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Protein

Cyclin-dependent kinase 10

Gene

Cdk10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66ATPPROSITE-ProRule annotation1
Active sitei161Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 51ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 10 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 10
Gene namesi
Name:Cdk10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1304851 Cdk10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002610291 – 358Cyclin-dependent kinase 10Add BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4KM47

PTM databases

iPTMnetiQ4KM47
PhosphoSitePlusiQ4KM47

Interactioni

Subunit structurei

Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059465

Structurei

3D structure databases

ProteinModelPortaliQ4KM47
SMRiQ4KM47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 321Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0663 Eukaryota
ENOG410XQ50 LUCA
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ4KM47
KOiK02449
PhylomeDBiQ4KM47

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KM47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQCQIWVRH HLCCSFQIPT LAASLFQLGR CRSVKEFEKL NRIGEGTYGI
60 70 80 90 100
VYRARDTQTD EIVALKKVRM DKEKDGIPIS SLREITLLLR LRHPNIVELK
110 120 130 140 150
EVVVGNHLES IFLVMGYCEQ DLASLLENMP TPFSEAQVKC ILLQVLRGLQ
160 170 180 190 200
YLHRSFIIHR DLKVSNLLMT DKGCVKTADF GLARAYGVPV KPMTPKVVTL
210 220 230 240 250
WYRAPELLLG TTTQTTSIDM WAVGCILAEL LAHKPLLPGT SEIHQIDLIV
260 270 280 290 300
QLLGTPSENI WPGFSKLPLA GQYSLRKQPY NNLKHKFPWL SEAGLRLLNF
310 320 330 340 350
LFMYDPKKRA TAGDCLESSY FKEKPLPCEP ELMPTFPHHR NKRAAPAATE

GQSKRCRP
Length:358
Mass (Da):40,634
Last modified:August 2, 2005 - v1
Checksum:iF10590B86C4D4782
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098804 mRNA Translation: AAH98804.1
RefSeqiNP_001020893.2, NM_001025722.2
NP_001103406.1, NM_001109936.1
NP_001103407.1, NM_001109937.1
UniGeneiRn.20472

Genome annotation databases

GeneIDi361434
KEGGirno:361434
UCSCiRGD:1304851 rat

Similar proteinsi

Entry informationi

Entry nameiCDK10_RAT
AccessioniPrimary (citable) accession number: Q4KM47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: August 2, 2005
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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