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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfk)
  4. Fructose-bisphosphate aldolase class 1 (fda)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175Proton acceptorUniRule annotation1
Active sitei212Schiff-base intermediate with dihydroxyacetone-PUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-421-MONOMER
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Ordered Locus Names:SH0450
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002169122 – 296Fructose-bisphosphate aldolase class 1Add BLAST295

Proteomic databases

PRIDEiQ4L9B6

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0450

Structurei

3D structure databases

ProteinModelPortaliQ4L9B6
SMRiQ4L9B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WYW Bacteria
COG3588 LUCA
HOGENOMiHOG000073502
KOiK01623
OMAiVFGTKER
OrthoDBiPOG091H05IF

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00729 FBP_aldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000741 FBA_I
IPR023014 FBA_I_Gram+-type
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4L9B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKEQLEKMT NGKGFIAALD QSGGSTPKAL KEYGVNEDEY SNDDEMFQLV
60 70 80 90 100
HDMRTRVVTS PSFSPDKILG AILFEQTMDR EVEGKYTGDY LADKGVVPFL
110 120 130 140 150
KVDKGLAEQQ NGVQLMKPID DLDDTLDRAV ERHIFGTKMR SNILELNEQG
160 170 180 190 200
IKDVVEQQFE FAKKIIAKGL VPIIEPEVNI NAKDKAEIEE VLKAELKKGL
210 220 230 240 250
DALNDDQLVM LKLTIPTKAN LYKELADHPN VVRVVVLSGG YSRDEANKLL
260 270 280 290
KDNDELIASF SRALASDLRA SQSQEEFDKA LGDAVDSIYD ASVNKN
Length:296
Mass (Da):32,968
Last modified:January 23, 2007 - v3
Checksum:i619D6086BE604E71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE03759.1
RefSeqiWP_011274776.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE03759; BAE03759; SH0450
GeneIDi24246348
KEGGisha:SH0450

Similar proteinsi

Entry informationi

Entry nameiALF1_STAHJ
AccessioniPrimary (citable) accession number: Q4L9B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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