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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18GTPUniRule annotation1
Binding sitei65GTPUniRule annotation1
Metal bindingi97MagnesiumUniRule annotation1
Binding sitei97GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 8GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-741-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:SH0783
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191591 – 201Probable molybdenum cofactor guanylyltransferaseAdd BLAST201

Interactioni

Protein-protein interaction databases

STRINGi279808.SH0783

Structurei

3D structure databases

ProteinModelPortaliQ4L8D3
SMRiQ4L8D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082CS Bacteria
COG0746 LUCA
HOGENOMiHOG000280425
KOiK03752
OMAiSVCYVQA
OrthoDBiPOG091H05CW

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L8D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAIILAGGH SERFGKAKAF AEIDGQLFYQ RIVQTLQETN MFNDIIISTN
60 70 80 90 100
DQLANQFKHD NVIIDDANNK NKGPLAGIHT VMKQYNDEEL FFVISVDTPM
110 120 130 140 150
VTGKAISALY QFLVSRLIED QIDIAAYSEH NRVIPTIAFY HPNCINVMDE
160 170 180 190 200
ALASNDYSLR HVYNNVTTEC LDVTNIQSPE YWYKNINYQE DLDDLKQQIN

H
Length:201
Mass (Da):23,037
Last modified:August 2, 2005 - v1
Checksum:iF4804A597938D49C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04092.1
RefSeqiWP_011275106.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE04092; BAE04092; SH0783
GeneIDi24247090
KEGGisha:SH0783

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE04092.1
RefSeqiWP_011275106.1, NC_007168.1

3D structure databases

ProteinModelPortaliQ4L8D3
SMRiQ4L8D3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi279808.SH0783

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE04092; BAE04092; SH0783
GeneIDi24247090
KEGGisha:SH0783

Phylogenomic databases

eggNOGiENOG41082CS Bacteria
COG0746 LUCA
HOGENOMiHOG000280425
KOiK03752
OMAiSVCYVQA
OrthoDBiPOG091H05CW

Enzyme and pathway databases

BioCyciSHAE279808:G1G27-741-MONOMER

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOBA_STAHJ
AccessioniPrimary (citable) accession number: Q4L8D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 2, 2005
Last modified: October 10, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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