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Entry version 137 (17 Jun 2020)
Sequence version 1 (02 Aug 2005)
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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

Gene

Plch1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei314PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi315Calcium 1; catalyticBy similarity1
Metal bindingi344Calcium 1; catalyticBy similarity1
Metal bindingi346Calcium 1; catalyticBy similarity1
Active sitei358PROSITE-ProRule annotation1
Metal bindingi393Calcium 1; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei442SubstrateBy similarity1
Binding sitei444SubstrateBy similarity1
Binding sitei628SubstrateBy similarity1
Binding sitei655SubstrateBy similarity1
Metal bindingi759Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi761Calcium 2By similarity1
Metal bindingi785Calcium 2By similarity1
Metal bindingi814Calcium 3By similarity1
Metal bindingi815Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi816Calcium 3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi155 – 166PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.11 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-eta-1
Phospholipase C-eta-1
Short name:
PLC-eta-1
Phospholipase C-like protein 3
Short name:
PLC-L3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plch1
Synonyms:Kiaa1069, Plcl3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2683547 Plch1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003290081 – 16821-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1Add BLAST1682

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4KWH5

PeptideAtlas

More...
PeptideAtlasi
Q4KWH5

PRoteomics IDEntifications database

More...
PRIDEi
Q4KWH5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4KWH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4KWH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036834 Expressed in optic fissure and 174 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4KWH5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000081122

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4KWH5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4KWH5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 128PHPROSITE-ProRule annotationAdd BLAST109
Domaini142 – 177EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini178 – 214EF-hand 2PROSITE-ProRule annotationAdd BLAST37
Domaini299 – 444PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST146
Domaini602 – 715PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST114
Domaini716 – 844C2PROSITE-ProRule annotationAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi591 – 594Poly-Arg4
Compositional biasi1027 – 1031Poly-Ser5

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0169 Eukaryota
ENOG410XPSW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157185

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002738_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4KWH5

KEGG Orthology (KO)

More...
KOi
K19006

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENKQQCV

Database of Orthologous Groups

More...
OrthoDBi
368239at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4KWH5

TreeFam database of animal gene trees

More...
TreeFami
TF313216

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR028392 PLC-eta1
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...
PANTHERi
PTHR10336 PTHR10336, 1 hit
PTHR10336:SF51 PTHR10336:SF51, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390 PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00054 EFh, 2 hits
SM00233 PH, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
PS50003 PH_DOMAIN, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4KWH5-1) [UniParc]FASTAAdd to basket
Also known as: PLC-eta-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADLEVYKNL SPEKVERCMS VMQSGTQMIK LKRGTKGLVR LFYLDEHRTR
60 70 80 90 100
LRWRPSRKSE KAKILIDSIY KVTEGRQSEI FHRQAEGNFD PSCCFTIYHG
110 120 130 140 150
NHMESLDLIT SNPEEARTWI TGLKYLMAGI SDEDSLAKRQ RTHDQWVKQT
160 170 180 190 200
FEEADKNGDG LLNIEEIHQL MHKLNVNLPR RKVRQMFQEA DTDENQGTLT
210 220 230 240 250
FEEFCVFYKM MSLRRDLYLL LLSYSDKKDH LTVEELAQFL KVEQKMSNVT
260 270 280 290 300
LDYCLDIIMK FEVSEENKVK NVLGIEGFTN FMRSPACDVF NPLHHEVYQD
310 320 330 340 350
MDQPLCNYYI ASSHNTYLTG DQLLSQSKVD MYARVLQEGC RCVEVDCWDG
360 370 380 390 400
PDGEPVVHHG YTLTSKILFR DVVETINKHA FVKNEFPVIL SIENHCSIQQ
410 420 430 440 450
QRKIAQYLKG ILQDKLDLSS VDTGECRQLP SPQSLKGKIL VKGKKLPYHL
460 470 480 490 500
GDDAEEGEVS DEDSADEIED ECKFKLHYSN GTTEHQVESF IRKKLESLLK
510 520 530 540 550
ESQIRDKEDP DSFTVRALLK ATHEGLNAHL KQNLDVKESG KKSHGRSLMA
560 570 580 590 600
NFGKHKQKAT KSRSKSYSTD DEDDSLQNPG KEGGQLYRLG RRRRTMKLCR
610 620 630 640 650
ELSDLVVYTN SVAAQDIVDD GTTGNVLSFS ETRAHQVVQQ KSEQFMIYNQ
660 670 680 690 700
KQLTRIYPSA YRIDSSNFNP LPYWNAGCQL VALNYQSEGR MMQINRAKFK
710 720 730 740 750
ANGNCGYILK PQQMCKGTFN PFSGDPLPAN PKKQLILKVI SGQQLPKPPD
760 770 780 790 800
SMFGDRGEII DPFVEVEIIG LPVDCCKDQT RVVDDNGFNP VWEETLTFTV
810 820 830 840 850
HMPEIALVRF LVWDHDPIGR DFVGQRTVTF SSLVPGYRHV YLEGLTEASI
860 870 880 890 900
FVHITINEIF GKWSPLILNP SYTILHFLGA TKNRQLQGLK GLFNKNPRHA
910 920 930 940 950
SSENNSHYVR KRSIGDRILR RTASAPAKGR KKSKVGFQEM VEIKDSVSEA
960 970 980 990 1000
SRDQDGVLRR TTRSLQVRPV SMPVDKSLLG ALSLPISEAA KDTDGKENCL
1010 1020 1030 1040 1050
AGDKDDRRKG AATRKDPHFS NFNKKLSSSS SALLHKDANQ GPTASVSNPE
1060 1070 1080 1090 1100
QCGGRGAKSE RIKPNMTNDC QENHNPPKFL SPRKHLALDP ATKGLQERLH
1110 1120 1130 1140 1150
GMKTNEKEHA EGFLGEKSML SGSVLSQSSL EVENLEGSRA KGRAATSFSL
1160 1170 1180 1190 1200
SDVSALCSDI PDLHSTAILQ DTEISNLIDD VTLTNENQSG SSISALIGQF
1210 1220 1230 1240 1250
EESNHPANVT VVSHLSTSGA SGSAPFQTPF KHGLSQGNQK ASFLCSSPEL
1260 1270 1280 1290 1300
NKLSSVETTK LANNAVPCGV IGSPISTPKP GDDPSDKAKT RVIEGNLPGF
1310 1320 1330 1340 1350
PDASPGQFPK SPTHGEDHSQ VMNSPALSTE LAIEDIIADP ALSINSAESS
1360 1370 1380 1390 1400
LVEIDGESEN LSLTTCDYRE EAPSQLVSPL KLQQSQEMVE HIQRGLRNGY
1410 1420 1430 1440 1450
CKETLLPSEI FNNIPGVKNH SISHLTYQGA GFVYNHFSSS DAKTNQICEP
1460 1470 1480 1490 1500
QQPRAPDMHA PTPTPSTHAP LAALKLPSPC KSKSLGDLTS EDIACNFESK
1510 1520 1530 1540 1550
YQCISRSFVT NGIRDKSVTM KTKSLEPLDA LTEQLRKLVS FDQEDSCQVL
1560 1570 1580 1590 1600
YSKQDVNQCP RALVRKLSSR SQSRVRNIAS RAKEKQEAGK QKAMAQSTRG
1610 1620 1630 1640 1650
GVVLRSKPPA PALAVNRHST GSYIASYLRN MKAGGLEGRG IPEGACTALR
1660 1670 1680
YGYMDQFCSD NSVLQTEPSS EDKPEIYFLL RL
Length:1,682
Mass (Da):187,743
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84B1BA6B4B6378A4
GO
Isoform 2 (identifier: Q4KWH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: Missing.
     557-557: Missing.
     863-882: Missing.

Show »
Length:1,640
Mass (Da):182,937
Checksum:iCF855C1012C31490
GO
Isoform 3 (identifier: Q4KWH5-3) [UniParc]FASTAAdd to basket
Also known as: PLC-eta-1b

The sequence of this isoform differs from the canonical sequence as follows:
     1001-1073: AGDKDDRRKG...PNMTNDCQEN → DLNRKQRKQE...VQRVRGSNQI
     1074-1682: Missing.

Show »
Length:1,073
Mass (Da):122,771
Checksum:i8FCD04B59FF7E5A5
GO
Isoform 4 (identifier: Q4KWH5-4) [UniParc]FASTAAdd to basket
Also known as: PLC-eta-1a

The sequence of this isoform differs from the canonical sequence as follows:
     1001-1003: AGD → VQI
     1004-1682: Missing.

Show »
Length:1,003
Mass (Da):114,547
Checksum:i14A27D8A1271B93C
GO
Isoform 5 (identifier: Q4KWH5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-563: Missing.
     564-584: SKSYSTDDEDDSLQNPGKEGG → MDFFSLHFKTWAVTMSSCHQR
     863-882: Missing.
     1001-1073: AGDKDDRRKG...PNMTNDCQEN → DLNRKQRKQE...VQRVRGSNQI
     1074-1682: Missing.

Show »
Length:490
Mass (Da):55,818
Checksum:iA256A8AE91E6F253
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BKK4H3BKK4_MOUSE
Phosphoinositide phospholipase C
Plch1
1,673Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKE1H3BKE1_MOUSE
Phosphoinositide phospholipase C
Plch1
968Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I1E4X6I1E4X6_MOUSE
Phosphoinositide phospholipase C
Plch1
1,681Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I1E4X4I1E4X4_MOUSE
Phosphoinositide phospholipase C
Plch1
1,643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQM2A0A0A0MQM2_MOUSE
Phosphoinositide phospholipase C
Plch1
1,073Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKX1H3BKX1_MOUSE
1-phosphatidylinositol 4,5-bisphosp...
Plch1
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CY47E0CY47_MOUSE
1-phosphatidylinositol 4,5-bisphosp...
Plch1
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CZ95E0CZ95_MOUSE
1-phosphatidylinositol 4,5-bisphosp...
Plch1
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti373 – 385VETIN…FVKNE → AIDRPWLCCCSLR in BAD32373 (PubMed:15368895).CuratedAdd BLAST13
Sequence conflicti523H → D in BAD32373 (PubMed:15368895).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0329071 – 563Missing in isoform 5. 1 PublicationAdd BLAST563
Alternative sequenceiVSP_0329081 – 21Missing in isoform 2. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_032909557Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_032910564 – 584SKSYS…GKEGG → MDFFSLHFKTWAVTMSSCHQ R in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_032911863 – 882Missing in isoform 2 and isoform 5. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_0329121001 – 1073AGDKD…DCQEN → DLNRKQRKQETRMTEEREPQ LEKTHIFQISTKSYPPPPVR SSTKMPTKGQLPVYQTQNSV EDEVQRVRGSNQI in isoform 3 and isoform 5. 2 PublicationsAdd BLAST73
Alternative sequenceiVSP_0329131001 – 1003AGD → VQI in isoform 4. 1 Publication3
Alternative sequenceiVSP_0329141004 – 1682Missing in isoform 4. 1 PublicationAdd BLAST679
Alternative sequenceiVSP_0329151074 – 1682Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST609

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY691172 mRNA Translation: AAW22609.1
AY691173 mRNA Translation: AAW22610.1
AY691174 mRNA Translation: AAW22611.1
BC042549 mRNA Translation: AAH42549.1
BC052372 mRNA Translation: AAH52372.1
BC055005 mRNA Translation: AAH55005.1
AK173095 mRNA Translation: BAD32373.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38444.2 [Q4KWH5-1]
CCDS50918.1 [Q4KWH5-3]
CCDS57215.1 [Q4KWH5-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001171203.1, NM_001177732.1 [Q4KWH5-4]
NP_001171204.1, NM_001177733.1 [Q4KWH5-3]
NP_899014.2, NM_183191.3 [Q4KWH5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000084105; ENSMUSP00000081122; ENSMUSG00000036834 [Q4KWH5-1]
ENSMUST00000159676; ENSMUSP00000124632; ENSMUSG00000036834 [Q4KWH5-3]
ENSMUST00000162269; ENSMUSP00000124463; ENSMUSG00000036834 [Q4KWH5-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
269437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:269437

UCSC genome browser

More...
UCSCi
uc008pju.2 mouse [Q4KWH5-5]
uc008pjv.2 mouse [Q4KWH5-2]
uc033htw.1 mouse [Q4KWH5-4]
uc033htx.1 mouse [Q4KWH5-3]
uc033hty.1 mouse [Q4KWH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691172 mRNA Translation: AAW22609.1
AY691173 mRNA Translation: AAW22610.1
AY691174 mRNA Translation: AAW22611.1
BC042549 mRNA Translation: AAH42549.1
BC052372 mRNA Translation: AAH52372.1
BC055005 mRNA Translation: AAH55005.1
AK173095 mRNA Translation: BAD32373.1
CCDSiCCDS38444.2 [Q4KWH5-1]
CCDS50918.1 [Q4KWH5-3]
CCDS57215.1 [Q4KWH5-4]
RefSeqiNP_001171203.1, NM_001177732.1 [Q4KWH5-4]
NP_001171204.1, NM_001177733.1 [Q4KWH5-3]
NP_899014.2, NM_183191.3 [Q4KWH5-1]

3D structure databases

SMRiQ4KWH5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081122

PTM databases

iPTMnetiQ4KWH5
PhosphoSitePlusiQ4KWH5

Proteomic databases

PaxDbiQ4KWH5
PeptideAtlasiQ4KWH5
PRIDEiQ4KWH5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
46750 75 antibodies

Genome annotation databases

EnsembliENSMUST00000084105; ENSMUSP00000081122; ENSMUSG00000036834 [Q4KWH5-1]
ENSMUST00000159676; ENSMUSP00000124632; ENSMUSG00000036834 [Q4KWH5-3]
ENSMUST00000162269; ENSMUSP00000124463; ENSMUSG00000036834 [Q4KWH5-4]
GeneIDi269437
KEGGimmu:269437
UCSCiuc008pju.2 mouse [Q4KWH5-5]
uc008pjv.2 mouse [Q4KWH5-2]
uc033htw.1 mouse [Q4KWH5-4]
uc033htx.1 mouse [Q4KWH5-3]
uc033hty.1 mouse [Q4KWH5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23007
MGIiMGI:2683547 Plch1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00940000157185
HOGENOMiCLU_002738_4_0_1
InParanoidiQ4KWH5
KOiK19006
OMAiENKQQCV
OrthoDBi368239at2759
PhylomeDBiQ4KWH5
TreeFamiTF313216

Enzyme and pathway databases

BRENDAi3.1.4.11 3474
ReactomeiR-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
269437 2 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Plch1 mouse

Protein Ontology

More...
PROi
PR:Q4KWH5
RNActiQ4KWH5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036834 Expressed in optic fissure and 174 other tissues
GenevisibleiQ4KWH5 MM

Family and domain databases

Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR028392 PLC-eta1
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF51 PTHR10336:SF51, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00054 EFh, 2 hits
SM00233 PH, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
PS50003 PH_DOMAIN, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCH1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4KWH5
Secondary accession number(s): Q4KWH6
, Q4KWH7, Q69ZS3, Q7TPQ1, Q8CFQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 2, 2005
Last modified: June 17, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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