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Entry version 138 (16 Oct 2019)
Sequence version 2 (03 Apr 2007)
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Protein

AT-rich interactive domain-containing protein 4B

Gene

ARID4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214815 HDACs deacetylate histones
R-HSA-427413 NoRC negatively regulates rRNA expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4B
Short name:
ARID domain-containing protein 4B
Alternative name(s):
180 kDa Sin3-associated polypeptide
Short name:
Sin3-associated polypeptide p180
Breast cancer-associated antigen BRCAA1
Histone deacetylase complex subunit SAP180
Retinoblastoma-binding protein 1-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID4B
Synonyms:BRCAA1, RBBP1L1, RBP1L1, SAP180
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:15550 ARID4B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609696 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4LE39

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51742

Open Targets

More...
OpenTargetsi
ENSG00000054267

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134940494

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4LE39

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARID4B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143955276

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002828631 – 1312AT-rich interactive domain-containing protein 4BAdd BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei276PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki429Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki462Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei483PhosphoserineCombined sources1
Cross-linki517Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei666PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Cross-linki751Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei778PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1
Modified residuei793PhosphothreonineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1026PhosphothreonineCombined sources1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1150PhosphothreonineCombined sources1
Modified residuei1152PhosphoserineCombined sources1
Modified residuei1153PhosphoserineCombined sources1
Modified residuei1155PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q4LE39

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q4LE39

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q4LE39

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q4LE39

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q4LE39

PeptideAtlas

More...
PeptideAtlasi
Q4LE39

PRoteomics IDEntifications database

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PRIDEi
Q4LE39

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62238 [Q4LE39-1]
62239 [Q4LE39-2]
62240 [Q4LE39-3]
62241 [Q4LE39-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q4LE39

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4LE39

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000054267 Expressed in 231 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q4LE39 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q4LE39 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027333
HPA053692

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2 (PubMed:12724404).

Interacts with ARID4A (PubMed:17043311).

Interacts with AR (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119708, 48 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q4LE39

Protein interaction database and analysis system

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IntActi
Q4LE39, 47 interactors

Molecular INTeraction database

More...
MINTi
Q4LE39

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264183

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4LE39

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini306 – 398ARIDPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni465 – 473Antigenic epitope9
Regioni1130 – 1137Antigenic epitope8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili728 – 754Sequence analysisAdd BLAST27
Coiled coili1231 – 1270Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 159Poly-Ser6
Compositional biasi268 – 567Glu-richAdd BLAST300
Compositional biasi1095 – 1101Poly-Ser7
Compositional biasi1271 – 1303Ser-richAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus mediates interaction with mSin3A corepressor complex.1 Publication
The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.1 Publication
The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2744 Eukaryota
KOG3001 Eukaryota
ENOG410Y2AP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158149

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q4LE39

KEGG Orthology (KO)

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KOi
K19195

Identification of Orthologs from Complete Genome Data

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OMAi
CKDCEKE

Database of Orthologous Groups

More...
OrthoDBi
329541at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q4LE39

TreeFam database of animal gene trees

More...
TreeFami
TF106427

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028853 ARID4B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016197 Chromo-like_dom_sf
IPR012603 RBB1NT
IPR002999 Tudor
IPR025995 Tudor-knot

The PANTHER Classification System

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PANTHERi
PTHR13964:SF24 PTHR13964:SF24, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01388 ARID, 1 hit
PF08169 RBB1NT, 1 hit
PF11717 Tudor-knot, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00501 BRIGHT, 1 hit
SM00333 TUDOR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46774 SSF46774, 1 hit
SSF54160 SSF54160, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51011 ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4LE39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE
60 70 80 90 100
VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT
110 120 130 140 150
LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP
160 170 180 190 200
EEESSSSSSD EDEDDRKQID ELLGKVVCVD YISLDKKKAL WFPALVVCPD
210 220 230 240 250
CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK PDAVLKQAFE
260 270 280 290 300
QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE
310 320 330 340 350
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL
360 370 380 390 400
GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA
410 420 430 440 450
NIEFQMALPE KVVNKQCKEC ENVKEIKVKE ENETEIKEIK MEEERNIIPR
460 470 480 490 500
EEKPIEDEIE RKENIKPSLG SKKNLLESIP THSDQEKEVN IKKPEDNENL
510 520 530 540 550
DDKDDDTTRV DESLNIKVEA EEEKAKSGDE TNKEEDEDDE EAEEEEEEEE
560 570 580 590 600
EEEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG
610 620 630 640 650
EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD
660 670 680 690 700
KDEKYSPKNC KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI
710 720 730 740 750
TSILNGLQAS ESSAEDSEQE DERGAQDMDN NGKEESKIDH LTNNRNDLIS
760 770 780 790 800
KEEQNSSSLL EENKVHADLV ISKPVSKSPE RLRKDIEVLS EDTDYEEDEV
810 820 830 840 850
TKKRKDVKKD TTDKSSKPQI KRGKRRYCNT EECLKTGSPG KKEEKAKNKE
860 870 880 890 900
SLCMENSSNS SSDEDEEETK AKMTPTKKYN GLEEKRKSLR TTGFYSGFSE
910 920 930 940 950
VAEKRIKLLN NSDERLQNSR AKDRKDVWSS IQGQWPKKTL KELFSDSDTE
960 970 980 990 1000
AAASPPHPAP EEGVAEESLQ TVAEEESCSP SVELEKPPPV NVDSKPIEEK
1010 1020 1030 1040 1050
TVEVNDRKAE FPSSGSNSVL NTPPTTPESP SSVTVTEGSR QQSSVTVSEP
1060 1070 1080 1090 1100
LAPNQEEVRS IKSETDSTIE VDSVAGELQD LQSEGNSSPA GFDASVSSSS
1110 1120 1130 1140 1150
SNQPEPEHPE KACTGQKRVK DAQGGGSSSK KQKRSHKATV VNNKKKGKGT
1160 1170 1180 1190 1200
NSSDSEELSA GESITKSQPV KSVSTGMKSH STKSPARTQS PGKCGKNGDK
1210 1220 1230 1240 1250
DPDLKEPSNR LPKVYKWSFQ MSDLENMTSA ERITILQEKL QEIRKHYLSL
1260 1270 1280 1290 1300
KSEVASIDRR RKRLKKKERE SAATSSSSSS PSSSSITAAV MLTLAEPSMS
1310
SASQNGMSVE CR
Length:1,312
Mass (Da):147,809
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4175FF80F5217EE
GO
Isoform 2 (identifier: Q4LE39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-614: Missing.

Show »
Length:1,226
Mass (Da):137,607
Checksum:i3ADAB4A897403AD9
GO
Isoform 3 (identifier: Q4LE39-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1150-1153: TNSS → SAPH
     1154-1312: Missing.

Show »
Length:1,153
Mass (Da):130,418
Checksum:i9C540DF507EBC220
GO
Isoform 4 (identifier: Q4LE39-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     1112-1122: ACTGQKRVKDA → GEKENVYVDLF
     1123-1312: Missing.

Show »
Length:803
Mass (Da):91,140
Checksum:iAC58481D8DE15417
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RCR8X6RCR8_HUMAN
AT-rich interactive domain-containi...
ARID4B
483Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5R6H7C5R6_HUMAN
AT-rich interactive domain-containi...
ARID4B
696Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7Y8H0Y7Y8_HUMAN
AT-rich interactive domain-containi...
ARID4B
553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD41239 differs from that shown. Reason: Frameshift.Curated
The sequence AAF23433 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14428 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE06114 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15D → G in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti79V → A in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti330R → Q in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti330R → Q in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti400A → P in BAA89794 (Ref. 4) Curated1
Sequence conflicti436I → IEFCGR in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti437K → Q in BAA89794 (Ref. 4) Curated1
Sequence conflicti559 – 561DNN → ATI in BAA89794 (Ref. 4) Curated3
Sequence conflicti568C → S in BAA89794 (Ref. 4) Curated1
Sequence conflicti575V → A in BAA89794 (Ref. 4) Curated1
Sequence conflicti584N → H in BAA89794 (Ref. 4) Curated1
Sequence conflicti605L → S in AAF36964 (Ref. 9) Curated1
Sequence conflicti616D → G in AAF36964 (Ref. 9) Curated1
Sequence conflicti813D → G in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti915 – 917RLQ → LP in AAF23433 (PubMed:15247124).Curated3
Sequence conflicti940L → R in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1000K → E in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti1000K → E in AAF36964 (Ref. 9) Curated1
Sequence conflicti1001T → Q in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1032S → P in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti1087S → N in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti1118R → G in CAI46047 (PubMed:17974005).Curated1
Sequence conflicti1144K → T in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1144K → T in AAD41239 (Ref. 10) Curated1
Sequence conflicti1243 – 1244IR → NQ in AAF23433 (PubMed:15247124).Curated2
Sequence conflicti1243 – 1244IR → NQ in AAD41239 (Ref. 10) Curated2
Sequence conflicti1290V → A in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti1290V → A in AAF36964 (Ref. 9) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0242301 – 319Missing in isoform 4. 1 PublicationAdd BLAST319
Alternative sequenceiVSP_024231529 – 614Missing in isoform 2. 4 PublicationsAdd BLAST86
Alternative sequenceiVSP_0242321112 – 1122ACTGQKRVKDA → GEKENVYVDLF in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0242331123 – 1312Missing in isoform 4. 1 PublicationAdd BLAST190
Alternative sequenceiVSP_0242341150 – 1153TNSS → SAPH in isoform 3. 1 Publication4
Alternative sequenceiVSP_0242351154 – 1312Missing in isoform 3. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF214114 mRNA Translation: AAF28341.2
AY220790 mRNA Translation: AAO63590.1
AF208045 mRNA Translation: AAF23433.3 Frameshift.
AB030181 mRNA Translation: BAA89794.1
AB210032 mRNA Translation: BAE06114.1 Different initiation.
AL133418 Genomic DNA No translation available.
AL391994 Genomic DNA No translation available.
BC048959 mRNA Translation: AAH48959.1 Different termination.
BC062536 mRNA Translation: AAH62536.1 Different termination.
BC104632 mRNA Translation: AAI04633.1 Different termination.
BC130418 mRNA Translation: AAI30419.1
BX648820 mRNA Translation: CAI46047.1
AL133594 mRNA Translation: CAB63731.1
AF227899 mRNA Translation: AAF36964.1
AF083249 mRNA Translation: AAD41239.1 Frameshift.
AK023144 mRNA Translation: BAB14428.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS31060.1 [Q4LE39-2]
CCDS31061.1 [Q4LE39-1]

Protein sequence database of the Protein Information Resource

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PIRi
T43497

NCBI Reference Sequences

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RefSeqi
NP_001193723.1, NM_001206794.1 [Q4LE39-1]
NP_057458.4, NM_016374.5 [Q4LE39-1]
NP_112739.2, NM_031371.3 [Q4LE39-2]
XP_011542514.1, XM_011544212.2 [Q4LE39-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264183; ENSP00000264183; ENSG00000054267 [Q4LE39-1]
ENST00000349213; ENSP00000264184; ENSG00000054267 [Q4LE39-2]
ENST00000366603; ENSP00000355562; ENSG00000054267 [Q4LE39-1]
ENST00000421364; ENSP00000394663; ENSG00000054267 [Q4LE39-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51742

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51742

UCSC genome browser

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UCSCi
uc001hwq.3 human [Q4LE39-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214114 mRNA Translation: AAF28341.2
AY220790 mRNA Translation: AAO63590.1
AF208045 mRNA Translation: AAF23433.3 Frameshift.
AB030181 mRNA Translation: BAA89794.1
AB210032 mRNA Translation: BAE06114.1 Different initiation.
AL133418 Genomic DNA No translation available.
AL391994 Genomic DNA No translation available.
BC048959 mRNA Translation: AAH48959.1 Different termination.
BC062536 mRNA Translation: AAH62536.1 Different termination.
BC104632 mRNA Translation: AAI04633.1 Different termination.
BC130418 mRNA Translation: AAI30419.1
BX648820 mRNA Translation: CAI46047.1
AL133594 mRNA Translation: CAB63731.1
AF227899 mRNA Translation: AAF36964.1
AF083249 mRNA Translation: AAD41239.1 Frameshift.
AK023144 mRNA Translation: BAB14428.1 Different initiation.
CCDSiCCDS31060.1 [Q4LE39-2]
CCDS31061.1 [Q4LE39-1]
PIRiT43497
RefSeqiNP_001193723.1, NM_001206794.1 [Q4LE39-1]
NP_057458.4, NM_016374.5 [Q4LE39-1]
NP_112739.2, NM_031371.3 [Q4LE39-2]
XP_011542514.1, XM_011544212.2 [Q4LE39-1]

3D structure databases

SMRiQ4LE39
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119708, 48 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiQ4LE39
IntActiQ4LE39, 47 interactors
MINTiQ4LE39
STRINGi9606.ENSP00000264183

PTM databases

iPTMnetiQ4LE39
PhosphoSitePlusiQ4LE39

Polymorphism and mutation databases

BioMutaiARID4B
DMDMi143955276

Proteomic databases

EPDiQ4LE39
jPOSTiQ4LE39
MassIVEiQ4LE39
MaxQBiQ4LE39
PaxDbiQ4LE39
PeptideAtlasiQ4LE39
PRIDEiQ4LE39
ProteomicsDBi62238 [Q4LE39-1]
62239 [Q4LE39-2]
62240 [Q4LE39-3]
62241 [Q4LE39-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51742

Genome annotation databases

EnsembliENST00000264183; ENSP00000264183; ENSG00000054267 [Q4LE39-1]
ENST00000349213; ENSP00000264184; ENSG00000054267 [Q4LE39-2]
ENST00000366603; ENSP00000355562; ENSG00000054267 [Q4LE39-1]
ENST00000421364; ENSP00000394663; ENSG00000054267 [Q4LE39-3]
GeneIDi51742
KEGGihsa:51742
UCSCiuc001hwq.3 human [Q4LE39-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51742
DisGeNETi51742

GeneCards: human genes, protein and diseases

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GeneCardsi
ARID4B
HGNCiHGNC:15550 ARID4B
HPAiHPA027333
HPA053692
MIMi609696 gene
neXtProtiNX_Q4LE39
OpenTargetsiENSG00000054267
PharmGKBiPA134940494

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
KOG3001 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00940000158149
InParanoidiQ4LE39
KOiK19195
OMAiCKDCEKE
OrthoDBi329541at2759
PhylomeDBiQ4LE39
TreeFamiTF106427

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-427413 NoRC negatively regulates rRNA expression

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARID4B human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ARID4B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51742
PharosiQ4LE39

Protein Ontology

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PROi
PR:Q4LE39

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000054267 Expressed in 231 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ4LE39 baseline and differential
GenevisibleiQ4LE39 HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR028853 ARID4B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016197 Chromo-like_dom_sf
IPR012603 RBB1NT
IPR002999 Tudor
IPR025995 Tudor-knot
PANTHERiPTHR13964:SF24 PTHR13964:SF24, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF08169 RBB1NT, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SM00333 TUDOR, 2 hits
SUPFAMiSSF46774 SSF46774, 1 hit
SSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI4B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LE39
Secondary accession number(s): A1L465
, Q3MHV4, Q5HY99, Q5T2C2, Q5T2C3, Q5T2C4, Q5T2C5, Q5T2C6, Q6P600, Q86UX1, Q86WR4, Q9H915, Q9NYU3, Q9NZB6, Q9NZG4, Q9P2W4, Q9UF62, Q9Y6E1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 16, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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