Sec22b

Functionⁱ

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.By similarity2 Publications

GO - Molecular functionⁱ

SNAP receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10930465

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ER to Golgi vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of autophagosome assembly Source: Ensembl
positive regulation of protein catabolic process Source: Ensembl
protein transport Source: UniProtKB-KW
retrograde vesicle-mediated transport, Golgi to ER
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vesicle fusion with Golgi apparatus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Protein transport, Transport

Biological process

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-RNO-1236974 ER-Phagosome pathway R-RNO-204005 COPII-mediated vesicle transport R-RNO-5694530 Cargo concentration in the ER R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Reactomeⁱ

R-RNO-1236974 ER-Phagosome pathway
R-RNO-204005 COPII-mediated vesicle transport
R-RNO-5694530 Cargo concentration in the ER
R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vesicle-trafficking protein SEC22b Alternative name(s): ER-Golgi SNARE of 24 kDa Short name: ERS-24 Short name: ERS24 SEC22 vesicle-trafficking protein homolog B SEC22 vesicle-trafficking protein-like 1
Gene namesⁱ	Name:Sec22b Synonyms:Sec22l1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 2

Organism-specific databases

Rat genome database More...RGDⁱ	1309988 Sec22b

RGDⁱ

1309988 Sec22b

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Topological domainⁱ	1 – 194	CytoplasmicSequence analysisAdd BLAST		194
Transmembraneⁱ	195 – 215	Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000253048	1 – 215	Vesicle-trafficking protein SEC22bAdd BLAST		215

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	38	N6-acetyllysineBy similarity	1
Modified residueⁱ	137	PhosphoserineCombined sources	1
Modified residueⁱ	140	PhosphothreonineBy similarity	1
Modified residueⁱ	164	PhosphoserineBy similarity	1
Modified residueⁱ	168	PhosphoserineCombined sources	1
Modified residueⁱ	174	PhosphoserineBy similarity	1
Modified residueⁱ	177	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q4KM74
PRIDEⁱ	Q4KM74

PTM databases

iPTMnetⁱ	Q4KM74
PhosphoSitePlusⁱ	Q4KM74

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000018673 Expressed in 9 organ(s), highest expression level in liver
Genevisibleⁱ	Q4KM74 RN

Interactionⁱ

Subunit structureⁱ

Interacts with STX17 (Probable). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B as subunit of either complex. Interacts with the COPII Sec23/24 complex composed of SEC23A and SEC24A; recruits SEC22B into COPII-coated vesicles to allow its transport from the endoplasmic reticulum to the Golgi (By similarity).By similarity1 Publication1 Publication

GO - Molecular functionⁱ

SNAP receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10930465

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	259729, 1 interactor
CORUMⁱ	Q4KM74
IntActⁱ	Q4KM74, 5 interactors
STRINGⁱ	10116.ENSRNOP00000025327

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q4KM74
SMRⁱ	Q4KM74
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 119	LonginPROSITE-ProRule annotationAdd BLAST		114
Domainⁱ	134 – 194	v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the synaptobrevin family.Sequence analysis

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0862 Eukaryota COG5143 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000046833
HOGENOMⁱ	HOG000044957
HOVERGENⁱ	HBG052748
InParanoidⁱ	Q4KM74
KEGG Orthology (KO) More...KOⁱ	K08517
OMAⁱ	DVTRIMV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MPE
PhylomeDBⁱ	Q4KM74
TreeFamⁱ	TF105933

Family and domain databases

InterProⁱ	View protein in InterPro IPR011012 Longin-like_dom_sf IPR010908 Longin_dom IPR001388 Synaptobrevin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13774 Longin, 1 hit PF00957 Synaptobrevin, 1 hit
PRINTSⁱ	PR00219 SYNAPTOBREVN
SMARTⁱ	View protein in SMART SM01270 Longin, 1 hit
SUPFAMⁱ	SSF64356 SSF64356, 1 hit
PROSITEⁱ	View protein in PROSITE PS50859 LONGIN, 1 hit PS50892 V_SNARE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4KM74-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT 
        60         70         80         90        100
RCTLEAGAMT FHYIIEQGVC YLVLCEAAFP KKLAFAYLED LHSEFDEQHG 
       110        120        130        140        150
KKVPTVSRPY SFIEFDTFIQ KTKKLYIDSR ARRNLGSINT ELQDVQRIMV 
       160        170        180        190        200
ANIEEVLQRG EALSALDSKA NNLSSLSKKY RQDAKYLNMR STYAKLAAVA 
       210 
VFFIMLIVYV RFWWL

Length:215

Mass (Da):24,741

Last modified:January 23, 2007 - v3

Checksum:ⁱ29B4C55961C5A044

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC098725 mRNA Translation: AAH98725.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001020857.1, NM_001025686.1
UniGeneⁱ	Rn.102384

Genome annotation databases

Ensemblⁱ	ENSRNOT00000025327; ENSRNOP00000025327; ENSRNOG00000018673
GeneIDⁱ	310710
KEGGⁱ	rno:310710
UCSC genome browser More...UCSCⁱ	RGD:1309988 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q4KM74	Vesicle-trafficking protein SEC22b	)	MOUSE		215	UniRef100_O08547
Vesicle-trafficking protein SEC22b		PONAB		215
SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)		MACMU		215
SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)		CALJA		215
SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)		MACFA		215
+23

Protein	Similar proteins		Species	Score	Length	Source
Q4KM74	Vesicle-trafficking protein SEC22b	)	MOUSE		215	UniRef90_O08547
Vesicle-trafficking protein SEC22b		PONAB		215
Vesicle-trafficking protein SEC22b		CHICK		215
Vesicle-trafficking protein SEC22b		CRIGR		215
SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)		MACMU		215
+199

Protein	Similar proteins		Species	Score	Length	Source
Q4KM74	Vesicle-trafficking protein SEC22b	)	HUMAN		215	UniRef50_O75396
Vesicle-trafficking protein SEC22b		XENTR		215
Vesicle-trafficking protein SEC22b		CRIGR		215
Vesicle-trafficking protein SEC22b	)	MOUSE		215
Vesicle-trafficking protein SEC22b		PONAB		215
+278

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC098725 mRNA Translation: AAH98725.1
RefSeqⁱ	NP_001020857.1, NM_001025686.1
UniGeneⁱ	Rn.102384

3D structure databases

ProteinModelPortalⁱ	Q4KM74
SMRⁱ	Q4KM74
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	259729, 1 interactor
CORUMⁱ	Q4KM74
IntActⁱ	Q4KM74, 5 interactors
STRINGⁱ	10116.ENSRNOP00000025327

PTM databases

iPTMnetⁱ	Q4KM74
PhosphoSitePlusⁱ	Q4KM74

Proteomic databases

PaxDbⁱ	Q4KM74
PRIDEⁱ	Q4KM74

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000025327; ENSRNOP00000025327; ENSRNOG00000018673
GeneIDⁱ	310710
KEGGⁱ	rno:310710
UCSCⁱ	RGD:1309988 rat

Organism-specific databases

CTDⁱ	9554
RGDⁱ	1309988 Sec22b

Phylogenomic databases

eggNOGⁱ	KOG0862 Eukaryota COG5143 LUCA
GeneTreeⁱ	ENSGT00510000046833
HOGENOMⁱ	HOG000044957
HOVERGENⁱ	HBG052748
InParanoidⁱ	Q4KM74
KOⁱ	K08517
OMAⁱ	DVTRIMV
OrthoDBⁱ	EOG091G0MPE
PhylomeDBⁱ	Q4KM74
TreeFamⁱ	TF105933

Enzyme and pathway databases

Reactomeⁱ	R-RNO-1236974 ER-Phagosome pathway R-RNO-204005 COPII-mediated vesicle transport R-RNO-5694530 Cargo concentration in the ER R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Reactomeⁱ

R-RNO-1236974 ER-Phagosome pathway
R-RNO-204005 COPII-mediated vesicle transport
R-RNO-5694530 Cargo concentration in the ER
R-RNO-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q4KM74

PROⁱ

PR:Q4KM74

Gene expression databases

Bgeeⁱ	ENSRNOG00000018673 Expressed in 9 organ(s), highest expression level in liver
Genevisibleⁱ	Q4KM74 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR011012 Longin-like_dom_sf IPR010908 Longin_dom IPR001388 Synaptobrevin
Pfamⁱ	View protein in Pfam PF13774 Longin, 1 hit PF00957 Synaptobrevin, 1 hit
PRINTSⁱ	PR00219 SYNAPTOBREVN
SMARTⁱ	View protein in SMART SM01270 Longin, 1 hit
SUPFAMⁱ	SSF64356 SSF64356, 1 hit
PROSITEⁱ	View protein in PROSITE PS50859 LONGIN, 1 hit PS50892 V_SNARE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SC22B_RAT
Accessionⁱ	Q4KM74Primary (citable) accession number: Q4KM74
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - Q4KM74 (SC22B_RAT)

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Vesicle-trafficking protein SEC22b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ