYLQ NEVFGLFQKL
810 820 830 840 850
ENINGVTDGY LNSLCTVRAL LQAILQTEDM LKVYEARLTE EETVCLDLDK
860 870 880 890 900
VEAYRCGLKK IKNDLNLKKS LLATMKTELQ KAQQIHSQTS QQYPLYDLDL
910 920 930 940 950
GKFGEKVTQL TDRWQRIDKQ IDFRLWDLEK QIKQLRNYRD NYQAFCKWLY
960 970 980 990 1000
DAKRRQDSLE SMKFGDSNTV MRFLNEQKNL HSEISGKRDK SEEVQKIAEL
1010 1020 1030 1040 1050
CANSIKDYEL QLASYTSGLE TLLNIPIKRT MIQSPSGVIL QEAADVHARY
1060 1070 1080 1090 1100
IELLTRSGDY YRFLSEMLKS LEDLKLKNTK IEVLEEELRL ARDANSENCN
1110 1120 1130 1140 1150
KNKFLDQNLQ KYQAECSQFK AKLASLEELK RQAELDGKSA KQNLDKCYGQ
1160 1170 1180 1190 1200
IKELNEKITR LTYEIEDEKR RRKSVEDRFD QQKNDYDQLQ KARQCEKENL
1210 1220 1230 1240 1250
GWQKLESEKA IKEKEYEIER LRVLLQEEGT RKREYENELA KASNRIQESK
1260 1270 1280 1290 1300
NQCTQVVQER ESLLVKIKVL EQDKARLQRL EDELNRAKST LEAETRVKQR
1310 1320 1330 1340 1350
LECEKQQIQN DLNQWKTQYS RKEEAIRKIE SEREKSEREK NSLRSEIERL
1360 1370 1380 1390 1400
QAEIKRIEER CRRKLEDSTR ETQSQLETER SRYQREIDKL RQRPYGSHRE
1410 1420 1430 1440 1450
TQTECEWTVD TSKLVFDGLR KKVTAMQLYE CQLIDKTTLD KLLKGKKSVE
1460 1470 1480 1490 1500
EVASEIQPFL RGAGSIAGAS ASPKEKYSLV EAKRKKLISP ESTVMLLEAQ
1510 1520 1530 1540 1550
AATGGIIDPH RNEKLTVDSA IARDLIDFDD RQQIYAAEKA ITGFDDPFSG
1560 1570 1580 1590 1600
KTVSVSEAIK KNLIDRETGM RLLEAQIASG GVVDPVNSVF LPKDVALARG
1610 1620 1630 1640 1650
LIDRDLYRSL NDPRDSQKNF VDPVTKKKVS YVQLKERCRI EPHTGLLLLS
1660 1670 1680 1690 1700
VQKRSMSFQG IRQPVTVTEL VDSGILRPST VNELESGQIS YDEVGERIKD
1710 1720 1730 1740 1750
FLQGSSCIAG IYNETTKQKL GIYEAMKIGL VRPGTALELL EAQAATGFIV
1760 1770 1780 1790 1800
DPVSNLRLPV EEAYKRGLVG IEFKEKLLSA ERAVTGYNDP ETGNIISLFQ
1810 1820 1830 1840 1850
AMNKELIEKG HGIRLLEAQI ATGGIIDPKE SHRLPVDIAY KRGYFNEELS
1860 1870 1880 1890 1900
EILSDPSDDT KGFFDPNTEE NLTYLQLKER CIKDEETGLC LLPLKEKKKQ
1910 1920 1930 1940 1950
VQTSQKNTLR KRRVVIVDPE TNKEMSVQEA YKKGLIDYET FKELCEQECE
1960 1970 1980 1990 2000
WEEITITGSD GSTRVVLVDR KTGSQYDIQD AIDKGLVDRK FFDQYRSGSL
2010 2020 2030 2040 2050
SLTQFADMIS LKNGVGTSSS MGSGVSDDVF SSSRHESVSK ISTISSVRNL
2060 2070 2080 2090 2100
TIRSSSFSDT LEESSPIAAI FDTENLEKIS ITEGIERGIV DSITGQRLLE
2110 2120 2130 2140 2150
AQACTGGIIH PTTGQKLSLQ DAVSQGVIDQ DMATRLKPAQ KAFIGFEGVK
2160 2170 2180 2190 2200
GKKKMSAAEA VKEKWLPYEA GQRFLEFQYL TGGLVDPEVH GRISTEEAIR
2210 2220 2230 2240 2250
KGFIDGRAAQ RLQDTSSYAK ILTCPKTKLK ISYKDAINRS MVEDITGLRL
2260 2270 2280 2290 2300
LEAASVSSKG LPSPYNMSSA PGSRSGSRSG SRSGSRSGSR SGSRRGSFDA
2310
TGNSSYSYSY SFSSSSIGH
Length:2,319
Mass (Da):265,195
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA226A8D19C52AF27
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB209992 mRNA Translation: BAE06074.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008844.1, NM_001008844.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1832

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209992 mRNA Translation: BAE06074.1
RefSeqiNP_001008844.1, NM_001008844.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ4LE79
PRIDEiQ4LE79

Genome annotation databases

GeneIDi1832

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1832

Phylogenomic databases

HOGENOMiHOG000112198
OrthoDBi7016at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DSP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1832

Family and domain databases

Gene3Di3.90.1290.10, 3 hits
InterProiView protein in InterPro
IPR028462 Desmoplakin
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
PANTHERiPTHR23169:SF26 PTHR23169:SF26, 2 hits
PfamiView protein in Pfam
PF00681 Plectin, 8 hits
PF17902 SH3_10, 1 hit
PF18373 Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00250 PLEC, 18 hits
SM00150 SPEC, 3 hits
SUPFAMiSSF75399 SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4LE79_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LE79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 31, 2019
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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