UniProtKB - Q4LDR2 (CTXN3_HUMAN)
Protein
Cortexin-3
Gene
CTXN3
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Cortexin-3Alternative name(s): Kidney and brain-expressed protein |
Gene namesi | Name:CTXN3 Synonyms:KABE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31110, CTXN3 |
MIMi | 618746, gene |
neXtProti | NX_Q4LDR2 |
VEuPathDBi | HostDB:ENSG00000205279.8 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 29 – 49 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 613212 |
OpenTargetsi | ENSG00000205279 |
PharmGKBi | PA134959223 |
Miscellaneous databases
Pharosi | Q4LDR2, Tbio |
Genetic variation databases
BioMutai | CTXN3 |
DMDMi | 121944345 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284513 | 1 – 81 | Cortexin-3Add BLAST | 81 |
Proteomic databases
PaxDbi | Q4LDR2 |
PRIDEi | Q4LDR2 |
ProteomicsDBi | 62236 |
PTM databases
iPTMneti | Q4LDR2 |
PhosphoSitePlusi | Q4LDR2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000205279, Expressed in kidney epithelium and 94 other tissues |
Genevisiblei | Q4LDR2, HS |
Organism-specific databases
HPAi | ENSG00000205279, Group enriched (brain, kidney) |
Interactioni
Binary interactionsi
Q4LDR2
Protein-protein interaction databases
BioGRIDi | 534792, 59 interactors |
IntActi | Q4LDR2, 58 interactors |
STRINGi | 9606.ENSP00000368758 |
Miscellaneous databases
RNActi | Q4LDR2, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cortexin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S3V3, Eukaryota |
GeneTreei | ENSGT00940000154412 |
HOGENOMi | CLU_193122_0_0_1 |
InParanoidi | Q4LDR2 |
OMAi | FSWLMEA |
OrthoDBi | 1640476at2759 |
PhylomeDBi | Q4LDR2 |
TreeFami | TF333403 |
Family and domain databases
InterProi | View protein in InterPro IPR020066, Cortexin |
PANTHERi | PTHR16736, PTHR16736, 1 hit |
Pfami | View protein in Pfam PF11057, Cortexin, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4LDR2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDGGQPIPSS LVPLGNESAD SSMSLEQKMT FVFVILLFIF LGILIVRCFR
60 70 80
ILLDPYRSMP TSTWADGLEG LEKGQFDHAL A
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031763 | 17 | E → V1 PublicationCorresponds to variant dbSNP:rs248709Ensembl. | 1 | |
Natural variantiVAR_053885 | 23 | M → I. Corresponds to variant dbSNP:rs2280170Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB219764 mRNA Translation: BAE06183.1 AB219832 mRNA Translation: BAE06184.1 CH471062 Genomic DNA Translation: EAW62400.1 CH471062 Genomic DNA Translation: EAW62401.1 BC147012 mRNA Translation: AAI47013.1 |
CCDSi | CCDS34221.1 |
RefSeqi | NP_001041717.1, NM_001048252.2 NP_001120857.1, NM_001127385.1 |
Genome annotation databases
Ensembli | ENST00000379445; ENSP00000368758; ENSG00000205279 ENST00000395322; ENSP00000378732; ENSG00000205279 ENST00000620385; ENSP00000482081; ENSG00000205279 |
GeneIDi | 613212 |
KEGGi | hsa:613212 |
UCSCi | uc003kul.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB219764 mRNA Translation: BAE06183.1 AB219832 mRNA Translation: BAE06184.1 CH471062 Genomic DNA Translation: EAW62400.1 CH471062 Genomic DNA Translation: EAW62401.1 BC147012 mRNA Translation: AAI47013.1 |
CCDSi | CCDS34221.1 |
RefSeqi | NP_001041717.1, NM_001048252.2 NP_001120857.1, NM_001127385.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 534792, 59 interactors |
IntActi | Q4LDR2, 58 interactors |
STRINGi | 9606.ENSP00000368758 |
PTM databases
iPTMneti | Q4LDR2 |
PhosphoSitePlusi | Q4LDR2 |
Genetic variation databases
BioMutai | CTXN3 |
DMDMi | 121944345 |
Proteomic databases
PaxDbi | Q4LDR2 |
PRIDEi | Q4LDR2 |
ProteomicsDBi | 62236 |
Genome annotation databases
Ensembli | ENST00000379445; ENSP00000368758; ENSG00000205279 ENST00000395322; ENSP00000378732; ENSG00000205279 ENST00000620385; ENSP00000482081; ENSG00000205279 |
GeneIDi | 613212 |
KEGGi | hsa:613212 |
UCSCi | uc003kul.5, human |
Organism-specific databases
CTDi | 613212 |
DisGeNETi | 613212 |
GeneCardsi | CTXN3 |
HGNCi | HGNC:31110, CTXN3 |
HPAi | ENSG00000205279, Group enriched (brain, kidney) |
MIMi | 618746, gene |
neXtProti | NX_Q4LDR2 |
OpenTargetsi | ENSG00000205279 |
PharmGKBi | PA134959223 |
VEuPathDBi | HostDB:ENSG00000205279.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S3V3, Eukaryota |
GeneTreei | ENSGT00940000154412 |
HOGENOMi | CLU_193122_0_0_1 |
InParanoidi | Q4LDR2 |
OMAi | FSWLMEA |
OrthoDBi | 1640476at2759 |
PhylomeDBi | Q4LDR2 |
TreeFami | TF333403 |
Enzyme and pathway databases
PathwayCommonsi | Q4LDR2 |
Miscellaneous databases
BioGRID-ORCSi | 613212, 2 hits in 869 CRISPR screens |
GenomeRNAii | 613212 |
Pharosi | Q4LDR2, Tbio |
PROi | PR:Q4LDR2 |
RNActi | Q4LDR2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000205279, Expressed in kidney epithelium and 94 other tissues |
Genevisiblei | Q4LDR2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR020066, Cortexin |
PANTHERi | PTHR16736, PTHR16736, 1 hit |
Pfami | View protein in Pfam PF11057, Cortexin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTXN3_HUMAN | |
Accessioni | Q4LDR2Primary (citable) accession number: Q4LDR2 Secondary accession number(s): B2RV32, D3DQ82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | August 2, 2005 | |
Last modified: | February 10, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants