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Protein

Cortexin-3

Gene

CTXN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Cortexin-3
Alternative name(s):
Kidney and brain-expressed protein
Gene namesi
Name:CTXN3
Synonyms:KABE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000205279.8
HGNCiHGNC:31110 CTXN3
neXtProtiNX_Q4LDR2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi613212
OpenTargetsiENSG00000205279
PharmGKBiPA134959223

Polymorphism and mutation databases

BioMutaiCTXN3
DMDMi121944345

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002845131 – 81Cortexin-3Add BLAST81

Proteomic databases

PaxDbiQ4LDR2
PRIDEiQ4LDR2
ProteomicsDBi62236

PTM databases

iPTMnetiQ4LDR2
PhosphoSitePlusiQ4LDR2

Expressioni

Gene expression databases

BgeeiENSG00000205279 Expressed in 73 organ(s), highest expression level in kidney epithelium
CleanExiHS_CTXN3
GenevisibleiQ4LDR2 HS

Interactioni

Protein-protein interaction databases

IntActiQ4LDR2, 51 interactors
STRINGi9606.ENSP00000368758

Structurei

3D structure databases

ProteinModelPortaliQ4LDR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cortexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MI Eukaryota
ENOG41120CA LUCA
GeneTreeiENSGT00390000018468
HOGENOMiHOG000273868
HOVERGENiHBG054879
InParanoidiQ4LDR2
OMAiQKTTFAF
OrthoDBiEOG091G15XU
PhylomeDBiQ4LDR2
TreeFamiTF333403

Family and domain databases

InterProiView protein in InterPro
IPR020066 Cortexin
PANTHERiPTHR16736 PTHR16736, 1 hit
PfamiView protein in Pfam
PF11057 Cortexin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD054489 Cortexin, 1 hit

Sequencei

Sequence statusi: Complete.

Q4LDR2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGGQPIPSS LVPLGNESAD SSMSLEQKMT FVFVILLFIF LGILIVRCFR
60 70 80
ILLDPYRSMP TSTWADGLEG LEKGQFDHAL A
Length:81
Mass (Da):8,933
Last modified:August 2, 2005 - v1
Checksum:i490CDAAC2ABE2A0B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03176317E → V1 PublicationCorresponds to variant dbSNP:rs248709Ensembl.1
Natural variantiVAR_05388523M → I. Corresponds to variant dbSNP:rs2280170Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219764 mRNA Translation: BAE06183.1
AB219832 mRNA Translation: BAE06184.1
CH471062 Genomic DNA Translation: EAW62400.1
CH471062 Genomic DNA Translation: EAW62401.1
BC147012 mRNA Translation: AAI47013.1
CCDSiCCDS34221.1
RefSeqiNP_001041717.1, NM_001048252.2
NP_001120857.1, NM_001127385.1
UniGeneiHs.66194

Genome annotation databases

EnsembliENST00000379445; ENSP00000368758; ENSG00000205279
ENST00000395322; ENSP00000378732; ENSG00000205279
ENST00000620385; ENSP00000482081; ENSG00000205279
GeneIDi613212
KEGGihsa:613212
UCSCiuc003kul.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219764 mRNA Translation: BAE06183.1
AB219832 mRNA Translation: BAE06184.1
CH471062 Genomic DNA Translation: EAW62400.1
CH471062 Genomic DNA Translation: EAW62401.1
BC147012 mRNA Translation: AAI47013.1
CCDSiCCDS34221.1
RefSeqiNP_001041717.1, NM_001048252.2
NP_001120857.1, NM_001127385.1
UniGeneiHs.66194

3D structure databases

ProteinModelPortaliQ4LDR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4LDR2, 51 interactors
STRINGi9606.ENSP00000368758

PTM databases

iPTMnetiQ4LDR2
PhosphoSitePlusiQ4LDR2

Polymorphism and mutation databases

BioMutaiCTXN3
DMDMi121944345

Proteomic databases

PaxDbiQ4LDR2
PRIDEiQ4LDR2
ProteomicsDBi62236

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379445; ENSP00000368758; ENSG00000205279
ENST00000395322; ENSP00000378732; ENSG00000205279
ENST00000620385; ENSP00000482081; ENSG00000205279
GeneIDi613212
KEGGihsa:613212
UCSCiuc003kul.5 human

Organism-specific databases

CTDi613212
DisGeNETi613212
EuPathDBiHostDB:ENSG00000205279.8
GeneCardsiCTXN3
HGNCiHGNC:31110 CTXN3
neXtProtiNX_Q4LDR2
OpenTargetsiENSG00000205279
PharmGKBiPA134959223
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0MI Eukaryota
ENOG41120CA LUCA
GeneTreeiENSGT00390000018468
HOGENOMiHOG000273868
HOVERGENiHBG054879
InParanoidiQ4LDR2
OMAiQKTTFAF
OrthoDBiEOG091G15XU
PhylomeDBiQ4LDR2
TreeFamiTF333403

Miscellaneous databases

GenomeRNAii613212
PROiPR:Q4LDR2

Gene expression databases

BgeeiENSG00000205279 Expressed in 73 organ(s), highest expression level in kidney epithelium
CleanExiHS_CTXN3
GenevisibleiQ4LDR2 HS

Family and domain databases

InterProiView protein in InterPro
IPR020066 Cortexin
PANTHERiPTHR16736 PTHR16736, 1 hit
PfamiView protein in Pfam
PF11057 Cortexin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD054489 Cortexin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTXN3_HUMAN
AccessioniPrimary (citable) accession number: Q4LDR2
Secondary accession number(s): B2RV32, D3DQ82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: August 2, 2005
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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