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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Staphylococcus haemolyticus (strain JCSC1435)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA
Ordered Locus Names:SH2210
OrganismiStaphylococcus haemolyticus (strain JCSC1435)
Taxonomic identifieri279808 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000543 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Transmembranei100 – 120HelicalUniRule annotationAdd BLAST21
Transmembranei124 – 144HelicalUniRule annotationAdd BLAST21
Transmembranei160 – 180HelicalUniRule annotationAdd BLAST21
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Transmembranei230 – 250HelicalUniRule annotationAdd BLAST21
Transmembranei270 – 290HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002276401 – 291Undecaprenyl-diphosphataseAdd BLAST291

Interactioni

Protein-protein interaction databases

STRINGi279808.SH2210

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218356
KOiK06153
OMAiVFKDRIL
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q4L4A6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIIIEFIKGL ILGIVEGLTE FAPVSSTGHM ILVDDMWLKS TEFLGPHSAF
60 70 80 90 100
TFKVVIQLGS VFAAAWVFRE RYFEMLHIGK YRNSSINEEF RSKPRRLNLL
110 120 130 140 150
HVLVGMIPAG ILGVLFDDFI EAHLFSVPTV MIGLFLGAIY MIIADKYSKK
160 170 180 190 200
VQNPKSVDQI NYVQAFVIGI SQAVAMWPGF SRSGSTISTG VLMKLDHKSA
210 220 230 240 250
SDFTFIMAVP IMLAASALSL VKNYQYIELA HIPFYLIGFL AAFIVGLIAI
260 270 280 290
KTFLHLINKV KLVPFAIYRI VLVIIIAILY FGFGIGQGIS G
Length:291
Mass (Da):32,304
Last modified:August 2, 2005 - v1
Checksum:i4B7EFAF378543C9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006716 Genomic DNA Translation: BAE05519.1
RefSeqiWP_011276470.1, NC_007168.1

Genome annotation databases

EnsemblBacteriaiBAE05519; BAE05519; SH2210
GeneIDi24245881
KEGGisha:SH2210

Similar proteinsi

Entry informationi

Entry nameiUPPP_STAHJ
AccessioniPrimary (citable) accession number: Q4L4A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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