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Protein

Histidinol-phosphate aminotransferase

Gene

hisC

Organism
Corynebacterium jeikeium (strain K411)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferaseUniRule annotation (EC:2.6.1.9UniRule annotation)
Alternative name(s):
Imidazole acetol-phosphate transaminaseUniRule annotation
Gene namesi
Name:hisCUniRule annotation
Ordered Locus Names:jk0787
OrganismiCorynebacterium jeikeium (strain K411)
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000545 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001533511 – 373Histidinol-phosphate aminotransferaseAdd BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei234N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi306537.jk0787

Structurei

3D structure databases

ProteinModelPortaliQ4JW58
SMRiQ4JW58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiTYGMYKV
OrthoDBiPOG091H05S1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit

Sequencei

Sequence statusi: Complete.

Q4JW58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEQNNQISL ADLPLREELR GKSAYGAPQL SVANQLNTNE NPYPPSPEIV
60 70 80 90 100
EGIARRVAEL GKQLNRYPDR DAVGLREALA AYVSQQTGVG VTKEQVWAAN
110 120 130 140 150
GSNEVLQQLL QAFGGPGRSA MGFVPSYSMH PILAAGTQTE FVTVERRAEN
160 170 180 190 200
RFDIDVDEAL AAIDERQPNV IFITTPNNPT GNSTPLADIE RILQAAPGIV
210 220 230 240 250
IVDEAYAEFS DEPSAVGLLE QYPTKLVVSR TMSKAFDFAG GRLGYFVAHP
260 270 280 290 300
AFIEAVMLVR LPYHLATLSQ AAAEVALEHS AATLQTVAKL RQERDRVVAR
310 320 330 340 350
LRELGYDVID SHSNFVFFGG FAHVGDSAAV WQRFLDQEVL IRDVGVAGWL
360 370
RATIGLPEEN DAFLAAAAKM MDD
Length:373
Mass (Da):40,621
Last modified:August 2, 2005 - v1
Checksum:iF2A7C3052AB2F737
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA Translation: CAI36949.1
RefSeqiWP_011273392.1, NC_007164.1

Genome annotation databases

EnsemblBacteriaiCAI36949; CAI36949; jk0787
GeneIDi3433178
KEGGicjk:jk0787
PATRICifig|306537.10.peg.796

Similar proteinsi

Entry informationi

Entry nameiHIS8_CORJK
AccessioniPrimary (citable) accession number: Q4JW58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 2, 2005
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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