UniProtKB - Q4LCT0 (TXA8_ANDAU)
Protein
Beta-toxin KAaH1
Gene
N/A
Organism
Androctonus australis (Sahara scorpion)
Status
Functioni
Inhibits the vertebrate potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3 in vitro with an IC50 of 5.3 nM and 50.0 nM respectively.1 Publication
Miscellaneous
This toxin is a weak beta toxin because it has no effect on Nav1.2a/SCN2A voltage-dependent sodium channels when perfused at a concentration of 100 nM, but when added to the extracellular bath solution at a concentration of 1 µM it shifts the voltage of activation toward more negative potentials. Has no effect on the Nav1.5/SCN5A voltage-dependent sodium channel. Administration to mice produces no toxic effects (PubMed:15656785).1 Publication
GO - Molecular functioni
- ion channel inhibitor activity Source: UniProtKB
- potassium channel inhibitor activity Source: UniProtKB
- sodium channel inhibitor activity Source: UniProtKB
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-toxin KAaH1Alternative name(s): Peptide AaF1CA8 |
Organismi | Androctonus australis (Sahara scorpion) |
Taxonomic identifieri | 6858 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Androctonus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000228819 | 23 – 80 | Beta-toxin KAaH1Add BLAST | 58 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 40 ↔ 63 | PROSITE-ProRule annotation | ||
Disulfide bondi | 49 ↔ 68 | PROSITE-ProRule annotation | ||
Disulfide bondi | 53 ↔ 70 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.2 Publications
Structurei
3D structure databases
ProteinModelPortali | Q4LCT0 |
SMRi | Q4LCT0 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 80 | LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST | 56 |
Sequence similaritiesi
Belongs to the long (3 C-C) scorpion toxin superfamily. Sodium/Potassium channel inhibitor family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q4LCT0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMKLMLFSII VILFSLIGSI HGADVPGNYP LDSSDDTYLC APLGENPFCI
60 70 80
KICRKHGVKY GYCYAFQCWC EYLEDKNVKI
Mass spectrometryi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ781832 mRNA Translation: CAH03778.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ781832 mRNA Translation: CAH03778.1 |
3D structure databases
ProteinModelPortali | Q4LCT0 |
SMRi | Q4LCT0 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR002061 Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537 Toxin_3, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS51863 LCN_CSAB, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TXA8_ANDAU | |
Accessioni | Q4LCT0Primary (citable) accession number: Q4LCT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | August 2, 2005 | |
Last modified: | July 18, 2018 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families