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Entry version 92 (07 Oct 2020)
Sequence version 1 (02 Aug 2005)
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Protein

Nuclear receptor corepressor 1

Gene

ncor1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates transcriptional repression by certain nuclear receptors. Participates in complexes which promote histone deacetylation and the formation of repressive chromatin structures which may impede access by the basal transcription machinery (By similarity). In association with hdac3, may play a role in the regulation of the circadian clock (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-3214815, HDACs deacetylate histones
R-XTR-350054, Notch-HLH transcription pathway
R-XTR-383280, Nuclear Receptor transcription pathway
R-XTR-400206, Regulation of lipid metabolism by PPARalpha
R-XTR-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-XTR-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor corepressor 1
Short name:
N-CoR
Short name:
N-CoR1
Short name:
xN-CoR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ncor1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-483288, ncor1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000556211 – 2494Nuclear receptor corepressor 1Add BLAST2494

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4KKX4

PRoteomics IDEntifications database

More...
PRIDEi
Q4KKX4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a large corepressor complex that contains sin3a/b, histone deacetylases hdac1 and hdac2, rbbp4 and possibly rbbp7.

Interacts with the thyroid receptor (TR, composed of rxra and thrb) and the retinoid acid receptor (RAR, composed of rxra and rara) in the absence of ligand.

Interacts with tbl1xr1.

Interacts with zbtb33/kaiso (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000014702

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4KKX4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini427 – 478SANT 1PROSITE-ProRule annotationAdd BLAST52
Domaini622 – 668SANT 2PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 304Interaction with tbl1xr1By similarityAdd BLAST151

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili168 – 208Sequence analysisAdd BLAST41
Coiled coili502 – 549Sequence analysisAdd BLAST48
Coiled coili698 – 726Sequence analysisAdd BLAST29
Coiled coili1771 – 1810Sequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2008 – 2012CORNR box 15
Motifi2119 – 2123CORNR box 25
Motifi2322 – 2326CORNR box 35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi504 – 537Glu-richAdd BLAST34
Compositional biasi594 – 611Thr-richAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CORNR box motifs in the C-terminal region may be necessary and sufficient for binding to unligated nuclear hormone receptors. Sequences flanking these motifs may determine the precise nuclear hormone receptor specificity (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1878, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4KKX4

KEGG Orthology (KO)

More...
KOi
K04650

Database of Orthologous Groups

More...
OrthoDBi
12227at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167, SANT, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR031557, N-CoR_GPS2_interact
IPR001005, SANT/Myb
IPR017884, SANT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15784, GPS2_interact, 1 hit
PF00249, Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51293, SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

Q4KKX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSGYPPNQ GAFSTEQGRY SSHPVQYTFP SSRHQQEFPV PEYRSSHLEA
60 70 80 90 100
SQLLQQQQLR RRPSLLSEFH PVSDRPQDRR QGYEQQYHSV TQNEHEALES
110 120 130 140 150
KRPRLDVSDS HYRVGAASVV PLVPTIQEGV RVQSEVKKEQ GLPSKHETTS
160 170 180 190 200
SPLSGQPGEE QEASPSKLSK EELIQSMDRV DREIAKVEQQ ILKLKKKQQQ
210 220 230 240 250
LEEEAAKPPE PEKPVSPPPV EQKHRSIVQI IYDENRKKAE EAHKILEGLG
260 270 280 290 300
PKVELPLYNQ PSDTKVYHEN IKTNQVMRKK LILFFKRRNH ARKLREQNIC
310 320 330 340 350
QRYDQLMEAW EKKVDRIENN PRRKAKESKT REYYEKQFPE IRKQREQQER
360 370 380 390 400
FQRVGQRGAG LSATIARSEH EISEIIDGLS EQENNEKQMR QLSVIPPMMF
410 420 430 440 450
DAEQRRVKFI NMNGLMEDPM KVYKDRQFMN VWTDHEKEIF KEKFVQHPKN
460 470 480 490 500
FGLIASYLER KTVSDCVLYY YLTKKNENFK ALVRRNYPKR RGRNQQQITR
510 520 530 540 550
PAQEEKEIEK VEEEKAERND KKEEERREEE EKEEKEELRD GTKDRTDAIA
560 570 580 590 600
EDGEDKEQST PRGRKTANSQ GRRKGRITRS MASEAAAAAN AASTATTAPA
610 620 630 640 650
TTTSTTATTT TAALVPVAPP PEEPTPPPTQ EQSLVEHGRN WGAIAKMVGS
660 670 680 690 700
KSESQCKNFY FNYKRRHNLD NLLQQHKQKS SRRPREERDV SQCESVASTV
710 720 730 740 750
SAQEDEENEA SNEEENAEDS EGAENSSDTE SAPSPSPAEA AKLGDDAVDR
760 770 780 790 800
TTSSVSIEAP PEQDAASKSV SDSSPTPTVE NIKPPETQYT ELKVKEEIST
810 820 830 840 850
ETEEAMEVEE RSQGAEIKST LSLPVQTKAE PDEVESKPSE SAEVKIEEDT
860 870 880 890 900
KDQDMERLMD RAEATDMVYA PPLHISRGRQ ESQSDNDSSA TCSADEEVDG
910 920 930 940 950
EPERPRIYTL DSKPSLLNPA GTILISSSMK QGPMDLQQLQ HRAAVIPPMA
960 970 980 990 1000
SCSPCNITTG TSNFSMYQRH LYENNLLEEQ RQRQEQLSLE SRMSASPGNM
1010 1020 1030 1040 1050
SKSPNMDWEG KSVYMPYTEV KRAFEHEAQM QNVARSVSPY RLSPREVSRA
1060 1070 1080 1090 1100
SPQVDMNPAR YCVPPVLQPA PHQVITSLSD GARLPVTRPT RPPPPLIPSS
1110 1120 1130 1140 1150
KTSATSSDKP SFITGGSISQ GTPGTYLTSL SQSYSQETVK PSVGSISLGL
1160 1170 1180 1190 1200
PRQQESAKTG SVTYIKQEEF SPRGQSSQPE GLLVRAQHEG VVRGTMTAIQ
1210 1220 1230 1240 1250
EGSITRGTPA TKVPIEAVST LRGSITQGTP ALSQSGIAAD VLLKTTITRL
1260 1270 1280 1290 1300
ATEDIGSPER CRDETSAKGH VIYEGKSGHI VSYDTAIKNM REGTRSPRTA
1310 1320 1330 1340 1350
PEVTLKRTFD TMEGNIKQAM SVREAAVSGP MEGLICRTLP KGSTHAEIKD
1360 1370 1380 1390 1400
RQVLSGSIMK GTPRTTSDSF EDGLKYAKQI KLESPPIRSF EGAISKGKPY
1410 1420 1430 1440 1450
ECVTTIKEMG RSIHEIPRQD LGSQESRKTP ESSRQIIEGS ISQGTPIKYE
1460 1470 1480 1490 1500
GTSGQSAIKH NVKSLITGPS NLSRGLPQME VMPENLKMGE RSKYEDTKSS
1510 1520 1530 1540 1550
EAIRSRHTSV VSSGPSVLRS TLHEASKSQL SPGVYEDNNA RRTPVNYPSP
1560 1570 1580 1590 1600
MSRSSPMARS AEVGLTPGKS SSHERKSTLT PTQRENIVVK SPVPGVDPTA
1610 1620 1630 1640 1650
AHSPFDPHLR GAPPGDVYRT HLPPHLDPAL QFHRPLDPAA AAAYLFQRQL
1660 1670 1680 1690 1700
SPTPGYPSQY QLYAMENTRQ TILNDYITSQ QMQVNLRPDV ARGLSPRDQG
1710 1720 1730 1740 1750
LAIPYPGARG IIDLTNMPPA ILVPHPGGTS TPPMDRITYI PGTQLAFPPR
1760 1770 1780 1790 1800
PYNPASMSPG HPTHLAAANS VSAERERERE RDRERDRERE KEQRERERDR
1810 1820 1830 1840 1850
ERERERLAAA PSDHYLRPVS EQPGRPGSHG FVRSPSPSVR AQESIMQQRP
1860 1870 1880 1890 1900
SIFQGTNGKS VITPLDAAQL RIMPPTPGAA SITQGIPASR YSTAADALAA
1910 1920 1930 1940 1950
LVDAAASAPQ MEVVKPKEMK HDPARSEESL SRRNVLEQQQ QQQQIDCERR
1960 1970 1980 1990 2000
VMQSPYTSSS FSGSKSQGQP SPAVYSEAGK EKTAHTKSRY VEELRMRGKT
2010 2020 2030 2040 2050
TITAANFIDV IITQQIASDK DGRDRNSQSS DSSSSHSSHR YDAPRDTIEV
2060 2070 2080 2090 2100
ISPANSPVQE KESYPPEIPK SSQTESESSR KYEGQPNRYR QQQESPSPQQ
2110 2120 2130 2140 2150
TIPGHVPQTH RLITLADHIC QIITQDFARN QPVNQALQQP PASTFQSTNP
2160 2170 2180 2190 2200
SSTPVRTKAS SRFSPESQVQ PVHNQRPASR VSPENVLDRP RGRPGKSPDR
2210 2220 2230 2240 2250
GHISEPYEPI SPPQAPLLHA KQDSMLLLSQ RQEPPEQRND SRSPGNISYL
2260 2270 2280 2290 2300
PSFFTKLENT SPMVMYKKQE IFRKLNSSGG GDSEMAAAQP GTEIFNLPAV
2310 2320 2330 2340 2350
TTSGAISSRG HSFADPASNL GLEDIIRKAL MGNFDDKSED HSVLVGVAQG
2360 2370 2380 2390 2400
NPSGTQNSEA RREEANPSPN SGGGTHKQKL ISKYGSRKTK SPISGSQTYL
2410 2420 2430 2440 2450
GAERPSSVSS VHSEGDYRQA SAWAWEDRPS STGSTQFPYN PLTMGMLNST
2460 2470 2480 2490
PPSSMSCAPT SMTQTSAHQQ SRIWEREPAP LLSEQYETLS DSDE
Length:2,494
Mass (Da):277,212
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E862943961012FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6X1Z0F6X1Z0_XENTR
Negative elongation factor E
ncor1 nelfe
338Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CQC9F7CQC9_XENTR
HAUS augmin-like complex subunit 1
nelfe haus1
156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XL77F6XL77_XENTR
StAR-related lipid transfer domain-...
stard4
643Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8QI43A0A6I8QI43_XENTR
Negative elongation factor E
nelfe
350Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5S6LYI0A0A5S6LYI0_XENTR
Leucine-rich repeat-containing prot...
lrrc40 ncor1
2,335Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6X1W5F6X1W5_XENTR
Nuclear receptor corepressor 1
stard4 ncor1
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8R6Z8A0A6I8R6Z8_XENTR
Nuclear receptor corepressor 1
ncor1
2,352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8RCY8A0A6I8RCY8_XENTR
Nuclear receptor corepressor 1
ncor1
2,369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8S9M9A0A6I8S9M9_XENTR
Nuclear receptor corepressor 1
ncor1
2,350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8RDF5A0A6I8RDF5_XENTR
Nuclear receptor corepressor 1
ncor1
2,253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC099620 mRNA Translation: AAH99620.1

NCBI Reference Sequences

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RefSeqi
NP_001027513.1, NM_001032342.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
613105

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
xtr:613105

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099620 mRNA Translation: AAH99620.1
RefSeqiNP_001027513.1, NM_001032342.1

3D structure databases

SMRiQ4KKX4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000014702

Proteomic databases

PaxDbiQ4KKX4
PRIDEiQ4KKX4

Genome annotation databases

GeneIDi613105
KEGGixtr:613105

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9611
XenbaseiXB-GENE-483288, ncor1

Phylogenomic databases

eggNOGiKOG1878, Eukaryota
InParanoidiQ4KKX4
KOiK04650
OrthoDBi12227at2759

Enzyme and pathway databases

ReactomeiR-XTR-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-XTR-3214815, HDACs deacetylate histones
R-XTR-350054, Notch-HLH transcription pathway
R-XTR-383280, Nuclear Receptor transcription pathway
R-XTR-400206, Regulation of lipid metabolism by PPARalpha
R-XTR-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-XTR-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

Family and domain databases

CDDicd00167, SANT, 2 hits
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR031557, N-CoR_GPS2_interact
IPR001005, SANT/Myb
IPR017884, SANT_dom
PfamiView protein in Pfam
PF15784, GPS2_interact, 1 hit
PF00249, Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717, SANT, 2 hits
SUPFAMiSSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293, SANT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOR1_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4KKX4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: October 7, 2020
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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