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Protein

Folic acid synthesis protein fol1

Gene

fol1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes three sequential steps of tetrahydrofolate biosynthesis.By similarity

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.By similarity
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.By similarity
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Folic acid synthesis protein fol1 (fol1)
  4. Folic acid synthesis protein fol1 (fol1)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Folic acid synthesis protein fol1 (fol1)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi472MagnesiumBy similarity1
Binding sitei5116-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei5466-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei5656-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei6376-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei6776-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Lyase, Multifunctional enzyme, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00154
UPA00077; UER00155
UPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Folic acid synthesis protein fol1
Including the following 3 domains:
Dihydroneopterin aldolase (EC:4.1.2.25)
Short name:
DHNA
Alternative name(s):
7,8-dihydroneopterin aldolase
FASA
FASB
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (EC:2.7.6.3)
Short name:
HPPK
Alternative name(s):
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
PPPK
FASC
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
FASD
Gene namesi
Name:fol1
ORF Names:SPBC1734.03, SPBC337.19
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.03
PomBaseiSPBC1734.03 fol1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003431641 – 733Folic acid synthesis protein fol1Add BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281Phosphotyrosine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ4LB35
PaxDbiQ4LB35
PRIDEiQ4LB35

PTM databases

iPTMnetiQ4LB35

Interactioni

Protein-protein interaction databases

BioGridi276399, 3 interactors
STRINGi4896.SPBC1734.03.1

Structurei

3D structure databases

SMRiQ4LB35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini465 – 724Pterin-bindingPROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 167DHNA 1Add BLAST113
Regioni179 – 277DHNA 2Add BLAST99
Regioni295 – 454HPKAdd BLAST160
Regioni467 – 733DHPSAdd BLAST267
Regioni712 – 7146-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

In the N-terminal section; belongs to the DHNA family.Curated
In the central section; belongs to the HPPK family.Curated
In the C-terminal section; belongs to the DHPS family.Curated

Phylogenomic databases

HOGENOMiHOG000217511
InParanoidiQ4LB35
KOiK13939
OMAiFESEPMY
OrthoDBiEOG092C20NY

Family and domain databases

CDDicd00534 DHNA_DHNTPE, 2 hits
cd00739 DHPS, 1 hit
cd00483 HPPK, 1 hit
Gene3Di3.20.20.20, 1 hit
3.30.70.560, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR006157 FolB_dom
IPR016261 Folic_acid_synth
IPR000550 Hppk
IPR035907 Hppk_sf
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF02152 FolB, 2 hits
PF01288 HPPK, 1 hit
PF00809 Pterin_bind, 1 hit
PIRSFiPIRSF000741 Folic_acid_synth, 1 hit
SMARTiView protein in SMART
SM00905 FolB, 2 hits
SUPFAMiSSF51717 SSF51717, 1 hit
SSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
TIGR01498 folK, 1 hit
PROSITEiView protein in PROSITE
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q4LB35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLVNLWGI YPFIRNNSLH GFAKIPRIVS TIPRQLRFSS LRHPTRQMDL
60 70 80 90 100
IHDTVVVENL NTFAVVGQDQ WKRKEPQPVQ IDVYMRNNVQ LAGEKDELKS
110 120 130 140 150
TIHYGIASKL LRKEIEGSFF TTPKDLVNKI ASLCFEDVID TSHVSIKLTL
160 170 180 190 200
PKCVLRSKNG LHYYAERERN STSNFVDRIE FSDLELATIL GIHAFERQEK
210 220 230 240 250
QRVCLNISFA NTEVEALEIA RAIAEYVEQS AFLTIEALVV NLSKYLCFTK
260 270 280 290 300
NLDDISIKAE KPSAITFANA SAVQIYRTRS YFLQESLHKY ESTKNKIAYL
310 320 330 340 350
SFGSNIGDKF EQIQTALSML HKIEGIRVLD VSPLYETEPM YYKDQPSFLN
360 370 380 390 400
GVCKIETRMS PINLLRACQS IEQEMGRIKT ILKGPRCIDL DIVLYEDCVY
410 420 430 440 450
ESEVLTIPHL GLQEREFVLR PLLALSPDLV HPYTHQPLQE ALDKLPSQGI
460 470 480 490 500
RLYSSFDNKK IINGALTMGI LNVTPDSFSD GGKVSQNNIL EKAKSMVGDG
510 520 530 540 550
ASILDIGGQS TKPGADPVSV EEELRRVIPM ISLLRSSGIT VPISIDTYYS
560 570 580 590 600
KVAKLAIEAG ANIINDVTGG MGDEKMLPLA ASLQVPICIM HMRGTPETMK
610 620 630 640 650
ALSIYEKDIV EEVAVELSSR VEAAVQSGVH RYNIILDPGF GFAKTPKQSA
660 670 680 690 700
GLLGRLHELM KKPQFKDMHW LSGPSRKGFT GYFTGDASPK DRIWGTSACV
710 720 730
TASVLQGVSI VRVHDTKEMS KVVGMANAIR YVP
Length:733
Mass (Da):81,926
Last modified:October 3, 2012 - v2
Checksum:iA4401685D5ACF5CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA21289.2
PIRiT39650
RefSeqiNP_595420.2, NM_001021327.2

Genome annotation databases

EnsemblFungiiSPBC1734.03.1; SPBC1734.03.1:pep; SPBC1734.03
GeneIDi2539851
KEGGispo:SPBC1734.03

Similar proteinsi

Entry informationi

Entry nameiFOL1_SCHPO
AccessioniPrimary (citable) accession number: Q4LB35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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