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Entry version 87 (02 Dec 2020)
Sequence version 1 (02 Aug 2005)
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Protein

Transmembrane 9 superfamily member 4

Gene

Tm9sf4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane 9 superfamily member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tm9sf4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
1307768, Tm9sf4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 282ExtracellularSequence analysisAdd BLAST259
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 347CytoplasmicSequence analysisAdd BLAST44
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 377ExtracellularSequence analysis9
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 417CytoplasmicSequence analysisAdd BLAST19
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 450ExtracellularSequence analysisAdd BLAST12
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
Topological domaini472 – 502CytoplasmicSequence analysisAdd BLAST31
Transmembranei503 – 523HelicalSequence analysisAdd BLAST21
Topological domaini524 – 536ExtracellularSequence analysisAdd BLAST13
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 571CytoplasmicSequence analysisAdd BLAST14
Transmembranei572 – 592HelicalSequence analysisAdd BLAST21
Topological domaini593 – 599ExtracellularSequence analysis7
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 643CytoplasmicSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031181224 – 643Transmembrane 9 superfamily member 4Add BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei313PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4KLL4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4KLL4

PRoteomics IDEntifications database

More...
PRIDEi
Q4KLL4

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q4KLL4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000009406, Expressed in liver and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4KLL4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4KLL4, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q4KLL4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000062975

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1278, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157198

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010714_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4KLL4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMVLTFW

Database of Orthologous Groups

More...
OrthoDBi
641127at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4KLL4

TreeFam database of animal gene trees

More...
TreeFami
TF354239

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004240, EMP70

The PANTHER Classification System

More...
PANTHERi
PTHR10766, PTHR10766, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02990, EMP70, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q4KLL4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAMIWWPR FLLLLCLTCK GSTFYVPGVA PINFHQNDPV EIKAVKLTSS
60 70 80 90 100
RTQLPYEYYS LPFCQPNKIT YKAENLGEVL RGDRIVNTPF QVLMNSEKKC
110 120 130 140 150
EVLCGQSNKP VILTVEQSRL VAERITEEYY VHLIADNLPV ATRLELYSSN
160 170 180 190 200
RDSDDKKKEK DVQFEHGYRL GFTDVNKIYL HNHLSFILYY HREDTEEDQE
210 220 230 240 250
HTYRVVRFEV IPQSIRLEDL KIDEKSSCTL PEGANSLPQE IDPTKENQLY
260 270 280 290 300
FTYSVHWEES DIKWASRWDT YLTMSDVQIH WFSIINSVVV VFFLSGILSM
310 320 330 340 350
IIIRTLRKDI ANYNKEDDIE DTMEESGWKL VHGDVFRPPQ YPMILSSLLG
360 370 380 390 400
SGIQLFCMIL IVIFVAMLGM LSPSSRGALM TTACFLFMFM GVFGGFSAGR
410 420 430 440 450
LYRTLKGHRW KKGAFCTATL YPGVVFGICF VLNCFIWGKH SSGAVPFPTM
460 470 480 490 500
VALLCMWFGI SLPLVYLGYY FGFRKQPYDN PVRTNQIPRQ IPEQRWYMNR
510 520 530 540 550
FVGILMAGIL PFGAMFIELF FIFSAIWENQ FYYLFGFLFL VFIILVVSCS
560 570 580 590 600
QISIVMVYFQ LCAEDYRWWW RNFLVSGGSA FYVLVYAIFY FVNKLDIVEF
610 620 630 640
IPSLLYFGYT TLMVLSFWLL TGTIGFYAAY MFVRKIYAAV KID
Length:643
Mass (Da):74,675
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D087E0F468402F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2KA25A0A0G2KA25_RAT
Transmembrane 9 superfamily member
Tm9sf4
643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC099133 mRNA Translation: AAH99133.1

NCBI Reference Sequences

More...
RefSeqi
NP_001020820.1, NM_001025649.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000067261; ENSRNOP00000062975; ENSRNOG00000009406

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
296279

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:296279

UCSC genome browser

More...
UCSCi
RGD:1307768, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099133 mRNA Translation: AAH99133.1
RefSeqiNP_001020820.1, NM_001025649.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ4KLL4, 1 interactor
STRINGi10116.ENSRNOP00000062975

PTM databases

SwissPalmiQ4KLL4

Proteomic databases

jPOSTiQ4KLL4
PaxDbiQ4KLL4
PRIDEiQ4KLL4

Genome annotation databases

EnsembliENSRNOT00000067261; ENSRNOP00000062975; ENSRNOG00000009406
GeneIDi296279
KEGGirno:296279
UCSCiRGD:1307768, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9777
RGDi1307768, Tm9sf4

Phylogenomic databases

eggNOGiKOG1278, Eukaryota
GeneTreeiENSGT00940000157198
HOGENOMiCLU_010714_4_1_1
InParanoidiQ4KLL4
OMAiLMVLTFW
OrthoDBi641127at2759
PhylomeDBiQ4KLL4
TreeFamiTF354239

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q4KLL4

Gene expression databases

BgeeiENSRNOG00000009406, Expressed in liver and 20 other tissues
ExpressionAtlasiQ4KLL4, baseline and differential
GenevisibleiQ4KLL4, RN

Family and domain databases

InterProiView protein in InterPro
IPR004240, EMP70
PANTHERiPTHR10766, PTHR10766, 1 hit
PfamiView protein in Pfam
PF02990, EMP70, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM9S4_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4KLL4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: August 2, 2005
Last modified: December 2, 2020
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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