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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Corynebacterium jeikeium (strain K411)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei615For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationSAAS annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotationImported
Ordered Locus Names:jk1735Imported
OrganismiCorynebacterium jeikeium (strain K411)Imported
Taxonomic identifieri306537 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000545 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi306537.jk1735

Structurei

3D structure databases

ProteinModelPortaliQ4JTE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 225Glutamine amidotransferase type-2InterPro annotationAdd BLAST224
Domaini291 – 431SISInterPro annotationAdd BLAST141
Domaini464 – 609SISInterPro annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili44 – 64Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4JTE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCAIVGYVGN SEALQIGLDA LERMEYRGYD SAGIAVVEQG SLHLEKKEGK
60 70 80 90 100
LQNLIDRIDE VGRDSFLGTA CIGHTRWATH GRPNDVNAHP HRSFDGKAAI
110 120 130 140 150
VHNGIIENFS TLRAEIEAAG IELESETDSE VAAHLLALAY NEGETAGDFQ
160 170 180 190 200
ASALKVLSRL DGAFTVLFVH DDHPGTIVAG RRSTPLIVGV GEGEMFLGSD
210 220 230 240 250
VAAFIDRTKN AVELGQDNAV VITADSYDIY DFDGNPVEGK PFTIDWDLDA
260 270 280 290 300
AQKDGFDSFM MKEIHEQPAA VRDTLAGHFD GRRIVLDEQR LSDEDLRGVE
310 320 330 340 350
KVFVVACGSA YHSGLLAKYA IEHWVRLPVE IEVASEFRYR DPVLDQRTLV
360 370 380 390 400
VAVSQSGETA DTLEAVRHAK MQGARVLAVC NTNGSQIPRE SDAVLYTHAG
410 420 430 440 450
PEIGVASTKA FLAQVAANYL VGLALAQARG TKYADEIAEI YYALEALPEK
460 470 480 490 500
IEKTLGLRDQ ILQLAEELGP VKTMLFLGRH VGFPVALEGA LKLKELAYIH
510 520 530 540 550
AEGFAAGELK HGPIALIEDD LPVVVVVPSP NGRPVLHSKI VSNIQEIRAR
560 570 580 590 600
GAKTIVIAEE GDEAVRPYAN WLLEIPGTTS LMQPLLSTVP LQFLAADIAR
610 620
QCGNEDIDKP RNLAKSVTVE
Length:620
Mass (Da):67,249
Last modified:August 2, 2005 - v1
Checksum:i44285D252952DAAA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA Translation: CAI37912.1
RefSeqiWP_005291824.1, NC_007164.1

Genome annotation databases

EnsemblBacteriaiCAI37912; CAI37912; jk1735
GeneIDi3433840
KEGGicjk:jk1735
PATRICifig|306537.10.peg.1757

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR931997 Genomic DNA Translation: CAI37912.1
RefSeqiWP_005291824.1, NC_007164.1

3D structure databases

ProteinModelPortaliQ4JTE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306537.jk1735

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI37912; CAI37912; jk1735
GeneIDi3433840
KEGGicjk:jk1735
PATRICifig|306537.10.peg.1757

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA
OrthoDBiPOG091H0061

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ4JTE5_CORJK
AccessioniPrimary (citable) accession number: Q4JTE5
Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: December 20, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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