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Protein

Oxidation resistance protein 1

Gene

Oxr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in protection from oxidative damage.

GO - Molecular functioni

  • oxidoreductase activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidation resistance protein 1
Alternative name(s):
Protein C7
Gene namesi
Name:Oxr1
Synonyms:C7, Gm1238
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2179326 Oxr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002316461 – 866Oxidation resistance protein 1Add BLAST866

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei202PhosphoserineBy similarity1
Modified residuei204PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei341PhosphothreonineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KMM3
PeptideAtlasiQ4KMM3
PRIDEiQ4KMM3

PTM databases

iPTMnetiQ4KMM3
PhosphoSitePlusiQ4KMM3

Expressioni

Tissue specificityi

Highly expressed in brain and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000022307 Expressed in 273 organ(s), highest expression level in medial dorsal nucleus of thalamus
CleanExiMM_OXR1
ExpressionAtlasiQ4KMM3 baseline and differential
GenevisibleiQ4KMM3 MM

Interactioni

Protein-protein interaction databases

IntActiQ4KMM3, 2 interactors
MINTiQ4KMM3
STRINGi10090.ENSMUSP00000105926

Structurei

3D structure databases

ProteinModelPortaliQ4KMM3
SMRiQ4KMM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 141LysMPROSITE-ProRule annotationAdd BLAST44
Domaini213 – 268GRAMAdd BLAST56
Domaini730 – 865TLDAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni543 – 570Mediates oxidative antimutator activityBy similarityAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi205 – 208Poly-Glu4

Sequence similaritiesi

Belongs to the OXR1 family.Curated

Phylogenomic databases

eggNOGiKOG2372 Eukaryota
ENOG4111QBZ LUCA
GeneTreeiENSGT00410000025363
HOGENOMiHOG000060321
HOVERGENiHBG065488
InParanoidiQ4KMM3
OrthoDBiEOG091G0L15
PhylomeDBiQ4KMM3
TreeFamiTF313530

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF01476 LysM, 1 hit
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 1 hit
SM00584 TLDc, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4KMM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVSNLSWLK KKSQSVDITA PGFNPLGGAG KQAPQASKPP APKTPIIEEE
60 70 80 90 100
QNNSANTQKH PSRKSELKRF YTIDTGQKKT LDKKDGRRMS FQKPKGTIEY
110 120 130 140 150
TVESRDSLNS IALKFDTTPN ELVQLNKLFS RAVVTGQVLY VPDPEYVSSV
160 170 180 190 200
ESSPSLSPVS PLSPTSSEAE FDKTTTPDVA HPKEAPPAST VSGIRPARVV
210 220 230 240 250
SSTSEEEEAF TEKFLKINCK YITIGKGTVS GVLLVTPNNI MFDPHKTDPL
260 270 280 290 300
VQENGCEEYG IMCPMEEVMS AAMYKEILDS KIKESLPIEL DQLSGRGSCH
310 320 330 340 350
SKKATGVSAE DADPRARDQG NDSASTAPRS TEESLSEDAF TESELSPIRE
360 370 380 390 400
ELLSSEPRQE KSSDASSESV QTVSQMEVQS LTATSEAANV PDRTSSNPGA
410 420 430 440 450
LSHETGLSGL ETATKGGDKA TESLQEVSGP KEQSTEVKGQ DNQDSSHQES
460 470 480 490 500
SLQQEAGEDS VSSGETVELK EKPAVLKDQQ GQELKRDSET EVEELRKLWK
510 520 530 540 550
THSMQQAKQQ RDTIQQVSQR ESKHSSAAAD AHGEGSSLLK EKRRHRLHKF
560 570 580 590 600
LCLRVGKPMR KTFVSQASAT MQQYAQRDKK HEYWFAVPQE RTDHLYAFFI
610 620 630 640 650
QWSPEIYAED SGEYTREPGF IVVKKMDESE ANEAPAGEAA AREWEVVSVA
660 670 680 690 700
EYHRRIDALN TEELRTLCRR LQITTREDIN SKQVAPAKAD LEPESFRPNL
710 720 730 740 750
SDPSELLLPD QIEKLTKHLP PRTIGYPWTL VYGTGKHGTS LKTLYRTMTG
760 770 780 790 800
LDTPVLMVIK DSDGQVFGAL ASEPFKVSDG FYGTGETFVF TFCPEFEVFK
810 820 830 840 850
WTGDNMFFIK GDMDSLAFGG GGGEFALWLD GDLYHGRSHS CKTFGNHTLS
860
KKEDFFIQDI EIWAFE
Length:866
Mass (Da):95,912
Last modified:April 20, 2010 - v3
Checksum:i15FB6B37144B1668
GO
Isoform 2 (identifier: Q4KMM3-2) [UniParc]FASTAAdd to basket
Also known as: C7B

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:778
Mass (Da):86,240
Checksum:iDEB2C7A23699830B
GO
Isoform 3 (identifier: Q4KMM3-3) [UniParc]FASTAAdd to basket
Also known as: C7A

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     646-672: Missing.

Show »
Length:751
Mass (Da):83,016
Checksum:i797716DA0A254741
GO
Isoform 4 (identifier: Q4KMM3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-672: Missing.

Show »
Length:839
Mass (Da):92,688
Checksum:iE8D5AA39662B4252
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q0A7E9Q0A7_MOUSE
Oxidation resistance protein 1
Oxr1
832Annotation score:
B1H3M0B1H3M0_MOUSE
OXR1 short isoform C7C
Oxr1
216Annotation score:
A0A2R8VI09A0A2R8VI09_MOUSE
Oxidation resistance protein 1
Oxr1
399Annotation score:
A0A2R8VKF8A0A2R8VKF8_MOUSE
Oxidation resistance protein 1
Oxr1
106Annotation score:
A0A2R8W6N3A0A2R8W6N3_MOUSE
Oxidation resistance protein 1
Oxr1
574Annotation score:
A0A2R8VHT3A0A2R8VHT3_MOUSE
Oxidation resistance protein 1
Oxr1
198Annotation score:
A0A2R8VHF5A0A2R8VHF5_MOUSE
Oxidation resistance protein 1
Oxr1
109Annotation score:
A0A2R8W6J0A0A2R8W6J0_MOUSE
Oxidation resistance protein 1
Oxr1
44Annotation score:
A0A2R8VHS5A0A2R8VHS5_MOUSE
Oxidation resistance protein 1
Oxr1
77Annotation score:

Sequence cautioni

The sequence AAH03927 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98491 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE34619 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107 – 109SLN → PLY in AAK29400 (PubMed:11237729).Curated3
Sequence conflicti156L → H in AAK29400 (PubMed:11237729).Curated1
Sequence conflicti308S → A in AAH89183 (PubMed:15489334).Curated1
Sequence conflicti308S → A in AAH98491 (PubMed:15489334).Curated1
Sequence conflicti435 – 437TEV → PEI in AAH89183 (PubMed:15489334).Curated3
Sequence conflicti435 – 437TEV → PEI in AAH98491 (PubMed:15489334).Curated3
Sequence conflicti451S → L in AAH89183 (PubMed:15489334).Curated1
Sequence conflicti451S → L in AAH98491 (PubMed:15489334).Curated1
Sequence conflicti814D → G in AAH98491 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0390151 – 88Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_039016646 – 672Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324899 mRNA Translation: AAK30368.1
AF333985 mRNA Translation: AAK29400.1
AK158703 mRNA Translation: BAE34619.1 Different initiation.
BC003927 mRNA Translation: AAH03927.1 Different initiation.
BC089183 mRNA Translation: AAH89183.1
BC098491 mRNA Translation: AAH98491.1 Different initiation.
CCDSiCCDS27448.1 [Q4KMM3-2]
CCDS49598.1 [Q4KMM3-1]
CCDS49600.1 [Q4KMM3-3]
RefSeqiNP_001123635.1, NM_001130163.1 [Q4KMM3-3]
NP_001123636.1, NM_001130164.1
NP_001123637.1, NM_001130165.1
NP_001123638.1, NM_001130166.1 [Q4KMM3-1]
NP_570955.1, NM_130885.2 [Q4KMM3-2]
XP_017171979.1, XM_017316490.1
XP_017171980.1, XM_017316491.1
UniGeneiMm.254267

Genome annotation databases

EnsembliENSMUST00000022918; ENSMUSP00000022918; ENSMUSG00000022307 [Q4KMM3-2]
ENSMUST00000090095; ENSMUSP00000087553; ENSMUSG00000022307 [Q4KMM3-3]
ENSMUST00000090096; ENSMUSP00000087554; ENSMUSG00000022307 [Q4KMM3-3]
ENSMUST00000110297; ENSMUSP00000105926; ENSMUSG00000022307 [Q4KMM3-1]
ENSMUST00000179393; ENSMUSP00000136923; ENSMUSG00000022307 [Q4KMM3-3]
ENSMUST00000230203; ENSMUSP00000155237; ENSMUSG00000022307 [Q4KMM3-4]
GeneIDi170719
KEGGimmu:170719
UCSCiuc007vot.2 mouse [Q4KMM3-1]
uc007vpa.1 mouse [Q4KMM3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF324899 mRNA Translation: AAK30368.1
AF333985 mRNA Translation: AAK29400.1
AK158703 mRNA Translation: BAE34619.1 Different initiation.
BC003927 mRNA Translation: AAH03927.1 Different initiation.
BC089183 mRNA Translation: AAH89183.1
BC098491 mRNA Translation: AAH98491.1 Different initiation.
CCDSiCCDS27448.1 [Q4KMM3-2]
CCDS49598.1 [Q4KMM3-1]
CCDS49600.1 [Q4KMM3-3]
RefSeqiNP_001123635.1, NM_001130163.1 [Q4KMM3-3]
NP_001123636.1, NM_001130164.1
NP_001123637.1, NM_001130165.1
NP_001123638.1, NM_001130166.1 [Q4KMM3-1]
NP_570955.1, NM_130885.2 [Q4KMM3-2]
XP_017171979.1, XM_017316490.1
XP_017171980.1, XM_017316491.1
UniGeneiMm.254267

3D structure databases

ProteinModelPortaliQ4KMM3
SMRiQ4KMM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4KMM3, 2 interactors
MINTiQ4KMM3
STRINGi10090.ENSMUSP00000105926

PTM databases

iPTMnetiQ4KMM3
PhosphoSitePlusiQ4KMM3

Proteomic databases

PaxDbiQ4KMM3
PeptideAtlasiQ4KMM3
PRIDEiQ4KMM3

Protocols and materials databases

DNASUi170719
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022918; ENSMUSP00000022918; ENSMUSG00000022307 [Q4KMM3-2]
ENSMUST00000090095; ENSMUSP00000087553; ENSMUSG00000022307 [Q4KMM3-3]
ENSMUST00000090096; ENSMUSP00000087554; ENSMUSG00000022307 [Q4KMM3-3]
ENSMUST00000110297; ENSMUSP00000105926; ENSMUSG00000022307 [Q4KMM3-1]
ENSMUST00000179393; ENSMUSP00000136923; ENSMUSG00000022307 [Q4KMM3-3]
ENSMUST00000230203; ENSMUSP00000155237; ENSMUSG00000022307 [Q4KMM3-4]
GeneIDi170719
KEGGimmu:170719
UCSCiuc007vot.2 mouse [Q4KMM3-1]
uc007vpa.1 mouse [Q4KMM3-3]

Organism-specific databases

CTDi55074
MGIiMGI:2179326 Oxr1

Phylogenomic databases

eggNOGiKOG2372 Eukaryota
ENOG4111QBZ LUCA
GeneTreeiENSGT00410000025363
HOGENOMiHOG000060321
HOVERGENiHBG065488
InParanoidiQ4KMM3
OrthoDBiEOG091G0L15
PhylomeDBiQ4KMM3
TreeFamiTF313530

Miscellaneous databases

ChiTaRSiOxr1 mouse
PROiPR:Q4KMM3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022307 Expressed in 273 organ(s), highest expression level in medial dorsal nucleus of thalamus
CleanExiMM_OXR1
ExpressionAtlasiQ4KMM3 baseline and differential
GenevisibleiQ4KMM3 MM

Family and domain databases

CDDicd00118 LysM, 1 hit
Gene3Di3.10.350.10, 1 hit
InterProiView protein in InterPro
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF01476 LysM, 1 hit
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00257 LysM, 1 hit
SM00584 TLDc, 1 hit
PROSITEiView protein in PROSITE
PS51782 LYSM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOXR1_MOUSE
AccessioniPrimary (citable) accession number: Q4KMM3
Secondary accession number(s): Q5FWW1
, Q99L06, Q99MK1, Q99MP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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