UniProtKB - Q4LE39 (ARI4B_HUMAN)
AT-rich interactive domain-containing protein 4B
ARID4B
Functioni
Acts as a transcriptional repressor (PubMed:12724404).
May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404).
Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).
By similarity1 PublicationGO - Molecular functioni
- transcription cis-regulatory region binding Source: GO_Central
GO - Biological processi
- establishment of Sertoli cell barrier Source: Ensembl
- histone H3-K9 trimethylation Source: Ensembl
- histone H4-K20 trimethylation Source: Ensembl
- negative regulation of cell migration Source: ComplexPortal
- negative regulation of stem cell population maintenance Source: ComplexPortal
- negative regulation of transcription by RNA polymerase II Source: ComplexPortal
- negative regulation of transforming growth factor beta receptor signaling pathway Source: ComplexPortal
- positive regulation of stem cell population maintenance Source: ComplexPortal
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of gene expression by genomic imprinting Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | Chromatin regulator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q4LE39 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | Q4LE39 |
Names & Taxonomyi
Protein namesi | Recommended name: AT-rich interactive domain-containing protein 4BShort name: ARID domain-containing protein 4B Alternative name(s): 180 kDa Sin3-associated polypeptide Short name: Sin3-associated polypeptide p180 Breast cancer-associated antigen BRCAA1 Histone deacetylase complex subunit SAP180 Retinoblastoma-binding protein 1-like 1 |
Gene namesi | Name:ARID4B Synonyms:BRCAA1, RBBP1L1, RBP1L1, SAP180 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15550, ARID4B |
MIMi | 609696, gene |
neXtProti | NX_Q4LE39 |
VEuPathDBi | HostDB:ENSG00000054267 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
- Sin3 complex Source: ComplexPortal
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51742 |
OpenTargetsi | ENSG00000054267 |
PharmGKBi | PA134940494 |
Miscellaneous databases
Pharosi | Q4LE39, Tbio |
Genetic variation databases
BioMutai | ARID4B |
DMDMi | 143955276 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000282863 | 1 – 1312 | AT-rich interactive domain-containing protein 4BAdd BLAST | 1312 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 276 | PhosphoserineCombined sources | 1 | |
Modified residuei | 295 | PhosphoserineBy similarity | 1 | |
Modified residuei | 296 | PhosphoserineBy similarity | 1 | |
Cross-linki | 429 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 440 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 462 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 483 | PhosphoserineCombined sources | 1 | |
Cross-linki | 517 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 666 | PhosphoserineCombined sources | 1 | |
Modified residuei | 675 | PhosphoserineCombined sources | 1 | |
Modified residuei | 717 | PhosphoserineCombined sources | 1 | |
Cross-linki | 751 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 778 | PhosphoserineCombined sources | 1 | |
Modified residuei | 790 | PhosphoserineCombined sources | 1 | |
Modified residuei | 793 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1014 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1026 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1029 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1150 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1152 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1153 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1155 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1159 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1754 |
EPDi | Q4LE39 |
jPOSTi | Q4LE39 |
MassIVEi | Q4LE39 |
MaxQBi | Q4LE39 |
PaxDbi | Q4LE39 |
PeptideAtlasi | Q4LE39 |
PRIDEi | Q4LE39 |
ProteomicsDBi | 62238 [Q4LE39-1] 62239 [Q4LE39-2] 62240 [Q4LE39-3] 62241 [Q4LE39-4] |
PTM databases
GlyGeni | Q4LE39, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q4LE39 |
PhosphoSitePlusi | Q4LE39 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000054267, Expressed in substantia nigra and 243 other tissues |
ExpressionAtlasi | Q4LE39, baseline and differential |
Genevisiblei | Q4LE39, HS |
Organism-specific databases
HPAi | ENSG00000054267, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q4LE39
With | #Exp. | IntAct |
---|---|---|
ETS1 [P14921] | 2 | EBI-2680990,EBI-913209 |
Isoform 3 [Q4LE39-3]
Protein-protein interaction databases
BioGRIDi | 119708, 114 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q4LE39 |
IntActi | Q4LE39, 95 interactors |
MINTi | Q4LE39 |
STRINGi | 9606.ENSP00000264183 |
Miscellaneous databases
RNActi | Q4LE39, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q4LE39 |
SMRi | Q4LE39 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 306 – 398 | ARIDPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 572 – 624 | Tudor-knotSequence analysisAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 166 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 266 – 306 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 458 – 577 | DisorderedSequence analysisAdd BLAST | 120 | |
Regioni | 465 – 473 | Antigenic epitope | 9 | |
Regioni | 635 – 680 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 708 – 894 | DisorderedSequence analysisAdd BLAST | 187 | |
Regioni | 909 – 1212 | DisorderedSequence analysisAdd BLAST | 304 | |
Regioni | 1130 – 1137 | Antigenic epitope | 8 | |
Regioni | 1252 – 1288 | DisorderedSequence analysisAdd BLAST | 37 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 728 – 754 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 1231 – 1270 | Sequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 144 – 166 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 274 – 306 | Acidic residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 479 – 531 | Basic and acidic residuesSequence analysisAdd BLAST | 53 | |
Compositional biasi | 532 – 566 | Acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 645 – 660 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 724 – 747 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 748 – 762 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 777 – 851 | Basic and acidic residuesSequence analysisAdd BLAST | 75 | |
Compositional biasi | 863 – 890 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 909 – 927 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 992 – 1007 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1010 – 1053 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 1079 – 1107 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 1144 – 1191 | Polar residuesSequence analysisAdd BLAST | 48 | |
Compositional biasi | 1194 – 1210 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 1273 – 1288 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2744, Eukaryota KOG3001, Eukaryota |
GeneTreei | ENSGT00940000158149 |
HOGENOMi | CLU_007419_0_0_1 |
InParanoidi | Q4LE39 |
OMAi | XCTGQKR |
PhylomeDBi | Q4LE39 |
TreeFami | TF106427 |
Family and domain databases
Gene3Di | 1.10.150.60, 1 hit |
InterProi | View protein in InterPro IPR028853, ARID4B IPR001606, ARID_dom IPR036431, ARID_dom_sf IPR016197, Chromo-like_dom_sf IPR012603, RBB1NT IPR002999, Tudor IPR025995, Tudor-knot |
PANTHERi | PTHR13964:SF24, PTHR13964:SF24, 1 hit |
Pfami | View protein in Pfam PF01388, ARID, 1 hit PF08169, RBB1NT, 1 hit PF11717, Tudor-knot, 1 hit |
SMARTi | View protein in SMART SM00501, BRIGHT, 1 hit SM00333, TUDOR, 2 hits |
SUPFAMi | SSF46774, SSF46774, 1 hit SSF54160, SSF54160, 1 hit |
PROSITEi | View protein in PROSITE PS51011, ARID, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE
60 70 80 90 100
VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT
110 120 130 140 150
LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP
160 170 180 190 200
EEESSSSSSD EDEDDRKQID ELLGKVVCVD YISLDKKKAL WFPALVVCPD
210 220 230 240 250
CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK PDAVLKQAFE
260 270 280 290 300
QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE
310 320 330 340 350
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL
360 370 380 390 400
GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA
410 420 430 440 450
NIEFQMALPE KVVNKQCKEC ENVKEIKVKE ENETEIKEIK MEEERNIIPR
460 470 480 490 500
EEKPIEDEIE RKENIKPSLG SKKNLLESIP THSDQEKEVN IKKPEDNENL
510 520 530 540 550
DDKDDDTTRV DESLNIKVEA EEEKAKSGDE TNKEEDEDDE EAEEEEEEEE
560 570 580 590 600
EEEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG
610 620 630 640 650
EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD
660 670 680 690 700
KDEKYSPKNC KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI
710 720 730 740 750
TSILNGLQAS ESSAEDSEQE DERGAQDMDN NGKEESKIDH LTNNRNDLIS
760 770 780 790 800
KEEQNSSSLL EENKVHADLV ISKPVSKSPE RLRKDIEVLS EDTDYEEDEV
810 820 830 840 850
TKKRKDVKKD TTDKSSKPQI KRGKRRYCNT EECLKTGSPG KKEEKAKNKE
860 870 880 890 900
SLCMENSSNS SSDEDEEETK AKMTPTKKYN GLEEKRKSLR TTGFYSGFSE
910 920 930 940 950
VAEKRIKLLN NSDERLQNSR AKDRKDVWSS IQGQWPKKTL KELFSDSDTE
960 970 980 990 1000
AAASPPHPAP EEGVAEESLQ TVAEEESCSP SVELEKPPPV NVDSKPIEEK
1010 1020 1030 1040 1050
TVEVNDRKAE FPSSGSNSVL NTPPTTPESP SSVTVTEGSR QQSSVTVSEP
1060 1070 1080 1090 1100
LAPNQEEVRS IKSETDSTIE VDSVAGELQD LQSEGNSSPA GFDASVSSSS
1110 1120 1130 1140 1150
SNQPEPEHPE KACTGQKRVK DAQGGGSSSK KQKRSHKATV VNNKKKGKGT
1160 1170 1180 1190 1200
NSSDSEELSA GESITKSQPV KSVSTGMKSH STKSPARTQS PGKCGKNGDK
1210 1220 1230 1240 1250
DPDLKEPSNR LPKVYKWSFQ MSDLENMTSA ERITILQEKL QEIRKHYLSL
1260 1270 1280 1290 1300
KSEVASIDRR RKRLKKKERE SAATSSSSSS PSSSSITAAV MLTLAEPSMS
1310
SASQNGMSVE CR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y7Y8 | H0Y7Y8_HUMAN | AT-rich interactive domain-containi... | ARID4B | 553 | Annotation score: | ||
X6RCR8 | X6RCR8_HUMAN | AT-rich interactive domain-containi... | ARID4B | 483 | Annotation score: | ||
H7C5R6 | H7C5R6_HUMAN | AT-rich interactive domain-containi... | ARID4B | 696 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | D → G in AAO63590 (PubMed:12724404).Curated | 1 | |
Sequence conflicti | 79 | V → A in AAO63590 (PubMed:12724404).Curated | 1 | |
Sequence conflicti | 330 | R → Q in AAF28341 (PubMed:11481388).Curated | 1 | |
Sequence conflicti | 330 | R → Q in AAF23433 (PubMed:15247124).Curated | 1 | |
Sequence conflicti | 400 | A → P in BAA89794 (Ref. 4) Curated | 1 | |
Sequence conflicti | 436 | I → IEFCGR in AAF23433 (PubMed:15247124).Curated | 1 | |
Sequence conflicti | 437 | K → Q in BAA89794 (Ref. 4) Curated | 1 | |
Sequence conflicti | 559 – 561 | DNN → ATI in BAA89794 (Ref. 4) Curated | 3 | |
Sequence conflicti | 568 | C → S in BAA89794 (Ref. 4) Curated | 1 | |
Sequence conflicti | 575 | V → A in BAA89794 (Ref. 4) Curated | 1 | |
Sequence conflicti | 584 | N → H in BAA89794 (Ref. 4) Curated | 1 | |
Sequence conflicti | 605 | L → S in AAF36964 (Ref. 9) Curated | 1 | |
Sequence conflicti | 616 | D → G in AAF36964 (Ref. 9) Curated | 1 | |
Sequence conflicti | 813 | D → G in AAO63590 (PubMed:12724404).Curated | 1 | |
Sequence conflicti | 915 – 917 | RLQ → LP in AAF23433 (PubMed:15247124).Curated | 3 | |
Sequence conflicti | 940 | L → R in AAF23433 (PubMed:15247124).Curated | 1 | |
Sequence conflicti | 1000 | K → E in AAF28341 (PubMed:11481388).Curated | 1 | |
Sequence conflicti | 1000 | K → E in AAF36964 (Ref. 9) Curated | 1 | |
Sequence conflicti | 1001 | T → Q in AAF23433 (PubMed:15247124).Curated | 1 | |
Sequence conflicti | 1032 | S → P in AAO63590 (PubMed:12724404).Curated | 1 | |
Sequence conflicti | 1087 | S → N in AAO63590 (PubMed:12724404).Curated | 1 | |
Sequence conflicti | 1118 | R → G in CAI46047 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1144 | K → T in AAF23433 (PubMed:15247124).Curated | 1 | |
Sequence conflicti | 1144 | K → T in AAD41239 (Ref. 10) Curated | 1 | |
Sequence conflicti | 1243 – 1244 | IR → NQ in AAF23433 (PubMed:15247124).Curated | 2 | |
Sequence conflicti | 1243 – 1244 | IR → NQ in AAD41239 (Ref. 10) Curated | 2 | |
Sequence conflicti | 1290 | V → A in AAF28341 (PubMed:11481388).Curated | 1 | |
Sequence conflicti | 1290 | V → A in AAF36964 (Ref. 9) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024230 | 1 – 319 | Missing in isoform 4. 1 PublicationAdd BLAST | 319 | |
Alternative sequenceiVSP_024231 | 529 – 614 | Missing in isoform 2. 4 PublicationsAdd BLAST | 86 | |
Alternative sequenceiVSP_024232 | 1112 – 1122 | ACTGQKRVKDA → GEKENVYVDLF in isoform 4. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_024233 | 1123 – 1312 | Missing in isoform 4. 1 PublicationAdd BLAST | 190 | |
Alternative sequenceiVSP_024234 | 1150 – 1153 | TNSS → SAPH in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_024235 | 1154 – 1312 | Missing in isoform 3. 1 PublicationAdd BLAST | 159 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF214114 mRNA Translation: AAF28341.2 AY220790 mRNA Translation: AAO63590.1 AF208045 mRNA Translation: AAF23433.3 Frameshift. AB030181 mRNA Translation: BAA89794.1 AB210032 mRNA Translation: BAE06114.1 Different initiation. AL133418 Genomic DNA No translation available. AL391994 Genomic DNA No translation available. BC048959 mRNA Translation: AAH48959.1 Different termination. BC062536 mRNA Translation: AAH62536.1 Different termination. BC104632 mRNA Translation: AAI04633.1 Different termination. BC130418 mRNA Translation: AAI30419.1 BX648820 mRNA Translation: CAI46047.1 AL133594 mRNA Translation: CAB63731.1 AF227899 mRNA Translation: AAF36964.1 AF083249 mRNA Translation: AAD41239.1 Frameshift. AK023144 mRNA Translation: BAB14428.1 Different initiation. |
CCDSi | CCDS31060.1 [Q4LE39-2] CCDS31061.1 [Q4LE39-1] |
PIRi | T43497 |
RefSeqi | NP_001193723.1, NM_001206794.1 [Q4LE39-1] NP_057458.4, NM_016374.5 [Q4LE39-1] NP_112739.2, NM_031371.3 [Q4LE39-2] XP_011542514.1, XM_011544212.2 [Q4LE39-1] |
Genome annotation databases
Ensembli | ENST00000264183.9; ENSP00000264183.3; ENSG00000054267.22 ENST00000349213.7; ENSP00000264184.4; ENSG00000054267.22 [Q4LE39-2] ENST00000366603.6; ENSP00000355562.2; ENSG00000054267.22 ENST00000421364.5; ENSP00000394663.1; ENSG00000054267.22 [Q4LE39-3] |
GeneIDi | 51742 |
KEGGi | hsa:51742 |
MANE-Selecti | ENST00000264183.9; ENSP00000264183.3; NM_016374.6; NP_057458.4 |
UCSCi | uc001hwq.3, human [Q4LE39-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF214114 mRNA Translation: AAF28341.2 AY220790 mRNA Translation: AAO63590.1 AF208045 mRNA Translation: AAF23433.3 Frameshift. AB030181 mRNA Translation: BAA89794.1 AB210032 mRNA Translation: BAE06114.1 Different initiation. AL133418 Genomic DNA No translation available. AL391994 Genomic DNA No translation available. BC048959 mRNA Translation: AAH48959.1 Different termination. BC062536 mRNA Translation: AAH62536.1 Different termination. BC104632 mRNA Translation: AAI04633.1 Different termination. BC130418 mRNA Translation: AAI30419.1 BX648820 mRNA Translation: CAI46047.1 AL133594 mRNA Translation: CAB63731.1 AF227899 mRNA Translation: AAF36964.1 AF083249 mRNA Translation: AAD41239.1 Frameshift. AK023144 mRNA Translation: BAB14428.1 Different initiation. |
CCDSi | CCDS31060.1 [Q4LE39-2] CCDS31061.1 [Q4LE39-1] |
PIRi | T43497 |
RefSeqi | NP_001193723.1, NM_001206794.1 [Q4LE39-1] NP_057458.4, NM_016374.5 [Q4LE39-1] NP_112739.2, NM_031371.3 [Q4LE39-2] XP_011542514.1, XM_011544212.2 [Q4LE39-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7DM4 | NMR | - | A | 1-151 | [»] | |
AlphaFoldDBi | Q4LE39 | |||||
SMRi | Q4LE39 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119708, 114 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q4LE39 |
IntActi | Q4LE39, 95 interactors |
MINTi | Q4LE39 |
STRINGi | 9606.ENSP00000264183 |
PTM databases
GlyGeni | Q4LE39, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q4LE39 |
PhosphoSitePlusi | Q4LE39 |
Genetic variation databases
BioMutai | ARID4B |
DMDMi | 143955276 |
Proteomic databases
CPTACi | CPTAC-1754 |
EPDi | Q4LE39 |
jPOSTi | Q4LE39 |
MassIVEi | Q4LE39 |
MaxQBi | Q4LE39 |
PaxDbi | Q4LE39 |
PeptideAtlasi | Q4LE39 |
PRIDEi | Q4LE39 |
ProteomicsDBi | 62238 [Q4LE39-1] 62239 [Q4LE39-2] 62240 [Q4LE39-3] 62241 [Q4LE39-4] |
Protocols and materials databases
ABCDi | Q4LE39, 1 sequenced antibody |
Antibodypediai | 20807, 159 antibodies from 30 providers |
DNASUi | 51742 |
Genome annotation databases
Ensembli | ENST00000264183.9; ENSP00000264183.3; ENSG00000054267.22 ENST00000349213.7; ENSP00000264184.4; ENSG00000054267.22 [Q4LE39-2] ENST00000366603.6; ENSP00000355562.2; ENSG00000054267.22 ENST00000421364.5; ENSP00000394663.1; ENSG00000054267.22 [Q4LE39-3] |
GeneIDi | 51742 |
KEGGi | hsa:51742 |
MANE-Selecti | ENST00000264183.9; ENSP00000264183.3; NM_016374.6; NP_057458.4 |
UCSCi | uc001hwq.3, human [Q4LE39-1] |
Organism-specific databases
CTDi | 51742 |
DisGeNETi | 51742 |
GeneCardsi | ARID4B |
HGNCi | HGNC:15550, ARID4B |
HPAi | ENSG00000054267, Low tissue specificity |
MIMi | 609696, gene |
neXtProti | NX_Q4LE39 |
OpenTargetsi | ENSG00000054267 |
PharmGKBi | PA134940494 |
VEuPathDBi | HostDB:ENSG00000054267 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2744, Eukaryota KOG3001, Eukaryota |
GeneTreei | ENSGT00940000158149 |
HOGENOMi | CLU_007419_0_0_1 |
InParanoidi | Q4LE39 |
OMAi | XCTGQKR |
PhylomeDBi | Q4LE39 |
TreeFami | TF106427 |
Enzyme and pathway databases
PathwayCommonsi | Q4LE39 |
Reactomei | R-HSA-3214815, HDACs deacetylate histones R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-9679191, Potential therapeutics for SARS |
SignaLinki | Q4LE39 |
Miscellaneous databases
BioGRID-ORCSi | 51742, 91 hits in 1091 CRISPR screens |
ChiTaRSi | ARID4B, human |
GeneWikii | ARID4B |
GenomeRNAii | 51742 |
Pharosi | Q4LE39, Tbio |
PROi | PR:Q4LE39 |
RNActi | Q4LE39, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000054267, Expressed in substantia nigra and 243 other tissues |
ExpressionAtlasi | Q4LE39, baseline and differential |
Genevisiblei | Q4LE39, HS |
Family and domain databases
Gene3Di | 1.10.150.60, 1 hit |
InterProi | View protein in InterPro IPR028853, ARID4B IPR001606, ARID_dom IPR036431, ARID_dom_sf IPR016197, Chromo-like_dom_sf IPR012603, RBB1NT IPR002999, Tudor IPR025995, Tudor-knot |
PANTHERi | PTHR13964:SF24, PTHR13964:SF24, 1 hit |
Pfami | View protein in Pfam PF01388, ARID, 1 hit PF08169, RBB1NT, 1 hit PF11717, Tudor-knot, 1 hit |
SMARTi | View protein in SMART SM00501, BRIGHT, 1 hit SM00333, TUDOR, 2 hits |
SUPFAMi | SSF46774, SSF46774, 1 hit SSF54160, SSF54160, 1 hit |
PROSITEi | View protein in PROSITE PS51011, ARID, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARI4B_HUMAN | |
Accessioni | Q4LE39Primary (citable) accession number: Q4LE39 Secondary accession number(s): A1L465 Q9Y6E1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | May 25, 2022 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references