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Protein

Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

Gene

NKAIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • regulation of sodium ion transport Source: GO_Central

Protein family/group databases

TCDBi8.B.27.1.2 the na(+)k(+)-atpase beta-subunit interacting nkain (nkain) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1
Short name:
Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 1
Alternative name(s):
Protein FAM77C
Gene namesi
Name:NKAIN1
Synonyms:FAM77C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000084628.9
HGNCiHGNC:25743 NKAIN1
MIMi612871 gene
neXtProtiNX_Q4KMZ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 34ExtracellularSequence analysisAdd BLAST13
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 61CytoplasmicSequence analysis6
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 146ExtracellularSequence analysisAdd BLAST64
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 207CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79570
OpenTargetsiENSG00000084628

Polymorphism and mutation databases

BioMutaiNKAIN1
DMDMi341942232

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000041216922 – 207Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1Add BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4KMZ8
PeptideAtlasiQ4KMZ8
PRIDEiQ4KMZ8
ProteomicsDBi62209

PTM databases

iPTMnetiQ4KMZ8
PhosphoSitePlusiQ4KMZ8

Expressioni

Gene expression databases

BgeeiENSG00000084628 Expressed in 91 organ(s), highest expression level in cerebellum
CleanExiHS_NKAIN1
ExpressionAtlasiQ4KMZ8 baseline and differential
GenevisibleiQ4KMZ8 HS

Organism-specific databases

HPAiHPA006873

Interactioni

Subunit structurei

Interacts with ATP1B1 C-terminus.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122717, 66 interactors
STRINGi9606.ENSP00000362841

Structurei

3D structure databases

ProteinModelPortaliQ4KMZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NKAIN family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4556 Eukaryota
ENOG410XS8X LUCA
GeneTreeiENSGT00390000013699
HOGENOMiHOG000293382
HOVERGENiHBG108190
InParanoidiQ4KMZ8
KOiK22735
OMAiLVICSLQ
OrthoDBiEOG091G0X6F
PhylomeDBiQ4KMZ8
TreeFamiTF321348

Family and domain databases

InterProiView protein in InterPro
IPR008516 Na/K-Atpase_Interacting
PANTHERiPTHR13084 PTHR13084, 1 hit
PfamiView protein in Pfam
PF05640 NKAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4KMZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKCSGRCTL VAFCCLQLVA ALERQIFDFL GYQWAPILAN FLHIMAVILG
60 70 80 90 100
IFGTVQYRSR YLILYAAWLV LWVGWNAFII CFYLEVGQLS QDRDFIMTFN
110 120 130 140 150
TSLHRSWWME NGPGCLVTPV LNSRLALEDH HVISVTGCLL DYPYIEALSS
160 170 180 190 200
ALQIFLALFG FVFACYVSKV FLEEEDSFDF IGGFDSYGYQ APQKTSHLQL

QPLYTSG
Length:207
Mass (Da):23,552
Last modified:July 27, 2011 - v3
Checksum:i5BDC3771B3E24E3E
GO
Isoform 2 (identifier: Q4KMZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     65-91: Missing.

Note: No experimental confirmation available.
Show »
Length:136
Mass (Da):15,436
Checksum:i3D5D16389B973CBE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNE2R4GNE2_HUMAN
Sodium/potassium-transporting ATPas...
NKAIN1
126Annotation score:
H0YDA0H0YDA0_HUMAN
Sodium/potassium-transporting ATPas...
NKAIN1
151Annotation score:

Sequence cautioni

The sequence AAH96707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98173 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98249 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI31519 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14196 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAX07629 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88Q → R in BAH13055 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0561131 – 44Missing in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_05611465 – 91Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022712 mRNA Translation: BAB14196.1 Different initiation.
AK298874 mRNA Translation: BAH12891.1
AK299507 mRNA Translation: BAH13055.1
AC114495 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07629.1 Sequence problems.
BC096707 mRNA Translation: AAH96707.2 Different initiation.
BC098173 mRNA Translation: AAH98173.2 Different initiation.
BC098249 mRNA Translation: AAH98249.2 Different initiation.
BC131518 mRNA Translation: AAI31519.1 Different initiation.
CCDSiCCDS339.2 [Q4KMZ8-1]
RefSeqiNP_078798.2, NM_024522.2 [Q4KMZ8-1]
UniGeneiHs.470259

Genome annotation databases

EnsembliENST00000373736; ENSP00000362841; ENSG00000084628 [Q4KMZ8-1]
GeneIDi79570
KEGGihsa:79570
UCSCiuc010ogd.3 human [Q4KMZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022712 mRNA Translation: BAB14196.1 Different initiation.
AK298874 mRNA Translation: BAH12891.1
AK299507 mRNA Translation: BAH13055.1
AC114495 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07629.1 Sequence problems.
BC096707 mRNA Translation: AAH96707.2 Different initiation.
BC098173 mRNA Translation: AAH98173.2 Different initiation.
BC098249 mRNA Translation: AAH98249.2 Different initiation.
BC131518 mRNA Translation: AAI31519.1 Different initiation.
CCDSiCCDS339.2 [Q4KMZ8-1]
RefSeqiNP_078798.2, NM_024522.2 [Q4KMZ8-1]
UniGeneiHs.470259

3D structure databases

ProteinModelPortaliQ4KMZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122717, 66 interactors
STRINGi9606.ENSP00000362841

Protein family/group databases

TCDBi8.B.27.1.2 the na(+)k(+)-atpase beta-subunit interacting nkain (nkain) family

PTM databases

iPTMnetiQ4KMZ8
PhosphoSitePlusiQ4KMZ8

Polymorphism and mutation databases

BioMutaiNKAIN1
DMDMi341942232

Proteomic databases

PaxDbiQ4KMZ8
PeptideAtlasiQ4KMZ8
PRIDEiQ4KMZ8
ProteomicsDBi62209

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373736; ENSP00000362841; ENSG00000084628 [Q4KMZ8-1]
GeneIDi79570
KEGGihsa:79570
UCSCiuc010ogd.3 human [Q4KMZ8-1]

Organism-specific databases

CTDi79570
DisGeNETi79570
EuPathDBiHostDB:ENSG00000084628.9
GeneCardsiNKAIN1
HGNCiHGNC:25743 NKAIN1
HPAiHPA006873
MIMi612871 gene
neXtProtiNX_Q4KMZ8
OpenTargetsiENSG00000084628
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4556 Eukaryota
ENOG410XS8X LUCA
GeneTreeiENSGT00390000013699
HOGENOMiHOG000293382
HOVERGENiHBG108190
InParanoidiQ4KMZ8
KOiK22735
OMAiLVICSLQ
OrthoDBiEOG091G0X6F
PhylomeDBiQ4KMZ8
TreeFamiTF321348

Miscellaneous databases

ChiTaRSiNKAIN1 human
GenomeRNAii79570
PROiPR:Q4KMZ8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000084628 Expressed in 91 organ(s), highest expression level in cerebellum
CleanExiHS_NKAIN1
ExpressionAtlasiQ4KMZ8 baseline and differential
GenevisibleiQ4KMZ8 HS

Family and domain databases

InterProiView protein in InterPro
IPR008516 Na/K-Atpase_Interacting
PANTHERiPTHR13084 PTHR13084, 1 hit
PfamiView protein in Pfam
PF05640 NKAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKAI1_HUMAN
AccessioniPrimary (citable) accession number: Q4KMZ8
Secondary accession number(s): A2VDJ3
, B7Z5F5, B7Z5W9, Q9H9M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 97 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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