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Entry version 134 (12 Aug 2020)
Sequence version 1 (02 Aug 2005)
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Protein

Phosphoinositide phospholipase C

Gene

PLCG1 variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+ARBA annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi287 – 298PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseUniRule annotationARBA annotation, TransducerARBA annotation
Biological processLipid degradationUniRule annotationARBA annotation, Lipid metabolism
LigandCalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingARBA annotation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q4LE43

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotationARBA annotation (EC:3.1.4.11UniRule annotationARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLCG1 variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33392

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q4LE43

PRoteomics IDEntifications database

More...
PRIDEi
Q4LE43

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4LE43, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q4LE43, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 264PHInterPro annotationAdd BLAST116
Domaini274 – 309EF-handInterPro annotationAdd BLAST36
Domaini672 – 779SH2InterPro annotationAdd BLAST108
Domaini790 – 878SH2InterPro annotationAdd BLAST89
Domaini913 – 973SH3InterPro annotationAdd BLAST61
Domaini1017 – 1053PHInterPro annotationAdd BLAST37
Domaini1075 – 1192PI-PLC Y-boxInterPro annotationAdd BLAST118
Domaini1197 – 1299C2InterPro annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 78DisorderedSequence analysisAdd BLAST78
Regioni644 – 666DisorderedSequence analysisAdd BLAST23
Regioni1393 – 1412DisorderedSequence analysisAdd BLAST20

Keywords - Domaini

RepeatARBA annotation, SH2 domainPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K01116

Database of Orthologous Groups

More...
OrthoDBi
368239at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09932, SH2_C-SH2_PLC_gamma_like, 1 hit
cd10341, SH2_N-SH2_PLC_gamma_like, 1 hit
cd11970, SH3_PLCgamma1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
3.30.505.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001192, PI-PLC_fam
IPR028380, PLC-gamma1
IPR035023, PLC-gamma_C-SH2
IPR035024, PLC-gamma_N-SH2
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR035724, PLCgamma1_SH3
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10336, PTHR10336, 1 hit
PTHR10336:SF173, PTHR10336:SF173, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PF00017, SH2, 2 hits
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390, PHPHLIPASEC
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 3 hits
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SM00252, SH2, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF50044, SSF50044, 1 hit
SSF51695, SSF51695, 1 hit
SSF55550, SSF55550, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS50008, PIPLC_Y_DOMAIN, 1 hit
PS50001, SH2, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q4LE43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ESSAGLRAGW VDRERRALPP PSRLRPRLRP VWGSRGAGAA GRRAGVLPTG
60 70 80 90 100
ARAPLFPAPK RGGASGQPRP AALRPRPVSA CRSRRRVPLV CRLSLSPNLS
110 120 130 140 150
RRRCACSRAV LACAAAAPSV GAMAGAASPC ANGCGPGAPS DAEVLHLCRS
160 170 180 190 200
LEVGTVMTLF YSKKSQRPER KTFQVKLETR QITWSRGADK IEGAIDIREI
210 220 230 240 250
KEIRPGKTSR DFDRYQEDPA FRPDQSHCFV ILYGMEFRLK TLSLQATSED
260 270 280 290 300
EVNMWIKGLT WLMEDTLQAP TPLQIERWLR KQFYSVDRNR EDRISAKDLK
310 320 330 340 350
NMLSQVNYRV PNMRFLRERL TDLEQRSGDI TYGQFAQLYR SLMYSAQKTM
360 370 380 390 400
DLPFLEASTL RAGERPELCR VSLPEFQQFL LDYQGELWAV DRLQVQEFML
410 420 430 440 450
SFLRDPLREI EEPYFFLDEF VTFLFSKENS VWNSQLDAVC PDTMNNPLSH
460 470 480 490 500
YWISSSHNTY LTGDQFSSES SLEAYARCLR MGCRCIELDC WDGPDGMPVI
510 520 530 540 550
YHGHTLTTKI KFSDVLHTIK EHAFVASEYP VILSIEDHCS IAQQRNMAQY
560 570 580 590 600
FKKVLGDTLL TKPVEISADG LPSPNQLKRK ILIKHKKLAE GSAYEEVPTS
610 620 630 640 650
MMYSENDISN SIKNGILYLE DPVNHEWYPH YFVLTSSKIY YSEETSSDQG
660 670 680 690 700
NEDEEEPKEV SSSTELHSNE KWFHGKLGAG RDGRHIAERL LTEYCIETGA
710 720 730 740 750
PDGSFLVRES ETFVGDYTLS FWRNGKVQHC RIHSRQDAGT PKFFLTDNLV
760 770 780 790 800
FDSLYDLITH YQQVPLRCNE FEMRLSEPVP QTNAHESKEW YHASLTRAQA
810 820 830 840 850
EHMLMRVPRD GAFLVRKRNE PNSYAISFRA EGKIKHCRVQ QEGQTVMLGN
860 870 880 890 900
SEFDSLVDLI SYYEKHPLYR KMKLRYPINE EALEKIGTAE PDYGALYEGR
910 920 930 940 950
NPGFYVEANP MPTFKCAVKA LFDYKAQRED ELTFTKSAII QNVEKQEGGW
960 970 980 990 1000
WRGDYGGKKQ LWFPSNYVEE MVNPVALEPE REHLDENSPL GDLLRGVLDV
1010 1020 1030 1040 1050
PACQIAIRPE GKNNRLFVFS ISMASVAHWS LDVAADSQEE LQDWVKKIRE
1060 1070 1080 1090 1100
VAQTADARLT EGKIMERRKK IALELSELVV YCRPVPFDEE KIGTERACYR
1110 1120 1130 1140 1150
DMSSFPETKA EKYVNKAKGK KFLQYNRLQL SRIYPKGQRL DSSNYDPLPM
1160 1170 1180 1190 1200
WICGSQLVAL NFQTPDKPMQ MNQALFMTGR HCGYVLQPST MRDEAFDPFD
1210 1220 1230 1240 1250
KSSLRGLEPC AISIEVLGAR HLPKNGRGIV CPFVEIEVAG AEYDSTKQKT
1260 1270 1280 1290 1300
EFVVDNGLNP VWPAKPFHFQ ISNPEFAFLR FVVYEEDMFS DQNFLAQATF
1310 1320 1330 1340 1350
PVKGLKTGYR AVPLKNNYSE DLELASLLIK IDIFPAKENG DLSPFSGTSL
1360 1370 1380 1390 1400
RERGSDASGQ LFHGRAREGS FESRYQQPFE DFRISQEHLA DHFDSRERRA
1410
PRRTRVNGDN RL
Length:1,412
Mass (Da):161,303
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B3233E8A77FAD3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB210028 mRNA Translation: BAE06110.1

NCBI Reference Sequences

More...
RefSeqi
NP_002651.2, NM_002660.2
NP_877963.1, NM_182811.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5335

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210028 mRNA Translation: BAE06110.1
RefSeqiNP_002651.2, NM_002660.2
NP_877963.1, NM_182811.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ4LE43, 1 interactor

Proteomic databases

PeptideAtlasiQ4LE43
PRIDEiQ4LE43

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5335

Genome annotation databases

GeneIDi5335
KEGGihsa:5335

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5335
PharmGKBiPA33392

Phylogenomic databases

KOiK01116
OrthoDBi368239at2759

Enzyme and pathway databases

SignaLinkiQ4LE43

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5335, 12 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLCG1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5335

Gene expression databases

GenevisibleiQ4LE43, HS

Family and domain databases

CDDicd09932, SH2_C-SH2_PLC_gamma_like, 1 hit
cd10341, SH2_N-SH2_PLC_gamma_like, 1 hit
cd11970, SH3_PLCgamma1, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001192, PI-PLC_fam
IPR028380, PLC-gamma1
IPR035023, PLC-gamma_C-SH2
IPR035024, PLC-gamma_N-SH2
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR035724, PLCgamma1_SH3
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR10336, PTHR10336, 1 hit
PTHR10336:SF173, PTHR10336:SF173, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PF00017, SH2, 2 hits
PF00018, SH3_1, 1 hit
PRINTSiPR00390, PHPHLIPASEC
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 3 hits
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SM00252, SH2, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF50044, SSF50044, 1 hit
SSF51695, SSF51695, 1 hit
SSF55550, SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS50008, PIPLC_Y_DOMAIN, 1 hit
PS50001, SH2, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4LE43_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LE43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: August 12, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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