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UniProtKB - Q4LB35 (FOL1_SCHPO)

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Protein

Folic acid synthesis protein fol1

Gene

fol1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes three sequential steps of tetrahydrofolate biosynthesis.By similarity

Catalytic activityi

7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde.By similarity
ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.By similarity
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Folic acid synthesis protein fol1 (fol1)
  4. Folic acid synthesis protein fol1 (fol1)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Folic acid synthesis protein fol1 (fol1)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi472MagnesiumBy similarity1
Binding sitei5116-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei5466-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei5656-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei6376-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei6776-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Lyase, Multifunctional enzyme, Transferase
Biological processFolate biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00154.
UPA00077; UER00155.
UPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Folic acid synthesis protein fol1
Including the following 3 domains:
Dihydroneopterin aldolase (EC:4.1.2.25)
Short name:
DHNA
Alternative name(s):
7,8-dihydroneopterin aldolase
FASA
FASB
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (EC:2.7.6.3)
Short name:
HPPK
Alternative name(s):
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
PPPK
FASC
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
FASD
Gene namesi
Name:fol1
ORF Names:SPBC1734.03, SPBC337.19
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.03.
PomBaseiSPBC1734.03. fol1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003431641 – 733Folic acid synthesis protein fol1Add BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei281Phosphotyrosine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ4LB35.
PaxDbiQ4LB35.
PRIDEiQ4LB35.

PTM databases

iPTMnetiQ4LB35.

Interactioni

Protein-protein interaction databases

BioGridi276399. 3 interactors.
STRINGi4896.SPBC1734.03.1.

Structurei

3D structure databases

SMRiQ4LB35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini465 – 724Pterin-bindingPROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 167DHNA 1Add BLAST113
Regioni179 – 277DHNA 2Add BLAST99
Regioni295 – 454HPKAdd BLAST160
Regioni467 – 733DHPSAdd BLAST267
Regioni712 – 7146-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

In the N-terminal section; belongs to the DHNA family.Curated
In the central section; belongs to the HPPK family.Curated
In the C-terminal section; belongs to the DHPS family.Curated

Phylogenomic databases

HOGENOMiHOG000217511.
InParanoidiQ4LB35.
KOiK13939.
OMAiFESEPMY.
OrthoDBiEOG092C20NY.

Family and domain databases

CDDicd00534. DHNA_DHNTPE. 2 hits.
cd00739. DHPS. 1 hit.
cd00483. HPPK. 1 hit.
Gene3Di3.20.20.20. 1 hit.
3.30.70.560. 1 hit.
InterProiView protein in InterPro
IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR006157. FolB_dom.
IPR016261. Folic_acid_synth.
IPR000550. Hppk.
IPR035907. Hppk_sf.
IPR000489. Pterin-binding_dom.
PfamiView protein in Pfam
PF02152. FolB. 2 hits.
PF01288. HPPK. 1 hit.
PF00809. Pterin_bind. 1 hit.
PIRSFiPIRSF000741. Folic_acid_synth. 1 hit.
SMARTiView protein in SMART
SM00905. FolB. 2 hits.
SUPFAMiSSF51717. SSF51717. 1 hit.
SSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEiView protein in PROSITE
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4LB35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLVNLWGI YPFIRNNSLH GFAKIPRIVS TIPRQLRFSS LRHPTRQMDL 
        60         70         80         90        100
IHDTVVVENL NTFAVVGQDQ WKRKEPQPVQ IDVYMRNNVQ LAGEKDELKS 
       110        120        130        140        150
TIHYGIASKL LRKEIEGSFF TTPKDLVNKI ASLCFEDVID TSHVSIKLTL 
       160        170        180        190        200
PKCVLRSKNG LHYYAERERN STSNFVDRIE FSDLELATIL GIHAFERQEK 
       210        220        230        240        250
QRVCLNISFA NTEVEALEIA RAIAEYVEQS AFLTIEALVV NLSKYLCFTK 
       260        270        280        290        300
NLDDISIKAE KPSAITFANA SAVQIYRTRS YFLQESLHKY ESTKNKIAYL 
       310        320        330        340        350
SFGSNIGDKF EQIQTALSML HKIEGIRVLD VSPLYETEPM YYKDQPSFLN 
       360        370        380        390        400
GVCKIETRMS PINLLRACQS IEQEMGRIKT ILKGPRCIDL DIVLYEDCVY 
       410        420        430        440        450
ESEVLTIPHL GLQEREFVLR PLLALSPDLV HPYTHQPLQE ALDKLPSQGI 
       460        470        480        490        500
RLYSSFDNKK IINGALTMGI LNVTPDSFSD GGKVSQNNIL EKAKSMVGDG 
       510        520        530        540        550
ASILDIGGQS TKPGADPVSV EEELRRVIPM ISLLRSSGIT VPISIDTYYS 
       560        570        580        590        600
KVAKLAIEAG ANIINDVTGG MGDEKMLPLA ASLQVPICIM HMRGTPETMK 
       610        620        630        640        650
ALSIYEKDIV EEVAVELSSR VEAAVQSGVH RYNIILDPGF GFAKTPKQSA 
       660        670        680        690        700
GLLGRLHELM KKPQFKDMHW LSGPSRKGFT GYFTGDASPK DRIWGTSACV 
       710        720        730 
TASVLQGVSI VRVHDTKEMS KVVGMANAIR YVP
Length:733
Mass (Da):81,926
Last modified:October 3, 2012 - v2
Checksum:iA4401685D5ACF5CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21289.2.
PIRiT39650.
RefSeqiNP_595420.2. NM_001021327.2.

Genome annotation databases

EnsemblFungiiSPBC1734.03.1; SPBC1734.03.1:pep; SPBC1734.03.
GeneIDi2539851.
KEGGispo:SPBC1734.03.

Similar proteinsi

Entry informationi

Entry nameiFOL1_SCHPO
AccessioniPrimary (citable) accession number: Q4LB35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 3, 2012
Last modified: March 28, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome