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UniProtKB - Q4LE39 (ARI4B_HUMAN)

Entry version 148 (07 Apr 2021)
Sequence version 2 (03 Apr 2007)
Previous versions | rss
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Protein

AT-rich interactive domain-containing protein 4B

Gene

ARID4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q4LE39

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214815, HDACs deacetylate histones
R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-9679191, Potential therapeutics for SARS

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4B
Short name:
ARID domain-containing protein 4B
Alternative name(s):
180 kDa Sin3-associated polypeptide
Short name:
Sin3-associated polypeptide p180
Breast cancer-associated antigen BRCAA1
Histone deacetylase complex subunit SAP180
Retinoblastoma-binding protein 1-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID4B
Synonyms:BRCAA1, RBBP1L1, RBP1L1, SAP180
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15550, ARID4B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609696, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q4LE39

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000054267.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51742

Open Targets

More...OpenTargetsi		ENSG00000054267

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134940494

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q4LE39, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARID4B

Domain mapping of disease mutations (DMDM)

More...DMDMi		143955276

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002828631 – 1312AT-rich interactive domain-containing protein 4BAdd BLAST1312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei276PhosphoserineCombined sources1
Modified residuei295PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki429Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki462Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei483PhosphoserineCombined sources1
Cross-linki517Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei666PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei717PhosphoserineCombined sources1
Cross-linki751Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei778PhosphoserineCombined sources1
Modified residuei790PhosphoserineCombined sources1
Modified residuei793PhosphothreonineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1026PhosphothreonineCombined sources1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1150PhosphothreonineCombined sources1
Modified residuei1152PhosphoserineCombined sources1
Modified residuei1153PhosphoserineCombined sources1
Modified residuei1155PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1754

Encyclopedia of Proteome Dynamics

More...EPDi		Q4LE39

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q4LE39

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q4LE39

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q4LE39

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4LE39

PeptideAtlas

More...PeptideAtlasi		Q4LE39

PRoteomics IDEntifications database

More...PRIDEi		Q4LE39

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62238 [Q4LE39-1]
62239 [Q4LE39-2]
62240 [Q4LE39-3]
62241 [Q4LE39-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4LE39

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4LE39

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000054267, Expressed in substantia nigra and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q4LE39, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4LE39, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000054267, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2 (PubMed:12724404).

Interacts with ARID4A (PubMed:17043311).

Interacts with AR (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119708, 67 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3321, SIN3A histone deacetylase complex
CPX-3322, SIN3B histone deacetylase complex
CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q4LE39

Protein interaction database and analysis system

More...IntActi		Q4LE39, 48 interactors

Molecular INTeraction database

More...MINTi		Q4LE39

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264183

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4LE39, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4LE39

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini306 – 398ARIDPROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni465 – 473Antigenic epitope9
Regioni1130 – 1137Antigenic epitope8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili728 – 754Sequence analysisAdd BLAST27
Coiled coili1231 – 1270Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 159Poly-Ser6
Compositional biasi268 – 567Glu-richAdd BLAST300
Compositional biasi1095 – 1101Poly-Ser7
Compositional biasi1271 – 1303Ser-richAdd BLAST33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus mediates interaction with mSin3A corepressor complex.1 Publication
The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.1 Publication
The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2744, Eukaryota
KOG3001, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158149

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007419_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4LE39

Identification of Orthologs from Complete Genome Data

More...OMAi		XCTGQKR

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4LE39

TreeFam database of animal gene trees

More...TreeFami		TF106427

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028853, ARID4B
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR016197, Chromo-like_dom_sf
IPR012603, RBB1NT
IPR002999, Tudor
IPR025995, Tudor-knot

The PANTHER Classification System

More...PANTHERi		PTHR13964:SF24, PTHR13964:SF24, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01388, ARID, 1 hit
PF08169, RBB1NT, 1 hit
PF11717, Tudor-knot, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00501, BRIGHT, 1 hit
SM00333, TUDOR, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46774, SSF46774, 1 hit
SSF54160, SSF54160, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51011, ARID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4LE39-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE 
        60         70         80         90        100
VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT 
       110        120        130        140        150
LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP 
       160        170        180        190        200
EEESSSSSSD EDEDDRKQID ELLGKVVCVD YISLDKKKAL WFPALVVCPD 
       210        220        230        240        250
CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK PDAVLKQAFE 
       260        270        280        290        300
QALEFHKSRT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE 
       310        320        330        340        350
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL 
       360        370        380        390        400
GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA 
       410        420        430        440        450
NIEFQMALPE KVVNKQCKEC ENVKEIKVKE ENETEIKEIK MEEERNIIPR 
       460        470        480        490        500
EEKPIEDEIE RKENIKPSLG SKKNLLESIP THSDQEKEVN IKKPEDNENL 
       510        520        530        540        550
DDKDDDTTRV DESLNIKVEA EEEKAKSGDE TNKEEDEDDE EAEEEEEEEE 
       560        570        580        590        600
EEEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG 
       610        620        630        640        650
EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD 
       660        670        680        690        700
KDEKYSPKNC KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI 
       710        720        730        740        750
TSILNGLQAS ESSAEDSEQE DERGAQDMDN NGKEESKIDH LTNNRNDLIS 
       760        770        780        790        800
KEEQNSSSLL EENKVHADLV ISKPVSKSPE RLRKDIEVLS EDTDYEEDEV 
       810        820        830        840        850
TKKRKDVKKD TTDKSSKPQI KRGKRRYCNT EECLKTGSPG KKEEKAKNKE 
       860        870        880        890        900
SLCMENSSNS SSDEDEEETK AKMTPTKKYN GLEEKRKSLR TTGFYSGFSE 
       910        920        930        940        950
VAEKRIKLLN NSDERLQNSR AKDRKDVWSS IQGQWPKKTL KELFSDSDTE 
       960        970        980        990       1000
AAASPPHPAP EEGVAEESLQ TVAEEESCSP SVELEKPPPV NVDSKPIEEK 
      1010       1020       1030       1040       1050
TVEVNDRKAE FPSSGSNSVL NTPPTTPESP SSVTVTEGSR QQSSVTVSEP 
      1060       1070       1080       1090       1100
LAPNQEEVRS IKSETDSTIE VDSVAGELQD LQSEGNSSPA GFDASVSSSS 
      1110       1120       1130       1140       1150
SNQPEPEHPE KACTGQKRVK DAQGGGSSSK KQKRSHKATV VNNKKKGKGT 
      1160       1170       1180       1190       1200
NSSDSEELSA GESITKSQPV KSVSTGMKSH STKSPARTQS PGKCGKNGDK 
      1210       1220       1230       1240       1250
DPDLKEPSNR LPKVYKWSFQ MSDLENMTSA ERITILQEKL QEIRKHYLSL 
      1260       1270       1280       1290       1300
KSEVASIDRR RKRLKKKERE SAATSSSSSS PSSSSITAAV MLTLAEPSMS 
      1310 
SASQNGMSVE CR
Length:1,312
Mass (Da):147,809
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4175FF80F5217EE
GO
Isoform 2 (identifier: Q4LE39-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-614: Missing.

Show »
Length:1,226
Mass (Da):137,607
Checksum:i3ADAB4A897403AD9
GO
Isoform 3 (identifier: Q4LE39-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1150-1153: TNSS → SAPH
     1154-1312: Missing.

Show »
Length:1,153
Mass (Da):130,418
Checksum:i9C540DF507EBC220
GO
Isoform 4 (identifier: Q4LE39-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     1112-1122: ACTGQKRVKDA → GEKENVYVDLF
     1123-1312: Missing.

Show »
Length:803
Mass (Da):91,140
Checksum:iAC58481D8DE15417
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7Y8H0Y7Y8_HUMAN
AT-rich interactive domain-containi...
ARID4B
553Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RCR8X6RCR8_HUMAN
AT-rich interactive domain-containi...
ARID4B
483Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5R6H7C5R6_HUMAN
AT-rich interactive domain-containi...
ARID4B
696Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD41239 differs from that shown. Reason: Frameshift.Curated
The sequence AAF23433 differs from that shown. Reason: Frameshift.Curated
The sequence BAB14428 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE06114 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15D → G in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti79V → A in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti330R → Q in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti330R → Q in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti400A → P in BAA89794 (Ref. 4) Curated1
Sequence conflicti436I → IEFCGR in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti437K → Q in BAA89794 (Ref. 4) Curated1
Sequence conflicti559 – 561DNN → ATI in BAA89794 (Ref. 4) Curated3
Sequence conflicti568C → S in BAA89794 (Ref. 4) Curated1
Sequence conflicti575V → A in BAA89794 (Ref. 4) Curated1
Sequence conflicti584N → H in BAA89794 (Ref. 4) Curated1
Sequence conflicti605L → S in AAF36964 (Ref. 9) Curated1
Sequence conflicti616D → G in AAF36964 (Ref. 9) Curated1
Sequence conflicti813D → G in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti915 – 917RLQ → LP in AAF23433 (PubMed:15247124).Curated3
Sequence conflicti940L → R in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1000K → E in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti1000K → E in AAF36964 (Ref. 9) Curated1
Sequence conflicti1001T → Q in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1032S → P in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti1087S → N in AAO63590 (PubMed:12724404).Curated1
Sequence conflicti1118R → G in CAI46047 (PubMed:17974005).Curated1
Sequence conflicti1144K → T in AAF23433 (PubMed:15247124).Curated1
Sequence conflicti1144K → T in AAD41239 (Ref. 10) Curated1
Sequence conflicti1243 – 1244IR → NQ in AAF23433 (PubMed:15247124).Curated2
Sequence conflicti1243 – 1244IR → NQ in AAD41239 (Ref. 10) Curated2
Sequence conflicti1290V → A in AAF28341 (PubMed:11481388).Curated1
Sequence conflicti1290V → A in AAF36964 (Ref. 9) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0242301 – 319Missing in isoform 4. 1 PublicationAdd BLAST319
Alternative sequenceiVSP_024231529 – 614Missing in isoform 2. 4 PublicationsAdd BLAST86
Alternative sequenceiVSP_0242321112 – 1122ACTGQKRVKDA → GEKENVYVDLF in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0242331123 – 1312Missing in isoform 4. 1 PublicationAdd BLAST190
Alternative sequenceiVSP_0242341150 – 1153TNSS → SAPH in isoform 3. 1 Publication4
Alternative sequenceiVSP_0242351154 – 1312Missing in isoform 3. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF214114 mRNA Translation: AAF28341.2
AY220790 mRNA Translation: AAO63590.1
AF208045 mRNA Translation: AAF23433.3 Frameshift.
AB030181 mRNA Translation: BAA89794.1
AB210032 mRNA Translation: BAE06114.1 Different initiation.
AL133418 Genomic DNA No translation available.
AL391994 Genomic DNA No translation available.
BC048959 mRNA Translation: AAH48959.1 Different termination.
BC062536 mRNA Translation: AAH62536.1 Different termination.
BC104632 mRNA Translation: AAI04633.1 Different termination.
BC130418 mRNA Translation: AAI30419.1
BX648820 mRNA Translation: CAI46047.1
AL133594 mRNA Translation: CAB63731.1
AF227899 mRNA Translation: AAF36964.1
AF083249 mRNA Translation: AAD41239.1 Frameshift.
AK023144 mRNA Translation: BAB14428.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31060.1 [Q4LE39-2]
CCDS31061.1 [Q4LE39-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T43497

NCBI Reference Sequences

More...RefSeqi		NP_001193723.1, NM_001206794.1 [Q4LE39-1]
NP_057458.4, NM_016374.5 [Q4LE39-1]
NP_112739.2, NM_031371.3 [Q4LE39-2]
XP_011542514.1, XM_011544212.2 [Q4LE39-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264183; ENSP00000264183; ENSG00000054267 [Q4LE39-1]
ENST00000349213; ENSP00000264184; ENSG00000054267 [Q4LE39-2]
ENST00000366603; ENSP00000355562; ENSG00000054267 [Q4LE39-1]
ENST00000421364; ENSP00000394663; ENSG00000054267 [Q4LE39-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51742

UCSC genome browser

More...UCSCi		uc001hwq.3, human [Q4LE39-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214114 mRNA Translation: AAF28341.2
AY220790 mRNA Translation: AAO63590.1
AF208045 mRNA Translation: AAF23433.3 Frameshift.
AB030181 mRNA Translation: BAA89794.1
AB210032 mRNA Translation: BAE06114.1 Different initiation.
AL133418 Genomic DNA No translation available.
AL391994 Genomic DNA No translation available.
BC048959 mRNA Translation: AAH48959.1 Different termination.
BC062536 mRNA Translation: AAH62536.1 Different termination.
BC104632 mRNA Translation: AAI04633.1 Different termination.
BC130418 mRNA Translation: AAI30419.1
BX648820 mRNA Translation: CAI46047.1
AL133594 mRNA Translation: CAB63731.1
AF227899 mRNA Translation: AAF36964.1
AF083249 mRNA Translation: AAD41239.1 Frameshift.
AK023144 mRNA Translation: BAB14428.1 Different initiation.
CCDSiCCDS31060.1 [Q4LE39-2]
CCDS31061.1 [Q4LE39-1]
PIRiT43497
RefSeqiNP_001193723.1, NM_001206794.1 [Q4LE39-1]
NP_057458.4, NM_016374.5 [Q4LE39-1]
NP_112739.2, NM_031371.3 [Q4LE39-2]
XP_011542514.1, XM_011544212.2 [Q4LE39-1]

3D structure databases

SMRiQ4LE39
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119708, 67 interactors
ComplexPortaliCPX-3321, SIN3A histone deacetylase complex
CPX-3322, SIN3B histone deacetylase complex
CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiQ4LE39
IntActiQ4LE39, 48 interactors
MINTiQ4LE39
STRINGi9606.ENSP00000264183

PTM databases

iPTMnetiQ4LE39
PhosphoSitePlusiQ4LE39

Genetic variation databases

BioMutaiARID4B
DMDMi143955276

Proteomic databases

CPTACiCPTAC-1754
EPDiQ4LE39
jPOSTiQ4LE39
MassIVEiQ4LE39
MaxQBiQ4LE39
PaxDbiQ4LE39
PeptideAtlasiQ4LE39
PRIDEiQ4LE39
ProteomicsDBi62238 [Q4LE39-1]
62239 [Q4LE39-2]
62240 [Q4LE39-3]
62241 [Q4LE39-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q4LE39, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20807, 151 antibodies

The DNASU plasmid repository

More...DNASUi		51742

Genome annotation databases

EnsembliENST00000264183; ENSP00000264183; ENSG00000054267 [Q4LE39-1]
ENST00000349213; ENSP00000264184; ENSG00000054267 [Q4LE39-2]
ENST00000366603; ENSP00000355562; ENSG00000054267 [Q4LE39-1]
ENST00000421364; ENSP00000394663; ENSG00000054267 [Q4LE39-3]
GeneIDi51742
KEGGihsa:51742
UCSCiuc001hwq.3, human [Q4LE39-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51742
DisGeNETi51742

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARID4B
HGNCiHGNC:15550, ARID4B
HPAiENSG00000054267, Low tissue specificity
MIMi609696, gene
neXtProtiNX_Q4LE39
OpenTargetsiENSG00000054267
PharmGKBiPA134940494
VEuPathDBiHostDB:ENSG00000054267.20

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2744, Eukaryota
KOG3001, Eukaryota
GeneTreeiENSGT00940000158149
HOGENOMiCLU_007419_0_0_1
InParanoidiQ4LE39
OMAiXCTGQKR
PhylomeDBiQ4LE39
TreeFamiTF106427

Enzyme and pathway databases

PathwayCommonsiQ4LE39
ReactomeiR-HSA-3214815, HDACs deacetylate histones
R-HSA-427413, NoRC negatively regulates rRNA expression
R-HSA-9679191, Potential therapeutics for SARS

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51742, 81 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARID4B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ARID4B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51742
PharosiQ4LE39, Tbio

Protein Ontology

More...PROi		PR:Q4LE39
RNActiQ4LE39, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000054267, Expressed in substantia nigra and 242 other tissues
ExpressionAtlasiQ4LE39, baseline and differential
GenevisibleiQ4LE39, HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR028853, ARID4B
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR016197, Chromo-like_dom_sf
IPR012603, RBB1NT
IPR002999, Tudor
IPR025995, Tudor-knot
PANTHERiPTHR13964:SF24, PTHR13964:SF24, 1 hit
PfamiView protein in Pfam
PF01388, ARID, 1 hit
PF08169, RBB1NT, 1 hit
PF11717, Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00501, BRIGHT, 1 hit
SM00333, TUDOR, 2 hits
SUPFAMiSSF46774, SSF46774, 1 hit
SSF54160, SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS51011, ARID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI4B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LE39
Secondary accession number(s): A1L465
, Q3MHV4, Q5HY99, Q5T2C2, Q5T2C3, Q5T2C4, Q5T2C5, Q5T2C6, Q6P600, Q86UX1, Q86WR4, Q9H915, Q9NYU3, Q9NZB6, Q9NZG4, Q9P2W4, Q9UF62, Q9Y6E1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: April 7, 2021
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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