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UniProtKB - Q4LDD4 (ARAP1_MOUSE)

Entry version 134 (11 Dec 2019)
Sequence version 2 (24 Mar 2009)
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Protein

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Gene

Arap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri552 – 575C4-typePROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-194840 Rho GTPase cycle
R-MMU-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Alternative name(s):
Centaurin-delta-2By similarity
Short name:
Cnt-d2By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arap1Imported
Synonyms:Centd2Imported, Kiaa0782Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1916960 Arap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003670291 – 1452Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1Add BLAST1452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei232PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei506PhosphotyrosineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei1430PhosphoserineBy similarity1
Modified residuei1437PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q4LDD4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4LDD4

PeptideAtlas

More...PeptideAtlasi		Q4LDD4

PRoteomics IDEntifications database

More...PRIDEi		Q4LDD4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4LDD4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4LDD4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q4LDD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000032812 Expressed in 171 organ(s), highest expression level in bone marrow macrophage

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q4LDD4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4LDD4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TNFRSF10A.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		213630, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q4LDD4, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000102624

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4LDD4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4LDD4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 70SAMPROSITE-ProRule annotationAdd BLAST65
Domaini329 – 421PH 1PROSITE-ProRule annotationAdd BLAST93
Domaini442 – 531PH 2PROSITE-ProRule annotationAdd BLAST90
Domaini537 – 662Arf-GAPPROSITE-ProRule annotationAdd BLAST126
Domaini745 – 852PH 3PROSITE-ProRule annotationAdd BLAST108
Domaini956 – 1141Rho-GAPPROSITE-ProRule annotationAdd BLAST186
Domaini1174 – 1263Ras-associatingPROSITE-ProRule annotationAdd BLAST90
Domaini1276 – 1398PH 4PROSITE-ProRule annotationAdd BLAST123

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri552 – 575C4-typePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1117 Eukaryota
COG5347 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157424

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4LDD4

KEGG Orthology (KO)

More...KOi		K18439

Database of Orthologous Groups

More...OrthoDBi		98944at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4LDD4

TreeFam database of animal gene trees

More...TreeFami		TF105769

Family and domain databases

Conserved Domains Database

More...CDDi		cd04385 RhoGAP_ARAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 4 hits
3.30.40.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 3 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00405 REVINTRACTNG

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4LDD4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGYDAALS VAEWLRALHL EQYTALFEQH GLVWATECQG LSDAGLLDMG 
        60         70         80         90        100
MHLPGHRRRI LAGLHRAHAP PVPLPRPAPR PVPMKRHIFR SPPVPVTPPE 
       110        120        130        140        150
PPPTAGEDEG LPAAPPIPPR RSCLPPACFT PTSTAAPDPV LPPLPAKRHL 
       160        170        180        190        200
VEPSVPPVPP RTGPPYPQAS LLAKEELLLP SVSPRSQPEP AETPSTLLPA 
       210        220        230        240        250
FPQGPLQPPS PPPCPPVIPP KPPRLLPEFD DSDYDDVPEE GPGAPASVMT 
       260        270        280        290        300
KEEPLPSRVP RAVRVASLLS EGEELSGDDS EDDDDHAYEG IPNGGWPTSG 
       310        320        330        340        350
LNPPLRSLIP DLPLHPMDEL PGGPTPITPV IKAGWLDKNP PQGSYIYQKR 
       360        370        380        390        400
WVRLDADYLR YFDSNKDAYS KRFVPVACIC RVAPIGDQKF EVITNNRTFA 
       410        420        430        440        450
FRAESDVERN EWMQALQQAV VEHRARFRLS SASVLGVRGS EQPDRAGSLE 
       460        470        480        490        500
LRGFKNKLYV AVTGDKVQLY KNLEEFHLGI GITFIDMNVG NVKEVDRRSF 
       510        520        530        540        550
DLTTPYRIFS FSADSELEKE QWLEAMQGAI AEALSTSEVA ERIWAAAPNR 
       560        570        580        590        600
FCADCGAAQP DWASINLCVV ICKRCAGEHR GLGAGVSKVR SLKMDRKVWT 
       610        620        630        640        650
EALIQLFLHL GNGPGNHFWA ANVPPSEALE PSSSPGARRY HLEAKYREGK 
       660        670        680        690        700
YRRYHPLFGN QEELDKALCA AVTTTDLAET QALLGCGAGV SCFSGDPAAP 
       710        720        730        740        750
TPLALAEQAG QTLQMEFLRN NQSTEVPRLD SVKPLEKHYS VTLPTVSHSG 
       760        770        780        790        800
FLYKTASAGK PLQDRRAREE FSRRWCVLSD GVLSYYENER AVTPNGEIRA 
       810        820        830        840        850
SEIVCLAVSP LDTHGFEHTF EVYTEGERLY LFGLENAELA HEWVKCIAKA 
       860        870        880        890        900
FVPPLAEDLL ARDFERLGRL PCKAGLSLQQ AQEGWFALTG SELRAVFPEG 
       910        920        930        940        950
PWEEPLQLRK LQELSIQGDS ENQVLVLVER RRTLYIQGER RLDFMAWLGV 
       960        970        980        990       1000
IQKAAASLGD TLSEQQLGDS DIPVIVYRCV DYITQCGLTS EGIYRKCGQT 
      1010       1020       1030       1040       1050
SKTQRLLDSL RQDARSVHLK EGEQHVDDVS SALKRFLRDL PDGLFTRAQR 
      1060       1070       1080       1090       1100
LAWLEASEIE DEEEKISRYR ELLVHLPPVN RATVKALISH LYCVQCFSDT 
      1110       1120       1130       1140       1150
NQMNTHNLAI VFGPTLFQTD GQDYKAGKVV EDLINHYVVV FSVDEEELRK 
      1160       1170       1180       1190       1200
QREEVTAIVK MRVAGTASGT QHAGDFICTV YLEEKKVETE QHVKIPASMT 
      1210       1220       1230       1240       1250
AEELTLEILD RRNVSIREKD YWTCFEVNEK EEAERPLHFA EKVLPIVHGL 
      1260       1270       1280       1290       1300
GIDSHLVVKK YQSMEAMLLY LASRVGDTKH GMMKFREDRS LLGLGLPSGG 
      1310       1320       1330       1340       1350
FHDRYFILNS SCLRLYKEVR SQRPWSGAPE TSHRPEKEWP VKSLKVYLGV 
      1360       1370       1380       1390       1400
KKKLRPPTCW GFTVVHETEK HEKQQWYLCC DTQMELREWF ATFLSVQHDG 
      1410       1420       1430       1440       1450
LVWPSEPSRV SRAVPEVRMG SVSLIPLRGS ENEMRRSVAA FTADPLSLLR 

HV
Length:1,452
Mass (Da):162,276
Last modified:March 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1606F3534555D4F6
GO
Isoform 22 Publications (identifier: Q4LDD4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1332: Missing.

Show »
Length:1,441
Mass (Da):161,079
Checksum:i8F819926E3F6AC40
GO
Isoform 31 Publication (identifier: Q4LDD4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-248: Missing.
     1322-1332: Missing.

Show »
Length:1,193
Mass (Da):134,632
Checksum:i6F5078812234CFE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUB0E9PUB0_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
727Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YWW7D3YWW7_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YY40D3YY40_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2X3D3Z2X3_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GSK4A0A1B0GSK4_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YZJ7D3YZJ7_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2S2D3Z2S2_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YYF5D3YYF5_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YVS8D3YVS8_MOUSE
Arf-GAP with Rho-GAP domain, ANK re...
Arap1
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti153P → S in AAI41180 (PubMed:15489334).Curated1
Sequence conflicti280S → A in AAI41180 (PubMed:15489334).Curated1
Sequence conflicti924V → G in CAF21318 (Ref. 1) Curated1
Sequence conflicti1331T → R in AAH57922 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0530471 – 248Missing in isoform 3. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_0530481322 – 1332Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ621558 mRNA Translation: CAF21318.1
AK137455 mRNA Translation: BAE23358.1
AK140646 mRNA Translation: BAE24434.1
AK150132 mRNA Translation: BAE29329.1
BC057922 mRNA Translation: AAH57922.1
BC091762 mRNA Translation: AAH91762.1
BC141179 mRNA Translation: AAI41180.1
AK129213 mRNA Translation: BAC98023.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS21510.1 [Q4LDD4-3]
CCDS40041.1 [Q4LDD4-2]

NCBI Reference Sequences

More...RefSeqi		NP_001035200.1, NM_001040111.1 [Q4LDD4-2]
NP_001035201.1, NM_001040112.1 [Q4LDD4-3]
NP_081456.2, NM_027180.3 [Q4LDD4-3]
NP_932764.1, NM_198096.1
XP_006508249.1, XM_006508186.3 [Q4LDD4-1]
XP_006508250.1, XM_006508187.1 [Q4LDD4-1]
XP_006508251.1, XM_006508188.3 [Q4LDD4-1]
XP_011240199.1, XM_011241897.2 [Q4LDD4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000084895; ENSMUSP00000081957; ENSMUSG00000032812 [Q4LDD4-3]
ENSMUST00000084896; ENSMUSP00000081958; ENSMUSG00000032812 [Q4LDD4-1]
ENSMUST00000107010; ENSMUSP00000102624; ENSMUSG00000032812 [Q4LDD4-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		69710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:69710

UCSC genome browser

More...UCSCi		uc009iok.1 mouse [Q4LDD4-2]
uc009iol.1 mouse [Q4LDD4-1]
uc009iom.1 mouse [Q4LDD4-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ621558 mRNA Translation: CAF21318.1
AK137455 mRNA Translation: BAE23358.1
AK140646 mRNA Translation: BAE24434.1
AK150132 mRNA Translation: BAE29329.1
BC057922 mRNA Translation: AAH57922.1
BC091762 mRNA Translation: AAH91762.1
BC141179 mRNA Translation: AAI41180.1
AK129213 mRNA Translation: BAC98023.1
CCDSiCCDS21510.1 [Q4LDD4-3]
CCDS40041.1 [Q4LDD4-2]
RefSeqiNP_001035200.1, NM_001040111.1 [Q4LDD4-2]
NP_001035201.1, NM_001040112.1 [Q4LDD4-3]
NP_081456.2, NM_027180.3 [Q4LDD4-3]
NP_932764.1, NM_198096.1
XP_006508249.1, XM_006508186.3 [Q4LDD4-1]
XP_006508250.1, XM_006508187.1 [Q4LDD4-1]
XP_006508251.1, XM_006508188.3 [Q4LDD4-1]
XP_011240199.1, XM_011241897.2 [Q4LDD4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XHZX-ray1.32C/D80-90[»]
SMRiQ4LDD4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi213630, 1 interactor
IntActiQ4LDD4, 1 interactor
STRINGi10090.ENSMUSP00000102624

PTM databases

iPTMnetiQ4LDD4
PhosphoSitePlusiQ4LDD4
SwissPalmiQ4LDD4

Proteomic databases

jPOSTiQ4LDD4
PaxDbiQ4LDD4
PeptideAtlasiQ4LDD4
PRIDEiQ4LDD4

Genome annotation databases

EnsembliENSMUST00000084895; ENSMUSP00000081957; ENSMUSG00000032812 [Q4LDD4-3]
ENSMUST00000084896; ENSMUSP00000081958; ENSMUSG00000032812 [Q4LDD4-1]
ENSMUST00000107010; ENSMUSP00000102624; ENSMUSG00000032812 [Q4LDD4-2]
GeneIDi69710
KEGGimmu:69710
UCSCiuc009iok.1 mouse [Q4LDD4-2]
uc009iol.1 mouse [Q4LDD4-1]
uc009iom.1 mouse [Q4LDD4-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		116985
MGIiMGI:1916960 Arap1

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1117 Eukaryota
COG5347 LUCA
GeneTreeiENSGT00940000157424
InParanoidiQ4LDD4
KOiK18439
OrthoDBi98944at2759
PhylomeDBiQ4LDD4
TreeFamiTF105769

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Arap1 mouse

Protein Ontology

More...PROi		PR:Q4LDD4
RNActiQ4LDD4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000032812 Expressed in 171 organ(s), highest expression level in bone marrow macrophage
ExpressionAtlasiQ4LDD4 baseline and differential
GenevisibleiQ4LDD4 MM

Family and domain databases

CDDicd04385 RhoGAP_ARAP, 1 hit
Gene3Di1.10.150.50, 1 hit
1.10.555.10, 1 hit
2.30.29.30, 4 hits
3.30.40.160, 1 hit
InterProiView protein in InterPro
IPR037278 ARFGAP/RecO
IPR001164 ArfGAP_dom
IPR038508 ArfGAP_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR037858 RhoGAP_ARAP
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF01412 ArfGap, 1 hit
PF00169 PH, 3 hits
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR00405 REVINTRACTNG
SMARTiView protein in SMART
SM00105 ArfGap, 1 hit
SM00233 PH, 5 hits
SM00324 RhoGAP, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
SSF57863 SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115 ARFGAP, 1 hit
PS50003 PH_DOMAIN, 4 hits
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARAP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4LDD4
Secondary accession number(s): B2RUJ3
, Q3UDD2, Q3US99, Q58ET6, Q6PEQ9, Q6ZQ48
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: December 11, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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