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Entry version 73 (16 Jan 2019)
Sequence version 2 (12 Apr 2017)
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Protein

GRB10-interacting GYF protein 2

Gene

gigyf2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRB10-interacting GYF protein 2
Alternative name(s):
PERQ amino acid-rich with GYF domain-containing protein 2
Trinucleotide repeat-containing gene 15 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gigyf2
Synonyms:perq2, tnrc15
ORF Names:zgc:111944
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050706-185 gigyf2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Morpholino knockdown show mild, intermediate, and severe phenotypes. Embryos with severe phenotype display a disrupted body pattern, embryos with intermediate phenotype show defects in the head and eye structures, while embryos with mild phenotype only show a twist in the terminal part of the tail. Embryos do not show important cell loss in diencephalic dopaminergic (DA) neuron clusters.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002708391 – 1329GRB10-interacting GYF protein 2Add BLAST1329

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4KME6

PRoteomics IDEntifications database

More...
PRIDEi
Q4KME6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Maternally expressed: detected from the 1-cell stage, prior to the onset of zygotic expression. From blastula until gastrula stages, strongly expressed throughout the blastoderm. At 28 hours post-fertilization (hpf), highly expressed in the central nervous system (CNS), whereas a weaker expression is found in the somites. At later stages of development (48 hpf), expression persists in well-defined structures of the CNS, such as the diencephalon, the mesencephalon, the cerebellum and the rhombencephalon, and remains detectable in the somites.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000009735 Expressed in 34 organ(s), highest expression level in female gonad

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 4EHP-GYF2 complex (By similarity).By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000056276

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q4KME6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4KME6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini556 – 604GYFPROSITE-ProRule annotationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi119 – 276Arg-richAdd BLAST158
Compositional biasi451 – 486Pro-richAdd BLAST36
Compositional biasi630 – 1059Gln-richAdd BLAST430
Compositional biasi773 – 919Glu-richAdd BLAST147
Compositional biasi1238 – 1282Gln-richAdd BLAST45

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIGYF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1862 Eukaryota
ENOG4111Q0Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290720

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082121

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4KME6

KEGG Orthology (KO)

More...
KOi
K18730

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLQDQYL

Database of Orthologous Groups

More...
OrthoDBi
412069at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4KME6

TreeFam database of animal gene trees

More...
TreeFami
TF325513

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072 GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003169 GYF
IPR035445 GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213 GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444 GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277 SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829 GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4KME6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAETQTLNFG PEWLRALAGG VGSSIVASPP LSPALPKYKL ADYRYGREEM
60 70 80 90 100
LALYVKDNMI PVDLHDKEFL PILQEEPLPP LALVPFTEEE QRNFSMSVNS
110 120 130 140 150
AAVLRLTGRG GGTVAGAPRG RSSSRGRGRG RGDGFYQRSF DDVEGGFGRG
160 170 180 190 200
GREMHRSQSW EERGDRRFEK PGRKDPDGAP AHFPLNHIRA NYEDPAAVNA
210 220 230 240 250
RKFIHAECDN WRTTRDELNG EEDDNGWRLA GARRENERWC PPSPDGPRSA
260 270 280 290 300
GWREHPDQRR RFGFGDEERS GYRRPRSGSG SAEEERDSLP EWCLEDAEEE
310 320 330 340 350
TGTFDSSGAF LSLKVRALEK APKEPILEEA ELDFRPLEEN DEYAEKDDSE
360 370 380 390 400
TEQTKDTDTN TRHESDRNEE NCKSEEPSPV AVPFSAVVTP PKATTPAPIQ
410 420 430 440 450
PVHLEKAEDK ERPSERTTLP EIRHELSKAP LHTALSNSIV EAISIPHVAN
460 470 480 490 500
KLPDLPVPAP SVLPVKSVPP QSQQVKPIEM PVSVPPALLR STGSVGPISR
510 520 530 540 550
PSALPSDLDE DEGLKHFEQE AEKMVAYLQD GGVDDERLAS KIGPKPSALP
560 570 580 590 600
ITNEAAFKWF YKDPQGEIQG PFNNQEMSEW FQAGYFTMTL QVKRGCDEMF
610 620 630 640 650
QPLGEMIKLW GRVPFTPGPT LPPILGDADQ ERMKRQQEIN ALNMYQLQQM
660 670 680 690 700
QYQYLLRQQY ALQQKVLNSA PPPPPPPQQQ LNLLLHQALK IRTPEPQQSL
710 720 730 740 750
LPPVTRSMSV PDSGSVWEMQ NPSTQASCSP NMQPAAPSTW EGSSVWDLPL
760 770 780 790 800
DNMPQASSIE QLQLEKAKAL KLEMERREAE LRAKREEEER KRLEEALRAR
810 820 830 840 850
QEEERKRLEE EELARRKQEE ALKRQREQEE AQRRKKEEEE RLAQEEALRR
860 870 880 890 900
LEERRREEEE RRQREEFLRK QQEEERRKQE ELEAQRRREE EKRLEEEAAA
910 920 930 940 950
AAAALLRQQQ EEQKKREQEA QRQQELQRQR QQQQEALRRL QQQQQQQQLA
960 970 980 990 1000
QMKLPSSSKW GQQSTTANSL SQSQNALSLA EIQKLEEERE RQTREEQRRQ
1010 1020 1030 1040 1050
QQELQRVQQQ QPQTKLPGWG SVAKQPMATK SLLEIQREEA QQMKQRKDQQ
1060 1070 1080 1090 1100
QQQQQQQQPP PQPQPQQHST NTQQNRTQNR AAINTSVWGS VNNVSSNWMM
1110 1120 1130 1140 1150
DSSVWGDTQN SNIGFWDEAV KEAAPPQTTR KSHTPKNKGN ANLSNSSSGK
1160 1170 1180 1190 1200
ASKKVEEEEK LLKLFQGANK NQDGFMQWCE QTLHTLNTAN NLDVPTFASF
1210 1220 1230 1240 1250
LKEVDSPYEV HDYVRAYLGD TPQAKDFAKQ FLERRAKQND NQQKPQQGQQ
1260 1270 1280 1290 1300
QKQQESVWGI REVPQSVLLQ QQQQQQLQQQ QQQRFETVTS GKKKKKQKMV
1310 1320
RADPSLLGFS VNASSERLNM GEIETVEDF
Length:1,329
Mass (Da):152,268
Last modified:April 12, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB974D4BEB2E8992F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti159S → N in AAH98603 (Ref. 2) Curated1
Sequence conflicti363H → Q in AAH98603 (Ref. 2) Curated1
Sequence conflicti388V → D in AAH98603 (Ref. 2) Curated1
Sequence conflicti597D → V in AAH98603 (Ref. 2) Curated1
Sequence conflicti914K → E in AAH98603 (Ref. 2) Curated1
Sequence conflicti1048D → DQQQQQQQ in AAH98603 (Ref. 2) Curated1
Sequence conflicti1071N → I in AAH98603 (Ref. 2) Curated1
Sequence conflicti1275 – 1277QQL → LQ in AAH98603 (Ref. 2) Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX677676 Genomic DNA No translation available.
BX890560 Genomic DNA No translation available.
BX890608 Genomic DNA No translation available.
BC098603 mRNA Translation: AAH98603.1

NCBI Reference Sequences

More...
RefSeqi
NP_001025332.2, NM_001030161.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.11432

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000056277; ENSDARP00000056276; ENSDARG00000009735

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
561830

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:561830

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX677676 Genomic DNA No translation available.
BX890560 Genomic DNA No translation available.
BX890608 Genomic DNA No translation available.
BC098603 mRNA Translation: AAH98603.1
RefSeqiNP_001025332.2, NM_001030161.2
UniGeneiDr.11432

3D structure databases

ProteinModelPortaliQ4KME6
SMRiQ4KME6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056276

Proteomic databases

PaxDbiQ4KME6
PRIDEiQ4KME6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000056277; ENSDARP00000056276; ENSDARG00000009735
GeneIDi561830
KEGGidre:561830

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26058
ZFINiZDB-GENE-050706-185 gigyf2

Phylogenomic databases

eggNOGiKOG1862 Eukaryota
ENOG4111Q0Y LUCA
GeneTreeiENSGT00940000156108
HOGENOMiHOG000290720
HOVERGENiHBG082121
InParanoidiQ4KME6
KOiK18730
OMAiMLQDQYL
OrthoDBi412069at2759
PhylomeDBiQ4KME6
TreeFamiTF325513

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q4KME6

Gene expression databases

BgeeiENSDARG00000009735 Expressed in 34 organ(s), highest expression level in female gonad

Family and domain databases

CDDicd00072 GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169 GYF
IPR035445 GYF-like_dom_sf
PfamiView protein in Pfam
PF02213 GYF, 1 hit
SMARTiView protein in SMART
SM00444 GYF, 1 hit
SUPFAMiSSF55277 SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829 GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGYF2_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4KME6
Secondary accession number(s): B0S7J5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: April 12, 2017
Last modified: January 16, 2019
This is version 73 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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