CTXN3

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cortexin-3 Alternative name(s): Kidney and brain-expressed protein
Gene namesⁱ	Name:CTXN3 Synonyms:KABE
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000205279.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31110 CTXN3
neXtProtⁱ	NX_Q4LDR2

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	29 – 49	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	613212
Open Targets More...OpenTargetsⁱ	ENSG00000205279
PharmGKBⁱ	PA134959223

Polymorphism and mutation databases

BioMutaⁱ	CTXN3
DMDMⁱ	121944345

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000284513	1 – 81	Cortexin-3Add BLAST		81

Proteomic databases

PaxDbⁱ	Q4LDR2
PRIDEⁱ	Q4LDR2
ProteomicsDBⁱ	62236

PTM databases

iPTMnetⁱ	Q4LDR2
PhosphoSitePlusⁱ	Q4LDR2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000205279 Expressed in 73 organ(s), highest expression level in kidney epithelium
CleanExⁱ	HS_CTXN3
Genevisibleⁱ	Q4LDR2 HS

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q4LDR2, 51 interactors
STRINGⁱ	9606.ENSP00000368758

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q4LDR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cortexin family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J0MI Eukaryota ENOG41120CA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018468
HOGENOMⁱ	HOG000273868
HOVERGENⁱ	HBG054879
InParanoidⁱ	Q4LDR2
OMAⁱ	QKTTFAF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15XU
PhylomeDBⁱ	Q4LDR2
TreeFamⁱ	TF333403

Family and domain databases

InterProⁱ	View protein in InterPro IPR020066 Cortexin
PANTHERⁱ	PTHR16736 PTHR16736, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11057 Cortexin, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD054489 Cortexin, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4LDR2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDGGQPIPSS LVPLGNESAD SSMSLEQKMT FVFVILLFIF LGILIVRCFR 
        60         70         80 
ILLDPYRSMP TSTWADGLEG LEKGQFDHAL A

Length:81

Mass (Da):8,933

Last modified:August 2, 2005 - v1

Checksum:ⁱ490CDAAC2ABE2A0B

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031763	17	E → V1 PublicationCorresponds to variant dbSNP:rs248709Ensembl.		1
Natural variantⁱVAR_053885	23	M → I. Corresponds to variant dbSNP:rs2280170Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB219764 mRNA Translation: BAE06183.1 AB219832 mRNA Translation: BAE06184.1 CH471062 Genomic DNA Translation: EAW62400.1 CH471062 Genomic DNA Translation: EAW62401.1 BC147012 mRNA Translation: AAI47013.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34221.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001041717.1, NM_001048252.2 NP_001120857.1, NM_001127385.1
UniGeneⁱ	Hs.66194

Genome annotation databases

Ensemblⁱ	ENST00000379445; ENSP00000368758; ENSG00000205279 ENST00000395322; ENSP00000378732; ENSG00000205279 ENST00000620385; ENSP00000482081; ENSG00000205279
GeneIDⁱ	613212
KEGGⁱ	hsa:613212
UCSC genome browser More...UCSCⁱ	uc003kul.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q4LDR2	Cortexin-3		MOUSE		80	UniRef90_Q4LDR2
cortexin-3		LIPVE		82
cortexin-3		TURTR		81
Uncharacterized protein		CAVPO		81
Cortexin 3		RABIT		81
+83

Protein	Similar proteins		Species	Score	Length	Source
Q4LDR2	Cortexin-3		MOUSE		80	UniRef50_Q4LDR2
cortexin-3		LIPVE		82
cortexin-3		TURTR		81
Cortexin 3		HORSE		81
cortexin-3		Florida manatee		81
+146

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB219764 mRNA Translation: BAE06183.1 AB219832 mRNA Translation: BAE06184.1 CH471062 Genomic DNA Translation: EAW62400.1 CH471062 Genomic DNA Translation: EAW62401.1 BC147012 mRNA Translation: AAI47013.1
CCDSⁱ	CCDS34221.1
RefSeqⁱ	NP_001041717.1, NM_001048252.2 NP_001120857.1, NM_001127385.1
UniGeneⁱ	Hs.66194

3D structure databases

ProteinModelPortalⁱ	Q4LDR2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q4LDR2, 51 interactors
STRINGⁱ	9606.ENSP00000368758

PTM databases

iPTMnetⁱ	Q4LDR2
PhosphoSitePlusⁱ	Q4LDR2

Polymorphism and mutation databases

BioMutaⁱ	CTXN3
DMDMⁱ	121944345

Proteomic databases

PaxDbⁱ	Q4LDR2
PRIDEⁱ	Q4LDR2
ProteomicsDBⁱ	62236

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000379445; ENSP00000368758; ENSG00000205279 ENST00000395322; ENSP00000378732; ENSG00000205279 ENST00000620385; ENSP00000482081; ENSG00000205279
GeneIDⁱ	613212
KEGGⁱ	hsa:613212
UCSCⁱ	uc003kul.5 human

Organism-specific databases

CTDⁱ	613212
DisGeNETⁱ	613212
EuPathDBⁱ	HostDB:ENSG00000205279.8
GeneCardsⁱ	CTXN3
HGNCⁱ	HGNC:31110 CTXN3
neXtProtⁱ	NX_Q4LDR2
OpenTargetsⁱ	ENSG00000205279
PharmGKBⁱ	PA134959223
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J0MI Eukaryota ENOG41120CA LUCA
GeneTreeⁱ	ENSGT00390000018468
HOGENOMⁱ	HOG000273868
HOVERGENⁱ	HBG054879
InParanoidⁱ	Q4LDR2
OMAⁱ	QKTTFAF
OrthoDBⁱ	EOG091G15XU
PhylomeDBⁱ	Q4LDR2
TreeFamⁱ	TF333403

Miscellaneous databases

GenomeRNAiⁱ	613212
Protein Ontology More...PROⁱ	PR:Q4LDR2

Gene expression databases

Bgeeⁱ	ENSG00000205279 Expressed in 73 organ(s), highest expression level in kidney epithelium
CleanExⁱ	HS_CTXN3
Genevisibleⁱ	Q4LDR2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR020066 Cortexin
PANTHERⁱ	PTHR16736 PTHR16736, 1 hit
Pfamⁱ	View protein in Pfam PF11057 Cortexin, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD054489 Cortexin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CTXN3_HUMAN
Accessionⁱ	Q4LDR2Primary (citable) accession number: Q4LDR2 Secondary accession number(s): B2RV32, D3DQ82
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
	Last sequence update:	August 2, 2005
	Last modified:	September 12, 2018
	This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q4LDR2 (CTXN3_HUMAN)

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Cortexin-3

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ