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Entry version 103 (13 Feb 2019)
Sequence version 3 (16 Jun 2009)
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Protein

Methylcytosine dioxygenase TET2

Gene

Tet2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.6 Publications

Caution

Subsequent steps in cytosine demethylation are subject to discussion. According to a first model cytosine demethylation occurs through deamination of 5hmC into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. According to another model, cytosine demethylation is rather mediated via conversion of 5hmC into 5fC and 5caC, followed by excision by TDG (PubMed:21817016).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1048Zinc 1By similarity1
Metal bindingi1106Zinc 2By similarity1
Metal bindingi1132Zinc 1; via pros nitrogenBy similarity1
Metal bindingi1134Zinc 1By similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei11742-oxoglutarateBy similarity1
Metal bindingi1184Zinc 2By similarity1
Metal bindingi1186Zinc 2By similarity1
Metal bindingi1202Zinc 3By similarity1
Metal bindingi1211Zinc 3By similarity1
Metal bindingi1271Zinc 3By similarity1
Binding sitei12872-oxoglutarateBy similarity1
Metal bindingi1293Zinc 2; via tele nitrogenBy similarity1
Metal bindingi1295Iron; catalyticBy similarity1
Metal bindingi1297Iron; catalyticBy similarity1
Binding sitei1300SubstrateBy similarity1
Binding sitei13292-oxoglutarateBy similarity1
Metal bindingi1795Iron; catalyticBy similarity1
Metal bindingi1826Zinc 3; via pros nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • ferrous iron binding Source: UniProtKB
  • iron ion binding Source: GO_Central
  • methylcytosine dioxygenase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Dioxygenase, DNA-binding, Oxidoreductase
Biological processCell cycle
LigandIron, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylcytosine dioxygenase TET2 (EC:1.14.11.n24 Publications)
Alternative name(s):
Protein Ayu17-449
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tet2
Synonyms:Kiaa1546
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443298 Tet2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile but develop chronic myelomonocytic leukemia probably caused by dysregulation of hematopoietic stem cells. Mice lacking both Tet1 and Tet2 are fertile, with females having smaller ovaries and reduced fertility. They display decreased 5-hydroxymethylcytosine (5hmC) and abnormal methylation at various imprinted loci. Embryonic stem cells lacking both Tet1 and Tet2 remain pluripotent but lack 5hmC, leading to developmental defects in chimeric embryos.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1204W → R: Impairs enzyme activity. 1 Publication1
Mutagenesisi1280P → S: Impairs enzyme activity. 1 Publication1
Mutagenesisi1295H → Y: Loss of enzyme activity; when associated with A-1297. 3 Publications1
Mutagenesisi1297D → A: Loss of enzyme activity; when associated with Y-1295. 3 Publications1
Mutagenesisi1795H → R or Q: Loss of enzyme activity. 1 Publication1
Mutagenesisi1810R → S or M: Impairs enzyme activity. 1 Publication1
Mutagenesisi1827C → D: Impairs enzyme activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003245891 – 1912Methylcytosine dioxygenase TET2Add BLAST1912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei76PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei1036PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be glycosylated. It is unclear whether interaction with OGT leads to GlcNAcylation. According to a report, it is GlcNAcylated by OGT (PubMed:23352454). In contrast, another group reports no GlcNAcylation by OGT in human ortholog.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4JK59

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4JK59

PeptideAtlas

More...
PeptideAtlasi
Q4JK59

PRoteomics IDEntifications database

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PRIDEi
Q4JK59

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4JK59

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q4JK59

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q4JK59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the brain, kidney, heart, lung, muscle and stomach. Present in embryonic stem cells (ES cells).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040943 Expressed in 229 organ(s), highest expression level in pineal body

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q4JK59 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q4JK59 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HCFC1 (By similarity). Interacts with OGT.By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
229496, 10 interactors

Protein interaction database and analysis system

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IntActi
Q4JK59, 2 interactors

Molecular INTeraction database

More...
MINTi
Q4JK59

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000096203

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q4JK59

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q4JK59

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1203 – 1216Interaction with DNABy similarityAdd BLAST14
Regioni1810 – 18122-oxoglutarate bindingBy similarity3
Regioni1816 – 1818Substrate bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi576 – 921Gln-richAdd BLAST346
Compositional biasi1364 – 1367Poly-Arg4
Compositional biasi1426 – 1475Gln-richAdd BLAST50
Compositional biasi1694 – 1699Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TET family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE22 Eukaryota
ENOG410XPWW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160003

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168510

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108562

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4JK59

Database of Orthologous Groups

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OrthoDBi
29059at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q4JK59

TreeFam database of animal gene trees

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TreeFami
TF337563

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024779 2OGFeDO_noxygenase_dom
IPR040175 TET1/2/3

The PANTHER Classification System

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PANTHERi
PTHR23358 PTHR23358, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12851 Tet_JBP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01333 Tet_JBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4JK59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQDRTTHAE GTRLSPFLIA PPSPISHTEP LAVKLQNGSP LAERPHPEVN
60 70 80 90 100
GDTKWQSSQS CYGISHMKGS QSSHESPHED RGYSRCLQNG GIKRTVSEPS
110 120 130 140 150
LSGLHPNKIL KLDQKAKGES NIFEESQERN HGKSSRQPNV SGLSDNGEPV
160 170 180 190 200
TSTTQESSGA DAFPTRNYNG VEIQVLNEQE GEKGRSVTLL KNKIVLMPNG
210 220 230 240 250
ATVSAHSEEN TRGELLEKTQ CYPDCVSIAV QSTASHVNTP SSQAAIELSH
260 270 280 290 300
EIPQPSLTSA QINFSQTSSL QLPPEPAAMV TKACDADNAS KPAIVPGTCP
310 320 330 340 350
FQKAEHQQKS ALDIGPSRAE NKTIQGSMEL FAEEYYPSSD RNLQASHGSS
360 370 380 390 400
EQYSKQKETN GAYFRQSSKF PKDSISPTTV TPPSQSLLAP RLVLQPPLEG
410 420 430 440 450
KGALNDVALE EHHDYPNRSN RTLLREGKID HQPKTSSSQS LNPSVHTPNP
460 470 480 490 500
PLMLPEQHQN DCGSPSPEKS RKMSEYLMYY LPNHGHSGGL QEHSQYLMGH
510 520 530 540 550
REQEIPKDAN GKQTQGSVQA APGWIELKAP NLHEALHQTK RKDISLHSVL
560 570 580 590 600
HSQTGPVNQM SSKQSTGNVN MPGGFQRLPY LQKTAQPEQK AQMYQVQVNQ
610 620 630 640 650
GPSPGMGDQH LQFQKALYQE CIPRTDPSSE AHPQAPSVPQ YHFQQRVNPS
660 670 680 690 700
SDKHLSQQAT ETQRLSGFLQ HTPQTQASQT PASQNSNFPQ ICQQQQQQQL
710 720 730 740 750
QRKNKEQMPQ TFSHLQGSND KQREGSCFGQ IKVEESFCVG NQYSKSSNFQ
760 770 780 790 800
THNNTQGGLE QVQNINKNFP YSKILTPNSS NLQILPSNDT HPACEREQAL
810 820 830 840 850
HPVGSKTSNL QNMQYFPNNV TPNQDVHRCF QEQAQKPQQA SSLQGLKDRS
860 870 880 890 900
QGESPAPPAE AAQQRYLVHN EAKALPVPEQ GGSQTQTPPQ KDTQKHAALR
910 920 930 940 950
WLLLQKQEQQ QTQQSQPGHN QMLRPIKTEP VSKPSSYRYP LSPPQENMSS
960 970 980 990 1000
RIKQEISSPS RDNGQPKSII ETMEQHLKQF QLKSLCDYKA LTLKSQKHVK
1010 1020 1030 1040 1050
VPTDIQAAES ENHARAAEPQ ATKSTDCSVL DDVSESDTPG EQSQNGKCEG
1060 1070 1080 1090 1100
CNPDKDEAPY YTHLGAGPDV AAIRTLMEER YGEKGKAIRI EKVIYTGKEG
1110 1120 1130 1140 1150
KSSQGCPIAK WVYRRSSEEE KLLCLVRVRP NHTCETAVMV IAIMLWDGIP
1160 1170 1180 1190 1200
KLLASELYSE LTDILGKCGI CTNRRCSQNE TRNCCCQGEN PETCGASFSF
1210 1220 1230 1240 1250
GCSWSMYYNG CKFARSKKPR KFRLHGAEPK EEERLGSHLQ NLATVIAPIY
1260 1270 1280 1290 1300
KKLAPDAYNN QVEFEHQAPD CCLGLKEGRP FSGVTACLDF SAHSHRDQQN
1310 1320 1330 1340 1350
MPNGSTVVVT LNREDNREVG AKPEDEQFHV LPMYIIAPED EFGSTEGQEK
1360 1370 1380 1390 1400
KIRMGSIEVL QSFRRRRVIR IGELPKSCKK KAEPKKAKTK KAARKRSSLE
1410 1420 1430 1440 1450
NCSSRTEKGK SSSHTKLMEN ASHMKQMTAQ PQLSGPVIRQ PPTLQRHLQQ
1460 1470 1480 1490 1500
GQRPQQPQPP QPQPQTTPQP QPQPQHIMPG NSQSVGSHCS GSTSVYTRQP
1510 1520 1530 1540 1550
TPHSPYPSSA HTSDIYGDTN HVNFYPTSSH ASGSYLNPSN YMNPYLGLLN
1560 1570 1580 1590 1600
QNNQYAPFPY NGSVPVDNGS PFLGSYSPQA QSRDLHRYPN QDHLTNQNLP
1610 1620 1630 1640 1650
PIHTLHQQTF GDSPSKYLSY GNQNMQRDAF TTNSTLKPNV HHLATFSPYP
1660 1670 1680 1690 1700
TPKMDSHFMG AASRSPYSHP HTDYKTSEHH LPSHTIYSYT AAASGSSSSH
1710 1720 1730 1740 1750
AFHNKENDNI ANGLSRVLPG FNHDRTASAQ ELLYSLTGSS QEKQPEVSGQ
1760 1770 1780 1790 1800
DAAAVQEIEY WSDSEHNFQD PCIGGVAIAP THGSILIECA KCEVHATTKV
1810 1820 1830 1840 1850
NDPDRNHPTR ISLVLYRHKN LFLPKHCLAL WEAKMAEKAR KEEECGKNGS
1860 1870 1880 1890 1900
DHVSQKNHGK QEKREPTGPQ EPSYLRFIQS LAENTGSVTT DSTVTTSPYA
1910
FTQVTGPYNT FV
Length:1,912
Mass (Da):212,130
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF49DEE206CD05670
GO
Isoform 2 (identifier: Q4JK59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1300: Missing.

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):68,060
Checksum:i09D5192CD8860AF5
GO
Isoform 3 (identifier: Q4JK59-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1332: Missing.

Note: No experimental confirmation available.
Show »
Length:580
Mass (Da):64,499
Checksum:i4B40A59555161AE5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JF55A0A0G2JF55_MOUSE
Methylcytosine dioxygenase TET2
Tet2
1,920Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JG87A0A0G2JG87_MOUSE
Methylcytosine dioxygenase TET2
Tet2
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JGM1A0A0G2JGM1_MOUSE
Methylcytosine dioxygenase TET2
Tet2
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY90126 differs from that shown. Reason: Frameshift at positions 1143 and 1182.Curated
The sequence BAC98199 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE30334 differs from that shown. Reason: Frameshift at positions 1749 and 1760.Curated
The sequence BAE30334 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE31106 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE31842 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE31892 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAE32012 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1225H → R in AAY90126 (PubMed:16722336).Curated1
Sequence conflicti1626Q → R in BAE32012 (PubMed:16141072).Curated1
Sequence conflicti1626Q → R in BAE31842 (PubMed:16141072).Curated1
Sequence conflicti1736L → V in BAE30334 (PubMed:16141072).Curated1
Sequence conflicti1737T → A in BAE30334 (PubMed:16141072).Curated1
Sequence conflicti1743K → E in BAE30334 (PubMed:16141072).Curated1
Sequence conflicti1767N → T in BAE30334 (PubMed:16141072).Curated1
Sequence conflicti1772C → A in BAE30334 (PubMed:16141072).Curated1
Sequence conflicti1773I → F in BAE30334 (PubMed:16141072).Curated1
Sequence conflicti1795H → N in BAE30334 (PubMed:16141072).Curated1
Sequence conflicti1795H → N in BAE31106 (PubMed:16141072).Curated1
Sequence conflicti1795H → N in BAE31892 (PubMed:16141072).Curated1
Sequence conflicti1795H → N in BAE31842 (PubMed:16141072).Curated1
Sequence conflicti1795H → N in BAE32012 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0322861 – 1332Missing in isoform 3. 1 PublicationAdd BLAST1332
Alternative sequenceiVSP_0322871 – 1300Missing in isoform 2. 2 PublicationsAdd BLAST1300

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ079067 mRNA Translation: AAY90126.1 Frameshift.
AK129389 mRNA Translation: BAC98199.1 Different initiation.
BC031159 mRNA Translation: AAH31159.1
BC040785 mRNA Translation: AAH40785.1
AK151359 mRNA Translation: BAE30334.1 Sequence problems.
AK152297 mRNA Translation: BAE31106.1 Different initiation.
AK153251 mRNA Translation: BAE31842.1 Different initiation.
AK153311 mRNA Translation: BAE31892.1 Different initiation.
AK153460 mRNA Translation: BAE32012.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS51071.1 [Q4JK59-1]

NCBI Reference Sequences

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RefSeqi
NP_001035490.2, NM_001040400.2 [Q4JK59-1]
NP_001333665.1, NM_001346736.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.347816

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000098603; ENSMUSP00000096203; ENSMUSG00000040943 [Q4JK59-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
214133

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:214133

UCSC genome browser

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UCSCi
uc008rko.2 mouse [Q4JK59-2]
uc008rkp.2 mouse [Q4JK59-3]
uc008rkq.2 mouse [Q4JK59-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ079067 mRNA Translation: AAY90126.1 Frameshift.
AK129389 mRNA Translation: BAC98199.1 Different initiation.
BC031159 mRNA Translation: AAH31159.1
BC040785 mRNA Translation: AAH40785.1
AK151359 mRNA Translation: BAE30334.1 Sequence problems.
AK152297 mRNA Translation: BAE31106.1 Different initiation.
AK153251 mRNA Translation: BAE31842.1 Different initiation.
AK153311 mRNA Translation: BAE31892.1 Different initiation.
AK153460 mRNA Translation: BAE32012.1 Different initiation.
CCDSiCCDS51071.1 [Q4JK59-1]
RefSeqiNP_001035490.2, NM_001040400.2 [Q4JK59-1]
NP_001333665.1, NM_001346736.1
UniGeneiMm.347816

3D structure databases

ProteinModelPortaliQ4JK59
SMRiQ4JK59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229496, 10 interactors
IntActiQ4JK59, 2 interactors
MINTiQ4JK59
STRINGi10090.ENSMUSP00000096203

PTM databases

iPTMnetiQ4JK59
PhosphoSitePlusiQ4JK59
SwissPalmiQ4JK59

Proteomic databases

EPDiQ4JK59
PaxDbiQ4JK59
PeptideAtlasiQ4JK59
PRIDEiQ4JK59

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000098603; ENSMUSP00000096203; ENSMUSG00000040943 [Q4JK59-1]
GeneIDi214133
KEGGimmu:214133
UCSCiuc008rko.2 mouse [Q4JK59-2]
uc008rkp.2 mouse [Q4JK59-3]
uc008rkq.2 mouse [Q4JK59-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54790
MGIiMGI:2443298 Tet2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IE22 Eukaryota
ENOG410XPWW LUCA
GeneTreeiENSGT00940000160003
HOGENOMiHOG000168510
HOVERGENiHBG108562
InParanoidiQ4JK59
OrthoDBi29059at2759
PhylomeDBiQ4JK59
TreeFamiTF337563

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tet2 mouse

Protein Ontology

More...
PROi
PR:Q4JK59

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040943 Expressed in 229 organ(s), highest expression level in pineal body
ExpressionAtlasiQ4JK59 baseline and differential
GenevisibleiQ4JK59 MM

Family and domain databases

InterProiView protein in InterPro
IPR024779 2OGFeDO_noxygenase_dom
IPR040175 TET1/2/3
PANTHERiPTHR23358 PTHR23358, 1 hit
PfamiView protein in Pfam
PF12851 Tet_JBP, 1 hit
SMARTiView protein in SMART
SM01333 Tet_JBP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4JK59
Secondary accession number(s): Q3U5R5
, Q3U633, Q3UAI0, Q6ZPN2, Q8K2K3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 16, 2009
Last modified: February 13, 2019
This is version 103 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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