Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neamine transaminase BtrB

Gene

btrB

Organism
Bacillus circulans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

6'-oxoglucosaminyl:L-glutamate aminotransferase that catalyzes pyridoxal-5'-phosphate-mediated transamination for the conversion of paromamine to neamine in the biosynthetic pathway of butirosin.1 Publication

Catalytic activityi

Neamine + 2-oxoglutarate = 6'-dehydroparomamine + L-glutamate.1 Publication

Cofactori

Pathwayi: butirosin biosynthesis

This protein is involved in the pathway butirosin biosynthesis, which is part of Antibiotic biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in the pathway butirosin biosynthesis and in Antibiotic biosynthesis.

GO - Molecular functioni

  • pyridoxal phosphate binding Source: InterPro
  • transaminase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAntibiotic biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-17279
UniPathwayi
UPA00964

Names & Taxonomyi

Protein namesi
Recommended name:
Neamine transaminase BtrB (EC:2.6.1.93)
Alternative name(s):
Butirosin biosynthesis protein B
Gene namesi
Name:btrB
OrganismiBacillus circulans
Taxonomic identifieri1397 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217341 – 432Neamine transaminase BtrBAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245N6-(pyridoxal phosphate)lysineBy similarity1

Structurei

3D structure databases

ProteinModelPortaliQ4H4F5
SMRiQ4H4F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK13553

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 2 hits
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q4H4F5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQETVKSSE QLLSVLGTYI DSPVDPFRKE RVMFSRGSGA YLFDYDGGNY
60 70 80 90 100
IDLMNGKGSI ILGHNDPSVN AALRNFLEQD REVVTGPSKP IIDLAERIKK
110 120 130 140 150
DSALPDAKVS FYTTGTAACR AAVYAARDYS GKKIVLSSGY HGWDPMWRQQ
160 170 180 190 200
GPLLEPNEDG VIEFYFIPEL LERALTAHKD QVALVIFSPD YTYLSASTME
210 220 230 240 250
RILGICRAHG VLVCCDDVKQ GYRHRQGSSL ELVTTEKADM YVFSKGLSNG
260 270 280 290 300
HRISCVVSSD EIMAETKEHT YTAYYQMLPI LSSLETLKKM ESGKGYDLIR
310 320 330 340 350
SYGQTLTGNL KELFVQSSLP IEVNGSSIFQ LVFGDEELEE AFYREAFIQG
360 370 380 390 400
LILFEGDNQS LSLCMDKDVQ VDLIRRFANV TDVLSEQFKH LRGKEVTTEQ
410 420 430
TFRTAWNMID GASDLLPYEK QLKLLDNLIG GG
Length:432
Mass (Da):48,380
Last modified:August 30, 2005 - v1
Checksum:i1EE9C0E9A7300F1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097196 Genomic DNA Translation: BAE07066.1
AJ781030 Genomic DNA Translation: CAG77420.1

Genome annotation databases

KEGGiag:BAE07066

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB097196 Genomic DNA Translation: BAE07066.1
AJ781030 Genomic DNA Translation: CAG77420.1

3D structure databases

ProteinModelPortaliQ4H4F5
SMRiQ4H4F5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:BAE07066

Phylogenomic databases

KOiK13553

Enzyme and pathway databases

UniPathwayi
UPA00964

BioCyciMetaCyc:MONOMER-17279

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 2 hits
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBTRB_BACCI
AccessioniPrimary (citable) accession number: Q4H4F5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again