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Entry version 110 (26 Feb 2020)
Sequence version 2 (04 Dec 2007)
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Protein

Filamin A-interacting protein 1-like

Gene

FILIP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Filamin A-interacting protein 1-like
Alternative name(s):
130 kDa GPBP-interacting protein
90 kDa GPBP-interacting protein
Protein down-regulated in ovarian cancer 1
Short name:
DOC-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FILIP1L
Synonyms:COL4A3BPIP, DOC1, GIP90
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24589 FILIP1L

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612993 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4L180

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11259

Open Targets

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OpenTargetsi
ENSG00000168386

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162388580

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4L180 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FILIP1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416295

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003094701 – 1135Filamin A-interacting protein 1-likeAdd BLAST1135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei791PhosphoserineCombined sources1
Modified residuei986PhosphothreonineBy similarity1
Modified residuei994PhosphothreonineBy similarity1
Modified residuei1052PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q4L180

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q4L180

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q4L180

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4L180

PeptideAtlas

More...
PeptideAtlasi
Q4L180

PRoteomics IDEntifications database

More...
PRIDEi
Q4L180

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62218 [Q4L180-1]
62219 [Q4L180-2]
62220 [Q4L180-3]
62221 [Q4L180-4]
62222 [Q4L180-5]
62223 [Q4L180-6]
62224 [Q4L180-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4L180

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4L180

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in endothelial cells with the angiogenesis inhibitors endostatin and fumagillin. By endothelial monocyte-activating polypeptide II in endothelial cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000168386 Expressed in thoracic aorta and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4L180 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4L180 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043133

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116419, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q4L180, 7 interactors

Molecular INTeraction database

More...
MINTi
Q4L180

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346560

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4L180 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4L180

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili164 – 782Sequence analysisAdd BLAST619

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FILIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKR8 Eukaryota
ENOG410ZUGY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182852

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_104016_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4L180

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQDNRTQ

Database of Orthologous Groups

More...
OrthoDBi
111454at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4L180

TreeFam database of animal gene trees

More...
TreeFami
TF331399

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019131 Cortactin-binding_p2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09727 CortBP2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4L180-1) [UniParc]FASTAAdd to basket
Also known as: a, d

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSRGSDTEG SAQKKFPRHT KGHSFQGPKN MKHRQQDKDS PSESDVILPC
60 70 80 90 100
PKAEKPHSGN GHQAEDLSRD DLLFLLSILE GELQARDEVI GILKAEKMDL
110 120 130 140 150
ALLEAQYGFV TPKKVLEALQ RDAFQAKSTP WQEDIYEKPM NELDKVVEKH
160 170 180 190 200
KESYRRILGQ LLVAEKSRRQ TILELEEEKR KHKEYMEKSD EFICLLEQEC
210 220 230 240 250
ERLKKLIDQE IKSQEEKEQE KEKRVTTLKE ELTKLKSFAL MVVDEQQRLT
260 270 280 290 300
AQLTLQRQKI QELTTNAKET HTKLALAEAR VQEEEQKATR LEKELQTQTT
310 320 330 340 350
KFHQDQDTIM AKLTNEDSQN RQLQQKLAAL SRQIDELEET NRSLRKAEEE
360 370 380 390 400
LQDIKEKISK GEYGNAGIMA EVEELRKRVL DMEGKDEELI KMEEQCRDLN
410 420 430 440 450
KRLERETLQS KDFKLEVEKL SKRIMALEKL EDAFNKSKQE CYSLKCNLEK
460 470 480 490 500
ERMTTKQLSQ ELESLKVRIK ELEAIESRLE KTEFTLKEDL TKLKTLTVMF
510 520 530 540 550
VDERKTMSEK LKKTEDKLQA ASSQLQVEQN KVTTVTEKLI EETKRALKSK
560 570 580 590 600
TDVEEKMYSV TKERDDLKNK LKAEEEKGND LLSRVNMLKN RLQSLEAIEK
610 620 630 640 650
DFLKNKLNQD SGKSTTALHQ ENNKIKELSQ EVERLKLKLK DMKAIEDDLM
660 670 680 690 700
KTEDEYETLE RRYANERDKA QFLSKELEHV KMELAKYKLA EKTETSHEQW
710 720 730 740 750
LFKRLQEEEA KSGHLSREVD ALKEKIHEYM ATEDLICHLQ GDHSVLQKKL
760 770 780 790 800
NQQENRNRDL GREIENLTKE LERYRHFSKS LRPSLNGRRI SDPQVFSKEV
810 820 830 840 850
QTEAVDNEPP DYKSLIPLER AVINGQLYEE SENQDEDPND EGSVLSFKCS
860 870 880 890 900
QSTPCPVNRK LWIPWMKSKE GHLQNGKMQT KPNANFVQPG DLVLSHTPGQ
910 920 930 940 950
PLHIKVTPDH VQNTATLEIT SPTTESPHSY TSTAVIPNCG TPKQRITILQ
960 970 980 990 1000
NASITPVKSK TSTEDLMNLE QGMSPITMAT FARAQTPESC GSLTPERTMS
1010 1020 1030 1040 1050
PIQVLAVTGS ASSPEQGRSP EPTEISAKHA IFRVSPDRQS SWQFQRSNSN
1060 1070 1080 1090 1100
SSSVITTEDN KIHIHLGSPY MQAVASPVRP ASPSAPLQDN RTQGLINGAL
1110 1120 1130
NKTTNKVTSS ITITPTATPL PRQSQITVEP LLLPH
Length:1,135
Mass (Da):130,382
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F1E896D20F5B776
GO
Isoform 2 (identifier: Q4L180-2) [UniParc]FASTAAdd to basket
Also known as: b, c

The sequence of this isoform differs from the canonical sequence as follows:
     1129-1135: EPLLLPH → SNIYN

Show »
Length:1,133
Mass (Da):130,173
Checksum:iFA11579689D6A0A5
GO
Isoform 3 (identifier: Q4L180-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     1129-1135: EPLLLPH → SNIYN

Show »
Length:893
Mass (Da):102,233
Checksum:i561BE17D6C10FDC4
GO
Isoform 4 (identifier: Q4L180-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-255: LKKLIDQEIK...QQRLTAQLTL → WSLALLPRLE...HHAQLVFVFL
     256-1135: Missing.

Show »
Length:255
Mass (Da):29,079
Checksum:iB4EE787EDB568A45
GO
Isoform 5 (identifier: Q4L180-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.
     373-386: Missing.
     1075-1080: Missing.
     1129-1135: EPLLLPH → SNIYN

Show »
Length:873
Mass (Da):99,925
Checksum:i340BCFF41853C42B
GO
Isoform 6 (identifier: Q4L180-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:711
Mass (Da):80,806
Checksum:i09960BC917887081
GO
Isoform 7 (identifier: Q4L180-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: Missing.

Show »
Length:895
Mass (Da):102,441
Checksum:iF2B59567961E52B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYJ6C9JYJ6_HUMAN
Filamin A-interacting protein 1-lik...
FILIP1L
837Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4M0H7C4M0_HUMAN
Filamin A-interacting protein 1-lik...
FILIP1L
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA98972 differs from that shown. Reason: Frameshift.Curated
The sequence AAN16206 differs from that shown. Reason: Frameshift.Curated
The sequence ACB37436 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti532V → A in ACB37437 (Ref. 5) Curated1
Sequence conflicti576E → G in ACB37436 (Ref. 5) Curated1
Sequence conflicti746 – 747LQ → CK in AAA98972 (Ref. 1) Curated2
Sequence conflicti919I → T in ACB37436 (Ref. 5) Curated1
Sequence conflicti961T → A in ACB37436 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050993168R → H2 PublicationsCorresponds to variant dbSNP:rs793440Ensembl.1
Natural variantiVAR_050994884A → P. Corresponds to variant dbSNP:rs28362487Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0365021 – 424Missing in isoform 6. 1 PublicationAdd BLAST424
Alternative sequenceiVSP_0292011 – 240Missing in isoform 3, isoform 5 and isoform 7. 3 PublicationsAdd BLAST240
Alternative sequenceiVSP_029202203 – 255LKKLI…AQLTL → WSLALLPRLECNGMILAHCN LCLLGSSDSPASAFQVAGIT GTRHHAQLVFVFL in isoform 4. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_029203256 – 1135Missing in isoform 4. 1 PublicationAdd BLAST880
Alternative sequenceiVSP_029204373 – 386Missing in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0292051075 – 1080Missing in isoform 5. 1 Publication6
Alternative sequenceiVSP_0292061129 – 1135EPLLLPH → SNIYN in isoform 2, isoform 3 and isoform 5. 3 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U53445 mRNA Translation: AAA98972.1 Frameshift.
AF329092 mRNA Translation: AAN16206.1 Frameshift.
AF514867 mRNA Translation: AAQ08177.1
AF514868 mRNA Translation: AAQ08178.1
AF514869 mRNA Translation: AAQ08179.1
AY642382 mRNA Translation: AAV34207.1
EU531865 mRNA Translation: ACB37436.1 Frameshift.
EU531866 mRNA Translation: ACB37437.1
AC024938 Genomic DNA No translation available.
AC069222 Genomic DNA No translation available.
AC117419 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79833.1
BC020941 mRNA Translation: AAH20941.1
BC027860 mRNA Translation: AAH27860.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43117.1 [Q4L180-1]
CCDS43118.1 [Q4L180-2]
CCDS43119.1 [Q4L180-3]
CCDS63700.1 [Q4L180-7]
CCDS74969.1 [Q4L180-6]

NCBI Reference Sequences

More...
RefSeqi
NP_001035924.1, NM_001042459.2 [Q4L180-2]
NP_001269722.1, NM_001282793.1 [Q4L180-6]
NP_001269723.1, NM_001282794.1 [Q4L180-7]
NP_055705.2, NM_014890.3 [Q4L180-3]
NP_878913.2, NM_182909.3 [Q4L180-1]
XP_006713549.1, XM_006713486.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000331335; ENSP00000327880; ENSG00000168386 [Q4L180-2]
ENST00000354552; ENSP00000346560; ENSG00000168386 [Q4L180-1]
ENST00000383694; ENSP00000373192; ENSG00000168386 [Q4L180-3]
ENST00000398326; ENSP00000381371; ENSG00000168386 [Q4L180-4]
ENST00000471562; ENSP00000419642; ENSG00000168386 [Q4L180-7]
ENST00000487087; ENSP00000417774; ENSG00000168386 [Q4L180-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11259

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11259

UCSC genome browser

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UCSCi
uc003dtm.4 human [Q4L180-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53445 mRNA Translation: AAA98972.1 Frameshift.
AF329092 mRNA Translation: AAN16206.1 Frameshift.
AF514867 mRNA Translation: AAQ08177.1
AF514868 mRNA Translation: AAQ08178.1
AF514869 mRNA Translation: AAQ08179.1
AY642382 mRNA Translation: AAV34207.1
EU531865 mRNA Translation: ACB37436.1 Frameshift.
EU531866 mRNA Translation: ACB37437.1
AC024938 Genomic DNA No translation available.
AC069222 Genomic DNA No translation available.
AC117419 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79833.1
BC020941 mRNA Translation: AAH20941.1
BC027860 mRNA Translation: AAH27860.1
CCDSiCCDS43117.1 [Q4L180-1]
CCDS43118.1 [Q4L180-2]
CCDS43119.1 [Q4L180-3]
CCDS63700.1 [Q4L180-7]
CCDS74969.1 [Q4L180-6]
RefSeqiNP_001035924.1, NM_001042459.2 [Q4L180-2]
NP_001269722.1, NM_001282793.1 [Q4L180-6]
NP_001269723.1, NM_001282794.1 [Q4L180-7]
NP_055705.2, NM_014890.3 [Q4L180-3]
NP_878913.2, NM_182909.3 [Q4L180-1]
XP_006713549.1, XM_006713486.2

3D structure databases

SMRiQ4L180
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116419, 1 interactor
IntActiQ4L180, 7 interactors
MINTiQ4L180
STRINGi9606.ENSP00000346560

PTM databases

iPTMnetiQ4L180
PhosphoSitePlusiQ4L180

Polymorphism and mutation databases

BioMutaiFILIP1L
DMDMi162416295

Proteomic databases

jPOSTiQ4L180
MassIVEiQ4L180
MaxQBiQ4L180
PaxDbiQ4L180
PeptideAtlasiQ4L180
PRIDEiQ4L180
ProteomicsDBi62218 [Q4L180-1]
62219 [Q4L180-2]
62220 [Q4L180-3]
62221 [Q4L180-4]
62222 [Q4L180-5]
62223 [Q4L180-6]
62224 [Q4L180-7]

Genome annotation databases

EnsembliENST00000331335; ENSP00000327880; ENSG00000168386 [Q4L180-2]
ENST00000354552; ENSP00000346560; ENSG00000168386 [Q4L180-1]
ENST00000383694; ENSP00000373192; ENSG00000168386 [Q4L180-3]
ENST00000398326; ENSP00000381371; ENSG00000168386 [Q4L180-4]
ENST00000471562; ENSP00000419642; ENSG00000168386 [Q4L180-7]
ENST00000487087; ENSP00000417774; ENSG00000168386 [Q4L180-6]
GeneIDi11259
KEGGihsa:11259
UCSCiuc003dtm.4 human [Q4L180-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11259
DisGeNETi11259

GeneCards: human genes, protein and diseases

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GeneCardsi
FILIP1L
HGNCiHGNC:24589 FILIP1L
HPAiHPA043133
MIMi612993 gene
neXtProtiNX_Q4L180
OpenTargetsiENSG00000168386
PharmGKBiPA162388580

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKR8 Eukaryota
ENOG410ZUGY LUCA
GeneTreeiENSGT00950000182852
HOGENOMiCLU_104016_0_0_1
InParanoidiQ4L180
OMAiPQDNRTQ
OrthoDBi111454at2759
PhylomeDBiQ4L180
TreeFamiTF331399

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FILIP1L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11259
PharosiQ4L180 Tbio

Protein Ontology

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PROi
PR:Q4L180
RNActiQ4L180 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168386 Expressed in thoracic aorta and 217 other tissues
ExpressionAtlasiQ4L180 baseline and differential
GenevisibleiQ4L180 HS

Family and domain databases

InterProiView protein in InterPro
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF09727 CortBP2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFIL1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4L180
Secondary accession number(s): B2CNV7
, B2CNV8, Q13597, Q2YDY5, Q6KFX5, Q6KFX6, Q6KFX7, Q8IUM3, Q8N6Z0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: February 26, 2020
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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