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UniProtKB - Q4LE39 (ARI4B_HUMAN)

Protein

AT-rich interactive domain-containing protein 4B

Gene

ARID4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).By similarity1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-427413 NoRC negatively regulates rRNA expression

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4B
Short name:
ARID domain-containing protein 4B
Alternative name(s):
180 kDa Sin3-associated polypeptide
Short name:
Sin3-associated polypeptide p180
Breast cancer-associated antigen BRCAA1
Histone deacetylase complex subunit SAP180
Retinoblastoma-binding protein 1-like 1
Gene namesi
Name:ARID4B
Synonyms:BRCAA1, RBBP1L1, RBP1L1, SAP180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000054267.20
HGNCiHGNC:15550 ARID4B
MIMi609696 gene
neXtProtiNX_Q4LE39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51742
OpenTargetsiENSG00000054267
PharmGKBiPA134940494

Polymorphism and mutation databases

BioMutaiARID4B
DMDMi143955276

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828631 – 1312AT-rich interactive domain-containing protein 4BAdd BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei276PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Cross-linki429Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki462Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei483PhosphoserineCombined sources1
Cross-linki517Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei666PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Cross-linki751Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei778PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1
Modified residuei793PhosphothreonineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1026PhosphothreonineCombined sources1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1150PhosphothreonineCombined sources1
Modified residuei1152PhosphoserineCombined sources1
Modified residuei1153PhosphoserineCombined sources1
Modified residuei1155PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ4LE39
MaxQBiQ4LE39
PaxDbiQ4LE39
PeptideAtlasiQ4LE39
PRIDEiQ4LE39
ProteomicsDBi62238
62239 [Q4LE39-2]
62240 [Q4LE39-3]
62241 [Q4LE39-4]

PTM databases

iPTMnetiQ4LE39
PhosphoSitePlusiQ4LE39

Expressioni

Tissue specificityi

Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.3 Publications

Gene expression databases

BgeeiENSG00000054267 Expressed in 231 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ4LE39 baseline and differential
GenevisibleiQ4LE39 HS

Organism-specific databases

HPAiHPA027333
HPA053692

Interactioni

Subunit structurei

Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2 (PubMed:12724404). Interacts with ARID4A (PubMed:17043311). Interacts with AR (By similarity).By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi119708, 39 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiQ4LE39
IntActiQ4LE39, 34 interactors
MINTiQ4LE39
STRINGi9606.ENSP00000264183

Structurei

3D structure databases

ProteinModelPortaliQ4LE39
SMRiQ4LE39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini306 – 398ARIDPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni465 – 473Antigenic epitope9
Regioni1130 – 1137Antigenic epitope8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili728 – 754Sequence analysisAdd BLAST27
Coiled coili1231 – 1270Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 159Poly-Ser6
Compositional biasi268 – 567Glu-richAdd BLAST300
Compositional biasi1095 – 1101Poly-Ser7
Compositional biasi1271 – 1303Ser-richAdd BLAST33

Domaini

The C-terminus mediates interaction with mSin3A corepressor complex.1 Publication
The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.1 Publication
The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
KOG3001 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00900000140901
HOVERGENiHBG058247
InParanoidiQ4LE39
KOiK19195
OMAiTHTRNDL
OrthoDBiEOG091G0EG4
PhylomeDBiQ4LE39
TreeFamiTF106427

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR028853 ARID4B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR012603 RBB1NT
IPR002999 Tudor
IPR025995 Tudor-knot
PANTHERiPTHR13964:SF24 PTHR13964:SF24, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF08169 RBB1NT, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SM00333 TUDOR, 2 hits
SUPFAMiSSF46774 SSF46774, 1 hit
SSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4LE39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE 
        60         70         80         90        100
VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT 
       110        120        130        140        150
LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP 
       160        170        180        190        200
EEESSSSSSD EDEDDRKQID ELLGKVVCVD YISLDKKKAL WFPALVVCPD 
       210        220        230        240        250
CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK PDAVLKQAFE 
       260        270        280        290        300
QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE 
       310        320        330        340        350
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL 
       360        370        380        390        400
GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA 
       410        420        430        440        450
NIEFQMALPE KVVNKQCKEC ENVKEIKVKE ENETEIKEIK MEEERNIIPR 
       460        470        480        490        500
EEKPIEDEIE RKENIKPSLG SKKNLLESIP THSDQEKEVN IKKPEDNENL 
       510        520        530        540        550
DDKDDDTTRV DESLNIKVEA EEEKAKSGDE TNKEEDEDDE EAEEEEEEEE 
       560        570        580        590        600
EEEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG 
       610        620        630        640        650
EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD 
       660        670        680        690        700
KDEKYSPKNC KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI 
       710        720        730        740        750
TSILNGLQAS ESSAEDSEQE DERGAQDMDN NGKEESKIDH LTNNRNDLIS 
       760        770        780        790        800
KEEQNSSSLL EENKVHADLV ISKPVSKSPE RLRKDIEVLS EDTDYEEDEV 
       810        820        830        840        850
TKKRKDVKKD TTDKSSKPQI KRGKRRYCNT EECLKTGSPG KKEEKAKNKE 
       860        870        880        890        900
SLCMENSSNS SSDEDEEETK AKMTPTKKYN GLEEKRKSLR TTGFYSGFSE 
       910        920        930        940        950
VAEKRIKLLN NSDERLQNSR AKDRKDVWSS IQGQWPKKTL KELFSDSDTE 
       960        970        980        990       1000
AAASPPHPAP EEGVAEESLQ TVAEEESCSP SVELEKPPPV NVDSKPIEEK 
      1010       1020       1030       1040       1050
TVEVNDRKAE FPSSGSNSVL NTPPTTPESP SSVTVTEGSR QQSSVTVSEP 
      1060       1070       1080       1090       1100
LAPNQEEVRS IKSETDSTIE VDSVAGELQD LQSEGNSSPA GFDASVSSSS 
      1110       1120       1130       1140       1150
SNQPEPEHPE KACTGQKRVK DAQGGGSSSK KQKRSHKATV VNNKKKGKGT 
      1160       1170       1180       1190       1200
NSSDSEELSA GESITKSQPV KSVSTGMKSH STKSPARTQS PGKCGKNGDK 
      1210       1220       1230       1240       1250
DPDLKEPSNR LPKVYKWSFQ MSDLENMTSA ERITILQEKL QEIRKHYLSL 
      1260       1270       1280       1290       1300
KSEVASIDRR RKRLKKKERE SAATSSSSSS PSSSSITAAV MLTLAEPSMS 
      1310 
SASQNGMSVE CR
Length:1,312
Mass (Da):147,809
Last modified:April 3, 2007 - v2
Checksum:iE4175FF80F5217EE
GO
Isoform 2 (identifier: Q4LE39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-614: Missing.

Show »
Length:1,226
Mass (Da):137,607
Checksum:i3ADAB4A897403AD9
GO
Isoform 3 (identifier: Q4LE39-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1150-1153: TNSS → SAPH
     1154-1312: Missing.

Show »
Length:1,153
Mass (Da):130,418
Checksum:i9C540DF507EBC220
GO
Isoform 4 (identifier: Q4LE39-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     1112-1122: ACTGQKRVKDA → GEKENVYVDLF
     1123-1312: Missing.

Show »
Length:803
Mass (Da):91,140
Checksum:iAC58481D8DE15417
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RCR8X6RCR8_HUMAN
AT-rich interactive domain-containi...
ARID4B
483Annotation score:
H7C5R6H7C5R6_HUMAN
AT-rich interactive domain-containi...
ARID4B
696Annotation score:
H0Y7Y8H0Y7Y8_HUMAN
AT-rich interactive domain-containi...
ARID4B
553Annotation score:

Sequence cautioni

The sequence AAD41239 differs from that shown. Reason: Frameshift at positions 859, 869, 1287 and 1311.Curated
The sequence AAF23433 differs from that shown. Reason: Frameshift at positions 1287 and 1311.Curated
The sequence BAB14428 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE06114 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15D → G in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti79V → A in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti330R → Q in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti330R → Q in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti400A → P in BAA89794 (Ref. 4) Curated1
Sequence conflicti436I → IEFCGR in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti437K → Q in BAA89794 (Ref. 4) Curated1
Sequence conflicti559 – 561DNN → ATI in BAA89794 (Ref. 4) Curated3
Sequence conflicti568C → S in BAA89794 (Ref. 4) Curated1
Sequence conflicti575V → A in BAA89794 (Ref. 4) Curated1
Sequence conflicti584N → H in BAA89794 (Ref. 4) Curated1
Sequence conflicti605L → S in AAF36964 (Ref. 9) Curated1
Sequence conflicti616D → G in AAF36964 (Ref. 9) Curated1
Sequence conflicti813D → G in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti915 – 917RLQ → LP in AAF23433 (PubMed:15247124).Curated3
Sequence conflicti940L → R in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1000K → E in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti1000K → E in AAF36964 (Ref. 9) Curated1
Sequence conflicti1001T → Q in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1032S → P in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti1087S → N in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti1118R → G in CAI46047 (PubMed:17974005).Curated1
Sequence conflicti1144K → T in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1144K → T in AAD41239 (Ref. 10) Curated1
Sequence conflicti1243 – 1244IR → NQ in AAF23433 (PubMed:15247124).Curated2
Sequence conflicti1243 – 1244IR → NQ in AAD41239 (Ref. 10) Curated2
Sequence conflicti1290V → A in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti1290V → A in AAF36964 (Ref. 9) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242301 – 319Missing in isoform 4. 1 PublicationAdd BLAST319
Alternative sequenceiVSP_024231529 – 614Missing in isoform 2. 4 PublicationsAdd BLAST86
Alternative sequenceiVSP_0242321112 – 1122ACTGQKRVKDA → GEKENVYVDLF in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0242331123 – 1312Missing in isoform 4. 1 PublicationAdd BLAST190
Alternative sequenceiVSP_0242341150 – 1153TNSS → SAPH in isoform 3. 1 Publication4
Alternative sequenceiVSP_0242351154 – 1312Missing in isoform 3. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214114 mRNA Translation: AAF28341.2
AY220790 mRNA Translation: AAO63590.1
AF208045 mRNA Translation: AAF23433.3 Frameshift.
AB030181 mRNA Translation: BAA89794.1
AB210032 mRNA Translation: BAE06114.1 Different initiation.
AL133418 Genomic DNA No translation available.
AL391994 Genomic DNA No translation available.
BC048959 mRNA Translation: AAH48959.1 Different termination.
BC062536 mRNA Translation: AAH62536.1 Different termination.
BC104632 mRNA Translation: AAI04633.1 Different termination.
BC130418 mRNA Translation: AAI30419.1
BX648820 mRNA Translation: CAI46047.1
AL133594 mRNA Translation: CAB63731.1
AF227899 mRNA Translation: AAF36964.1
AF083249 mRNA Translation: AAD41239.1 Frameshift.
AK023144 mRNA Translation: BAB14428.1 Different initiation.
CCDSiCCDS31060.1 [Q4LE39-2]
CCDS31061.1 [Q4LE39-1]
PIRiT43497
RefSeqiNP_001193723.1, NM_001206794.1 [Q4LE39-1]
NP_057458.4, NM_016374.5 [Q4LE39-1]
NP_112739.2, NM_031371.3 [Q4LE39-2]
XP_011542514.1, XM_011544212.2 [Q4LE39-1]
UniGeneiHs.575782

Genome annotation databases

EnsembliENST00000264183; ENSP00000264183; ENSG00000054267 [Q4LE39-1]
ENST00000349213; ENSP00000264184; ENSG00000054267 [Q4LE39-2]
ENST00000366603; ENSP00000355562; ENSG00000054267 [Q4LE39-1]
ENST00000421364; ENSP00000394663; ENSG00000054267 [Q4LE39-3]
GeneIDi51742
KEGGihsa:51742
UCSCiuc001hwq.3 human [Q4LE39-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214114 mRNA Translation: AAF28341.2
AY220790 mRNA Translation: AAO63590.1
AF208045 mRNA Translation: AAF23433.3 Frameshift.
AB030181 mRNA Translation: BAA89794.1
AB210032 mRNA Translation: BAE06114.1 Different initiation.
AL133418 Genomic DNA No translation available.
AL391994 Genomic DNA No translation available.
BC048959 mRNA Translation: AAH48959.1 Different termination.
BC062536 mRNA Translation: AAH62536.1 Different termination.
BC104632 mRNA Translation: AAI04633.1 Different termination.
BC130418 mRNA Translation: AAI30419.1
BX648820 mRNA Translation: CAI46047.1
AL133594 mRNA Translation: CAB63731.1
AF227899 mRNA Translation: AAF36964.1
AF083249 mRNA Translation: AAD41239.1 Frameshift.
AK023144 mRNA Translation: BAB14428.1 Different initiation.
CCDSiCCDS31060.1 [Q4LE39-2]
CCDS31061.1 [Q4LE39-1]
PIRiT43497
RefSeqiNP_001193723.1, NM_001206794.1 [Q4LE39-1]
NP_057458.4, NM_016374.5 [Q4LE39-1]
NP_112739.2, NM_031371.3 [Q4LE39-2]
XP_011542514.1, XM_011544212.2 [Q4LE39-1]
UniGeneiHs.575782

3D structure databases

ProteinModelPortaliQ4LE39
SMRiQ4LE39
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119708, 39 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiQ4LE39
IntActiQ4LE39, 34 interactors
MINTiQ4LE39
STRINGi9606.ENSP00000264183

PTM databases

iPTMnetiQ4LE39
PhosphoSitePlusiQ4LE39

Polymorphism and mutation databases

BioMutaiARID4B
DMDMi143955276

Proteomic databases

EPDiQ4LE39
MaxQBiQ4LE39
PaxDbiQ4LE39
PeptideAtlasiQ4LE39
PRIDEiQ4LE39
ProteomicsDBi62238
62239 [Q4LE39-2]
62240 [Q4LE39-3]
62241 [Q4LE39-4]

Protocols and materials databases

DNASUi51742
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264183; ENSP00000264183; ENSG00000054267 [Q4LE39-1]
ENST00000349213; ENSP00000264184; ENSG00000054267 [Q4LE39-2]
ENST00000366603; ENSP00000355562; ENSG00000054267 [Q4LE39-1]
ENST00000421364; ENSP00000394663; ENSG00000054267 [Q4LE39-3]
GeneIDi51742
KEGGihsa:51742
UCSCiuc001hwq.3 human [Q4LE39-1]

Organism-specific databases

CTDi51742
DisGeNETi51742
EuPathDBiHostDB:ENSG00000054267.20
GeneCardsiARID4B
HGNCiHGNC:15550 ARID4B
HPAiHPA027333
HPA053692
MIMi609696 gene
neXtProtiNX_Q4LE39
OpenTargetsiENSG00000054267
PharmGKBiPA134940494
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
KOG3001 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00900000140901
HOVERGENiHBG058247
InParanoidiQ4LE39
KOiK19195
OMAiTHTRNDL
OrthoDBiEOG091G0EG4
PhylomeDBiQ4LE39
TreeFamiTF106427

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-427413 NoRC negatively regulates rRNA expression

Miscellaneous databases

ChiTaRSiARID4B human
GeneWikiiARID4B
GenomeRNAii51742
PROiPR:Q4LE39
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054267 Expressed in 231 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ4LE39 baseline and differential
GenevisibleiQ4LE39 HS

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR028853 ARID4B
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR012603 RBB1NT
IPR002999 Tudor
IPR025995 Tudor-knot
PANTHERiPTHR13964:SF24 PTHR13964:SF24, 1 hit
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF08169 RBB1NT, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SM00333 TUDOR, 2 hits
SUPFAMiSSF46774 SSF46774, 1 hit
SSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARI4B_HUMAN
AccessioniPrimary (citable) accession number: Q4LE39
Secondary accession number(s): A1L465
, Q3MHV4, Q5HY99, Q5T2C2, Q5T2C3, Q5T2C4, Q5T2C5, Q5T2C6, Q6P600, Q86UX1, Q86WR4, Q9H915, Q9NYU3, Q9NZB6, Q9NZG4, Q9P2W4, Q9UF62, Q9Y6E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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