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Protein

TBC1 domain family member 10B

Gene

TBC1D10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 10B
Alternative name(s):
Rab27A-GAP-beta
Gene namesi
ORF Names:FP2461
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000169221.13
HGNCiHGNC:24510 TBC1D10B
MIMi613620 gene
neXtProtiNX_Q4KMP7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi409R → L: Loss of GAP activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000169221
PharmGKBiPA142670835

Polymorphism and mutation databases

BioMutaiTBC1D10B
DMDMi294862492

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157161 – 808TBC1 domain family member 10BAdd BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei141PhosphoserineBy similarity1
Modified residuei152PhosphothreonineBy similarity1
Modified residuei186Omega-N-methylarginineBy similarity1
Modified residuei658PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ4KMP7
MaxQBiQ4KMP7
PaxDbiQ4KMP7
PeptideAtlasiQ4KMP7
PRIDEiQ4KMP7
ProteomicsDBi62197
62198 [Q4KMP7-2]

PTM databases

iPTMnetiQ4KMP7
PhosphoSitePlusiQ4KMP7

Expressioni

Gene expression databases

BgeeiENSG00000169221 Expressed in 211 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TBC1D10B
ExpressionAtlasiQ4KMP7 baseline and differential
GenevisibleiQ4KMP7 HS

Organism-specific databases

HPAiHPA048894

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117476, 15 interactors
IntActiQ4KMP7, 5 interactors
STRINGi9606.ENSP00000386538

Structurei

3D structure databases

ProteinModelPortaliQ4KMP7
SMRiQ4KMP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini360 – 548Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST189

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili716 – 782Sequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 175Pro-richAdd BLAST169
Compositional biasi677 – 682Poly-Pro6

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2221 Eukaryota
ENOG410XPSR LUCA
GeneTreeiENSGT00920000148983
HOVERGENiHBG070028
InParanoidiQ4KMP7
KOiK19944
OMAiTGPSGTC
OrthoDBiEOG091G07CB
PhylomeDBiQ4KMP7
TreeFamiTF313293

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4KMP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METGTAPLVA PPRRHGAPAA PSPPPRGSRA GPVVVVAPGP PVTTATSAPV
60 70 80 90 100
TLVAPGEARP AWVPGSAETS APAPAPAPAP APAVTGSTVV VLTLEASPEA
110 120 130 140 150
PKPQLPSGPE SPEPAAVAGV ETSRALAAGA DSPKTEEARP SPAPGPGTPT
160 170 180 190 200
GTPTRTPSRT APGALTAKPP LAPKPGTTVA SGVTARSASG QVTGGHGAAA
210 220 230 240 250
ATSASAGQAP EDPSGPGTGP SGTCEAPVAV VTVTPAPEPA ENSQDLGSTS
260 270 280 290 300
SLGPGISGPR GQAPDTLSYL DSVSLMSGTL ESLADDVSSM GSDSEINGLA
310 320 330 340 350
LRKTDKYGFL GGSQYSGSLE SSIPVDVARQ RELKWLDMFS NWDKWLSRRF
360 370 380 390 400
QKVKLRCRKG IPSSLRAKAW QYLSNSKELL EQNPGKFEEL ERAPGDPKWL
410 420 430 440 450
DVIEKDLHRQ FPFHEMFAAR GGHGQQDLYR ILKAYTIYRP DEGYCQAQAP
460 470 480 490 500
VAAVLLMHMP AEQAFWCLVQ ICDKYLPGYY SAGLEAIQLD GEIFFALLRR
510 520 530 540 550
ASPLAHRHLR RQRIDPVLYM TEWFMCIFAR TLPWASVLRV WDMFFCEGVK
560 570 580 590 600
IIFRVALVLL RHTLGSVEKL RSCQGMYETM EQLRNLPQQC MQEDFLVHEV
610 620 630 640 650
TNLPVTEALI ERENAAQLKK WRETRGELQY RPSRRLHGSR AIHEERRRQQ
660 670 680 690 700
PPLGPSSSLL SLPGLKSRGS RAAGGAPSPP PPVRRASAGP APGPVVTAEG
710 720 730 740 750
LHPSLPSPTG NSTPLGSSKE TRKQEKERQK QEKERQKQEK EREKERQKQE
760 770 780 790 800
KEREKQEKER EKQEKERQKQ EKKAQGRKLS LRRKADGPPG PHDGGDRPSA

EARQDAYF
Note: No experimental confirmation available. Gene prediction based on similarity to mouse ortholog.
Length:808
Mass (Da):87,199
Last modified:April 20, 2010 - v3
Checksum:i50D8884B8E3BBFBE
GO
Isoform 2 (identifier: Q4KMP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-575: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):26,577
Checksum:i7EF7FD363D887C28
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSE1H3BSE1_HUMAN
TBC1 domain family member 10B
TBC1D10B
184Annotation score:

Sequence cautioni

The sequence AAH50523 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH63112 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH72453 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH93814 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH93816 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98419 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ15206 differs from that shown. Reason: Frameshift at positions 154, 379 and 401.Curated
The sequence BAA92086 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14454 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAH16638 differs from that shown. Probable cloning artifact.Curated
The sequence EAW52256 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187S → G in AAH50523 (PubMed:15489334).Curated1
Sequence conflicti350F → L in AAQ15206 (PubMed:15498874).Curated1
Sequence conflicti669G → D in BAH16638 (PubMed:19077034).Curated1
Sequence conflicti690P → S in BAH16638 (PubMed:19077034).Curated1
Sequence conflicti761E → G in AAH50523 (PubMed:15489334).Curated1
Sequence conflicti761E → G in AAH63112 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0306701 – 575Missing in isoform 2. 1 PublicationAdd BLAST575

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117408 mRNA Translation: CAB55908.1
AC106782 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52256.1 Sequence problems.
AK002101 mRNA Translation: BAA92086.1 Different initiation.
AK023192 mRNA Translation: BAB14454.1 Different initiation.
BC050523 mRNA Translation: AAH50523.2 Different initiation.
BC063112 mRNA Translation: AAH63112.1 Different initiation.
BC072453 mRNA Translation: AAH72453.2 Different initiation.
BC093814 mRNA Translation: AAH93814.1 Different initiation.
BC093816 mRNA Translation: AAH93816.1 Different initiation.
BC098419 mRNA Translation: AAH98419.1 Different initiation.
AB449895 mRNA Translation: BAH16638.1 Sequence problems.
AF370370 mRNA Translation: AAQ15206.1 Frameshift.
CCDSiCCDS10676.2 [Q4KMP7-1]
PIRiT17218
RefSeqiNP_056342.3, NM_015527.3 [Q4KMP7-1]
UniGeneiHs.632182

Genome annotation databases

EnsembliENST00000409939; ENSP00000386538; ENSG00000169221 [Q4KMP7-1]
GeneIDi26000
KEGGihsa:26000
UCSCiuc002dxu.3 human [Q4KMP7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117408 mRNA Translation: CAB55908.1
AC106782 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52256.1 Sequence problems.
AK002101 mRNA Translation: BAA92086.1 Different initiation.
AK023192 mRNA Translation: BAB14454.1 Different initiation.
BC050523 mRNA Translation: AAH50523.2 Different initiation.
BC063112 mRNA Translation: AAH63112.1 Different initiation.
BC072453 mRNA Translation: AAH72453.2 Different initiation.
BC093814 mRNA Translation: AAH93814.1 Different initiation.
BC093816 mRNA Translation: AAH93816.1 Different initiation.
BC098419 mRNA Translation: AAH98419.1 Different initiation.
AB449895 mRNA Translation: BAH16638.1 Sequence problems.
AF370370 mRNA Translation: AAQ15206.1 Frameshift.
CCDSiCCDS10676.2 [Q4KMP7-1]
PIRiT17218
RefSeqiNP_056342.3, NM_015527.3 [Q4KMP7-1]
UniGeneiHs.632182

3D structure databases

ProteinModelPortaliQ4KMP7
SMRiQ4KMP7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117476, 15 interactors
IntActiQ4KMP7, 5 interactors
STRINGi9606.ENSP00000386538

PTM databases

iPTMnetiQ4KMP7
PhosphoSitePlusiQ4KMP7

Polymorphism and mutation databases

BioMutaiTBC1D10B
DMDMi294862492

Proteomic databases

EPDiQ4KMP7
MaxQBiQ4KMP7
PaxDbiQ4KMP7
PeptideAtlasiQ4KMP7
PRIDEiQ4KMP7
ProteomicsDBi62197
62198 [Q4KMP7-2]

Protocols and materials databases

DNASUi26000
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409939; ENSP00000386538; ENSG00000169221 [Q4KMP7-1]
GeneIDi26000
KEGGihsa:26000
UCSCiuc002dxu.3 human [Q4KMP7-1]

Organism-specific databases

CTDi26000
EuPathDBiHostDB:ENSG00000169221.13
GeneCardsiTBC1D10B
H-InvDBiHIX0012950
HGNCiHGNC:24510 TBC1D10B
HPAiHPA048894
MIMi613620 gene
neXtProtiNX_Q4KMP7
OpenTargetsiENSG00000169221
PharmGKBiPA142670835
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2221 Eukaryota
ENOG410XPSR LUCA
GeneTreeiENSGT00920000148983
HOVERGENiHBG070028
InParanoidiQ4KMP7
KOiK19944
OMAiTGPSGTC
OrthoDBiEOG091G07CB
PhylomeDBiQ4KMP7
TreeFamiTF313293

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs

Miscellaneous databases

ChiTaRSiTBC1D10B human
GenomeRNAii26000
PROiPR:Q4KMP7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169221 Expressed in 211 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TBC1D10B
ExpressionAtlasiQ4KMP7 baseline and differential
GenevisibleiQ4KMP7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTB10B_HUMAN
AccessioniPrimary (citable) accession number: Q4KMP7
Secondary accession number(s): B9A6L0
, Q6IN54, Q6P530, Q71RG7, Q86VC5, Q9H8Z2, Q9NUN6, Q9UFP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 20, 2010
Last modified: September 12, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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