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Protein

Palmitoyltransferase AKR1

Gene

AKR1

Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Palmitoyltransferase specific for casein kinase 1.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei481S-palmitoyl cysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase AKR1 (EC:2.3.1.225)
Alternative name(s):
Ankyrin repeat-containing protein AKR1
Gene namesi
Name:AKR1
ORF Names:FGRRES_06542_M, FGSG_06542
OrganismiGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
Taxonomic identifieri229533 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusarium
Proteomesi
  • UP000070720 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:FGRAMPH1_01G22541

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 303CytoplasmicSequence analysisAdd BLAST303
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 326LumenalSequence analysis2
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Topological domaini348 – 364CytoplasmicSequence analysisAdd BLAST17
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 397LumenalSequence analysisAdd BLAST12
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 495CytoplasmicSequence analysisAdd BLAST77
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 547LumenalSequence analysisAdd BLAST31
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Topological domaini569 – 725CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129241 – 725Palmitoyltransferase AKR1Add BLAST725

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ4I8B6

Interactioni

Protein-protein interaction databases

STRINGi229533.XP_386718.1

Structurei

3D structure databases

ProteinModelPortaliQ4I8B6
SMRiQ4I8B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati84 – 113ANK 1Add BLAST30
Repeati118 – 147ANK 2Add BLAST30
Repeati151 – 180ANK 3Add BLAST30
Repeati184 – 213ANK 4Add BLAST30
Repeati217 – 246ANK 5Add BLAST30
Domaini451 – 501DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
InParanoidiQ4I8B6
KOiK20032
OrthoDBiEOG092C216R

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF01529 DHHC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q4I8B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTIAMASIN TTSTSGGSAA PIQMSGKANA ATPKLNSEVE MGSLPGDAQT
60 70 80 90 100
QEDDIMQVAR VGDVPAMEKL FESGEYDATY HDDEGITPLH WAAINNQYAM
110 120 130 140 150
CKFLIEHGAE INRKGGESIA TPLQWAAQRC HYYTVNLLLQ HGADPLVTDA
160 170 180 190 200
QGYNTLHIST FNGNVLLLVL LLHQGIPVDV IDTFGHTALM WAAYKGFPQC
210 220 230 240 250
VDLFLRWGAS VHATDEQGFT ALHWALVKGS PGCILKLIEY GADRFAKTQT
260 270 280 290 300
GKTPSVTAKE LNTEVAWHRA LTECGFDEDG HPAVPPWPGA SYFLKDKRSF
310 320 330 340 350
VTRFLFFWPF VLVWAMLVAM SSAPVYIGVP LGIAAVYAIQ WVAQQVLEYA
360 370 380 390 400
PSDMRHFHKT PWLTGIFAAT LFWTGVNWLT TVLFATTLGA PEGKGHGILN
410 420 430 440 450
FLFALFFGFT VYFYIASMRY DPGFVPKMNG IAEQKAVIDE LLAQWKYDET
460 470 480 490 500
NFCVTCMIQT PLRSKHCRRC QRCVAKHDHH CPWVYNCVGI NNHRHFFFYL
510 520 530 540 550
ISLTMGIVSY DFLLYYYFDT VSKNASETCN VLSPTLCKYI NADSYTSILA
560 570 580 590 600
IWITMQLLWV TMLLFTQFIQ VARAMTTYEN MFGIRDGTNI TALTSTGAPL
610 620 630 640 650
DPNHPSLSAT GPAAAHSHKH KGGMLKSLSR TLGVDPFIET ITGRGAVSGK
660 670 680 690 700
NKRKKKNPYS KGCITNCKDF WCDPAPIFGQ RENGSAVLGG ERVDYSAMYE
710 720
SPSLMTITGR RDRGGYEAVG TEDVV
Length:725
Mass (Da):80,316
Last modified:September 7, 2016 - v2
Checksum:i7218BD622651F67C
GO

Sequence cautioni

The sequence ESU12646 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231666 Genomic DNA Translation: ESU12646.1 Different initiation.
HG970335 Genomic DNA Translation: CEF83441.1
RefSeqiXP_011326153.1, XM_011327851.1

Genome annotation databases

GeneIDi23553671
KEGGifgr:FGSG_06542

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS231666 Genomic DNA Translation: ESU12646.1 Different initiation.
HG970335 Genomic DNA Translation: CEF83441.1
RefSeqiXP_011326153.1, XM_011327851.1

3D structure databases

ProteinModelPortaliQ4I8B6
SMRiQ4I8B6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi229533.XP_386718.1

Proteomic databases

PRIDEiQ4I8B6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23553671
KEGGifgr:FGSG_06542

Organism-specific databases

EuPathDBiFungiDB:FGRAMPH1_01G22541

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
InParanoidiQ4I8B6
KOiK20032
OrthoDBiEOG092C216R

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF01529 DHHC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAKR1_GIBZE
AccessioniPrimary (citable) accession number: Q4I8B6
Secondary accession number(s): A0A098DNJ1, A0A0E0SAH8, V6RE25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: September 7, 2016
Last modified: February 28, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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