Tfeb

Functionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

humoral immune response Source: InterPro
positive regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Transcription factor EBImported Submitted name: Transcription factor EB, isoform CRA_cImported
Gene namesⁱ	Name:TfebImported Synonyms:TcfebImported ORF Names:rCG_43444Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus

Organism-specific databases

Rat genome database More...RGDⁱ	1309583 Tfeb

RGDⁱ

1309583 Tfeb

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	294 – 347	BHLHInterPro annotationAdd BLAST		54

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	67 – 87	Sequence analysisAdd BLAST		21

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410INSB Eukaryota ENOG410XS3U LUCA
HOGENOMⁱ	HOG000231368
HOVERGENⁱ	HBG006768
KEGG Orthology (KO) More...KOⁱ	K15590
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QCO
TreeFamⁱ	TF317174

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR024097 bHLH_ZIP_TF IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR031867 MiT/TFE_N IPR024098 TFEB
PANTHERⁱ	PTHR12565 PTHR12565, 1 hit PTHR12565:SF133 PTHR12565:SF133, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4KLM8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQLAQRSWA NPFCPDSVSP YAQWEQPYLG QPTLKDSEDD EYFMDLSSLD 
        60         70         80         90        100
CREPESTAAM ASRIGLRMQL MREQAQQEEQ RERMQQQAVM HYMQQQQQQQ 
       110        120        130        140        150
QQQLGGPPTP AINTPVHFQS PPPVPGEVLK VQSYLENPTS YHLQQSQHQK 
       160        170        180        190        200
VREYLSETYG NKFAAHVSPA QGSPKPPPAA SPGVRAGHVL STSAGNSAPN 
       210        220        230        240        250
SPMAMLHISS NPEKEFDDVI DNIMRLDSVL GYINPEMQMP NTLPLSSSHL 
       260        270        280        290        300
NVYSGDPQVT ASLVGVTSSS CPADLTQKRE LTDAESRALA KERQKKDNHN 
       310        320        330        340        350
LIERRRRFNI NDRIKELGML IPKANDLDVR WNKGTILKAS VDYIRRMQKD 
       360        370        380        390        400
LQKSRELENH SRRLEMTNKQ LWLRIQELEM QARVHGLPTT SPSGVNMAEL 
       410        420        430        440        450
AQQVVKQELP SEDNPGETLM LGSEVPDPEP MPALPPQAPL PSAAQPQSPF 
       460        470        480        490        500
HHLDFSHGLS FGGGGDEGPA GYPDPLGTEH GSPFPNLSKK DLDLMLLDDS 
       510        520        530 
LLPLASDPLF STMSPEASKA SSRRSSFSME EGDVL

Length:535

Mass (Da):59,448

Last modified:August 2, 2005 - v1

Checksum:ⁱ6C6B2E3344F4DF20

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC099102 mRNA Translation: AAH99102.1 CH473987 Genomic DNA Translation: EDM18901.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001020878.1, NM_001025707.1
UniGeneⁱ	Rn.22098

Genome annotation databases

GeneIDⁱ	316214
KEGGⁱ	rno:316214
UCSC genome browser More...UCSCⁱ	RGD:1309583 rat

Protein	Similar proteins		Species	Score	Length	Source
Q4KLM8	Transcription factor EB		RAT		476	UniRef100_Q4KLM8

Protein	Similar proteins		Species	Score	Length	Source
Q4KLM8	Transcription factor EB		MOUSE		475	UniRef90_Q9R210
Transcription factor EB		RAT		476
transcription factor EB isoform X1		MESAU		531
Transcription factor EB		CRIGR		476
UPI00042AB031		PERMB		537
+17

Protein	Similar proteins		Species	Score	Length	Source
Q4KLM8	Transcription factor EB		MOUSE		475	UniRef50_Q9R210
Transcription factor EB		HUMAN		476
Transcription factor EB		RAT		476
transcription factor EB isoform X1		MESAU		531
Transcription factor EB		CRIGR		476
+323

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC099102 mRNA Translation: AAH99102.1 CH473987 Genomic DNA Translation: EDM18901.1
RefSeqⁱ	NP_001020878.1, NM_001025707.1
UniGeneⁱ	Rn.22098

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	316214
KEGGⁱ	rno:316214
UCSCⁱ	RGD:1309583 rat

Organism-specific databases

CTDⁱ	7942
RGDⁱ	1309583 Tfeb

Phylogenomic databases

eggNOGⁱ	ENOG410INSB Eukaryota ENOG410XS3U LUCA
HOGENOMⁱ	HOG000231368
HOVERGENⁱ	HBG006768
KOⁱ	K15590
OrthoDBⁱ	EOG091G0QCO
TreeFamⁱ	TF317174

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR024097 bHLH_ZIP_TF IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR031867 MiT/TFE_N IPR024098 TFEB
PANTHERⁱ	PTHR12565 PTHR12565, 1 hit PTHR12565:SF133 PTHR12565:SF133, 1 hit
Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q4KLM8_RAT
Accessionⁱ	Q4KLM8Primary (citable) accession number: Q4KLM8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	August 2, 2005
	Last sequence update:	August 2, 2005
	Last modified:	November 7, 2018
	This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q4KLM8 (Q4KLM8_RAT)

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Transcription factor EB

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

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Annotation systems

Supporting data

UniProtKB - Q4KLM8 (Q4KLM8_RAT)

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Transcription factor EB

Tfeb

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ