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Entry version 114 (26 Feb 2020)
Sequence version 1 (02 Aug 2005)
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Protein
Submitted name:

TNC variant protein

Gene

TNC variant protein

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TNC variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNC variant proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35103

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi222 ↔ 232PROSITE-ProRule annotation
Disulfide bondi239 ↔ 248PROSITE-ProRule annotation
Disulfide bondi316 ↔ 326PROSITE-ProRule annotation
Disulfide bondi333 ↔ 342PROSITE-ProRule annotation
Disulfide bondi409 ↔ 419PROSITE-ProRule annotation
Disulfide bondi426 ↔ 435PROSITE-ProRule annotation
Disulfide bondi502 ↔ 512PROSITE-ProRule annotation
Disulfide bondi519 ↔ 528PROSITE-ProRule annotation
Disulfide bondi595 ↔ 605PROSITE-ProRule annotation
Disulfide bondi612 ↔ 621PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q4LE33

PRoteomics IDEntifications database

More...
PRIDEi
Q4LE33

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4LE33 HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini218 – 249EGF-likeInterPro annotationAdd BLAST32
Domaini312 – 343EGF-likeInterPro annotationAdd BLAST32
Domaini405 – 436EGF-likeInterPro annotationAdd BLAST32
Domaini498 – 529EGF-likeInterPro annotationAdd BLAST32
Domaini591 – 622EGF-likeInterPro annotationAdd BLAST32
Domaini657 – 747Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini748 – 836Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini837 – 926Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini927 – 1022Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1023 – 1107Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini1108 – 1197Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1199 – 1288Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1290 – 1382Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1383 – 1471Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1472 – 1563Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini1565 – 1653Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1654 – 1743Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1744 – 1833Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1834 – 1920Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1921 – 2009Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini2007 – 2222Fibrinogen C-terminalInterPro annotationAdd BLAST216

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni101 – 122DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili151 – 171Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA

KEGG Orthology (KO)

More...
KOi
K06252

Database of Orthologous Groups

More...
OrthoDBi
18592at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 15 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 15 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC

The PANTHER Classification System

More...
PANTHERi
PTHR46708:SF1 PTHR46708:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 4 hits
PF18720 EGF_Tenascin, 9 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 15 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 12 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q4LE33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
SLLCASKSPI LLKVRYPRAL EPQQHPAKPT STMGAMTQLL AGVFLAFLAL
60 70 80 90 100
ATEGGVLKKV IRHKRQSGVN ATLPEENQPV VFNHVYNIKL PVGSQCSVDL
110 120 130 140 150
ESASGEKDLA PPSEPSESFQ EHTVDGENQI VFTHRINIPR RACGCAAAPD
160 170 180 190 200
VKELLSRLEE LENLVSSLRE QCTAGAGCCL QPATGRLDTR PFCSGRGNFS
210 220 230 240 250
TEGCGCVCEP GWKGPNCSEP ECPGNCHLRG RCIDGQCICD DGFTGEDCSQ
260 270 280 290 300
LACPSDCNDQ GKCVNGVCIC FEGYAGADCS REICPVPCSE EHGTCVDGLC
310 320 330 340 350
VCHDGFAGDD CNKPLCLNNC YNRGRCVENE CVCDEGFTGE DCSELICPND
360 370 380 390 400
CFDRGRCING TCYCEEGFTG EDCGKPTCPH ACHTQGRCEE GQCVCDEGFA
410 420 430 440 450
GVDCSEKRCP ADCHNRGRCV DGRCECDDGF TGADCGELKC PNGCSGHGRC
460 470 480 490 500
VNGQCVCDEG YTGEDCSQLR CPNDCHSRGR CVEGKCVCEQ GFKGYDCSDM
510 520 530 540 550
SCPNDCHQHG RCVNGMCVCD DGYTGEDCRD RQCPRDCSNR GLCVDGQCVC
560 570 580 590 600
EDGFTGPDCA ELSCPNDCHG RGRCVNGQCV CHEGFMGKDC KEQRCPSDCH
610 620 630 640 650
GQGRCVDGQC ICHEGFTGLD CGQHSCPSDC NNLGQCVSGR CICNEGYSGE
660 670 680 690 700
DCSEVSPPKD LVVTEVTEET VNLAWDNEMR VTEYLVVYTP THEGGLEMQF
710 720 730 740 750
RVPGDQTSTI IRELEPGVEY FIRVFAILEN KKSIPVSARV ATYLPAPEGL
760 770 780 790 800
KFKSIKETSV EVEWDPLDIA FETWEIIFRN MNKEDEGEIT KSLRRPETSY
810 820 830 840 850
RQTGLAPGQE YEISLHIVKN NTRGPGLKRV TTTRLDAPSQ IEVKDVTDTT
860 870 880 890 900
ALITWFKPLA EIDGIELTYG IKDVPGDRTT IDLTEDENQY SIGNLKPDTE
910 920 930 940 950
YEVSLISRRG DMSSNPAKET FTTGLDAPRN LRRVSQTDNS ITLEWRNGKA
960 970 980 990 1000
AIDSYRIKYA PISGGDHAEV DVPKSQQATT KTTLTGLRPG TEYGIGVSAV
1010 1020 1030 1040 1050
KEDKESNPAT INAATELDTP KDLQVSETAE TSLTLLWKTP LAKFDRYRLN
1060 1070 1080 1090 1100
YSLPTGQWVG VQLPRNTTSY VLRGLEPGQE YNVLLTAEKG RHKSKPAHVK
1110 1120 1130 1140 1150
ASTEQAPELE NLTVTEVGWD GLRLNWTAAD QAYEHFIIQV QEANKVEAAR
1160 1170 1180 1190 1200
NLTVPGSLRA VDIPGLKAAT PYTVSIYGVI QGYRTPVLSA EASTGETPNL
1210 1220 1230 1240 1250
GEVVVAEVGW DALKLNWTAP EGAYEYFFIQ VQEADTVEAA QNLTVPGGLR
1260 1270 1280 1290 1300
STDLPGLKAA THYTITIRGV TQDFSTTPLS VEVLTEEVPD MGNLTVTEVS
1310 1320 1330 1340 1350
WDALRLNWTT PDGTYDQFTI QVQEADQVEE AHNLTVPGSL RSMEIPGLRA
1360 1370 1380 1390 1400
GTPYTVTLHG EVRGHSTRPL AVEVVTEDLP QLGDLAVSEV GWDGLRLNWT
1410 1420 1430 1440 1450
AADNAYEHFV IQVQEVNKVE AAQNLTLPGS LRAVDIPGLE AATPYRVSIY
1460 1470 1480 1490 1500
GVIRGYRTPV LSAEASTAKE PEIGNLNVSD ITPESFNLSW MATDGIFETF
1510 1520 1530 1540 1550
TIEIIDSNRL LETVEYNISG AERTAHISGL PPSTDFIVYL SGLAPSIRTK
1560 1570 1580 1590 1600
TISATATTEA LPLLENLTIS DINPYGFTVS WMASENAFDS FLVTVVDSGK
1610 1620 1630 1640 1650
LLDPQEFTLS GTQRKLELRG LITGIGYEVM VSGFTQGHQT KPLRAEIVTE
1660 1670 1680 1690 1700
AEPEVDNLLV SDATPDGFRL SWTADEGVFD NFVLKIRDTK KQSEPLEITL
1710 1720 1730 1740 1750
LAPERTRDIT GLREATEYEI ELYGISKGRR SQTVSAIATT AMGSPKEVIF
1760 1770 1780 1790 1800
SDITENSATV SWRAPTAQVE SFRITYVPIT GGTPSMVTVD GTKTQTRLVK
1810 1820 1830 1840 1850
LIPGVEYLVS IIAMKGFEES EPVSGSFTTA LDGPSGLVTA NITDSEALAR
1860 1870 1880 1890 1900
WQPAIATVDS YVISYTGEKV PEITRTVSGN TVEYALTDLE PATEYTLRIF
1910 1920 1930 1940 1950
AEKGPQKSST ITAKFTTDLD SPRDLTATEV QSETALLTWR PPRASVTGYL
1960 1970 1980 1990 2000
LVYESVDGTV KEVIVGPDTT SYSLADLSPS THYTAKIQAL NGPLRSNMIQ
2010 2020 2030 2040 2050
TIFTTIGLLY PFPKDCSQAM LNGDTTSGLY TIYLNGDKAE ALEVFCDMTS
2060 2070 2080 2090 2100
DGGGWIVFLR RKNGRENFYQ NWKAYAAGFG DRREEFWLGL DNLNKITAQG
2110 2120 2130 2140 2150
QYELRVDLRD HGETAFAVYD KFSVGDAKTR YKLKVEGYSG TAGDSMAYHN
2160 2170 2180 2190 2200
GRSFSTFDKD TDSAITNCAL SYKGAFWYRN CHRVNLMGRY GDNNHSQGVN
2210 2220 2230
WFHWKGHEHS IQFAEMKLRP SNFRNLEGRR KRA
Length:2,233
Mass (Da):244,404
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AB15331FB1E92E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB210038 mRNA Translation: BAE06120.1

NCBI Reference Sequences

More...
RefSeqi
NP_002151.2, NM_002160.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3371

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB210038 mRNA Translation: BAE06120.1
RefSeqiNP_002151.2, NM_002160.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ4LE33
PRIDEiQ4LE33

Genome annotation databases

GeneIDi3371
KEGGihsa:3371

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3371
PharmGKBiPA35103

Phylogenomic databases

eggNOGiKOG1225 Eukaryota
KOG2579 Eukaryota
ENOG410ZYS4 LUCA
KOiK06252
OrthoDBi18592at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNC human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3371

Gene expression databases

GenevisibleiQ4LE33 HS

Family and domain databases

CDDicd00063 FN3, 15 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 15 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC
PANTHERiPTHR46708:SF1 PTHR46708:SF1, 1 hit
PfamiView protein in Pfam
PF07974 EGF_2, 4 hits
PF18720 EGF_Tenascin, 9 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 15 hits
SMARTiView protein in SMART
SM00181 EGF, 14 hits
SM00186 FBG, 1 hit
SM00060 FN3, 15 hits
SUPFAMiSSF49265 SSF49265, 12 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4LE33_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LE33
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: February 26, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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