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Entry version 87 (10 Feb 2021)
Sequence version 1 (02 Aug 2005)
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Protein
Submitted name:

NUMA1 variant protein

Gene

NUMA1 variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NUMA1 variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NUMA1 variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31844

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4LE64

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4LE64, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni555 – 599DisorderedSequence analysisAdd BLAST45
Regioni752 – 772DisorderedSequence analysisAdd BLAST21
Regioni932 – 963DisorderedSequence analysisAdd BLAST32
Regioni1096 – 1231DisorderedSequence analysisAdd BLAST136
Regioni1281 – 1302DisorderedSequence analysisAdd BLAST22
Regioni1740 – 1767DisorderedSequence analysisAdd BLAST28
Regioni1832 – 1907DisorderedSequence analysisAdd BLAST76
Regioni1961 – 2121DisorderedSequence analysisAdd BLAST161

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili222 – 256Sequence analysisAdd BLAST35
Coiled coili284 – 325Sequence analysisAdd BLAST42
Coiled coili333 – 406Sequence analysisAdd BLAST74
Coiled coili421 – 455Sequence analysisAdd BLAST35
Coiled coili474 – 497Sequence analysisAdd BLAST24
Coiled coili795 – 829Sequence analysisAdd BLAST35
Coiled coili834 – 868Sequence analysisAdd BLAST35
Coiled coili873 – 928Sequence analysisAdd BLAST56
Coiled coili973 – 1046Sequence analysisAdd BLAST74
Coiled coili1373 – 1411Sequence analysisAdd BLAST39
Coiled coili1415 – 1449Sequence analysisAdd BLAST35
Coiled coili1468 – 1517Sequence analysisAdd BLAST50
Coiled coili1522 – 1549Sequence analysisAdd BLAST28
Coiled coili1578 – 1699Sequence analysisAdd BLAST122

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi555 – 570PolarSequence analysisAdd BLAST16
Compositional biasi571 – 599PolyampholyteSequence analysisAdd BLAST29
Compositional biasi932 – 959PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1096 – 1110PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1150 – 1167PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1201 – 1231PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1740 – 1762PolarSequence analysisAdd BLAST23
Compositional biasi1836 – 1868PolarSequence analysisAdd BLAST33
Compositional biasi1879 – 1901PolarSequence analysisAdd BLAST23
Compositional biasi1970 – 1993PolarSequence analysisAdd BLAST24
Compositional biasi2020 – 2034PolyampholyteSequence analysisAdd BLAST15
Compositional biasi2035 – 2064PolarSequence analysisAdd BLAST30
Compositional biasi2079 – 2106PolarSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
524033at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026650, NUMA1

The PANTHER Classification System

More...
PANTHERi
PTHR18902:SF24, PTHR18902:SF24, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q4LE64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LSGITKMTLH ATRGAALLSW VNSLHVADPV EAVLQLQDCS IFIKIIDRIH
60 70 80 90 100
GTEEGQQILK QPVSERLDFV CSFLQKNRKH PSSPECLVSA QKVLEGSELE
110 120 130 140 150
LAKMTMLLLY HSTMSSKSPR DWEQFEYKIQ AELAVILKFV LDHEDGLNLN
160 170 180 190 200
EDLENFLQKA PVPSTCSSTF PEELSPPSHQ AKREIRFLEL QKVASSSSGN
210 220 230 240 250
NFLSGSPASP MGDILQTPQF QMRRLKKQLA DERSNRDELE LELAENRKLL
260 270 280 290 300
TEKDAQIAMM QQRIDRLALL NEKQAASPLE PKELEELRDK NESLTMRLHE
310 320 330 340 350
TLKQCQDLKT EKSQMDRKIN QLSEENGDLS FKLREFASHL QQLQDALNEL
360 370 380 390 400
TEEHSKATQE WLEKQAQLEK ELSAALQDKK CLEEKNEILQ GKLSQLEEHL
410 420 430 440 450
SQLQDNPPQE KGEVLGDVLQ LETLKQEAAT LAANNTQLQA RVEMLETERG
460 470 480 490 500
QQEAKLLAER GHFEEEKQQL SSLITDLQSS ISNLSQAKEE LEQASQAHGA
510 520 530 540 550
RLTAQVASLT SELTTLNATI QQQDQELAGL KQQAKEKQAQ LAQTLQQQEQ
560 570 580 590 600
ASQGLRHQVE QLSSSLKQKE QQLKEVAEKQ EATRQDHAQQ LATAAEEREA
610 620 630 640 650
SLRERDAALK QLEALEKEKA AKLEILQQQL QVANEARDSA QTSVTQAQRE
660 670 680 690 700
KAELSRKVEE LQACVETARQ EQHEAQAQVA ELELQLRSEQ QKATEKERVA
710 720 730 740 750
QEKDQLQEQL QALKESLKVT KGSLEEEKRR AADALEEQQR CISELKAETR
760 770 780 790 800
SLVEQHKRER KELEEERAGR KGLEARLQQL GEAHQAETEV LRRELAEAMA
810 820 830 840 850
AQHTAESECE QLVKEVAAWR ERYEDSQQEE AQYGAMFQEQ LMTLKEECEK
860 870 880 890 900
ARQELQEAKE KVAGIESHSE LQISRQQNEL AELHANLARA LQQVQEKEVR
910 920 930 940 950
AQKLADDLST LQEKMAATSK EVARLETLVR KAGEQQETAS RELVKEPARA
960 970 980 990 1000
GDRQPEWLEE QQGRQFCSTQ AALQAMEREA EQMGNELERL RAALMESQGQ
1010 1020 1030 1040 1050
QQEERGQQER EVARLTQERG RAQADLALEK AARAELEMRL QNALNEQRVE
1060 1070 1080 1090 1100
FATLQEALAH ALTEKEGKDQ ELAKLRGLEA AQIKELEELR QTVKQLKEQL
1110 1120 1130 1140 1150
AKKEKEHASG SGAQSEAAGR TEPTGPKLEA LRAEVSKLEQ QCQKQQEQAD
1160 1170 1180 1190 1200
SLERSLEAER ASRAERDSAL ETLQGQLEEK AQELGHSQSA LASAQRELAA
1210 1220 1230 1240 1250
FRTKVQDHSK AEDEWKAQVA RGRQEAERKN SLISSLEEEV SILNRQVLEK
1260 1270 1280 1290 1300
EGESKELKRL VMAESEKSQK LEERLRLLQA ETASNSARAA ERSSALREEV
1310 1320 1330 1340 1350
QSLREEAEKQ RVASENLRQE LTSQAERAEE LGQELKAWQE KFFQKEQALS
1360 1370 1380 1390 1400
TLQLEHTSTQ ALVSELLPAK HLCQQLQAEQ AAAEKRHREE LEQSKQAAGG
1410 1420 1430 1440 1450
LRAELLRAQR ELGELIPLRQ KVAEQERTAQ QLRAEKASYA EQLSMLKKAH
1460 1470 1480 1490 1500
GLLAEENRGL GERANLGRQF LEVELDQARE KYVQELAAVR ADAETRLAEV
1510 1520 1530 1540 1550
QREAQSTARE LEVMTAKYEG AKVKVLEERQ RFQEERQKLT AQVEQLEVFQ
1560 1570 1580 1590 1600
REQTKQVEEL SKKLADSDQA SKVQQQKLKA VQAQGGESQQ EAQRLQAQLN
1610 1620 1630 1640 1650
ELQAQLSQKE QAAEHYKLQM EKAKTHYDAK KQQNQELQEQ LRSLEQLQKE
1660 1670 1680 1690 1700
NKELRAEAER LGHELQQAGL KTKEAEQTCR HLTAQVRSLE AQVAHADQQL
1710 1720 1730 1740 1750
RDLGKFQVAT DALKSREPQA KPQLDLSIDS LDLSCEEGTP LSITSKLPRT
1760 1770 1780 1790 1800
QPDGTSVPGE PASPISQRLP PKVESLESLY FTPIPARSQA PLESSLDSLG
1810 1820 1830 1840 1850
DVFLDSGRKT RSARRRTTQI INITMTKKLD VEEPDSANSS FYSTRSAPAS
1860 1870 1880 1890 1900
QASLRATSST QSLARLGSPD YGNSALLSLP GYRPTTRSSA RRSQAGVSSG
1910 1920 1930 1940 1950
APPGRNSFYM GTCQDEPEQL DDWNRIAELQ QRNRVCPPHL KTCYPLESRP
1960 1970 1980 1990 2000
SLSLGTITDE EMKTGDPQET LRRASMQPIQ IAEGTGITTR QQRKRVSLEP
2010 2020 2030 2040 2050
HQGPGTPESK KATSCFPRPM TPRDRHEGRK QSTTEAQKKA APASTKQADR
2060 2070 2080 2090 2100
RQSMAFSILN TPKKLGNSLL RRGASKKALS KASPNTRSGT RRSPRIATTT
2110 2120
ASAATAAAIG ATPRAKGKAK H
Length:2,121
Mass (Da):238,859
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32080FE79C65BA1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB210007 mRNA Translation: BAE06089.1

NCBI Reference Sequences

More...
RefSeqi
NP_001273490.1, NM_001286561.1
NP_006176.2, NM_006185.3
XP_006718627.1, XM_006718564.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4926

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4926

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210007 mRNA Translation: BAE06089.1
RefSeqiNP_001273490.1, NM_001286561.1
NP_006176.2, NM_006185.3
XP_006718627.1, XM_006718564.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ4LE64

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4926

Genome annotation databases

GeneIDi4926
KEGGihsa:4926

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4926
PharmGKBiPA31844

Phylogenomic databases

OrthoDBi524033at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4926, 439 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NUMA1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4926

Gene expression databases

GenevisibleiQ4LE64, HS

Family and domain databases

InterProiView protein in InterPro
IPR026650, NUMA1
PANTHERiPTHR18902:SF24, PTHR18902:SF24, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4LE64_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LE64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: February 10, 2021
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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