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UniProtKB - Q4JFN6 (Q4JFN6_MOUSE)

Entry version 129 (02 Dec 2020)
Sequence version 1 (02 Aug 2005)
Previous versions | rss
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Protein

NADH-ubiquinone oxidoreductase chain 1

Gene

mt-Nd1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported
Biological processTransportARBA annotation
LigandNADUniRule annotation, UbiquinoneUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 1UniRule annotation (EC:7.1.1.2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mt-Nd1Imported
Synonyms:ND1Imported, Nd1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrionImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:101787, mt-Nd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 23HelicalSequence analysisAdd BLAST18
Transmembranei64 – 86HelicalSequence analysisAdd BLAST23
Transmembranei98 – 119HelicalSequence analysisAdd BLAST22
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Transmembranei231 – 249HelicalSequence analysisAdd BLAST19
Transmembranei293 – 314HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, MitochondrionUniRule annotationImported

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000064341, Expressed in forelimb bud and 53 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I subunit 1 family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015134_0_1_1

Identification of Orthologs from Complete Genome Data

More...OMAi		WKNFLPL

Database of Orthologous Groups

More...OrthoDBi		1214989at2759

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_01350, NDH1_NuoH, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001694, NADH_UbQ_OxRdtase_su1/FPO
IPR018086, NADH_UbQ_OxRdtase_su1_CS

The PANTHER Classification System

More...PANTHERi		PTHR11432, PTHR11432, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00146, NADHdh, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00667, COMPLEX1_ND1_1, 1 hit
PS00668, COMPLEX1_ND1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4JFN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFINILTLL VPILIAMAFL TLVERKILGY MQLRKGPNIV GPYGILQPFA 
        60         70         80         90        100
DAMKLFMKEP MRPLTTSMSL FIIAPTLSLT LALSLWVPLP MPHPLINLNL 
       110        120        130        140        150
GILFILATSS LSVYSILWSG WASNSKYSLF GALRAVAQTI SYEVTMAIIL 
       160        170        180        190        200
LSVLLMNGSY SLQTLITTQE HMWLLLPAWP MAMMWFISTL AETNRAPFDL 
       210        220        230        240        250
TEGESELVSG FNVEYAAGPF ALFFMAEYTN IILMNALTTI IFLGPLYYIN 
       260        270        280        290        300
LPELYSTNFM MEALLLSSTF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL 
       310 
CMWHISLPIF TAGVPPYM
Length:318
Mass (Da):36,059
Last modified:August 2, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECFAB96696610024
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY466499 Genomic DNA Translation: AAR21195.1
AY999076 Genomic DNA Translation: AAX83012.1
DQ106412 Genomic DNA Translation: AAY96689.1
DQ106413 Genomic DNA Translation: AAY96702.1
EF108330 Genomic DNA Translation: ABK79093.1
EF108331 Genomic DNA Translation: ABK79106.1
EF108332 Genomic DNA Translation: ABK79119.1
EF108333 Genomic DNA Translation: ABK79132.1
EF108334 Genomic DNA Translation: ABK79145.1
EF108335 Genomic DNA Translation: ABK79158.1
EF108336 Genomic DNA Translation: ABK79171.1
EF108337 Genomic DNA Translation: ABK79184.1
EF108338 Genomic DNA Translation: ABK79197.1
EF108339 Genomic DNA Translation: ABK79210.1
EF108340 Genomic DNA Translation: ABK79223.1
EF108341 Genomic DNA Translation: ABK79236.1
EU312160 Genomic DNA Translation: ABX79702.1
EU312161 Genomic DNA Translation: ABX79715.1
EU315228 Genomic DNA Translation: ABX79728.1
EU315229 Genomic DNA Translation: ABX79741.1
EU450583 Genomic DNA Translation: ACA01523.1
FJ803909 Genomic DNA Translation: ACN91095.1
HQ586004 Genomic DNA Translation: ADR03156.1
HQ877407 Genomic DNA Translation: ADW83067.1
JF286601 Genomic DNA Translation: ADZ23167.1
HQ675026 Genomic DNA Translation: AEN03369.1
HQ675027 Genomic DNA Translation: AEN03382.1
HQ675028 Genomic DNA Translation: AEN03395.1
HQ675029 Genomic DNA Translation: AEN03408.1
HQ675031 Genomic DNA Translation: AEN03434.1
JQ003190 Genomic DNA Translation: AEV56597.1
KP090294 Genomic DNA Translation: AJE26556.1
KP260514 Genomic DNA Translation: AJK91486.1
KP260515 Genomic DNA Translation: AJK91499.1
KP260516 Genomic DNA Translation: AJK91512.1
KP260517 Genomic DNA Translation: AJK91525.1
KR020497 Genomic DNA Translation: AKS10712.1
KY018919 Genomic DNA Translation: ART65693.1
AP013030 Genomic DNA Translation: BAM93583.1
AP013031 Genomic DNA Translation: BAM93596.1
AP013054 Genomic DNA Translation: BAN16592.1
AP014540 Genomic DNA Translation: BAO42850.1
AP014541 Genomic DNA Translation: BAO42863.1
AP014941 Genomic DNA Translation: BAS29532.1
MN964117 Genomic DNA Translation: QKJ82476.1

NCBI Reference Sequences

More...RefSeqi		NP_904328.1, NC_005089.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		17716

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:17716

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466499 Genomic DNA Translation: AAR21195.1
AY999076 Genomic DNA Translation: AAX83012.1
DQ106412 Genomic DNA Translation: AAY96689.1
DQ106413 Genomic DNA Translation: AAY96702.1
EF108330 Genomic DNA Translation: ABK79093.1
EF108331 Genomic DNA Translation: ABK79106.1
EF108332 Genomic DNA Translation: ABK79119.1
EF108333 Genomic DNA Translation: ABK79132.1
EF108334 Genomic DNA Translation: ABK79145.1
EF108335 Genomic DNA Translation: ABK79158.1
EF108336 Genomic DNA Translation: ABK79171.1
EF108337 Genomic DNA Translation: ABK79184.1
EF108338 Genomic DNA Translation: ABK79197.1
EF108339 Genomic DNA Translation: ABK79210.1
EF108340 Genomic DNA Translation: ABK79223.1
EF108341 Genomic DNA Translation: ABK79236.1
EU312160 Genomic DNA Translation: ABX79702.1
EU312161 Genomic DNA Translation: ABX79715.1
EU315228 Genomic DNA Translation: ABX79728.1
EU315229 Genomic DNA Translation: ABX79741.1
EU450583 Genomic DNA Translation: ACA01523.1
FJ803909 Genomic DNA Translation: ACN91095.1
HQ586004 Genomic DNA Translation: ADR03156.1
HQ877407 Genomic DNA Translation: ADW83067.1
JF286601 Genomic DNA Translation: ADZ23167.1
HQ675026 Genomic DNA Translation: AEN03369.1
HQ675027 Genomic DNA Translation: AEN03382.1
HQ675028 Genomic DNA Translation: AEN03395.1
HQ675029 Genomic DNA Translation: AEN03408.1
HQ675031 Genomic DNA Translation: AEN03434.1
JQ003190 Genomic DNA Translation: AEV56597.1
KP090294 Genomic DNA Translation: AJE26556.1
KP260514 Genomic DNA Translation: AJK91486.1
KP260515 Genomic DNA Translation: AJK91499.1
KP260516 Genomic DNA Translation: AJK91512.1
KP260517 Genomic DNA Translation: AJK91525.1
KR020497 Genomic DNA Translation: AKS10712.1
KY018919 Genomic DNA Translation: ART65693.1
AP013030 Genomic DNA Translation: BAM93583.1
AP013031 Genomic DNA Translation: BAM93596.1
AP013054 Genomic DNA Translation: BAN16592.1
AP014540 Genomic DNA Translation: BAO42850.1
AP014541 Genomic DNA Translation: BAO42863.1
AP014941 Genomic DNA Translation: BAS29532.1
MN964117 Genomic DNA Translation: QKJ82476.1
RefSeqiNP_904328.1, NC_005089.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		35355, 213 antibodies

Genome annotation databases

GeneIDi17716
KEGGimmu:17716

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4535
MGIiMGI:101787, mt-Nd1

Phylogenomic databases

HOGENOMiCLU_015134_0_1_1
OMAiWKNFLPL
OrthoDBi1214989at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		mt-Nd1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000064341, Expressed in forelimb bud and 53 other tissues

Family and domain databases

HAMAPiMF_01350, NDH1_NuoH, 1 hit
InterProiView protein in InterPro
IPR001694, NADH_UbQ_OxRdtase_su1/FPO
IPR018086, NADH_UbQ_OxRdtase_su1_CS
PANTHERiPTHR11432, PTHR11432, 1 hit
PfamiView protein in Pfam
PF00146, NADHdh, 1 hit
PROSITEiView protein in PROSITE
PS00667, COMPLEX1_ND1_1, 1 hit
PS00668, COMPLEX1_ND1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4JFN6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4JFN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 2, 2005
Last sequence update: August 2, 2005
Last modified: December 2, 2020
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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