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Entry version 145 (12 Aug 2020)
Sequence version 3 (18 May 2010)
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Protein

Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

Gene

SVEP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the cell attachment process.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q4LDE5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1
Alternative name(s):
CCP module-containing protein 22
Polydom
Selectin-like osteoblast-derived protein
Short name:
SEL-OB
Serologically defined breast cancer antigen NY-BR-38
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SVEP1
Synonyms:C9orf13, CCP22, SELOB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165124.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15985, SVEP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611691, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4LDE5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79987

Open Targets

More...
OpenTargetsi
ENSG00000165124

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25971

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4LDE5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SVEP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452942

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032017918 – 3571Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1Add BLAST3554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi378 ↔ 420By similarity
Disulfide bondi406 ↔ 433By similarity
Disulfide bondi438 ↔ 480By similarity
Disulfide bondi466 ↔ 493By similarity
Disulfide bondi498 ↔ 544By similarity
Disulfide bondi529 ↔ 559By similarity
Disulfide bondi727 ↔ 769By similarity
Disulfide bondi753 ↔ 787By similarity
Glycosylationi847N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1197 ↔ 1208By similarity
Disulfide bondi1202 ↔ 1217By similarity
Disulfide bondi1219 ↔ 1228By similarity
Disulfide bondi1235 ↔ 1246By similarity
Disulfide bondi1240 ↔ 1255By similarity
Disulfide bondi1257 ↔ 1266By similarity
Disulfide bondi1273 ↔ 1284By similarity
Disulfide bondi1278 ↔ 1293By similarity
Disulfide bondi1295 ↔ 1304By similarity
Disulfide bondi1311 ↔ 1322By similarity
Disulfide bondi1316 ↔ 1331By similarity
Disulfide bondi1333 ↔ 1342By similarity
Disulfide bondi1349 ↔ 1360By similarity
Disulfide bondi1354 ↔ 1369By similarity
Disulfide bondi1371 ↔ 1380By similarity
Disulfide bondi1387 ↔ 1398By similarity
Disulfide bondi1392 ↔ 1407By similarity
Disulfide bondi1409 ↔ 1418By similarity
Disulfide bondi1631 ↔ 1672By similarity
Disulfide bondi1658 ↔ 1685By similarity
Disulfide bondi1690 ↔ 1730By similarity
Disulfide bondi1716 ↔ 1743By similarity
Disulfide bondi1749 ↔ 1761By similarity
Disulfide bondi1755 ↔ 1770By similarity
Disulfide bondi1772 ↔ 1783By similarity
Disulfide bondi1789 ↔ 1829By similarity
Disulfide bondi1815 ↔ 1842By similarity
Disulfide bondi1847 ↔ 1887By similarity
Disulfide bondi1873 ↔ 1900By similarity
Disulfide bondi1905 ↔ 1945By similarity
Disulfide bondi1931 ↔ 1958By similarity
Disulfide bondi1963 ↔ 2003By similarity
Disulfide bondi1989 ↔ 2016By similarity
Disulfide bondi2021 ↔ 2061By similarity
Disulfide bondi2047 ↔ 2078By similarity
Disulfide bondi2083 ↔ 2126By similarity
Disulfide bondi2112 ↔ 2141By similarity
Disulfide bondi2146 ↔ 2186By similarity
Disulfide bondi2172 ↔ 2199By similarity
Disulfide bondi2204 ↔ 2245By similarity
Disulfide bondi2231 ↔ 2259By similarity
Disulfide bondi2264 ↔ 2304By similarity
Disulfide bondi2290 ↔ 2318By similarity
Disulfide bondi2323 ↔ 2363By similarity
Disulfide bondi2349 ↔ 2376By similarity
Disulfide bondi2381 ↔ 2422By similarity
Disulfide bondi2408 ↔ 2435By similarity
Disulfide bondi2440 ↔ 2480By similarity
Disulfide bondi2466 ↔ 2493By similarity
Disulfide bondi2498 ↔ 2538By similarity
Disulfide bondi2524 ↔ 2551By similarity
Disulfide bondi2556 ↔ 2596By similarity
Disulfide bondi2582 ↔ 2608By similarity
Disulfide bondi2685 ↔ 2712By similarity
Disulfide bondi2717 ↔ 2757By similarity
Disulfide bondi2743 ↔ 2770By similarity
Disulfide bondi2775 ↔ 2815By similarity
Disulfide bondi2801 ↔ 2828By similarity
Disulfide bondi2833 ↔ 2873By similarity
Disulfide bondi2859 ↔ 2886By similarity
Disulfide bondi2891 ↔ 2931By similarity
Disulfide bondi2917 ↔ 2944By similarity
Disulfide bondi2949 ↔ 2989By similarity
Disulfide bondi2975 ↔ 3002By similarity
Disulfide bondi3007 ↔ 3046By similarity
Glycosylationi3018N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3032 ↔ 3059By similarity
Disulfide bondi3064 ↔ 3104By similarity
Disulfide bondi3090 ↔ 3117By similarity
Disulfide bondi3122 ↔ 3163By similarity
Disulfide bondi3148 ↔ 3176By similarity
Disulfide bondi3181 ↔ 3221By similarity
Glycosylationi3186N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi3207 ↔ 3236By similarity
Disulfide bondi3241 ↔ 3281By similarity
Disulfide bondi3267 ↔ 3294By similarity
Disulfide bondi3299 ↔ 3339By similarity
Disulfide bondi3325 ↔ 3352By similarity
Disulfide bondi3384 ↔ 3411By similarity
Disulfide bondi3416 ↔ 3456By similarity
Disulfide bondi3442 ↔ 3468By similarity
Disulfide bondi3504 ↔ 3514By similarity
Disulfide bondi3508 ↔ 3520By similarity
Disulfide bondi3522 ↔ 3531By similarity
Disulfide bondi3536 ↔ 3546By similarity
Disulfide bondi3540 ↔ 3552By similarity
Disulfide bondi3554 ↔ 3563By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4LDE5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4LDE5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q4LDE5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q4LDE5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4LDE5

PeptideAtlas

More...
PeptideAtlasi
Q4LDE5

PRoteomics IDEntifications database

More...
PRIDEi
Q4LDE5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62229 [Q4LDE5-1]
62230 [Q4LDE5-2]
62231 [Q4LDE5-3]
62232 [Q4LDE5-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1781, 17 N-Linked glycans (9 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q4LDE5, 17 sites, 2 O-linked glycans (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4LDE5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4LDE5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in mesenchymal primary cultured cell lysates (at protein level). Highly expressed in placenta. Also expressed in marrow stromal cell. Weakly or not expressed in other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165124, Expressed in placenta and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4LDE5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4LDE5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165124, Tissue enriched (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123051, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q4LDE5, 15 interactors

Molecular INTeraction database

More...
MINTi
Q4LDE5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384917

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4LDE5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4LDE5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini83 – 264VWFAPROSITE-ProRule annotationAdd BLAST182
Domaini376 – 435Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini436 – 495Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini496 – 561Sushi 3PROSITE-ProRule annotationAdd BLAST66
Domaini560 – 642HYR 1PROSITE-ProRule annotationAdd BLAST83
Domaini643 – 724HYR 2PROSITE-ProRule annotationAdd BLAST82
Domaini725 – 789Sushi 4PROSITE-ProRule annotationAdd BLAST65
Domaini1193 – 1229EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini1231 – 1267EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1269 – 1305EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1307 – 1343EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1345 – 1381EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1383 – 1419EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1424 – 1628Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST205
Domaini1629 – 1687Sushi 5PROSITE-ProRule annotationAdd BLAST59
Domaini1688 – 1745Sushi 6PROSITE-ProRule annotationAdd BLAST58
Domaini1745 – 1784EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini1787 – 1844Sushi 7PROSITE-ProRule annotationAdd BLAST58
Domaini1845 – 1902Sushi 8PROSITE-ProRule annotationAdd BLAST58
Domaini1903 – 1960Sushi 9PROSITE-ProRule annotationAdd BLAST58
Domaini1961 – 2018Sushi 10PROSITE-ProRule annotationAdd BLAST58
Domaini2019 – 2080Sushi 11PROSITE-ProRule annotationAdd BLAST62
Domaini2081 – 2143Sushi 12PROSITE-ProRule annotationAdd BLAST63
Domaini2144 – 2201Sushi 13PROSITE-ProRule annotationAdd BLAST58
Domaini2202 – 2261Sushi 14PROSITE-ProRule annotationAdd BLAST60
Domaini2262 – 2320Sushi 15PROSITE-ProRule annotationAdd BLAST59
Domaini2321 – 2378Sushi 16PROSITE-ProRule annotationAdd BLAST58
Domaini2379 – 2437Sushi 17PROSITE-ProRule annotationAdd BLAST59
Domaini2438 – 2495Sushi 18PROSITE-ProRule annotationAdd BLAST58
Domaini2496 – 2553Sushi 19PROSITE-ProRule annotationAdd BLAST58
Domaini2554 – 2610Sushi 20PROSITE-ProRule annotationAdd BLAST57
Domaini2663 – 2714Sushi 21PROSITE-ProRule annotationAdd BLAST52
Domaini2715 – 2772Sushi 22PROSITE-ProRule annotationAdd BLAST58
Domaini2773 – 2830Sushi 23PROSITE-ProRule annotationAdd BLAST58
Domaini2831 – 2888Sushi 24PROSITE-ProRule annotationAdd BLAST58
Domaini2889 – 2946Sushi 25PROSITE-ProRule annotationAdd BLAST58
Domaini2947 – 3004Sushi 26PROSITE-ProRule annotationAdd BLAST58
Domaini3005 – 3061Sushi 27PROSITE-ProRule annotationAdd BLAST57
Domaini3062 – 3119Sushi 28PROSITE-ProRule annotationAdd BLAST58
Domaini3120 – 3178Sushi 29PROSITE-ProRule annotationAdd BLAST59
Domaini3179 – 3238Sushi 30PROSITE-ProRule annotationAdd BLAST60
Domaini3239 – 3296Sushi 31PROSITE-ProRule annotationAdd BLAST58
Domaini3297 – 3354Sushi 32PROSITE-ProRule annotationAdd BLAST58
Domaini3355 – 3413Sushi 33PROSITE-ProRule annotationAdd BLAST59
Domaini3414 – 3470Sushi 34PROSITE-ProRule annotationAdd BLAST57
Domaini3500 – 3532EGF-like 8PROSITE-ProRule annotationAdd BLAST33
Domaini3533 – 3564EGF-like 9PROSITE-ProRule annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni887 – 894O-glycosylated at one site8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2845 – 2847Cell attachment siteSequence analysis3

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000343_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4LDE5

KEGG Orthology (KO)

More...
KOi
K17495

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4LDE5

TreeFam database of animal gene trees

More...
TreeFami
TF342247

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 32 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR003410, HYR_dom
IPR001759, Pentraxin-related
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 6 hits
PF07645, EGF_CA, 1 hit
PF07699, Ephrin_rec_like, 4 hits
PF12661, hEGF, 1 hit
PF02494, HYR, 2 hits
PF00354, Pentaxin, 1 hit
PF00084, Sushi, 33 hits
PF00092, VWA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00895, PENTAXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 34 hits
SM00181, EGF, 10 hits
SM00179, EGF_CA, 8 hits
SM01411, Ephrin_rec_like, 4 hits
SM00159, PTX, 1 hit
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 1 hit
SSF57184, SSF57184, 3 hits
SSF57535, SSF57535, 33 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS00022, EGF_1, 9 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 9 hits
PS01187, EGF_CA, 6 hits
PS50825, HYR, 2 hits
PS51828, PTX_2, 1 hit
PS50923, SUSHI, 34 hits
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4LDE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPRLAFCCW GLALVSGWAT FQQMSPSRNF SFRLFPETAP GAPGSIPAPP
60 70 80 90 100
APGDEAAGSR VERLGQAFRR RVRLLRELSE RLELVFLVDD SSSVGEVNFR
110 120 130 140 150
SELMFVRKLL SDFPVVPTAT RVAIVTFSSK NYVVPRVDYI STRRARQHKC
160 170 180 190 200
ALLLQEIPAI SYRGGGTYTK GAFQQAAQIL LHARENSTKV VFLITDGYSN
210 220 230 240 250
GGDPRPIAAS LRDSGVEIFT FGIWQGNIRE LNDMASTPKE EHCYLLHSFE
260 270 280 290 300
EFEALARRAL HEDLPSGSFI QDDMVHCSYL CDEGKDCCDR MGSCKCGTHT
310 320 330 340 350
GHFECICEKG YYGKGLQYEC TACPSGTYKP EGSPGGISSC IPCPDENHTS
360 370 380 390 400
PPGSTSPEDC VCREGYRASG QTCELVHCPA LKPPENGYFI QNTCNNHFNA
410 420 430 440 450
ACGVRCHPGF DLVGSSIILC LPNGLWSGSE SYCRVRTCPH LRQPKHGHIS
460 470 480 490 500
CSTREMLYKT TCLVACDEGY RLEGSDKLTC QGNSQWDGPE PRCVERHCST
510 520 530 540 550
FQMPKDVIIS PHNCGKQPAK FGTICYVSCR QGFILSGVKE MLRCTTSGKW
560 570 580 590 600
NVGVQAAVCK DVEAPQINCP KDIEAKTLEQ QDSANVTWQI PTAKDNSGEK
610 620 630 640 650
VSVHVHPAFT PPYLFPIGDV AIVYTATDLS GNQASCIFHI KVIDAEPPVI
660 670 680 690 700
DWCRSPPPVQ VSEKVHAASW DEPQFSDNSG AELVITRSHT QGDLFPQGET
710 720 730 740 750
IVQYTATDPS GNNRTCDIHI VIKGSPCEIP FTPVNGDFIC TPDNTGVNCT
760 770 780 790 800
LTCLEGYDFT EGSTDKYYCA YEDGVWKPTY TTEWPDCAKK RFANHGFKSF
810 820 830 840 850
EMFYKAARCD DTDLMKKFSE AFETTLGKMV PSFCSDAEDI DCRLEENLTK
860 870 880 890 900
KYCLEYNYDY ENGFAIGPGG WGAANRLDYS YDDFLDTVQE TATSIGNAKS
910 920 930 940 950
SRIKRSAPLS DYKIKLIFNI TASVPLPDER NDTLEWENQQ RLLQTLETIT
960 970 980 990 1000
NKLKRTLNKD PMYSFQLASE ILIADSNSLE TKKASPFCRP GSVLRGRMCV
1010 1020 1030 1040 1050
NCPLGTYYNL EHFTCESCRI GSYQDEEGQL ECKLCPSGMY TEYIHSRNIS
1060 1070 1080 1090 1100
DCKAQCKQGT YSYSGLETCE SCPLGTYQPK FGSRSCLSCP ENTSTVKRGA
1110 1120 1130 1140 1150
VNISACGVPC PEGKFSRSGL MPCHPCPRDY YQPNAGKAFC LACPFYGTTP
1160 1170 1180 1190 1200
FAGSRSITEC SSFSSTFSAA EESVVPPASL GHIKKRHEIS SQVFHECFFN
1210 1220 1230 1240 1250
PCHNSGTCQQ LGRGYVCLCP LGYTGLKCET DIDECSPLPC LNNGVCKDLV
1260 1270 1280 1290 1300
GEFICECPSG YTGQRCEENI NECSSSPCLN KGICVDGVAG YRCTCVKGFV
1310 1320 1330 1340 1350
GLHCETEVNE CQSNPCLNNA VCEDQVGGFL CKCPPGFLGT RCGKNVDECL
1360 1370 1380 1390 1400
SQPCKNGATC KDGANSFRCL CAAGFTGSHC ELNINECQSN PCRNQATCVD
1410 1420 1430 1440 1450
ELNSYSCKCQ PGFSGKRCET EQSTGFNLDF EVSGIYGYVM LDGMLPSLHA
1460 1470 1480 1490 1500
LTCTFWMKSS DDMNYGTPIS YAVDNGSDNT LLLTDYNGWV LYVNGREKIT
1510 1520 1530 1540 1550
NCPSVNDGRW HHIAITWTSA NGIWKVYIDG KLSDGGAGLS VGLPIPGGGA
1560 1570 1580 1590 1600
LVLGQEQDKK GEGFSPAESF VGSISQLNLW DYVLSPQQVK SLATSCPEEL
1610 1620 1630 1640 1650
SKGNVLAWPD FLSGIVGKVK IDSKSIFCSD CPRLGGSVPH LRTASEDLKP
1660 1670 1680 1690 1700
GSKVNLFCDP GFQLVGNPVQ YCLNQGQWTQ PLPHCERISC GVPPPLENGF
1710 1720 1730 1740 1750
HSADDFYAGS TVTYQCNNGY YLLGDSRMFC TDNGSWNGVS PSCLDVDECA
1760 1770 1780 1790 1800
VGSDCSEHAS CLNVDGSYIC SCVPPYTGDG KNCAEPIKCK APGNPENGHS
1810 1820 1830 1840 1850
SGEIYTVGAE VTFSCQEGYQ LMGVTKITCL ESGEWNHLIP YCKAVSCGKP
1860 1870 1880 1890 1900
AIPENGCIEE LAFTFGSKVT YRCNKGYTLA GDKESSCLAN SSWSHSPPVC
1910 1920 1930 1940 1950
EPVKCSSPEN INNGKYILSG LTYLSTASYS CDTGYSLQGP SIIECTASGI
1960 1970 1980 1990 2000
WDRAPPACHL VFCGEPPAIK DAVITGNNFT FRNTVTYTCK EGYTLAGLDT
2010 2020 2030 2040 2050
IECLADGKWS RSDQQCLAVS CDEPPIVDHA SPETAHRLFG DIAFYYCSDG
2060 2070 2080 2090 2100
YSLADNSQLL CNAQGKWVPP EGQDMPRCIA HFCEKPPSVS YSILESVSKA
2110 2120 2130 2140 2150
KFAAGSVVSF KCMEGFVLNT SAKIECMRGG QWNPSPMSIQ CIPVRCGEPP
2160 2170 2180 2190 2200
SIMNGYASGS NYSFGAMVAY SCNKGFYIKG EKKSTCEATG QWSSPIPTCH
2210 2220 2230 2240 2250
PVSCGEPPKV ENGFLEHTTG RIFESEVRYQ CNPGYKSVGS PVFVCQANRH
2260 2270 2280 2290 2300
WHSESPLMCV PLDCGKPPPI QNGFMKGENF EVGSKVQFFC NEGYELVGDS
2310 2320 2330 2340 2350
SWTCQKSGKW NKKSNPKCMP AKCPEPPLLE NQLVLKELTT EVGVVTFSCK
2360 2370 2380 2390 2400
EGHVLQGPSV LKCLPSQQWN DSFPVCKIVL CTPPPLISFG VPIPSSALHF
2410 2420 2430 2440 2450
GSTVKYSCVG GFFLRGNSTT LCQPDGTWSS PLPECVPVEC PQPEEIPNGI
2460 2470 2480 2490 2500
IDVQGLAYLS TALYTCKPGF ELVGNTTTLC GENGHWLGGK PTCKAIECLK
2510 2520 2530 2540 2550
PKEILNGKFS YTDLHYGQTV TYSCNRGFRL EGPSALTCLE TGDWDVDAPS
2560 2570 2580 2590 2600
CNAIHCDSPQ PIENGFVEGA DYSYGAIIIY SCFPGFQVAG HAMQTCEESG
2610 2620 2630 2640 2650
WSSSIPTCMP IDCGLPPHID FGDCTKLKDD QGYFEQEDDM MEVPYVTPHP
2660 2670 2680 2690 2700
PYHLGAVAKT WENTKESPAT HSSNFLYGTM VSYTCNPGYE LLGNPVLICQ
2710 2720 2730 2740 2750
EDGTWNGSAP SCISIECDLP TAPENGFLRF TETSMGSAVQ YSCKPGHILA
2760 2770 2780 2790 2800
GSDLRLCLEN RKWSGASPRC EAISCKKPNP VMNGSIKGSN YTYLSTLYYE
2810 2820 2830 2840 2850
CDPGYVLNGT ERRTCQDDKN WDEDEPICIP VDCSSPPVSA NGQVRGDEYT
2860 2870 2880 2890 2900
FQKEIEYTCN EGFLLEGARS RVCLANGSWS GATPDCVPVR CATPPQLANG
2910 2920 2930 2940 2950
VTEGLDYGFM KEVTFHCHEG YILHGAPKLT CQSDGNWDAE IPLCKPVNCG
2960 2970 2980 2990 3000
PPEDLAHGFP NGFSFIHGGH IQYQCFPGYK LHGNSSRRCL SNGSWSGSSP
3010 3020 3030 3040 3050
SCLPCRCSTP VIEYGTVNGT DFDCGKAARI QCFKGFKLLG LSEITCEADG
3060 3070 3080 3090 3100
QWSSGFPHCE HTSCGSLPMI PNAFISETSS WKENVITYSC RSGYVIQGSS
3110 3120 3130 3140 3150
DLICTEKGVW SQPYPVCEPL SCGSPPSVAN AVATGEAHTY ESEVKLRCLE
3160 3170 3180 3190 3200
GYTMDTDTDT FTCQKDGRWF PERISCSPKK CPLPENITHI LVHGDDFSVN
3210 3220 3230 3240 3250
RQVSVSCAEG YTFEGVNISV CQLDGTWEPP FSDESCSPVS CGKPESPEHG
3260 3270 3280 3290 3300
FVVGSKYTFE STIIYQCEPG YELEGNRERV CQENRQWSGG VAICKETRCE
3310 3320 3330 3340 3350
TPLEFLNGKA DIENRTTGPN VVYSCNRGYS LEGPSEAHCT ENGTWSHPVP
3360 3370 3380 3390 3400
LCKPNPCPVP FVIPENALLS EKEFYVDQNV SIKCREGFLL QGHGIITCNP
3410 3420 3430 3440 3450
DETWTQTSAK CEKISCGPPA HVENAIARGV HYQYGDMITY SCYSGYMLEG
3460 3470 3480 3490 3500
FLRSVCLENG TWTSPPICRA VCRFPCQNGG ICQRPNACSC PEGWMGRLCE
3510 3520 3530 3540 3550
EPICILPCLN GGRCVAPYQC DCPPGWTGSR CHTAVCQSPC LNGGKCVRPN
3560 3570
RCHCLSSWTG HNCSRKRRTG F
Length:3,571
Mass (Da):390,170
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F52DE456CED5DED
GO
Isoform 2 (identifier: Q4LDE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     868-868: P → N
     869-3571: Missing.

Show »
Length:868
Mass (Da):96,134
Checksum:i516974CD450855FD
GO
Isoform 3 (identifier: Q4LDE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2074: Missing.

Show »
Length:1,497
Mass (Da):163,559
Checksum:i98D8650DB3B69DD4
GO
Isoform 4 (identifier: Q4LDE5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1547-3571: Missing.

Show »
Length:1,546
Mass (Da):170,093
Checksum:iB304C96189C62CD1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSD0A0A0A0MSD0_HUMAN
Sushi, von Willebrand factor type A...
SVEP1
3,574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG48257 differs from that shown. Reason: Frameshift.Curated
The sequence AAG48257 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14617 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB55420 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti429S → L in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti429S → L in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti604H → R in BAB14617 (PubMed:14702039).Curated1
Sequence conflicti822F → L in BAB14617 (PubMed:14702039).Curated1
Sequence conflicti842C → W in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti842C → W in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti980E → G in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti980E → G in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti1063Y → C in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti1063Y → C in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti1442D → V in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti1442D → V in BAB55420 (PubMed:14702039).Curated1
Sequence conflicti1546P → PGMF in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti1775P → S in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti2179K → E in CAD97901 (PubMed:17974005).Curated1
Sequence conflicti2189T → S in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2237S → P in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2246Q → H in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2259C → W in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2299D → G in CAD97988 (PubMed:17974005).Curated1
Sequence conflicti2454Q → R in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2519T → I in CAD97901 (PubMed:17974005).Curated1
Sequence conflicti2623D → A in AAG48257 (PubMed:12747765).Curated1
Sequence conflicti2705W → R in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2753D → G in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2833C → R in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti2857Y → H in CAD97901 (PubMed:17974005).Curated1
Sequence conflicti3005C → F in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti3186N → S in CAD97988 (PubMed:17974005).Curated1
Sequence conflicti3302P → Q in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti3302P → Q in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti3398C → Y in CAF04067 (PubMed:16206243).Curated1
Sequence conflicti3398C → Y in BAC11489 (PubMed:14702039).Curated1
Sequence conflicti3565R → G in CAD97988 (PubMed:17974005).Curated1
Sequence conflicti3567R → G in CAD97988 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039153332G → A1 PublicationCorresponds to variant dbSNP:rs3818764Ensembl.1
Natural variantiVAR_039154428G → S. Corresponds to variant dbSNP:rs10980419Ensembl.1
Natural variantiVAR_039155507V → I. Corresponds to variant dbSNP:rs872665Ensembl.1
Natural variantiVAR_039156581Q → H. Corresponds to variant dbSNP:rs10817033Ensembl.1
Natural variantiVAR_039157637I → V. Corresponds to variant dbSNP:rs13286541Ensembl.1
Natural variantiVAR_039158899K → R. Corresponds to variant dbSNP:rs10817025Ensembl.1
Natural variantiVAR_0391591157I → V. Corresponds to variant dbSNP:rs7038903Ensembl.1
Natural variantiVAR_0391601330L → M. Corresponds to variant dbSNP:rs10817021Ensembl.1
Natural variantiVAR_0391611416K → Q. Corresponds to variant dbSNP:rs1889323Ensembl.1
Natural variantiVAR_0391621444M → L. Corresponds to variant dbSNP:rs7863519Ensembl.1
Natural variantiVAR_0391631648L → V. Corresponds to variant dbSNP:rs7852962Ensembl.1
Natural variantiVAR_0391641810E → A. Corresponds to variant dbSNP:rs2986671Ensembl.1
Natural variantiVAR_0391651953R → K. Corresponds to variant dbSNP:rs17204832Ensembl.1
Natural variantiVAR_0391662607T → A. Corresponds to variant dbSNP:rs3802433Ensembl.1
Natural variantiVAR_0391672750A → V1 PublicationCorresponds to variant dbSNP:rs7030192Ensembl.1
Natural variantiVAR_0391682922I → V. Corresponds to variant dbSNP:rs16914996Ensembl.1
Natural variantiVAR_0391693161F → I1 PublicationCorresponds to variant dbSNP:rs3739451Ensembl.1
Natural variantiVAR_0391703230P → T. Corresponds to variant dbSNP:rs16914992Ensembl.1
Natural variantiVAR_0391713559T → M. Corresponds to variant dbSNP:rs17204533Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0316251 – 2074Missing in isoform 3. 2 PublicationsAdd BLAST2074
Alternative sequenceiVSP_031626868P → N in isoform 2. 2 Publications1
Alternative sequenceiVSP_031627869 – 3571Missing in isoform 2. 2 PublicationsAdd BLAST2703
Alternative sequenceiVSP_0316281547 – 3571Missing in isoform 4. 1 PublicationAdd BLAST2025

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ619977 mRNA Translation: CAF04067.1
AY916667 mRNA Translation: AAX12481.1
AK023591 mRNA Translation: BAB14617.1 Different initiation.
AK075235 mRNA Translation: BAC11489.1
AK027870 mRNA Translation: BAB55420.1 Different initiation.
AL158158 Genomic DNA No translation available.
AL354982 Genomic DNA No translation available.
AL592463 Genomic DNA No translation available.
BC030816 mRNA Translation: AAH30816.1
BX537918 mRNA Translation: CAD97901.1
BX538049 mRNA Translation: CAD97988.1
AF308289 mRNA Translation: AAG48257.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48004.1 [Q4LDE5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_699197.3, NM_153366.3 [Q4LDE5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374461; ENSP00000363585; ENSG00000165124 [Q4LDE5-2]
ENST00000374469; ENSP00000363593; ENSG00000165124 [Q4LDE5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79987

UCSC genome browser

More...
UCSCi
uc010mtz.4, human [Q4LDE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ619977 mRNA Translation: CAF04067.1
AY916667 mRNA Translation: AAX12481.1
AK023591 mRNA Translation: BAB14617.1 Different initiation.
AK075235 mRNA Translation: BAC11489.1
AK027870 mRNA Translation: BAB55420.1 Different initiation.
AL158158 Genomic DNA No translation available.
AL354982 Genomic DNA No translation available.
AL592463 Genomic DNA No translation available.
BC030816 mRNA Translation: AAH30816.1
BX537918 mRNA Translation: CAD97901.1
BX538049 mRNA Translation: CAD97988.1
AF308289 mRNA Translation: AAG48257.1 Sequence problems.
CCDSiCCDS48004.1 [Q4LDE5-1]
RefSeqiNP_699197.3, NM_153366.3 [Q4LDE5-1]

3D structure databases

SMRiQ4LDE5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123051, 6 interactors
IntActiQ4LDE5, 15 interactors
MINTiQ4LDE5
STRINGi9606.ENSP00000384917

PTM databases

GlyConnecti1781, 17 N-Linked glycans (9 sites)
GlyGeniQ4LDE5, 17 sites, 2 O-linked glycans (5 sites)
iPTMnetiQ4LDE5
PhosphoSitePlusiQ4LDE5

Polymorphism and mutation databases

BioMutaiSVEP1
DMDMi296452942

Proteomic databases

EPDiQ4LDE5
jPOSTiQ4LDE5
MassIVEiQ4LDE5
MaxQBiQ4LDE5
PaxDbiQ4LDE5
PeptideAtlasiQ4LDE5
PRIDEiQ4LDE5
ProteomicsDBi62229 [Q4LDE5-1]
62230 [Q4LDE5-2]
62231 [Q4LDE5-3]
62232 [Q4LDE5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
7229, 19 antibodies

Genome annotation databases

EnsembliENST00000374461; ENSP00000363585; ENSG00000165124 [Q4LDE5-2]
ENST00000374469; ENSP00000363593; ENSG00000165124 [Q4LDE5-1]
GeneIDi79987
KEGGihsa:79987
UCSCiuc010mtz.4, human [Q4LDE5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79987
DisGeNETi79987
EuPathDBiHostDB:ENSG00000165124.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SVEP1
HGNCiHGNC:15985, SVEP1
HPAiENSG00000165124, Tissue enriched (placenta)
MIMi611691, gene
neXtProtiNX_Q4LDE5
OpenTargetsiENSG00000165124
PharmGKBiPA25971

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
KOG4297, Eukaryota
GeneTreeiENSGT00940000156061
HOGENOMiCLU_000343_0_0_1
InParanoidiQ4LDE5
KOiK17495
PhylomeDBiQ4LDE5
TreeFamiTF342247

Enzyme and pathway databases

PathwayCommonsiQ4LDE5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
79987, 4 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SVEP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79987
PharosiQ4LDE5, Tbio

Protein Ontology

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PROi
PR:Q4LDE5
RNActiQ4LDE5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165124, Expressed in placenta and 210 other tissues
ExpressionAtlasiQ4LDE5, baseline and differential
GenevisibleiQ4LDE5, HS

Family and domain databases

CDDicd00033, CCP, 32 hits
Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR003410, HYR_dom
IPR001759, Pentraxin-related
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF00008, EGF, 6 hits
PF07645, EGF_CA, 1 hit
PF07699, Ephrin_rec_like, 4 hits
PF12661, hEGF, 1 hit
PF02494, HYR, 2 hits
PF00354, Pentaxin, 1 hit
PF00084, Sushi, 33 hits
PF00092, VWA, 1 hit
PRINTSiPR00895, PENTAXIN
SMARTiView protein in SMART
SM00032, CCP, 34 hits
SM00181, EGF, 10 hits
SM00179, EGF_CA, 8 hits
SM01411, Ephrin_rec_like, 4 hits
SM00159, PTX, 1 hit
SM00327, VWA, 1 hit
SUPFAMiSSF49899, SSF49899, 1 hit
SSF53300, SSF53300, 1 hit
SSF57184, SSF57184, 3 hits
SSF57535, SSF57535, 33 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 6 hits
PS00022, EGF_1, 9 hits
PS01186, EGF_2, 11 hits
PS50026, EGF_3, 9 hits
PS01187, EGF_CA, 6 hits
PS50825, HYR, 2 hits
PS51828, PTX_2, 1 hit
PS50923, SUSHI, 34 hits
PS50234, VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSVEP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LDE5
Secondary accession number(s): Q0P675
, Q5D213, Q5T938, Q5VTE4, Q5VTE5, Q7Z387, Q7Z3G3, Q8NBT9, Q96JU7, Q9H284, Q9H8J9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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