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Protein

Zinc finger protein with KRAB and SCAN domains 1

Gene

Zkscan1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri376 – 398C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 1
Gene namesi
Name:Zkscan1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1560616 Zkscan1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477561 – 562Zinc finger protein with KRAB and SCAN domains 1Add BLAST562

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki227Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki278Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki302Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki411Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki439Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki477Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki559Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ4KLI1
PRIDEiQ4KLI1

PTM databases

iPTMnetiQ4KLI1
PhosphoSitePlusiQ4KLI1

Expressioni

Gene expression databases

BgeeiENSRNOG00000001335 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ4KLI1 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051042

Structurei

3D structure databases

ProteinModelPortaliQ4KLI1
SMRiQ4KLI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 138SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini226 – 305KRABAdd BLAST80

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri376 – 398C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ4KLI1
KOiK09229
OMAiSQGCENR
OrthoDBiEOG091G046Q
PhylomeDBiQ4KLI1
TreeFamiTF350830

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q4KLI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DASLQETPPP
60 70 80 90 100
DPEVFRQRFR RFCYQNTFGP REALNRLKEL CHQWLRPEVN TKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGVVPL DPVQESSSFD HHEAAQSHFK HSSRKPRLLS PRALPATHVP
210 220 230 240 250
APQHEGNPRD QAMASALLTA DSQAMVKIED MAVSLILEEW GCQNLARRNL
260 270 280 290 300
NRDSRQMNLG TVFSQGSENR NGSESTSKAE VKGDSTSHGE IAGRFQKEFG
310 320 330 340 350
EKREQQGRVI ERQQKNPEEK TGKEKKAPGP PTAKEKKPTT GERGPREKGK
360 370 380 390 400
GLGRSFSLSA NFNNTPEEIP SGAKTHRCDE CGKCFTRSSS LIRHKIIHTG
410 420 430 440 450
EKPYECNECG KAFSLNSNLV LHQRIHTGEK PHECNECGKA FSHSSNLILH
460 470 480 490 500
QRIHSGEKPY ECNECGKAFS QSSDLTKHQR IHTGEKPYEC SECGKAFNRN
510 520 530 540 550
SYLILHRRIH TREKPYKCTK CGKAFTRSST LTLHHRIHAR ERASEYSPAS
560
LDTFGAFLKS CV
Length:562
Mass (Da):63,365
Last modified:August 2, 2005 - v1
Checksum:i06DE99D78EBB4572
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099191 mRNA Translation: AAH99191.1
RefSeqiNP_001020931.1, NM_001025760.1
UniGeneiRn.113295

Genome annotation databases

EnsembliENSRNOT00000045379; ENSRNOP00000051042; ENSRNOG00000001335
GeneIDi498160
KEGGirno:498160
UCSCiRGD:1560616 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099191 mRNA Translation: AAH99191.1
RefSeqiNP_001020931.1, NM_001025760.1
UniGeneiRn.113295

3D structure databases

ProteinModelPortaliQ4KLI1
SMRiQ4KLI1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051042

PTM databases

iPTMnetiQ4KLI1
PhosphoSitePlusiQ4KLI1

Proteomic databases

PaxDbiQ4KLI1
PRIDEiQ4KLI1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045379; ENSRNOP00000051042; ENSRNOG00000001335
GeneIDi498160
KEGGirno:498160
UCSCiRGD:1560616 rat

Organism-specific databases

CTDi7586
RGDi1560616 Zkscan1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118881
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ4KLI1
KOiK09229
OMAiSQGCENR
OrthoDBiEOG091G046Q
PhylomeDBiQ4KLI1
TreeFamiTF350830

Enzyme and pathway databases

ReactomeiR-RNO-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:Q4KLI1

Gene expression databases

BgeeiENSRNOG00000001335 Expressed in 9 organ(s), highest expression level in adult mammalian kidney
GenevisibleiQ4KLI1 RN

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZKSC1_RAT
AccessioniPrimary (citable) accession number: Q4KLI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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