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UniProtKB - Q4KM34 (CDK20_RAT)
Protein
Cyclin-dependent kinase 20
Gene
Cdk20
Organism
Rattus norvegicus (Rat)
Status
Functioni
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity).
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 127 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- embryonic brain development Source: RGD
- embryonic camera-type eye development Source: RGD
- embryonic skeletal system development Source: RGD
- floor plate formation Source: RGD
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: RGD
- neural tube closure Source: RGD
- protein localization to cilium Source: RGD
- protein phosphorylation Source: GO_Central
- regulation of protein maturation Source: RGD
- regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: RGD
- roof of mouth development Source: RGD
Keywordsi
Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 20 (EC:2.7.11.22)Alternative name(s): Cell cycle-related kinase Cell division protein kinase 20 |
Gene namesi | Name:Cdk20 Synonyms:Ccrk |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1305219, Cdk20 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085705 | 1 – 346 | Cyclin-dependent kinase 20Add BLAST | 346 |
Proteomic databases
jPOSTi | Q4KM34 |
PaxDbi | Q4KM34 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000017991, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | Q4KM34, RN |
Interactioni
Subunit structurei
Monomer.
Interacts with TBC1D32 and MAK.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024466 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 288 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 285 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 298 – 324 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 298 – 316 | Pro residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0659, Eukaryota |
GeneTreei | ENSGT00940000159128 |
HOGENOMi | CLU_000288_181_1_1 |
InParanoidi | Q4KM34 |
OMAi | YGARYYT |
OrthoDBi | 1367115at2759 |
PhylomeDBi | Q4KM34 |
TreeFami | TF327240 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4KM34-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR
60 70 80 90 100
EIKALQEIED SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA
110 120 130 140 150
PAQVKSYLQM LLKGVAFCHA NNIVHRDLKP ANLLISASGQ LKIADFGLAR
160 170 180 190 200
VFSPDGGRLY THQVATRWYR APELLYGARQ YDQGVDLWAV GCIMGELLNG
210 220 230 240 250
SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI SFKEQAPVPL
260 270 280 290 300
EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL
310 320 330 340
PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC098838 mRNA Translation: AAH98838.1 Sequence problems. |
RefSeqi | NP_001020923.2, NM_001025752.2 |
Genome annotation databases
Ensembli | ENSRNOT00000024466; ENSRNOP00000024466; ENSRNOG00000017991 |
GeneIDi | 364666 |
KEGGi | rno:364666 |
UCSCi | RGD:1305219, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC098838 mRNA Translation: AAH98838.1 Sequence problems. |
RefSeqi | NP_001020923.2, NM_001025752.2 |
3D structure databases
SMRi | Q4KM34 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000024466 |
Proteomic databases
jPOSTi | Q4KM34 |
PaxDbi | Q4KM34 |
Genome annotation databases
Ensembli | ENSRNOT00000024466; ENSRNOP00000024466; ENSRNOG00000017991 |
GeneIDi | 364666 |
KEGGi | rno:364666 |
UCSCi | RGD:1305219, rat |
Organism-specific databases
CTDi | 23552 |
RGDi | 1305219, Cdk20 |
Phylogenomic databases
eggNOGi | KOG0659, Eukaryota |
GeneTreei | ENSGT00940000159128 |
HOGENOMi | CLU_000288_181_1_1 |
InParanoidi | Q4KM34 |
OMAi | YGARYYT |
OrthoDBi | 1367115at2759 |
PhylomeDBi | Q4KM34 |
TreeFami | TF327240 |
Miscellaneous databases
PROi | PR:Q4KM34 |
Gene expression databases
Bgeei | ENSRNOG00000017991, Expressed in skeletal muscle tissue and 21 other tissues |
Genevisiblei | Q4KM34, RN |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDK20_RAT | |
Accessioni | Q4KM34Primary (citable) accession number: Q4KM34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families