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Protein
Submitted name:

Transcription factor EB

Gene

Tfeb

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Transcription factor EBImported
Submitted name:
Transcription factor EB, isoform CRA_cImported
Gene namesi
Name:TfebImported
Synonyms:TcfebImported
ORF Names:rCG_43444Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1309583 Tfeb

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 347BHLHInterPro annotationAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili67 – 87Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410INSB Eukaryota
ENOG410XS3U LUCA
HOGENOMiHOG000231368
HOVERGENiHBG006768
KOiK15590
OrthoDBiEOG091G0QCO
TreeFamiTF317174

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR031867 MiT/TFE_N
IPR024098 TFEB
PANTHERiPTHR12565 PTHR12565, 1 hit
PTHR12565:SF133 PTHR12565:SF133, 1 hit
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q4KLM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLAQRSWA NPFCPDSVSP YAQWEQPYLG QPTLKDSEDD EYFMDLSSLD
60 70 80 90 100
CREPESTAAM ASRIGLRMQL MREQAQQEEQ RERMQQQAVM HYMQQQQQQQ
110 120 130 140 150
QQQLGGPPTP AINTPVHFQS PPPVPGEVLK VQSYLENPTS YHLQQSQHQK
160 170 180 190 200
VREYLSETYG NKFAAHVSPA QGSPKPPPAA SPGVRAGHVL STSAGNSAPN
210 220 230 240 250
SPMAMLHISS NPEKEFDDVI DNIMRLDSVL GYINPEMQMP NTLPLSSSHL
260 270 280 290 300
NVYSGDPQVT ASLVGVTSSS CPADLTQKRE LTDAESRALA KERQKKDNHN
310 320 330 340 350
LIERRRRFNI NDRIKELGML IPKANDLDVR WNKGTILKAS VDYIRRMQKD
360 370 380 390 400
LQKSRELENH SRRLEMTNKQ LWLRIQELEM QARVHGLPTT SPSGVNMAEL
410 420 430 440 450
AQQVVKQELP SEDNPGETLM LGSEVPDPEP MPALPPQAPL PSAAQPQSPF
460 470 480 490 500
HHLDFSHGLS FGGGGDEGPA GYPDPLGTEH GSPFPNLSKK DLDLMLLDDS
510 520 530
LLPLASDPLF STMSPEASKA SSRRSSFSME EGDVL
Length:535
Mass (Da):59,448
Last modified:August 2, 2005 - v1
Checksum:i6C6B2E3344F4DF20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099102 mRNA Translation: AAH99102.1
CH473987 Genomic DNA Translation: EDM18901.1
RefSeqiNP_001020878.1, NM_001025707.1
UniGeneiRn.22098

Genome annotation databases

GeneIDi316214
KEGGirno:316214
UCSCiRGD:1309583 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099102 mRNA Translation: AAH99102.1
CH473987 Genomic DNA Translation: EDM18901.1
RefSeqiNP_001020878.1, NM_001025707.1
UniGeneiRn.22098

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi316214
KEGGirno:316214
UCSCiRGD:1309583 rat

Organism-specific databases

CTDi7942
RGDi1309583 Tfeb

Phylogenomic databases

eggNOGiENOG410INSB Eukaryota
ENOG410XS3U LUCA
HOGENOMiHOG000231368
HOVERGENiHBG006768
KOiK15590
OrthoDBiEOG091G0QCO
TreeFamiTF317174

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR031867 MiT/TFE_N
IPR024098 TFEB
PANTHERiPTHR12565 PTHR12565, 1 hit
PTHR12565:SF133 PTHR12565:SF133, 1 hit
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ4KLM8_RAT
AccessioniPrimary (citable) accession number: Q4KLM8
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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