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Entry version 100 (31 Jul 2019)
Sequence version 1 (02 Aug 2005)
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Protein
Submitted name:

PIK4CA variant protein

Gene

PIK4CA variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PIK4CA variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIK4CA variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162399305

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4LE69

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4LE69 HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1549 – 1737PIK helicalInterPro annotationAdd BLAST189
Domaini1864 – 2121PI3K/PI4KInterPro annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0902 Eukaryota
COG5032 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007272

KEGG Orthology (KO)

More...
KOi
K00888

Database of Orthologous Groups

More...
OrthoDBi
1147978at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR015433 PI_Kinase

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00613 PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q4LE69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GRSRARSGEP AGSAAAREVM AAAPARGGGG GGGGGGGCSG SGSSASRGFY
60 70 80 90 100
FNTVLSLARS LAVQRPASLE KVQKLLCMCP VDFHGIFQLD ERRRDAVIAL
110 120 130 140 150
GIFLIESDLQ HKDCVVPYLL RLLKGLPKVY WVEESTARKG RGALPVAESF
160 170 180 190 200
SFCLVTLLSD VAYRDPSLRD EILEVLLQVL HVLLGMCQAL EIQDKEYLCK
210 220 230 240 250
YAIPCLIGIS RAFGRYSNME ESLLSKLFPK IPPHSLRVLE ELEGVRRRSF
260 270 280 290 300
NDFRSILPSN LLTVCQEGTL KRKTSSVSSI SQVSPERGMP PPSSPGGSAF
310 320 330 340 350
HYFEASCLPD GTALEPEYYF STISSSFSVS PLFNGVTYKE FNIPLEMLRE
360 370 380 390 400
LLNLVKKIVE EAVLKSLDAI VASVMEANPS ADLYYTSFSD PLYLTMFKML
410 420 430 440 450
RDTLYYMKDL PTSFVKEIHD FVLEQFNTSQ GELQKILHDA DRIHNELSPL
460 470 480 490 500
KLRCQANAAC VDLMVWAVKD EQGAENLCIK LSEKLQSKTS SKVIIAHLPL
510 520 530 540 550
LICCLQGLGR LCERFPVVVH SVTPSLRDFL VIPSPVLVKL YKYHSQYHTV
560 570 580 590 600
AGNDIKISVT NEHSESTLNV MSGKKSQPSM YEQLRDIAID NICRCLKAGL
610 620 630 640 650
TVDPVIVEAF LASLSNRLYI SQESDKDAHL IPDHTIRALG HIAVALRDTP
660 670 680 690 700
KVMEPILQIL QQKFCQPPSP LDVLIIDQLG CLVITGNQYI YQEVWNLFQQ
710 720 730 740 750
ISVKASSVVY SATKDYKDHG YRHCSLAVIN ALANIAANIQ DEHLVDELLM
760 770 780 790 800
NLLELFVQLG LEGKRASERA SEKGPALKAS SSAGNLGVLI PVIAVLTRRL
810 820 830 840 850
PPIKEAKPRL QKLFRDFWLY SVLMGFAVEG SGLWPEEWYE GVCEIATKSP
860 870 880 890 900
LLTFPSKEPL RSVLQYNSAM KNDTVTPAEL SELRSTIINL LDPPPEVSAL
910 920 930 940 950
INKLDFAMST YLLSVYRLEY MRVLRSTDPD RFQVMFCYFE DKAIQKDKSG
960 970 980 990 1000
MMQCVIAVAD KVFDAFLNMM ADKAKTKENE EELERHAQFL LVNFNHIHKR
1010 1020 1030 1040 1050
IRRVADKYLS GLVDKFPHLL WSGTVLKTML DILQTLSLSL SADIHKDQPY
1060 1070 1080 1090 1100
YDIPDAPYRI TVPDTYEARE SIVKDFAARC GMILQEAMKW APTVTKSHLQ
1110 1120 1130 1140 1150
EYLNKHQNWV SGLSQHTGLA MATESILHFA GYNKQNTTLG ATQLSERPAC
1160 1170 1180 1190 1200
VKKDYSNFMA SLNLRNRYAG EVYGMIRFSG TTGQMSDLNK MMVQDLHSAL
1210 1220 1230 1240 1250
DRSHPQHYTQ AMFKLTAMLI SSKDCDPQLL HHLCWGPLRM FNEHGMETAL
1260 1270 1280 1290 1300
ACWEWLLAGK DGVEVPFMRE MAGAWHMTVE QKFGLFSAEI KEADPLAASE
1310 1320 1330 1340 1350
ASQPKPCPPE VTPHYIWIDF LVQRFEIAKY CSSDQVEIFS SLLQRSMSLN
1360 1370 1380 1390 1400
IGGAKGSMNR HVAAIGPRFK LLTLGLSLLH ADVVPNATIR NVLREKIYST
1410 1420 1430 1440 1450
AFDYFSCPPK FPTQGEKRLR EDISIMIKFW TAMFSDKKYL TASQLVPPDN
1460 1470 1480 1490 1500
QDTRSNLDIT VGSRQQATQG WINTYPLSSG MSTISKKSGM SKKTNRGSQL
1510 1520 1530 1540 1550
HKYYMKRRTL LLSLLATEIE RLITWYNPLS APELELDQAG ENSVANWRSK
1560 1570 1580 1590 1600
YISLSEKQWK DNVNLAWSIS PYLAVQLPAR FKNTEAIGNE VTRLVRLDPG
1610 1620 1630 1640 1650
AVSDVPEAIK FLVTWHTIDA DAPELSHVLC WAPTDPPTGL SYFSSMYPPH
1660 1670 1680 1690 1700
PLTAQYGVKV LRSFPPDAIL FYIPQIVQAL RYDKMGYVRE YILWAASKSQ
1710 1720 1730 1740 1750
LLAHQFIWNM KTNIYLDEEG HQKDPDIGDL LDQLVEEITG SLSGPAKDFY
1760 1770 1780 1790 1800
QREFDFFNKI TNVSAIIKPY PKGDERKKAC LSALSEVKVQ PGCYLPSNPE
1810 1820 1830 1840 1850
AIVLDIDYKS GTPMQSAAKA PYLAKFKVKR CGVSELEKEG LRCRSDSEDE
1860 1870 1880 1890 1900
CSTQEADGQK ISWQAAIFKV GDDCRQDMLA LQIIDLFKNI FQLVGLDLFV
1910 1920 1930 1940 1950
FPYRVVATAP GCGVIECIPD CTSRDQLGRQ TDFGMYDYFT RQYGDESTLA
1960 1970 1980 1990 2000
FQQARYNFIR SMAAYSLLLF LLQIKDRHNG NIMLDKKGHI IHIDFGFMFE
2010 2020 2030 2040 2050
SSPGGNLGWE PDIKLTDEMV MIMGGKMEAT PFKWFMEMCV RGYLAVRPYM
2060 2070 2080 2090 2100
DAVVSLVTLM LDTGLPCFRG QTIKLLKHRF SPNMTEREAA NFIMKVIQSC
2110 2120
FLSNRSRTYD MIQYYQNDIP Y
Length:2,121
Mass (Da):238,697
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B3CEC2D4645DFB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB210002 mRNA Translation: BAE06084.1

NCBI Reference Sequences

More...
RefSeqi
NP_477352.3, NM_058004.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5297

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5297

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210002 mRNA Translation: BAE06084.1
RefSeqiNP_477352.3, NM_058004.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ4LE69

Genome annotation databases

GeneIDi5297
KEGGihsa:5297

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5297
PharmGKBiPA162399305

Phylogenomic databases

eggNOGiKOG0902 Eukaryota
COG5032 LUCA
HOGENOMiHOG000007272
KOiK00888
OrthoDBi1147978at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PI4KA human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5297

Gene expression databases

GenevisibleiQ4LE69 HS

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR015433 PI_Kinase
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PF00613 PI3Ka, 1 hit
SMARTiView protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4LE69_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LE69
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: July 31, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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