The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q4KLM8 (Q4KLM8_RAT)
Protein
Submitted name:
Transcription factor EB
Gene
Tfeb
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- enzyme binding Source: RGD
- protein heterodimerization activity Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- transcription cis-regulatory region binding Source: RGD
GO - Biological processi
- cellular response to amino acid starvation Source: RGD
- cellular response to starvation Source: RGD
- defense response to Gram-negative bacterium Source: RGD
- embryonic placenta development Source: RGD
- humoral immune response Source: RGD
- lysosome localization Source: RGD
- lysosome organization Source: RGD
- positive regulation of autophagy Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of gene expression Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor EBImportedSubmitted name: Transcription factor EB, isoform CRA_cImported |
Gene namesi | ORF Names:rCG_43444Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Organism-specific databases
RGDi | 1309583, Tfeb |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol Source: RGD
Lysosome
- lysosomal membrane Source: RGD
Nucleus
- nucleus Source: RGD
Other locations
- cytoplasm Source: RGD
- transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationInteractioni
GO - Molecular functioni
- enzyme binding Source: RGD
- protein heterodimerization activity Source: RGD
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 294 – 347 | BHLHInterPro annotationAdd BLAST | 54 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 166 – 185 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 410 – 489 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 505 – 535 | DisorderedSequence analysisAdd BLAST | 31 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 67 – 87 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 428 – 443 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 511 – 528 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the MiT/TFE family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_031638_3_1_1 |
OrthoDBi | 1211990at2759 |
TreeFami | TF317174 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR021802, MiT/TFE_C IPR031867, MiT/TFE_N IPR024098, TFEB |
PANTHERi | PTHR45776:SF5, PTHR45776:SF5, 1 hit |
Pfami | View protein in Pfam PF11851, DUF3371, 1 hit PF00010, HLH, 1 hit PF15951, MITF_TFEB_C_3_N, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4KLM8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQLAQRSWA NPFCPDSVSP YAQWEQPYLG QPTLKDSEDD EYFMDLSSLD
60 70 80 90 100
CREPESTAAM ASRIGLRMQL MREQAQQEEQ RERMQQQAVM HYMQQQQQQQ
110 120 130 140 150
QQQLGGPPTP AINTPVHFQS PPPVPGEVLK VQSYLENPTS YHLQQSQHQK
160 170 180 190 200
VREYLSETYG NKFAAHVSPA QGSPKPPPAA SPGVRAGHVL STSAGNSAPN
210 220 230 240 250
SPMAMLHISS NPEKEFDDVI DNIMRLDSVL GYINPEMQMP NTLPLSSSHL
260 270 280 290 300
NVYSGDPQVT ASLVGVTSSS CPADLTQKRE LTDAESRALA KERQKKDNHN
310 320 330 340 350
LIERRRRFNI NDRIKELGML IPKANDLDVR WNKGTILKAS VDYIRRMQKD
360 370 380 390 400
LQKSRELENH SRRLEMTNKQ LWLRIQELEM QARVHGLPTT SPSGVNMAEL
410 420 430 440 450
AQQVVKQELP SEDNPGETLM LGSEVPDPEP MPALPPQAPL PSAAQPQSPF
460 470 480 490 500
HHLDFSHGLS FGGGGDEGPA GYPDPLGTEH GSPFPNLSKK DLDLMLLDDS
510 520 530
LLPLASDPLF STMSPEASKA SSRRSSFSME EGDVL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC099102 mRNA Translation: AAH99102.1 CH473987 Genomic DNA Translation: EDM18901.1 |
RefSeqi | NP_001020878.1, NM_001025707.1 |
Genome annotation databases
GeneIDi | 316214 |
KEGGi | rno:316214 |
UCSCi | RGD:1309583, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC099102 mRNA Translation: AAH99102.1 CH473987 Genomic DNA Translation: EDM18901.1 |
RefSeqi | NP_001020878.1, NM_001025707.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 316214 |
KEGGi | rno:316214 |
UCSCi | RGD:1309583, rat |
Organism-specific databases
CTDi | 7942 |
RGDi | 1309583, Tfeb |
Phylogenomic databases
HOGENOMi | CLU_031638_3_1_1 |
OrthoDBi | 1211990at2759 |
TreeFami | TF317174 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR021802, MiT/TFE_C IPR031867, MiT/TFE_N IPR024098, TFEB |
PANTHERi | PTHR45776:SF5, PTHR45776:SF5, 1 hit |
Pfami | View protein in Pfam PF11851, DUF3371, 1 hit PF00010, HLH, 1 hit PF15951, MITF_TFEB_C_3_N, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4KLM8_RAT | |
Accessioni | Q4KLM8Primary (citable) accession number: Q4KLM8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 2, 2005 |
Last sequence update: | August 2, 2005 | |
Last modified: | January 19, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |