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Entry version 98 (26 Feb 2020)
Sequence version 1 (02 Aug 2005)
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Protein
Submitted name:

APC variant protein

Gene

APC variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q4LE70

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
APC variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APC variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24875

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4LE70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4LE70 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 57APC_N_CCInterPro annotationAdd BLAST52
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati662 – 704ARMPROSITE-ProRule annotationAdd BLAST43
Domaini2226 – 2577APC_basicInterPro annotationAdd BLAST352
Domaini2672 – 2845EB1_bindingInterPro annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni241 – 307DisorderedSequence analysisAdd BLAST67
Regioni830 – 880DisorderedSequence analysisAdd BLAST51
Regioni925 – 945DisorderedSequence analysisAdd BLAST21
Regioni960 – 989DisorderedSequence analysisAdd BLAST30
Regioni1101 – 1171DisorderedSequence analysisAdd BLAST71
Regioni1192 – 1246DisorderedSequence analysisAdd BLAST55
Regioni1313 – 1378DisorderedSequence analysisAdd BLAST66
Regioni1405 – 1477DisorderedSequence analysisAdd BLAST73
Regioni1528 – 1571DisorderedSequence analysisAdd BLAST44
Regioni1585 – 1613DisorderedSequence analysisAdd BLAST29
Regioni1665 – 1719DisorderedSequence analysisAdd BLAST55
Regioni1731 – 1838DisorderedSequence analysisAdd BLAST108
Regioni1883 – 1954DisorderedSequence analysisAdd BLAST72
Regioni1967 – 2013DisorderedSequence analysisAdd BLAST47
Regioni2045 – 2074DisorderedSequence analysisAdd BLAST30
Regioni2149 – 2637DisorderedSequence analysisAdd BLAST489
Regioni2669 – 2716DisorderedSequence analysisAdd BLAST48
Regioni2731 – 2845DisorderedSequence analysisAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili8 – 56Sequence analysisAdd BLAST49
Coiled coili136 – 170Sequence analysisAdd BLAST35
Coiled coili209 – 229Sequence analysisAdd BLAST21
Coiled coili532 – 552Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi246 – 264PolyampholyteSequence analysisAdd BLAST19
Compositional biasi268 – 306PolarSequence analysisAdd BLAST39
Compositional biasi844 – 859PolyampholyteSequence analysisAdd BLAST16
Compositional biasi928 – 945PolarSequence analysisAdd BLAST18
Compositional biasi960 – 977PolarSequence analysisAdd BLAST18
Compositional biasi1103 – 1132PolarSequence analysisAdd BLAST30
Compositional biasi1134 – 1171PolyampholyteSequence analysisAdd BLAST38
Compositional biasi1329 – 1352PolarSequence analysisAdd BLAST24
Compositional biasi1359 – 1376PolarSequence analysisAdd BLAST18
Compositional biasi1435 – 1449Pro-richSequence analysisAdd BLAST15
Compositional biasi1538 – 1564PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1682 – 1696PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1697 – 1714PolarSequence analysisAdd BLAST18
Compositional biasi1751 – 1765PolarSequence analysisAdd BLAST15
Compositional biasi1789 – 1818PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1883 – 1897PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1898 – 1940PolarSequence analysisAdd BLAST43
Compositional biasi1980 – 1997PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2172 – 2193PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2202 – 2227PolarSequence analysisAdd BLAST26
Compositional biasi2236 – 2251PolarSequence analysisAdd BLAST16
Compositional biasi2260 – 2428PolarSequence analysisAdd BLAST169
Compositional biasi2463 – 2503PolarSequence analysisAdd BLAST41
Compositional biasi2521 – 2535PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2559 – 2582PolarSequence analysisAdd BLAST24
Compositional biasi2583 – 2598PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2619 – 2637PolarSequence analysisAdd BLAST19
Compositional biasi2671 – 2688PolarSequence analysisAdd BLAST18
Compositional biasi2699 – 2713PolarSequence analysisAdd BLAST15
Compositional biasi2739 – 2815PolarSequence analysisAdd BLAST77
Compositional biasi2825 – 2845PolarSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2122 Eukaryota
ENOG410XR2V LUCA

KEGG Orthology (KO)

More...
KOi
K02085

Database of Orthologous Groups

More...
OrthoDBi
31524at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026836 APC
IPR009240 APC_15aa_rpt
IPR009234 APC_basic_dom
IPR026831 APC_dom
IPR026818 Apc_fam
IPR032038 APC_N
IPR036149 APC_N_sf
IPR041257 APC_rep
IPR009223 APC_rpt
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR009232 EB1-bd
IPR009224 SAMP

The PANTHER Classification System

More...
PANTHERi
PTHR12607 PTHR12607, 1 hit
PTHR12607:SF11 PTHR12607:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05972 APC_15aa, 3 hits
PF05956 APC_basic, 1 hit
PF16689 APC_N_CC, 1 hit
PF05923 APC_r, 7 hits
PF18797 APC_rep, 1 hit
PF00514 Arm, 2 hits
PF05937 EB1_binding, 1 hit
PF05924 SAMP, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF58050 SSF58050, 1 hit
SSF82931 SSF82931, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q4LE70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PRMAAASYDQ LLKQVEALKM ENSNLRQELE DNSNHLTKLE TEASNMKEVL
60 70 80 90 100
KQLQGSIEDE AMASSGQIDL LERLKELNLD SSNFPGVKLR SKMSLRSYGS
110 120 130 140 150
REGSVSSRSG ECSPVPMGSF PRRGFVNGSR ESTGYLEELE KERSLLLADL
160 170 180 190 200
DKEEKEKDWY YAQLQNLTKR IDSLPLTENF SLQTDMTRRQ LEYEARQIRV
210 220 230 240 250
AMEEQLGTCQ DMEKRAQRRI ARIQQIEKDI LRIRQLLQSQ ATEAERSSQN
260 270 280 290 300
KHETGSHDAE RQNEGQGVGE INMATSGNGQ GSTTRMDHET ASVLSSSSTH
310 320 330 340 350
SAPRRLTSHL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCISMR
360 370 380 390 400
QSGCLPLLIQ LLHGNDKDSV LLGNSRGSKE ARARASAALH NIIHSQPDDK
410 420 430 440 450
RGRREIRVLH LLEQIRAYCE TCWEWQEAHE PGMDQDKNPM PAPVEHQICP
460 470 480 490 500
AVCVLMKLSF DEEHRHAMNE LGGLQAIAEL LQVDCEMYGL TNDHYSITLR
510 520 530 540 550
RYAGMALTNL TFGDVANKAT LCSMKGCMRA LVAQLKSESE DLQQVIASVL
560 570 580 590 600
RNLSWRADVN SKKTLREVGS VKALMECALE VKKESTLKSV LSALWNLSAH
610 620 630 640 650
CTENKADICA VDGALAFLVG TLTYRSQTNT LAIIESGGGI LRNVSSLIAT
660 670 680 690 700
NEDHRQILRE NNCLQTLLQH LKSHSLTIVS NACGTLWNLS ARNPKDQEAL
710 720 730 740 750
WDMGAVSMLK NLIHSKHKMI AMGSAAALRN LMANRPAKYK DANIMSPGSS
760 770 780 790 800
LPSLHVRKQK ALEAELDAQH LSETFDNIDN LSPKASHRSK QRHKQSLYGD
810 820 830 840 850
YVFDTNRHDD NRSDNFNTGN MTVLSPYLNT TVLPSSSSSR GSLDSSRSEK
860 870 880 890 900
DRSLERERGI GLGNYHPATE NPGTSSKRGL QISTTAAQIA KVMEEVSAIH
910 920 930 940 950
TSQEDRSSGS TTELHCVTDE RNALRRSSAA HTHSNTYNFT KSENSNRTCS
960 970 980 990 1000
MPYAKLEYKR SSNDSLNSVS SSDGYGKRGQ MKPSIESYSE DDESKFCSYG
1010 1020 1030 1040 1050
QYPADLAHKI HSANHMDDND GELDTPINYS LKYSDEQLNS GRQSPSQNER
1060 1070 1080 1090 1100
WARPKHIIED EIKQSEQRQS RNQSTTYPVY TESTDDKHLK FQPHFGQQEC
1110 1120 1130 1140 1150
VSPYRSRGAN GSETNRVGSN HGINQNVSQS LCQEDDYEDD KPTNYSERYS
1160 1170 1180 1190 1200
EEEQHEEEER PTNYSIKYNE EKRHVDQPID YSLKYATDIP SSQKQSFSFS
1210 1220 1230 1240 1250
KSSSGQSSKT EHMSSSSENT STPSSNAKRQ NQLHPSSAQS RSGQPQKAAT
1260 1270 1280 1290 1300
CKVSSINQET IQTYCVEDTP ICFSRCSSLS SLSSAEDEIG CNQTTQEADS
1310 1320 1330 1340 1350
ANTLQIAEIK EKIGTRSAED PVSEVPAVSQ HPRTKSSRLQ GSSLSSESAR
1360 1370 1380 1390 1400
HKAVEFSSGA KSPSKSGAQT PKSPPEHYVQ ETPLMFSRCT SVSSLDSFES
1410 1420 1430 1440 1450
RSIASSVQSE PCSGMVSGII SPSDLPDSPG QTMPPSRSKT PPPPPQTAQT
1460 1470 1480 1490 1500
KREVPKNKAP TAEKRESGPK QAAVNAAVQR VQVLPDADTL LHFATESTPD
1510 1520 1530 1540 1550
GFSCSSSLSA LSLDEPFIQK DVELRIMPPV QENDNGNETE SEQPKESNEN
1560 1570 1580 1590 1600
QEKEAEKTID SEKDLLDDSD DDDIEILEEC IISAMPTKSS RKAKKPAQTA
1610 1620 1630 1640 1650
SKLPPPVARK PSQLPVYKLL PSQNRLQPQK HVSFTPGDDM PRVYCVEGTP
1660 1670 1680 1690 1700
INFSTATSLS DLTIESPPNE LAAGEGVRGG AQSGEFEKRD TIPTEGRSTD
1710 1720 1730 1740 1750
EAQGGKTSSV TIPELDDNKA EEGDILAECI NSAMPKGKSH KPFRVKKIMD
1760 1770 1780 1790 1800
QVQQASASSS APNKNQLDGK KKKPTSPVKP IPQNTEYRTR VRKNADSKNN
1810 1820 1830 1840 1850
LNAERVFSDN KDSKKQNLKN NSKVFNDKLP NNEDRVRGSF AFDSPHHYTP
1860 1870 1880 1890 1900
IEGTPYCFSR NDSLSSLDFD DDDVDLSREK AELRKAKENK ESEAKVTSHT
1910 1920 1930 1940 1950
ELTSNQQSAN KTQAIAKQPI NRGQPKPILQ KQSTFPQSSK DIPDRGAATD
1960 1970 1980 1990 2000
EKLQNFAIEN TPVCFSHNSS LSSLSDIDQE NNNKENEPIK ETEPPDSQGE
2010 2020 2030 2040 2050
PSKPQASGYA PKSFHVEDTP VCFSRNSSLS SLSIDSEDDL LQECISSAMP
2060 2070 2080 2090 2100
KKKKPSRLKG DNEKHSPRNM GGILGEDLTL DLKDIQRPDS EHGLSPDSEN
2110 2120 2130 2140 2150
FDWKAIQEGA NSIVSSLHQA AAAACLSRQA SSDSDSILSL KSGISLGSPF
2160 2170 2180 2190 2200
HLTPDQEEKP FTSNKGPRIL KPGEKSTLET KKIESESKGI KGGKKVYKSL
2210 2220 2230 2240 2250
ITGKVRSNSE ISGQMKQPLQ ANMPSISRGR TMIHIPGVRN SSSSTSPVSK
2260 2270 2280 2290 2300
KGPPLKTPAS KSPSEGQTAT TSPRGAKPSV KSELSPVARQ TSQIGGSSKA
2310 2320 2330 2340 2350
PSRSGSRDST PSRPAQQPLS RPIQSPGRNS ISPGRNGISP PNKLSQLPRT
2360 2370 2380 2390 2400
SSPSTASTKS SGSGKMSYTS PGRQMSQQNL TKQTGLSKNA SSIPRSESAS
2410 2420 2430 2440 2450
KGLNQMNNGN GANKKVELSR MSSTKSSGSE SDRSERPVLV RQSTFIKEAP
2460 2470 2480 2490 2500
SPTLRRKLEE SASFESLSPS SRPASPTRSQ AQTPVLSPSL PDMSLSTHSS
2510 2520 2530 2540 2550
VQAGGWRKLP PNLSPTIEYN DGRPAKRHDI ARSHSESPSR LPINRSGTWK
2560 2570 2580 2590 2600
REHSKHSSSL PRVSTWRRTG SSSSILSASS ESSEKAKSED EKHVNSISGT
2610 2620 2630 2640 2650
KQSKENQVSA KGTWRKIKEN EFSPTNSTSQ TVSSGATNGA ESKTLIYQMA
2660 2670 2680 2690 2700
PAVSKTEDVW VRIEDCPINN PRSGRSPTGN TPPVIDSVSE KANPNIKDSK
2710 2720 2730 2740 2750
DNQAKQNVGN GSVPMRTVGL ENRLNSFIQV DAPDQKGTEI KPGQNNPVPV
2760 2770 2780 2790 2800
SETNESSIVE RTPFSSSSSS KHSSPSGTVA ARVTPFNYNP SPRKSSADST
2810 2820 2830 2840
SARPSQIPTP VNNNTKKRDS KTDSTESSGT QSPKRHSGSY LVTSV
Length:2,845
Mass (Da):311,899
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB83A16839FB61181
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB210001 mRNA Translation: BAE06083.1

NCBI Reference Sequences

More...
RefSeqi
NP_000029.2, NM_000038.5
NP_001120982.1, NM_001127510.2
NP_001120983.2, NM_001127511.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:324

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210001 mRNA Translation: BAE06083.1
RefSeqiNP_000029.2, NM_000038.5
NP_001120982.1, NM_001127510.2
NP_001120983.2, NM_001127511.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ4LE70

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
324

Genome annotation databases

GeneIDi324
KEGGihsa:324

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
324
PharmGKBiPA24875

Phylogenomic databases

eggNOGiKOG2122 Eukaryota
ENOG410XR2V LUCA
KOiK02085
OrthoDBi31524at2759

Enzyme and pathway databases

SignaLinkiQ4LE70

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
APC human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
324

Gene expression databases

GenevisibleiQ4LE70 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR026836 APC
IPR009240 APC_15aa_rpt
IPR009234 APC_basic_dom
IPR026831 APC_dom
IPR026818 Apc_fam
IPR032038 APC_N
IPR036149 APC_N_sf
IPR041257 APC_rep
IPR009223 APC_rpt
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR009232 EB1-bd
IPR009224 SAMP
PANTHERiPTHR12607 PTHR12607, 1 hit
PTHR12607:SF11 PTHR12607:SF11, 1 hit
PfamiView protein in Pfam
PF05972 APC_15aa, 3 hits
PF05956 APC_basic, 1 hit
PF16689 APC_N_CC, 1 hit
PF05923 APC_r, 7 hits
PF18797 APC_rep, 1 hit
PF00514 Arm, 2 hits
PF05937 EB1_binding, 1 hit
PF05924 SAMP, 3 hits
SMARTiView protein in SMART
SM00185 ARM, 7 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF58050 SSF58050, 1 hit
SSF82931 SSF82931, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4LE70_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LE70
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: February 26, 2020
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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