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Entry version 135 (29 Sep 2021)
Sequence version 3 (20 Apr 2010)
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Protein

TBC1 domain family member 10B

Gene

TBC1D10B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q4KMP7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8854214, TBC/RABGAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 10B
Alternative name(s):
Rab27A-GAP-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:FP2461
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24510, TBC1D10B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613620, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4KMP7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000169221

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi409R → L: Loss of GAP activity. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000169221

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670835

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4KMP7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBC1D10B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862492

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157161 – 808TBC1 domain family member 10BAdd BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei141PhosphoserineBy similarity1
Modified residuei152PhosphothreonineBy similarity1
Modified residuei186Omega-N-methylarginineBy similarity1
Modified residuei658PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4KMP7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4KMP7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q4KMP7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q4KMP7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4KMP7

PeptideAtlas

More...
PeptideAtlasi
Q4KMP7

PRoteomics IDEntifications database

More...
PRIDEi
Q4KMP7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62197 [Q4KMP7-1]
62198 [Q4KMP7-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q4KMP7, 6 sites, 1 O-linked glycan (6 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4KMP7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4KMP7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169221, Expressed in C1 segment of cervical spinal cord and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4KMP7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4KMP7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000169221, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117476, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q4KMP7, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386538

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4KMP7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4KMP7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini360 – 548Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni60 – 225DisorderedSequence analysisAdd BLAST166
Regioni237 – 264DisorderedSequence analysisAdd BLAST28
Regioni629 – 808DisorderedSequence analysisAdd BLAST180

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili716 – 782Sequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 28Pro residuesSequence analysisAdd BLAST15
Compositional biasi237 – 256Polar residuesSequence analysisAdd BLAST20
Compositional biasi629 – 650Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi704 – 718Polar residuesSequence analysisAdd BLAST15
Compositional biasi719 – 800Basic and acidic residuesSequence analysisAdd BLAST82

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2221, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159805

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005350_8_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4KMP7

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNWDKWL

Database of Orthologous Groups

More...
OrthoDBi
976276at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4KMP7

TreeFam database of animal gene trees

More...
TreeFami
TF313293

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00566, RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00164, TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923, SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4KMP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METGTAPLVA PPRRHGAPAA PSPPPRGSRA GPVVVVAPGP PVTTATSAPV
60 70 80 90 100
TLVAPGEARP AWVPGSAETS APAPAPAPAP APAVTGSTVV VLTLEASPEA
110 120 130 140 150
PKPQLPSGPE SPEPAAVAGV ETSRALAAGA DSPKTEEARP SPAPGPGTPT
160 170 180 190 200
GTPTRTPSRT APGALTAKPP LAPKPGTTVA SGVTARSASG QVTGGHGAAA
210 220 230 240 250
ATSASAGQAP EDPSGPGTGP SGTCEAPVAV VTVTPAPEPA ENSQDLGSTS
260 270 280 290 300
SLGPGISGPR GQAPDTLSYL DSVSLMSGTL ESLADDVSSM GSDSEINGLA
310 320 330 340 350
LRKTDKYGFL GGSQYSGSLE SSIPVDVARQ RELKWLDMFS NWDKWLSRRF
360 370 380 390 400
QKVKLRCRKG IPSSLRAKAW QYLSNSKELL EQNPGKFEEL ERAPGDPKWL
410 420 430 440 450
DVIEKDLHRQ FPFHEMFAAR GGHGQQDLYR ILKAYTIYRP DEGYCQAQAP
460 470 480 490 500
VAAVLLMHMP AEQAFWCLVQ ICDKYLPGYY SAGLEAIQLD GEIFFALLRR
510 520 530 540 550
ASPLAHRHLR RQRIDPVLYM TEWFMCIFAR TLPWASVLRV WDMFFCEGVK
560 570 580 590 600
IIFRVALVLL RHTLGSVEKL RSCQGMYETM EQLRNLPQQC MQEDFLVHEV
610 620 630 640 650
TNLPVTEALI ERENAAQLKK WRETRGELQY RPSRRLHGSR AIHEERRRQQ
660 670 680 690 700
PPLGPSSSLL SLPGLKSRGS RAAGGAPSPP PPVRRASAGP APGPVVTAEG
710 720 730 740 750
LHPSLPSPTG NSTPLGSSKE TRKQEKERQK QEKERQKQEK EREKERQKQE
760 770 780 790 800
KEREKQEKER EKQEKERQKQ EKKAQGRKLS LRRKADGPPG PHDGGDRPSA

EARQDAYF
Length:808
Mass (Da):87,199
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50D8884B8E3BBFBE
GO
Isoform 2 (identifier: Q4KMP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-575: Missing.

Show »
Length:233
Mass (Da):26,577
Checksum:i7EF7FD363D887C28
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSE1H3BSE1_HUMAN
TBC1 domain family member 10B
TBC1D10B
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH50523 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH63112 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH72453 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH93814 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH93816 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH98419 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAQ15206 differs from that shown. Reason: Frameshift.Curated
The sequence BAA92086 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14454 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAH16638 differs from that shown. Probable cloning artifact.Curated
The sequence EAW52256 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187S → G in AAH50523 (PubMed:15489334).Curated1
Sequence conflicti350F → L in AAQ15206 (PubMed:15498874).Curated1
Sequence conflicti669G → D in BAH16638 (PubMed:19077034).Curated1
Sequence conflicti690P → S in BAH16638 (PubMed:19077034).Curated1
Sequence conflicti761E → G in AAH50523 (PubMed:15489334).Curated1
Sequence conflicti761E → G in AAH63112 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0306701 – 575Missing in isoform 2. 1 PublicationAdd BLAST575

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL117408 mRNA Translation: CAB55908.1
AC106782 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52256.1 Sequence problems.
AK002101 mRNA Translation: BAA92086.1 Different initiation.
AK023192 mRNA Translation: BAB14454.1 Different initiation.
BC050523 mRNA Translation: AAH50523.2 Different initiation.
BC063112 mRNA Translation: AAH63112.1 Different initiation.
BC072453 mRNA Translation: AAH72453.2 Different initiation.
BC093814 mRNA Translation: AAH93814.1 Different initiation.
BC093816 mRNA Translation: AAH93816.1 Different initiation.
BC098419 mRNA Translation: AAH98419.1 Different initiation.
AB449895 mRNA Translation: BAH16638.1 Sequence problems.
AF370370 mRNA Translation: AAQ15206.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10676.2 [Q4KMP7-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17218

NCBI Reference Sequences

More...
RefSeqi
NP_056342.3, NM_015527.3 [Q4KMP7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409939; ENSP00000386538; ENSG00000169221 [Q4KMP7-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26000

UCSC genome browser

More...
UCSCi
uc002dxu.3, human [Q4KMP7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117408 mRNA Translation: CAB55908.1
AC106782 Genomic DNA No translation available.
CH471192 Genomic DNA Translation: EAW52256.1 Sequence problems.
AK002101 mRNA Translation: BAA92086.1 Different initiation.
AK023192 mRNA Translation: BAB14454.1 Different initiation.
BC050523 mRNA Translation: AAH50523.2 Different initiation.
BC063112 mRNA Translation: AAH63112.1 Different initiation.
BC072453 mRNA Translation: AAH72453.2 Different initiation.
BC093814 mRNA Translation: AAH93814.1 Different initiation.
BC093816 mRNA Translation: AAH93816.1 Different initiation.
BC098419 mRNA Translation: AAH98419.1 Different initiation.
AB449895 mRNA Translation: BAH16638.1 Sequence problems.
AF370370 mRNA Translation: AAQ15206.1 Frameshift.
CCDSiCCDS10676.2 [Q4KMP7-1]
PIRiT17218
RefSeqiNP_056342.3, NM_015527.3 [Q4KMP7-1]

3D structure databases

SMRiQ4KMP7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117476, 28 interactors
IntActiQ4KMP7, 6 interactors
STRINGi9606.ENSP00000386538

PTM databases

GlyGeniQ4KMP7, 6 sites, 1 O-linked glycan (6 sites)
iPTMnetiQ4KMP7
PhosphoSitePlusiQ4KMP7

Genetic variation databases

BioMutaiTBC1D10B
DMDMi294862492

Proteomic databases

EPDiQ4KMP7
jPOSTiQ4KMP7
MassIVEiQ4KMP7
MaxQBiQ4KMP7
PaxDbiQ4KMP7
PeptideAtlasiQ4KMP7
PRIDEiQ4KMP7
ProteomicsDBi62197 [Q4KMP7-1]
62198 [Q4KMP7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
27194, 105 antibodies

The DNASU plasmid repository

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DNASUi
26000

Genome annotation databases

EnsembliENST00000409939; ENSP00000386538; ENSG00000169221 [Q4KMP7-1]
GeneIDi26000
KEGGihsa:26000
UCSCiuc002dxu.3, human [Q4KMP7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26000

GeneCards: human genes, protein and diseases

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GeneCardsi
TBC1D10B
HGNCiHGNC:24510, TBC1D10B
HPAiENSG00000169221, Low tissue specificity
MIMi613620, gene
neXtProtiNX_Q4KMP7
OpenTargetsiENSG00000169221
PharmGKBiPA142670835
VEuPathDBiHostDB:ENSG00000169221

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2221, Eukaryota
GeneTreeiENSGT00940000159805
HOGENOMiCLU_005350_8_0_1
InParanoidiQ4KMP7
OMAiNNWDKWL
OrthoDBi976276at2759
PhylomeDBiQ4KMP7
TreeFamiTF313293

Enzyme and pathway databases

PathwayCommonsiQ4KMP7
ReactomeiR-HSA-8854214, TBC/RABGAPs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26000, 29 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBC1D10B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26000
PharosiQ4KMP7, Tbio

Protein Ontology

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PROi
PR:Q4KMP7
RNActiQ4KMP7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169221, Expressed in C1 segment of cervical spinal cord and 222 other tissues
ExpressionAtlasiQ4KMP7, baseline and differential
GenevisibleiQ4KMP7, HS

Family and domain databases

InterProiView protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566, RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164, TBC, 1 hit
SUPFAMiSSF47923, SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTB10B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4KMP7
Secondary accession number(s): B9A6L0
, Q6IN54, Q6P530, Q71RG7, Q86VC5, Q9H8Z2, Q9NUN6, Q9UFP2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 20, 2010
Last modified: September 29, 2021
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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